The Cocoon Group

Members

Le Cocon is both a research team and a think tank. 

Research in “Le Cocon” team focuses on two main topics: multiscale evolution on one hand (i.e., studying the evolution of genetic systems while considering different levels -nucleotides, transposable elements, genes, genomes, microbiomes, organisms, populations, species, geography-), and environmental issues on the other hand. In both cases, we rely on modeling and data analysis, using a combination of statistics and computer science.

Le Cocon is also a place to think about the responsibilities of research and researchers in the anthropocene era, and about the role of non-researcher citizens in orienting and conducting research.

Multiscale evolution

  • We have a long history of working on gene transfers. We develop new methods to detect these events in complex systems involving more than two levels (host, symbiont and parasites for example) and
  • We use horizontal transfer detection to date species trees and to infer yet unknown biodiversity (extinct and unsampled) (Sthoriz (ANR, 2018)) .
  • We have a lasting interest into convergent genomic evolution (Convergenomics - ANR, 2015)
  • We question the usual way of testing bioinformatic methods (Evoluthon - ANR, 2019)
  • We study the interaction between human populations, their lifestyles, and their gut microbiota (Microregal - ANR, 2015). We are notably interested in identifying cases of host-microbe coevolution and in better understanding transmission dynamics.

Environmental issues

  • We develop computational methods to support an agriculture that relies on ecosystemic relationships between crops, the soil, its microbiota, and wild plants and animals (Community Garden Book - Inria, 2019)
  • We develop statistical approaches to understand and predict crop yield variability with respect to meteorological conditions

Research in the anthropocene

  • We participate to the science shop (UdL), the ethics platform (UdL), Labo1.5, the open science committee, Sciences Citoyennes, the shift project
  • We organize a series of seminars to help us think about the position of scientific research in the history of the anthropocene, and about the position of scientists in the future of the anthropocene.
  • We assemble committees of citizens to investigate to what extent scientific research can be democratized.

Teaching and outreach

  • We teach at University of Lyon, University Lyon 1, INSA, Inria, ENS Lyon, we organize bioinformatics internships 
  • We regularly participate in the Fête de la Science, have contributed videos in the public transportation system in Lyon, give conferences at Université Populaire and contribute articles in general public journals.
  • We develop the software Lifemap to explore the tree of life on computers and smartphones.

 
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.

Publications

Display of 91 to 120 publications on 309 in total

Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology

S. Pantalacci, Laurent Guéguen, C. Petit, A. Lambert, R. Peterkova, M. Sémon

Genome Biology . 18 : 29

DOI: 10.1186/s13059-017-1157-7

Journal article

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SONIFICATION OF PHYLOGENETIC TREES: LISTENING TO EVOLUTION

Henri Boutin, Damien de Vienne

Journées d'Informatique Musicale (JIM) 2017 .

Conference paper

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DeCoSTAR: Reconstructing the ancestral organization of genes or genomes using reconciled phylogenies

Wandrille Duchemin, Yoann Anselmetti, Murray Patterson, Yann Ponty, Sèverine Bérard, Cedric Chauve...

Genome Biology and Evolution . 9 ( 5 ) : 1312-1319

DOI: 10.1093/gbe/evx069

Journal article

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Algorithms for computing the double cut and join distance on both gene order and intergenic sizes

Guillaume Fertin, Géraldine Jean, Eric Tannier

Algorithms for Molecular Biology . 12 : 16 (11 pages)

DOI: 10.1186/s13015-017-0107-y

Journal article

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Resolution and reconciliation of non-binary gene trees with transfers, duplications and losses

Edwin Jacox, Mathias Weller, Eric Tannier, Celine Scornavacca

Bioinformatics . 33 ( 7 ) : 980-987

DOI: 10.1093/bioinformatics/btw778

Journal article

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Ecological networks to unravel the routes to horizontal transposon transfers

Samuel Venner, Vincent Miele, Christophe Terzian, Christian Biemont, Vincent Daubin, Cedric Feschotte...

PLoS Biology . 15 ( 2 ) : np

DOI: 10.1371/journal.pbio.2001536

Journal article

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Ancestral Genome Estimation Reveals the History of Ecological Diversification in Agrobacterium

Florent Lassalle, Rémi Planel, Simon Penel, David Chapulliot, Valérie Barbe, Audrey Dubost...

Genome Biology and Evolution . 9 ( 12 ) : 3413 - 3431

DOI: 10.1093/gbe/evx255

Journal article

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Comparative Methods for Reconstructing Ancient Genome Organization

Yoann Anselmetti, Nina Luhmann, Sèverine Bérard, Eric Tannier, Cedric Chauve

Comparative Genomics: Methods and Protocols . : 343 - 362

DOI: 10.1007/978-1-4939-7463-4_13

Book chapter

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MaxTiC: Fast Ranking Of A Phylogenetic Tree By Maximum Time Consistency With Lateral Gene Transfers

Cédric Chauve, Akbar A Rafiey, Adrian A Davin, Celine Scornavacca, Philippe Veber, Bastien Boussau...

