GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 121 to 150 publications on 1402 in total

Mutations in the non-coding RNU4ATAC gene affect the homeostasis and function of the Integrator complex

Fatimat Almentina Ramos Shidi, Audric Cologne, Marion Delous, Alicia Besson, Audrey Putoux, Anne-Louise Leutenegger...

Nucleic Acids Research .

DOI: 10.1093/nar/gkac1182

Journal article

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Geometric programming to Solve Optimal Concentrations of Metabolites and Enzymes in Constraint-based modelling

Sabine Peres, Marc Dinh, Vincent Fromion

International Conference on System Biology .

Conference paper

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Special Issue on “Frontiers in Connecting Steady-State and Dynamic Approaches for Modelling Cell Metabolic Behavior”

Sabine Peres, Mario Jolicoeur

Processes . 10 ( 8 ) : 1612

DOI: 10.3390/pr10081612

Journal article

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Hybrid metabolic modeling to identify new control strategies of living organisms

Sabine Peres

Hybrid models and methods in systems medicine .

Conference paper

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Mod ́elisation m ́etabolique pour identifier de nouvelles strat ́egies de contrˆole des organismes vivants

Sabine Peres

Meetochondrie .

Conference paper

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BrumiR: A toolkit for de novo discovery of microRNAs from sRNA-seq data

Carol Moraga, Evelyn Sanchez, Mariana Galvão Ferrarini, Rodrigo A Gutierrez, Elena A Vidal, Marie-France Sagot

GigaScience . 11

DOI: 10.1093/gigascience/giac093

Journal article

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Codiversification of gut microbiota with humans

Taichi Suzuki, J. Liam Fitzstevens, Victor Schmidt, Hagay Enav, Kelsey Huus, Mirabeau Mbong Ngwese...

Science . 377 ( 6612 ) : 1328-1332

DOI: 10.1126/science.abm7759

Journal article

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Protein conformational space at the edge of allostery: turning a nonallosteric malate dehydrogenase into an “allosterized” enzyme using evolution-guided punctual mutations

Antonio Iorio, Céline Brochier-Armanet, Caroline Mas, Fabio Sterpone, Dominique Madern

Molecular Biology and Evolution . 39 ( 9 ) : msac186

DOI: 10.1093/molbev/msac186

Journal article

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An Improved Codon Modeling Approach for Accurate Estimation of the Mutation Bias

Thibault Latrille, Nicolas Lartillot

Molecular Biology and Evolution . 39

DOI: 10.1093/molbev/msac005

Journal article

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Efficiently sparse listing of classes of optimal cophylogeny reconciliations

Yishu Wang, Marie-France Sagot, Arnaud Mary, Blerina Sinaimeri

Algorithms for Molecular Biology . 17 ( 1 ) : 1-16

DOI: 10.1186/s13015-022-00206-y

Journal article

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Totoro: Identifying Active Reactions During the Transient State for Metabolic Perturbations

Mariana Galvão Ferrarini, Irene Ziska, Ricardo Andrade, Alice Julien-Laferrière, Louis Duchemin, Roberto Marcondes César...

Frontiers in Genetics . 13 : 1-12

DOI: 10.3389/fgene.2022.815476

Journal article

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Labile sex expression in angiosperm species with sex chromosomes

Jos Käfer, Marcos Méndez, Sylvain Mousset

Philosophical Transactions of the Royal Society B: Biological Sciences . 377 ( 1850 )

DOI: 10.1098/rstb.2021.0216

Journal article

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CALDERA: Finding all significant de Bruijn subgraphs for bacterial GWAS

Hector Roux de Bézieux, Leandro Lima, Fanny Perraudeau, Arnaud Mary, Sandrine Dudoit, Laurent Jacob

Bioinformatics .

DOI: 10.1093/bioinformatics/btac238

Journal article

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A divide-and-conquer phylogenomic approach based on character supermatrices resolves early steps in the evolution of the Archaea

Monique Aouad, Jean-Pierre Flandrois, Frédéric Jauffrit, Manolo Gouy, Simonetta Gribaldo, Celine Brochier-Armanet

BMC Ecology and Evolution . 22 ( 1 ) : 1-12

DOI: 10.1186/s12862-021-01952-0

Journal article

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Sex‐related differences in aging rate are associated with sex chromosome system in amphibians

Hugo Cayuela, Jean-François Lemaître Lemaître, Jean‐paul Léna, Victor Ronget, Iñigo Martínez‐solano, Erin Muths...

