The Cocoon Group

Members

Le Cocon is both a research team and a think tank. 

Research in “Le Cocon” team focuses on two main topics: multiscale evolution on one hand (i.e., studying the evolution of genetic systems while considering different levels -nucleotides, transposable elements, genes, genomes, microbiomes, organisms, populations, species, geography-), and environmental issues on the other hand. In both cases, we rely on modeling and data analysis, using a combination of statistics and computer science.

Le Cocon is also a place to think about the responsibilities of research and researchers in the anthropocene era, and about the role of non-researcher citizens in orienting and conducting research.

Multiscale evolution

  • We have a long history of working on gene transfers. We develop new methods to detect these events in complex systems involving more than two levels (host, symbiont and parasites for example) and
  • We use horizontal transfer detection to date species trees and to infer yet unknown biodiversity (extinct and unsampled) (Sthoriz (ANR, 2018)) .
  • We have a lasting interest into convergent genomic evolution (Convergenomics - ANR, 2015)
  • We question the usual way of testing bioinformatic methods (Evoluthon - ANR, 2019)
  • We study the interaction between human populations, their lifestyles, and their gut microbiota (Microregal - ANR, 2015). We are notably interested in identifying cases of host-microbe coevolution and in better understanding transmission dynamics.

Environmental issues

  • We develop computational methods to support an agriculture that relies on ecosystemic relationships between crops, the soil, its microbiota, and wild plants and animals (Community Garden Book - Inria, 2019)
  • We develop statistical approaches to understand and predict crop yield variability with respect to meteorological conditions

Research in the anthropocene

  • We participate to the science shop (UdL), the ethics platform (UdL), Labo1.5, the open science committee, Sciences Citoyennes, the shift project
  • We organize a series of seminars to help us think about the position of scientific research in the history of the anthropocene, and about the position of scientists in the future of the anthropocene.
  • We assemble committees of citizens to investigate to what extent scientific research can be democratized.

Teaching and outreach

  • We teach at University of Lyon, University Lyon 1, INSA, Inria, ENS Lyon, we organize bioinformatics internships 
  • We regularly participate in the Fête de la Science, have contributed videos in the public transportation system in Lyon, give conferences at Université Populaire and contribute articles in general public journals.
  • We develop the software Lifemap to explore the tree of life on computers and smartphones.

 
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.

Publications

Display of 61 to 90 publications on 309 in total

Global survey of mobile DNA horizontal transfer in arthropods reveals Lepidoptera as a prime hotspot

Daphné Reiss, Gladys Mialdea, Vincent Miele, Damien M. de Vienne, Jean Peccoud, Clément Gilbert...

PLoS Genetics . 15 ( 2 ) : e1007965

DOI: 10.1371/journal.pgen.1007965

Journal article

see the publication

L'arbre du vivant

Damien de Vienne

101 secrets de l'adn . 978-2-271-12323-7 : 358

Book chapter

see the publication

Zombi: A phylogenetic simulator of trees, genomes and sequences that accounts for dead lineages

Adrian A Davin, Theo Tricou, Eric Tannier, Damien M. de Vienne, Gergely J Szöllosi

Bioinformatics .

DOI: 10.1093/bioinformatics/btz710

Journal article

see the publication

Sciences, Environnements et Sociétés

Françoise Berthoud, Pascal Guitton, Laurent Lefèvre, Sophie Quinton, Antoine Rousseau, Jacques Sainte-Marie...

Report

see the publication

Tracing Human Ancestral Migrations Using Symbiotic Bacteria

Alexia Nguyen Trung, Bastien Boussau, Vincent Daubin

Groupe des Méthodes Pluridisciplinaires Contribuant à l'Archéologie (GMPCA) .

Conference paper

see the publication

Tanglegrams Are Misleading for Visual Evaluation of Tree Congruence

Damien M. de Vienne

Molecular Biology and Evolution . 36 ( 1 ) : 174-176

DOI: 10.1093/molbev/msy196

Journal article

see the publication

Gene tree reconciliation including transfers with replacement is NP-hard and FPT

Damir Hasic, Eric Tannier

Journal of Combinatorial Optimization . 38 ( 2 ) : 502–544

DOI: 10.1007/s10878-019-00396-z

Journal article

see the publication

Dynamic Interactions Between the Genome and an Endogenous Retrovirus: Tirant in Drosophila simulans Wild-Type Strains

Marie Fablet, Angelo Jacquet, Rita Rebollo, Annabelle A. Haudry, Carine Rey, Judit Salces-Ortiz...

G3 . 9 ( 3 ) : 855-865

DOI: 10.1534/g3.118.200789

Journal article

see the publication

GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes

Paulina Bolívar, Laurent Guéguen, Laurent Duret, Hans Ellegren, Carina Mugal

Genome Biology . 20 ( 1 )

DOI: 10.1186/s13059-018-1613-z

Journal article

see the publication

Detecting adaptive convergent amino acid evolution

Carine Rey, Vincent Lanore, Philippe Veber, Laurent Guéguen, Nicolas Lartillot, Marie Sémon...

