GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 181 to 210 publications on 1378 in total

Expanding the Geographic Characterisation of Epstein–Barr Virus Variation through Gene-Based Approaches

Marco Telford, David Hughes, David Juan, Mark Stoneking, Arcadi Navarro, Gabriel Santpere

Microorganisms . 8 ( 11 ) : 1686

DOI: 10.3390/microorganisms8111686

Journal article

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Ancient DNA indicates human population shifts and admixture in northern and southern China

Melinda Yang, Xuechun Fan, Bo Sun, Chungyu Chen, Jianfeng Lang, Ying-Chin Ko...

Science . 369 ( 6501 ) : 282-288

DOI: 10.1126/science.aba0909

Journal article

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Cultural variation impacts paternal and maternal genetic lineages of the Hmong-Mien and Sino-Tibetan groups from Thailand

Wibhu Kutanan, Rasmi Shoocongdej, Metawee Srikummool, Alexander Hübner, Thanatip Suttipai, Suparat Srithawong...

European Journal of Human Genetics . 28 : 1563 - 1579

DOI: 10.1038/s41431-020-0693-x

Journal article

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Papuan mitochondrial genomes and the settlement of Sahul

Nicole Pedro, Nicolas Brucato, Verónica Fernandes, Mathilde André, Lauri Saag, William Pomat...

Journal of Human Genetics .

DOI: 10.1038/s10038-020-0781-3

Journal article

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The paternal and maternal genetic history of Vietnamese populations

Enrico Macholdt, Leonardo Arias, Nguyen Thuy Duong, Nguyen Dang Ton, Nguyen Van Phong, Roland Schröder...

European Journal of Human Genetics . 28 ( 5 ) : 636-645

DOI: 10.1038/s41431-019-0557-4

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Extensive Ethnolinguistic Diversity in Vietnam Reflects Multiple Sources of Genetic Diversity

Dang Liu, Nguyen Thuy Duong, Nguyen Dang Ton, Nguyen van Phong, Brigitte Pakendorf, Nong van Hai...

Molecular Biology and Evolution . 37 ( 9 ) : 2503 - 2519

DOI: 10.1093/molbev/msaa099

Journal article

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Tissue-specific patterns of regulatory changes underlying gene expression differences among Ficedula flycatchers and their naturally occurring F 1 hybrids

Carina Mugal, Mi Wang, Niclas Backström, David Wheatcroft, Murielle Ålund, Marie Sémon...

Genome Research . 30 ( 12 ) : 1727-1739

DOI: 10.1101/gr.254508.119

Journal article

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Polymorphism Data Assist Estimation of the Nonsynonymous over Synonymous Fixation Rate Ratio ω for Closely Related Species

Carina Mugal, Verena Kutschera, Fidel Botero-Castro, Jochen Wolf, Ingemar Kaj

Molecular Biology and Evolution . 37 ( 1 ) : 260-279

DOI: 10.1093/molbev/msz203

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Cancer and Alzheimer’s disease: intracellular pH scales the metabolic disorders

Laurent Schwartz, Sabine S. Peres, Mario Jolicoeur, Jorgelindo da Veiga Moreira

Biogerontology . 21 ( 6 ) : 683-694

DOI: 10.1007/s10522-020-09888-6

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Scalable Empirical Mixture Models That Account for Across-Site Compositional Heterogeneity

Dominik Schrempf, Nicolas Lartillot, Gergely Szöllősi

Molecular Biology and Evolution . 37 : 3616 - 3631

DOI: 10.1093/molbev/msaa145

Journal article

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Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA

Laure Ségurel, Perle Guarino-Vignon, Nina Marchi, Sophie Lafosse, Romain Laurent, Céline Bon...

PLoS Biology . 18 ( 6 ) : e3000742

DOI: 10.1371/journal.pbio.3000742

Journal article

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Response of the human gut and saliva microbiome to urbanization in cameroon

Ana Lokmer, Sophie Aflalo, Norbert N. Amougou, Sophie Lafosse, Alain Froment, Francis Ekwin Tabe...

Scientific Reports . 10 ( 1 )

DOI: 10.1038/s41598-020-59849-9

Journal article

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How consistent is RAD‐seq divergence with DNA‐barcode based clustering in insects?

Marie Cariou, Hélène Henri, Sonia Martinez, Laurent Duret, Sylvain Charlat

Molecular Ecology Resources . 20 ( 5 ) : 1294-1298

DOI: 10.1111/1755-0998.13178

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Evolutionary plasticity of mating-type determination mechanisms in Paramecium aurelia sibling species

Natalia Sawka-Gądek, Alexey Potekhin, Deepankar Pratap Singh, Inessa Grevtseva, Olivier Arnaiz, Simon Penel...

