GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 61 to 90 publications on 1416 in total

ISMB/ECCB 2023 organization benefited from the strengths of the French bioinformatics community

Anna-Sophie Fiston-Lavier, Sandra Dérozier, Guy Perrière, Marie-France Sagot

Bioinformatics Advances . 4 ( 1 ) : vbae040

DOI: 10.1093/bioadv/vbae040

Journal article

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Bradyrhizobium hardenbergiae sp. nov., isolated from Hardenbergia violacea in Australia, represents a novel basal lineage of the B. elkanii supergroup

Bénédicte Lafay, Elina Coquery, Phil M. Oger

Preprint

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A Wright–Fisher graph model and the impact of directional selection on genetic variation

Ingemar Kaj, Carina Mugal, Rebekka Müller-Widmann

Theoretical Population Biology . 159 : 13-24

DOI: 10.1016/j.tpb.2024.07.004

Journal article

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Investigating demic versus cultural diffusion and sex bias in the spread of Austronesian languages in Vietnam

Dinh Huong Thao, Tran Huu Dinh, Shigeki Mitsunaga, La Duc Duy, Nguyen Thanh Phuong, Nguyen Phuong Anh...

PLoS ONE . 19 ( 6 ) : e0304964

DOI: 10.1371/journal.pone.0304964

Journal article

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Complete mitochondrial genomes of patients from Thailand with cardiovascular diseases

Wipada Woravatin, Rattanasak Wongkomonched, Wichittra Tassaneeyakul, Mark Stoneking, Pattarapong Makarawate, Wibhu Kutanan

PLoS ONE . 19 ( 7 ) : e0307036

DOI: 10.1371/journal.pone.0307036

Journal article

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GTDrift: a resource for exploring the interplay between genetic drift, genomic and transcriptomic characteristics in eukaryotes

Florian Bénitière, Laurent Duret, Anamaria Necsulea

NAR Genomics and Bioinformatics . 6 ( 2 ) : lqae064

DOI: 10.1093/nargab/lqae064

Journal article

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Logic programming-based Minimal Cut Sets reveal consortium-level therapeutic targets for chronic wound infections

Maxime Mahout, Ross Carlson, Laurent Simon, Sabine Peres

npj Systems Biology and Applications . 10 ( 1 ) : 34

DOI: 10.1038/s41540-024-00360-6

Journal article

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Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring F1 hybrids

Jesper Boman, Anna Qvarnström, Carina Mugal

BMC Biology . 22 ( 1 ) : 124

DOI: 10.1186/s12915-024-01920-2

Journal article

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High prevalence of PRDM9-independent recombination hotspots in placental mammals

Julien Joseph, Djivan Prentout, Alexandre Laverré, Théo Tricou, Laurent Duret

Proceedings of the National Academy of Sciences of the United States of America . 121 ( 23 ) : e2401973121

DOI: 10.1073/pnas.2401973121

Journal article

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Persistent homology reveals strong phylogenetic signal in 3D protein structures

Léa Bou Dagher, Dominique Madern, Philippe Malbos, Céline Brochier-Armanet

PNAS Nexus . 3 ( 4 ) : 158

DOI: 10.1093/pnasnexus/pgae158

Journal article

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The genetic legacy of the expansion of Bantu-speaking peoples in Africa

Cesar A Fortes-Lima, Concetta Burgarella, Rickard Hammarén, Anders Eriksson, Mário Vicente, Cecile Jolly...

Nature . 625 ( 7995 ) : 540–547

DOI: 10.1038/s41586-023-06770-6

Journal article

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PRDM9 drives the location and rapid evolution of recombination hotspots in salmonids

Marie Raynaud, Paola Sanna, Julien Joseph, Julie A. J. Clément, Yukiko Imai, Jean-Jacques Lareyre...

DOI: 10.1101/2024.03.06.583651

Preprint

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The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome

Madeline Chase, Maurine Vilcot, Carina Mugal

Proceedings of the Royal Society B: Biological Sciences . 291 ( 2015 ) : 20232382

DOI: 10.1098/rspb.2023.2382

Journal article

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Description of a new genus of the Pectobacteriaceae family isolated from water in coastal brackish wetlands of the French Camargue region, Prodigiosinella gen. nov., including the new species Prodigiosinella aquatilis sp. nov

Nicole Hugouvieux-Cotte-Pattat, Jean-Pierre Flandrois, Jérôme Briolay, Sylvie Reverchon, Céline Brochier-Armanet

Systematic and Applied Microbiology . 47 ( 2-3 ) : 126497

DOI: 10.1016/j.syapm.2024.126497

Journal article

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MicroAnnot: A Dedicated Workflow for Accurate Microsporidian Genome Annotation

Jérémy Tournayre, Valérie Polonais, Ivan Wawrzyniak, Reginald Florian Akossi, Nicolas Parisot, Emmanuelle Lerat...