DOI: 10.1101/127548

Other publication

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Integrative modeling of gene and genome evolution roots the archaeal tree of life

Tom Williams, Gergely Szöllősi, Anja Spang, Peter Foster, Sarah Heaps, Bastien Boussau...

Proceedings of the National Academy of Sciences of the United States of America . 114 ( 23 ) : E4602-E4611

DOI: 10.1073/pnas.1618463114

Journal article

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Less effective selection leads to larger genomes

Tristan Lefébure, Claire Morvan, Florian Malard, Clémentine François, Lara Konecny-Dupré, Laurent Guéguen...

Genome Research . 27 : 1016-1028

DOI: 10.1101/gr.212589.116

Journal article

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Dating with transfers

Adrián Davín, Gergely J Szöllosi, Eric Tannier, Bastien Boussau, Vincent Daubin

Journées Ouvertes Biologie Informatique Mathématiques .

Conference paper

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Nucleotide, gene and genome evolution : a score to bind them all

Wandrille Duchemin, Vincent Daubin, Eric Tannier

Journées Ouvertes Biologie Informatique Mathématiques .

Conference paper

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Genome Rearrangements on both Gene Order and Intergenic Regions

Guillaume Fertin, Géraldine Jean, Eric Tannier

WABI 2016 . 9838 : 162-173

Conference paper

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Francisella IglG protein and the DUF4280 proteins: PAAR-like proteins in non-canonical Type VI secretion systems?

Claire Lays, Eric Tannier, Thomas Henry

Microbial Cell . 3 ( 11 ) : 576-578

DOI: 10.15698/mic2016.11.543

Journal article

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Comment la reconstruction de génomes ancestraux peut aider à l'assemblage de génomes actuels

Yoann Anselmetti, Vincent Berry, Cedric Chauve, Annie Chateau, Eric Tannier, Sèverine Bérard

Journées Ouvertes Biologie Informatique Mathématiques .

Conference paper

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SENCA: A Multilayered Codon Model to Study the Origins and Dynamics of Codon Usage

F. Pouyet, M. Bailly-Bechet, Dominique Mouchiroud, Laurent Guéguen

Genome Biology and Evolution . 8 : 2427-41

DOI: 10.1093/gbe/evw165

Journal article

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Gene Acquisitions from Bacteria at the Origins of Major Archaeal Clades Are Vastly Overestimated

Mathieu Groussin, Bastien Boussau, Gergely J Szollosi, Laura Eme, Manolo Gouy, Céline Brochier-Armanet...

Molecular Biology and Evolution . 33 ( 2 ) : 305 - 310

DOI: 10.1093/molbev/msv249

Journal article

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Efficient gene tree correction guided by genome evolution

Emmanuel Noutahi, Magali Semeria, Manuel Lafond, Jonathan Seguin, Bastien Boussau, Laurent Guéguen...

PLoS ONE . 11 ( 8 ) : e0159559 (22 pages)

DOI: 10.1371/journal.pone.0159559

Journal article

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RiboDB database: a comprehensive resource for prokaryotic systematics

Frédéric Jauffrit, Simon Penel, Stéphane Delmotte, Carine Rey, Damien M de Vienne, Manolo Gouy...

Molecular Biology and Evolution . 33 ( 8 ) : 2170--2172

DOI: 10.1093/molbev/msw088

Journal article

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In silico experimental evolution provides independent and challenging benchmarks for comparative genomics

Priscila Biller, Eric Tannier, Guillaume Beslon, Carole Knibbe

Journées ouvertes Biologie Informatique Mathématiques . : 79-82

Conference paper

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Comparative Genomics on Artificial Life

Priscila Biller, Carole Knibbe, Guillaume Beslon, Eric Tannier

Computability in Europe . 9709 : 35-44

Conference paper

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Breaking Good: Accounting for Fragility of Genomic Regions in Rearrangement Distance Estimation

Priscila Biller, Laurent Guéguen, Carole Knibbe, Eric Tannier

Genome Biology and Evolution . 8 ( 5 ) : 1427-1439

DOI: 10.1093/gbe/evw083

Journal article

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Sorting Signed Permutations by Reversal (Reversal Sequence)

Eric Tannier

Encyclopedia of Algorithms . 978-1-4939-2863-7 : 2028-2032

Book chapter

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Genome rearrangements with indels in intergenes restrict the scenario space

Laurent Bulteau, Guillaume Fertin, Eric Tannier

BMC Bioinformatics . 17 ( Suppl 14 ) : 426 (7 pages)

DOI: 10.1186/s12859-016-1264-6

Journal article

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Strong phylogenetic inertia on genome size and transposable element content among 26 species of flies

Camille Sessegolo, Nelly Burlet, Annabelle A. Haudry

Biology Letters . 12 ( 8 )

DOI: 10.1098/rsbl.2016.0407

Journal article

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RevBayes: Bayesian Phylogenetic Inference Using Graphical Models and an Interactive Model-Specification Language

S. Hohna, M. J. Landis, T. A. Heath, Bastien Boussau, Nicolas Lartillot, B. R. Moore...

Systematic Biology . 65 : 726-36

DOI: 10.1093/sysbio/syw021

Journal article

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