Genome Biology and Evolution . ( evaa258 )

DOI: 10.1093/gbe/evaa258

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Efficient hybrid de novo assembly of human genomes with WENGAN

Alex Di Genova, Elena Buena-Atienza, Stephan Ossowski, Marie-France Sagot

Nature Biotechnology . 39 : 422–430

DOI: 10.1038/s41587-020-00747-w

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MOMO - multi-objective metabolic mixed integer optimization: application to yeast strain engineering

Ricardo Andrade, Mahdi Doostmohammadi, João Santos, Marie-France Sagot, Nuno P Mira, Susana Vinga

BMC Bioinformatics . 21 ( 1 ) : 1-13

DOI: 10.1186/s12859-020-3377-1

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A Family of Tree-Based Generators for Bubbles in Directed Graphs

Vicente Acuña, Leandro Ishi Soares de Lima, Giuseppe F Italiano, Luca Pepè Sciarria, Marie-France Sagot, Blerina Sinaimeri

IWOCA 2020 - 31st International Workshop on Combinatorial Algorithms . 12126 : 17-29

DOI: 10.1007/978-3-030-48966-3_2

Conference paper

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MOOMIN – Mathematical explOration of ’Omics data on a MetabolIc Network

Taneli Pusa, Mariana G. Ferrarini, Ricardo Andrade, Arnaud Mary, Alberto Marchetti-Spaccamela, Leen Stougie...

Bioinformatics . 36 ( 2 ) : 514-523

DOI: 10.1093/bioinformatics/btz584

Journal article

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Mycoplasma hyopneumoniae J elicits an antioxidant response and decreases the expression of ciliary genes in infected swine epithelial cells

Scheila Gabriele Mucha, Mariana G. Ferrarini, Carol Moraga, Alex Di Genova, Laurent Guyon, Florence Tardy...

Scientific Reports . 10 ( 13707 )

DOI: 10.1038/s41598-020-70040-y

Journal article

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Exploring protein space: From hydrolase to ligase by substitution

Nir Hecht, Caroline Monteil, Guy Perriere, Marina Vishkautzan, Eyal Gur

Molecular Biology and Evolution .

DOI: 10.1093/molbev/msaa215

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Repeated horizontal gene transfers triggered parallel evolution of magnetotaxis in two evolutionary divergent lineages of magnetotactic bacteria

Caroline Monteil, Denis Grouzdev, Guy Perriere, Béatrice Alonso, Zoé Rouy, Stéphane Cruveiller...

The International Society of Microbiologial Ecology Journal .

DOI: 10.1038/s41396-020-0647-x

Journal article

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Treerecs: an integrated phylogenetic tool, from sequences to reconciliations.

Nicolas Comte, Benoît Morel, Damir Hasic, Laurent Guéguen, Bastien Boussau, Vincent Daubin...

Bioinformatics . 36 ( 18 ) : 4822-4824

DOI: 10.1093/bioinformatics/btaa615

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Influenza virus infection induces widespread alterations of host cell splicing

Usama Ashraf, Clara Benoit-Pilven, Vincent Navratil, Cécile Ligneau, Guillaume Fournier, Sandie Munier...

NAR Genomics and Bioinformatics . 2 ( 4 )

DOI: 10.1093/nargab/lqaa095

Journal article

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The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans

Irene da Cruz, Celine Brochier-Armanet, Ricardo Benavente

BMC Evolutionary Biology . 20 ( 1 )

DOI: 10.1186/s12862-020-01612-9

Journal article

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Hepatitis B virus preS2Δ38–55 variants: A newly identified risk factor for hepatocellular carcinoma

Damien Cohen, Sumantra Ghosh, Yusuke Shimakawa, Njie Ramou, Pierre Simon Garcia, Anaëlle Dubois...

JHEP Reports Innovation in Hepatology . 2 ( 5 ) : 100144

DOI: 10.1016/j.jhepr.2020.100144

Journal article

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The Bayesian Approach to Molecular Phylogeny

Nicolas Lartillot

Phylogenetics in the Genomic Era . : 1.4:1--1.4:17

Book chapter

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PhyloBayes: Bayesian Phylogenetics Using Site-heterogeneous Models

Nicolas Lartillot

Phylogenetics in the Genomic Era . : 1.5:1--1.5:16

Book chapter

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