International Journal of Molecular Sciences . 25 ( 2 ) : 880

DOI: 10.3390/ijms25020880

Journal article

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Identification and quantification of transposable element transcripts using Long-Read RNA-seq in Drosophila germline tissues

Rita Rebollo, Pierre Gerenton, Eric Cumunel, Arnaud Mary, François Sabot, Nelly Burlet...

Peer Community Journal . 4 ( e89 )

DOI: 10.24072/pcjournal.457

Journal article

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Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans

Florian Bénitière, Anamaria Necsulea, Laurent Duret

eLife . 13 : RP93629

DOI: 10.7554/eLife.93629.3

Journal article

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Imbalanced speciation pulses sustain the radiation of mammals

Ignacio Quintero, Nicolas Lartillot, Hélène Morlon

Science . 384 ( 6699 ) : 1007-1012

DOI: 10.1126/science.adj2793

Journal article

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Transposable element expression with variation in sex chromosome number: insights into a toxic Y effect on human longevity

Jordan Teoli, Miriam Merenciano, Marie Fablet, Anamaria Necsulea, Daniel Siqueira-De-Oliveira, Alessandro Brandulas-Cammarata...

Peer Community In Genomics .

DOI: 10.1101/2023.08.03.550779

Journal article

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MacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes

Bertrand Néron, Rémi Denise, Charles Coluzzi, Marie Touchon, Eduardo P.C. Rocha, Sophie Abby

Peer Community Journal . 3 : e28

DOI: 10.24072/pcjournal.250

Journal article

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Chance Favors the Prepared Genomes: Horizontal Transfer Shapes the Emergence of Antibiotic Resistance Mutations in Core Genes

Charles Coluzzi, Martin Guillemet, Fanny Mazzamurro, Marie Touchon, Maxime Godfroid, Guillaume Achaz...

Molecular Biology and Evolution . 40 ( 10 ) : msad217

DOI: 10.1093/molbev/msad217

Journal article

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The evolution of GC-biased gene conversion by means of natural selection

Nicolas Lartillot, Julien Joseph, Augustin Clessin

ETEE'2023: Empiricism & Theory in Ecology and Evolution .

Conference paper

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Geographic origin and social status of the Gallic warriors from Ribemont‐sur‐Ancre (France) studied through isotope systematics of bone remains

Thibault Clauzel, Pascale Richardin, Jannick Ricard, Gilles Prilaux, Jeremy E. Martin, Romain Amiot...

International Journal of Osteoarchaeology . 33 ( 1 ) : 39-50

DOI: 10.1002/oa.3172

Journal article

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Experimental analysis of diverse actin-like proteins from various magnetotactic bacteria by functional expression in Magnetospirillum gryphiswaldense

Ram Prasad Awal, Frank D Müller, Daniel Pfeiffer, Caroline L Monteil, Guy Perrière, Christopher T Lefèvre...

mBio . 14 ( 5 )

DOI: 10.1128/mbio.01649-23

Journal article

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A first step towards the characterization of endogenous retroviruses’ evolutionary history and impact on small ruminant genomes

Marie Verneret, Caroline Leroux, Vincent Navratil, Thomas Faraut, Emmanuelle Lerat, Jocelyn Turpin

CNET 2023 : 24th National Congress on Transposable Elements 2023 .

Conference paper

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OVINE β-ENDOGENOUS RETROVIRUSES : FROM INTEGRATION TO COPY-SPECIFIC TRANSCRIPTION

Marie Verneret, Caroline Leroux, Emmanuelle Lerat, Vincent Navratil, Jocelyn Turpin

XXVèmes Journées Francophones de Virologie .

Poster

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De novo analysis of splicing from RNA-seq data: models, algorithms and applications

Vincent Lacroix

HDR

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Mitigation of the diagenesis risk in biological apatite δ18O interpretation

Christophe Lécuyer, Jean-Pierre Flandrois

Palaeogeography, Palaeoclimatology, Palaeoecology . 630 : 111812

DOI: 10.1016/j.palaeo.2023.111812

Journal article

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δ2H and δ18O of river water from a high-altitude humid plain of the southern Alps: Implications for the interpretation of the isotopic compositions of bioapatite from humans living close to mountain areas

Christophe Lécuyer, François Atrops, François Fourel, Thibault Clauzel, Jean-Pierre Flandrois

Journal of Archaeological Science: Reports . 49 : 104020

DOI: 10.1016/j.jasrep.2023.104020

Journal article

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Evolution of sex-biased gene expression during transitions to separate sexes in the Silene genus

Djivan Prentout, Aline Muyle, Niklaus Zemp, Adil El Filali, Bastien Boussau, Pascal Touzet...

DOI: 10.1101/2023.10.02.560480

Preprint

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