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Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Lega Jean-Christophe
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
Mon travail est centré sur la balance bénéfice risque et le niveau de preuve de l'effet traitement des antithrombotiques et des immunosuppresseurs, en rapport avec mon activité hospitalière aux Hospices Civils de Lyon. Cette modélisation est notamment basée sur la réalisation de méta-analyse (risque de base, stratification du risque et interaction de l'effet traitement, effet des sous-populations humaines et médecine personnalisée).
La constitution de registre à partir des base de données hospitalières des HCL est aussi un axe émergent, en utilisant des approches natural language processing, pour l'estimation de la safety et l'effectiveness des thérapeutiques.
Je suis responsable de l'Equipe Modélisation et Modélisation des Effets Thérapeutiques depuis janvier 2021.
Publications
Display of 1 to 30 publications on 47 in total
Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study
Blood . 141 ( 1 ) : 11-21
Journal article
see the publicationTreatment strategy for acquired pure red cell aplasia: a systematic review and meta-analysis
Blood Advances . 7 ( 21 ) : 6451-6465
Journal article
see the publicationPlatelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents
Blood . 142 ( 12 ) : 1099-1101
Journal article
see the publicationProlonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study
Blood .
Journal article
see the publicationImmune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study
Blood . 141 ( 1 ) : 11-21
Journal article
see the publicationProlonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study
Blood .
Journal article
see the publicationPopulation designations in biomedical research: Limitations and perspectives
HLA: Immune Response Genetics . 101 ( 1 ) : 3-15
DOI: 10.1111/tan.14852
Journal article
see the publicationA call for evidence in connective tissue diseases-associated interstitial lung disease
Joint Bone Spine . 89 ( 1 ) : 105274
Journal article
see the publicationA call for evidence in connective tissue diseases-associated interstitial lung disease
Joint Bone Spine . 89 ( 1 ) : 105274
Journal article
see the publicationSplenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment
American Journal of Hematology . 97 ( 1 ) : 10-17
DOI: 10.1002/ajh.26378
Journal article
see the publicationManagement and Outcome of COVID-19 Positive and Negative Patients in French Emergency Departments During the First COVID-19 Outbreak: A Prospective Controlled Cohort Study
Western Journal of Emergency Medicine . 23 ( 6 ) : 897-906
Journal article
see the publicationHuman Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination
Journal of Clinical Medicine . 11 ( 14 ) : 4137
DOI: 10.3390/jcm11144137
Journal article
see the publicationPopulation designations in biomedical research: limitations and perspectives
HLA: Immune Response Genetics .
DOI: 10.1111/tan.14852
Journal article
see the publicationPrevention of venous thromboembolism in nephrotic syndrome: the quest towards precision medicine
Nephrology Dialysis Transplantation . 36 ( 7 ) : 1151-1154
DOI: 10.1093/ndt/gfaa337
Journal article
see the publicationBladder endometriosis: Preoperative MRI analysis with assessment of extension to ureteral orifices
Diagnostic and Interventional Imaging . 102 ( 4 ) : 255-263
Journal article
see the publicationSplenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment
American Journal of Hematology . 97 ( 1 ) : 10-17
DOI: 10.1002/ajh.26378
Journal article
see the publicationArterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Thorax . 76 ( 10 ) : 970-979
Journal article
see the publicationImmune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients.
Rheumatology .
Journal article
see the publicationArterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Thorax . 76 ( 10 ) : 970-979
Journal article
see the publicationAssessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department
Annales de Biologie Clinique . 79 ( 4 ) : 315-324
Journal article
see the publicationAnalysis of ncidence of hrombotic omplications in the resence of ompeting isks
Thrombosis Research . 191 : 152
Journal article
see the publicationEarly-onset autoimmunity associated with SOCS1 haploinsufficiency
Nature Communications . 11 ( 1 )
Journal article
see the publicationEarly trajectories of skin thickening are associated with severity and mortality in systemic sclerosis
Arthritis Research and Therapy . 22 ( 1 ) : 30
Journal article
see the publicationFrench recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)
Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351
Journal article
see the publicationContribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
The Lancet Rheumatology . 2 ( 2 ) : e99-e109
Journal article
see the publicationSurvival and prognosis factors in systemic sclerosis data of a French multicenter cohort, systematic review, and meta-analysis of the literature
Arthritis Research and Therapy . 21 ( 1 ) : 86
Journal article
see the publicationMonogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 )
Journal article
see the publicationTreatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis
Autoimmunity Reviews . 18 ( 2 ) : 113 - 122
Journal article
see the publicationExtended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis
PLoS ONE . 14 ( 4 ) : e0214134
Journal article
see the publicationMortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry
Autoimmunity Reviews . 17 ( 7 ) : 653--659
Journal article
see the publication