GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 511 to 540 publications on 1402 in total

Why Time Matters: Codon Evolution and the Temporal Dynamics of dN/dS

Carina Mugal, Jochen B.W. Wolf, Ingemar Kaj

Molecular Biology and Evolution . 31 ( 1 ) : 212-231

DOI: 10.1093/molbev/mst192

Journal article

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SAT-Based Metabolics Pathways Analysis without Compilation

Sabine Pérès, Morterol Martin, Laurent Simon

CMSB 2014 .

Conference paper

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Systematic study of a metabolic network

Bertrand P Beauvoit, Sophie Colombié, Jean-Pierre Mazat, Christine Nazaret, Sabine Pérès

advances in Systems and Synthetic Biology . 978-2-7598-1201-1 : 173 p.

Conference paper

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Preserving immune diversity through ancient inheritance and admixture

Laure L. Segurel, Lluis Quintana-Murci

Current Opinion in Immunology . 30 : 79-84

DOI: 10.1016/j.coi.2014.08.002

Journal article

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TroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception

Amir Kermany, Laure L. Segurel, Tiffany Oliver, Molly Przeworski

Bioinformatics . 30 ( 14 ) : 2035-2042

DOI: 10.1093/bioinformatics/btu159

Journal article

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Microsatellite data show recent demographic expansions in sedentary but not in nomadic human populations in Africa and Eurasia

Carla Aimé, Paul Verdu, Laure L. Segurel, Begoña Martinez-Cruz, Tatyana Hegay, Evelyne Heyer...

European Journal of Human Genetics . 22 ( 10 ) : 1201-1207

DOI: 10.1038/ejhg.2014.2

Journal article

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A call for benchmarking transposable element annotation methods.

Douglas R Hoen, Glenn Hickey, Guillaume Bourque, Josep Casacuberta, Richard Cordaux, Cédric Feschotte...

Mobile DNA . 6 : 13

DOI: 10.1186/s13100-015-0044-6

Journal article

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Subcellular Localization of ENS-1/ERNI in Chick Embryonic Stem Cells

Sophie Blanc, Florence Ruggiero, Anne-Marie Birot, Hervé Acloque, Didier Decimo, Emmanuelle Lerat...

PLoS ONE . 9 ( 3 ) : e92039

DOI: 10.1371/journal.pone.0092039

Journal article

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The spatiotemporal program of DNA replication is associated with specific combinations of chromatin marks in human cells.

Franck Picard, Jean-Charles Cadoret, Benjamin Audit, Alain Arneodo, Adriana A. Alberti, Christophe Battail...

PLoS Genetics . 10 ( 5 ) : e1004282

DOI: 10.1371/journal.pgen.1004282

Journal article

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The Red Queen Model of Recombination Hotspots Evolution in the Light of Archaic and Modern Human Genomes

Y Lesecque, S. S. Glemin, N. Lartillot, D. Mouchiroud, L. Duret

PLoS Genetics . 10 : e1004790

DOI: 10.1371/journal.pgen.1004790

Journal article

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Strong heterogeneity in mutation rate causes misleading hallmarks of natural selection on indel mutations in the human genome

E. M. Kvikstad, L. Duret

Molecular Biology and Evolution . 31 : 23-36

DOI: 10.1093/molbev/mst185

Journal article

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Annotating arthropods genome to study and compare their metabolism: the ArthropodaCyc collection of Cyc databases powered by CycADS

Patrice Baa-Puyoulet, Augusto Vellozo, Jaime Huerta-Cepas, Gérard Febvay, Federica Calevro, Marie-France Sagot...