Evolution - International Journal of Organic Evolution . 76 ( 2 ) : 346-356

DOI: 10.1111/evo.14410

Journal article

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Sex chromosomes, sex ratios and sex gaps in longevity in plants

Gabriel Marais, Jean-François Lemaître Lemaître

Philosophical Transactions of the Royal Society B: Biological Sciences . 377 ( 1850 )

DOI: 10.1098/rstb.2021.0219

Journal article

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A derived ZW chromosome system in Amborella trichopoda, representing the sister lineage to all other extant flowering plants

Jos Käfer, Adam Bewick, Amélie Andres‐robin, Garance Lapetoule, Alex Harkess, José Caïus...

New Phytologist . 233 : 1636-1642

DOI: 10.1111/nph.17662

Journal article

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Exploring correlations in genetic and cultural variation across language families in northeast Asia

Hiromi Matsumae, Peter Ranacher, Patrick Savage, Damián Blasi, Thomas Currie, Kae Koganebuchi...

Science Advances . 7 ( 34 )

DOI: 10.1126/sciadv.abd9223

Journal article

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Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn

Song Guo, Shuyun Huang, Xi Jiang, Haiyang Hu, Dingding Han, Carlos S Moreno...

BMC Genomics . 22 : 286

DOI: 10.1186/s12864-021-07542-0

Journal article

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Reconstructing the Human Genetic History of Mainland Southeast Asia: Insights from Genome-Wide Data from Thailand and Laos

Wibhu Kutanan, Dang Liu, Jatupol Kampuansai, Metawee Srikummool, Suparat Srithawong, Rasmi Shoocongdej...

Molecular Biology and Evolution . 38 ( 8 ) : 3459 - 3477

DOI: 10.1093/molbev/msab124

Journal article

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Genomic insights into population history and biological adaptation in Oceania

Jeremy Choin, Javier Mendoza-Revilla, Lara R Arauna, Sebastian Cuadros-Espinoza, Olivier Cassar, Maximilian Larena...

Nature . 592 ( 7855 ) : 583-589

DOI: 10.1038/s41586-021-03236-5

Journal article

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The genomic prehistory of peoples speaking Khoisan languages

Brigitte Pakendorf, Mark Stoneking

Human Molecular Genetics . 30 ( 2 ) : R49-R55

DOI: 10.1093/hmg/ddaa221

Journal article

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Positive selection plays a major role in shaping signatures of differentiation across the genomic landscape of two independent Ficedula flycatcher species pairs

Madeline Chase, Hans Ellegren, Carina Mugal

Evolution - International Journal of Organic Evolution . 75 ( 9 ) : 2179-2196

DOI: 10.1111/evo.14234

Journal article

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The Effects of GC-Biased Gene Conversion on Patterns of Genetic Diversity among and across Butterfly Genomes

Jesper Boman, Carina Mugal, Niclas Backström

Genome Biology and Evolution . 13 ( 5 )

DOI: 10.1093/gbe/evab064

Journal article

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Les isotopes de l'hydrogène contenus dans les tissus osseux et dentaires de populations archéologiques et leurs usages comme proxys paléoclimatiques et paléoalimentaires

Thibault Clauzel, Pascale Richardin, Jannick Ricard, Yves Le Béchennec, Romain Amiot, Fourel François...

27e édition de la Réunion des Sciences de la Terre .

Conference paper

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Answer set programming to compute constraint elementary flux modes

Maxime Mahout, Laurent Simon, Sabine Peres

Computational Methods in System Biology .

Conference paper

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Answer set programming to compute constraint elementary flux modes

Maxime Mahout, Laurent Simon, Sabine Peres

Metabolic Pathway Analysis .

Conference paper

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Fine-tuning mitochondrial activity in Yarrowia lipolytica for citrate overproduction

Jorgelindo da Veiga Moreira, Mario Jolicoeur, Laurent Schwartz, Sabine Peres

Scientific Reports . 11 ( 1 ) : 878

DOI: 10.1038/s41598-020-79577-4

Journal article

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Combining Kinetic and Constraint-Based Modelling to Better Understand Metabolism Dynamics

Cecile Moulin, Laurent Tournier, Sabine S. Peres

Processes . 9 ( 10 ) : 1701

DOI: 10.3390/pr9101701

Journal article

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