Philosophical Transactions of the Royal Society B: Biological Sciences . 374 ( 1777 ) : 1-11

DOI: 10.1098/rstb.2018.0234

Journal article

see the publication

Gene transfers can date the tree of life

Adrián Davín, Eric Tannier, Tom A Williams, Bastien Boussau, Vincent Daubin, Gergely Szöllősi

Nature Ecology & Evolution . 2 ( 5 ) : 904-909

DOI: 10.1038/s41559-018-0525-3

Journal article

see the publication

Théorie des codes - 3e édition

Jean-Guillaume Dumas, Jean-Louis Roch, Eric Tannier, Sébastien Varrette

9782100781096 : 416

Book

see the publication

Coexistence of two sympatric cryptic bat species in French Guiana: insights from genetic, acoustic and ecological data

Ondine Filippi-Codaccioni, Marie-Pauline Beugin, Damien de Vienne, Elodie Portanier, David Fouchet, Cécile Kaerle...

BMC Evolutionary Biology . 18 ( 1 )

DOI: 10.1186/s12862-018-1289-8

Journal article

see the publication

Coexistence de deux espèces cryptiques de chauves-souris en Guyane française : apprentissages à partir de la génétique de l’acoustique et de l’écologie

Ondine Filippi-Codaccioni, Marie-Pauline Beugin, Damien M. de Vienne, Elodie Portanier, David Fouchet, Cécile Kaerle...

Plume de Naturalistes . 2 : 169-190

Journal article

see the publication

Co-occurrence among three divergent plant-castrating fungi in the same Silene host species

Jessica Lee Abbate, Pierre Gladieux, Michael E Hood, Damien de Vienne, Janis Antonovics, Alodie Snirc...

Molecular Ecology . 27 ( 16 ) : 3357 - 3370

DOI: 10.1111/mec.14805

Journal article

see the publication

Gearing up to handle the mosaic nature of life in the quest for orthologs

Kristoffer Forslund, Cécile Pereira, Salvador Capella-Gutiérrez, Alan Sousa da Silva, Adrian M Altenhoff, Jaime Huerta-Cepas...

Bioinformatics . 34 ( 2 ) : 323-329

DOI: 10.1093/bioinformatics/btx542

Journal article

see the publication

Unbiased Estimate of Synonymous and Nonsynonymous Substitution Rates with Nonstationary Base Composition

Laurent Guéguen, Laurent Duret

Molecular Biology and Evolution . 35 ( 3 ) : 734-742

DOI: 10.1093/molbev/msx308

Journal article

see the publication

RecPhyloXML: a format for reconciled gene trees

Wandrille Duchemin, Guillaume Gence, Anne-Muriel Arigon Chifolleau, Lars Arvestad, Mukul Bansal, Vincent Berry...

Bioinformatics . 34 ( 21 ) : 3646-3652

DOI: 10.1093/bioinformatics/bty389

Journal article

see the publication

Overtraining often results in topologically incorrect species trees with maximum likelihood methods

Damien M. de Vienne, Fran Supek, Toni Gabaldon

DOI: 10.1101/140780

Preprint

see the publication

Multiple convergent supergene evolution events in mating-type chromosomes

Sara E Branco, Fantin E Carpentier, Ricardo Rodriguez de La Vega, Hélène Badouin, Alodie Snirc, Stéphanie Le Prieur...

Nature Communications . 9 ( 1 ) : 2000

DOI: 10.1038/s41467-018-04380-9

Journal article

see the publication

Tanglegrams are misleading for visual evaluation of tree congruence

Damien M. de Vienne

Preprint

see the publication

Phylogenetic signal from rearrangements in 18 Anopheles species by joint scaffolding extant and ancestral genomes

Yoann Anselmetti, Wandrille Duchemin, Eric Tannier, Cedric Chauve, Sèverine Bérard

BMC Genomics . 19 ( S2 ) : 1-15

DOI: 10.1186/s12864-018-4466-7

Journal article

see the publication

Helena and BS: two travellers between the genera Drosophila and Zaprionus

M C Simão, Annabelle A. Haudry, A Granzotto, N de Setta, C M A Carareto

Genome Biology and Evolution .

DOI: 10.1093/gbe/evy184

Journal article

see the publication

Life History Traits Impact the Nuclear Rate of Substitution but Not the Mitochondrial Rate in Isopods

Nathanaëlle Saclier, Clémentine François, Lara Konecny-Dupré, Nicolas Lartillot, Laurent Guéguen, L. Duret...

Molecular Biology and Evolution . 35 ( 12 ) : 2900-2912

DOI: 10.1093/molbev/msy184

Journal article

see the publication

Biodiversité, évolution et fonctionnement des écosystèmes

Isabelle Arzul, Salvador Bailon, David Bass, Pierre Boudry, Philippe Béarez, Elodie Blanchard...

Les Cahiers des prospectives . hors série : 25-33.

Book chapter

see the publication

MareyMap online: A user-friendly web application and database service for estimating recombination rates using physical and genetic maps

Aurélie Siberchicot, Adrien Bessy, Laurent Gueguen, Gabriel A. B. Marais

Genome Biology and Evolution . 9 ( 10 ) : 2506-2509

DOI: 10.1093/gbe/evx178

Journal article

see the publication

Pitfalls in supermatrix phylogenomics

Herve Philippe, Damien M. de Vienne, Vincent Ranwez, Béatrice Roure, Denis Baurain, Frédéric Delsuc

European Journal of Taxonomy . 283 : 1-25

DOI: 10.5852/ejt.2017.283

Journal article

see the publication