13. European Conference on Computational Biology (ECCB) . : 1 p.

Poster

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Amortized Õ(\textbarV)-Delay Algorithm for Listing Chordless Cycles in Undirected Graphs

R. Ferreira, R. Grossi, R. Rizzi, Gustavo Sacomoto, Marie-France Sagot

Lecture Notes in Computer Science . 8737 : 418-429

Journal article

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On the Enumeration of Minimal Dominating Sets and Related Notions

Mamadou Moustapha Kanté, Vincent Limouzy, Arnaud Mary, Lhouari Nourine

SIAM Journal on Discrete Mathematics . 28 ( 4 ) : 1916 - 1929

DOI: 10.1137/120862612

Journal article

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Diet of ancient Egyptians inferred from stable isotope systematics

Alexandra Touzeau, Romain Amiot, Janne Blichert-Toft, Jean-Pierre Flandrois, François Fourel, Vincent Grossi...

Journal of Archaeological Science . 46 : 114-124

DOI: 10.1016/j.jas.2014.03.005

Journal article

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MUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis.

Jean-Pierre Flandrois, Gérard Lina, Oana Dumitrescu

BMC Bioinformatics . 15 ( 1 ) : 107

DOI: 10.1186/1471-2105-15-107

Journal article

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Mycobacterium Species Related to M. leprae and M. lepromatosis from Cows with Bovine Nodular Thelitis

D. Pin, V. Guerin-Faublee, V. Garreau, F. Breysse, Oana Dumitrescu, Jean-Pierre Flandrois...

Emerging Infectious Diseases . 20 : 2111-4

DOI: 10.3201/eid2012.140184

Journal article

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Reference-free detection of isolated SNPs

Raluca Uricaru, Guillaume Rizk, Vincent Lacroix, Elsa Quillery, Olivier Plantard, Rayan Chikhi...

Nucleic Acids Research . 43 ( 2 ) : e11

DOI: 10.1093/nar/gku1187

Journal article

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Promiscuous Nickel Import in Human Pathogens: Structure, Thermodynamics, and Evolution of Extracytoplasmic Nickel-Binding Proteins

Hugo Lebrette, Céline Brochier-Armanet, Barbara Zambelli, Hilde de Reuse, Elise Borezée-Durant, Stéfano Ciurli...

Structure . 22 ( 10 ) : 1421-1432

DOI: 10.1016/j.str.2014.07.012

Journal article

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Protein SYCP2 Is an Ancient Component of the Metazoan Synaptonemal Complex

J. Fraune, M. Alsheimer, J. Redolfi, Céline Brochier-Armanet, R. Benavente

Cytogenetic and genome research . 144 : 299-305

DOI: 10.1159/000381080

Journal article

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Plant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family

R. Zallot, Céline Brochier-Armanet, K. W. Gaston, F. Forouhar, P. A. Limbach, J. F. Hunt...

ACS Chemical Biology . 9 ( 8 ) : 1812-1825

DOI: 10.1021/cb500278k

Journal article

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Ail and PagC-Related Proteins in the Entomopathogenic Bacteria of Photorhabdus Genus

Annabelle Mouammine, Anne Lanois, Sylvie Pages, Bénédicte Lafay, Virginie Molle, Marc Canova...

PLoS ONE . 9 ( 10 ) : e110060

DOI: 10.1371/journal.pone.0110060

Journal article

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Contribution of graphs to the analysis of bacterial genome architecture

Olivier Poirion, Bénédicte Lafay

BioNetVisA workshop, ECCB'14, the 13th European Conference on Computational Biology .

Conference paper

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Structuration of the bacterial replicon space

Olivier Poirion, Bénédicte Lafay

ECCB'14 . CD

Conference paper

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Chromosome formation in bacteria

Olivier Poirion, Bénédicte Lafay

EMBO Conference "Microbiology after the genomics revolution : Genomes 2014" .

Conference paper

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Hijacking of Host Cellular Functions by an Intracellular Parasite, the Microsporidian Anncaliia algerae

Johan Panek, Hicham El Alaoui, Anne Mone, Serge Urbach, Edith Demettre, Catherine Texier...

PLoS ONE . 9 ( 6 ) : e100791

DOI: 10.1371/journal.pone.0100791

Journal article

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