GECO Génomique Computationnelle et Evolutive

Equipe Bioinformatique, Phylogénie et Génomique Evolutive

Segurel Laure

Chargée de recherche

CNRS

Adresse : 43 bd du 11 novembre 1918
69622 VILLEURBANNE cedex

Tél : 04 72 43 26 28

Courriel

Batiment Mendel, 2ème étage. Bureau 12.025

Parcours Académique

2025 : Soutenance d’HDR, UCBL, Lyon

Depuis 2020 : CR CNRS, UMR 5558 Biométrie et Biologie Evolutive (LBBE), Lyon

2013-2020 : CR CNRS, UMR 7206 Eco-anthropologie (EA), Paris

2010-2013 : Post-doctorat dans le laboratoire de Molly Przeworski, Département de Génétique Humaine, Université de Chicago, USA

2006-2010 : Thèse de Doctorat en Anthropologie génétique (UPMC) sous la co-direction de Evelyne Heyer et Renaud Vitalis, UMR 7206 Eco-Anthropologie, Paris

2003-2006 : Licence et Master du Magistère Européen de Génétique, spécialité «Evolution et Génétique des populations", Univ Paris Diderot, France

 

Broad research interests

I am a CNRS researcher in population genetics, broadly interested in using genetic data to understand species evolution, more specifically to investigate how species adapt to their environment. During my PhD at the Musée de l'Homme with E Heyer and R Vitalis (UMR7206 - Paris), I worked in anthropological genetics, to decipher how various cultural features (matrimonial rules, language) shape the genetic diversity in Central Asia. I further worked on identifying selective pressures on various metabolic genes involved in adaptation to diet in herders and farmers from Central Asia. During my post-doc at UChicago with M Przeworski, I studied how recombination evolved between humans and chimpanzees, and across human populations, and I looked for signatures of balancing selection in humans and chimpanzees genomes. I also investigated what are the different determinants of neutral genetic diversity, as well as the factors influencing mutation rates. Since I got recruited at the CNRS in 2013 (UMR7206 - Paris), I continued working on human adaptation to changes in diet by studying lactase persistence using both modern and ancient DNA. In parallel, I am interested in understanding how humans and their associated microbes are co-evolving. Specifically, I developed a project in Cameroon to better understand how the human gut (and oral) microbiota evolved in response to changes in human diet, especially linked to the growing urbanisation and industrialisation of human populations. I am currently working at the LBBE (UMR5558 - Lyon) and developing projects on balancing selection (a mode of adaptation that maintains genetic diversity), to study its prevalence and underlying mechanisms both in primates and in birds, which have contrasted recombination landscapes and effective population sizes.

 

Publications

Affichage des publications 1 à 30 sur 44 au total

The porphyran degradation system is complete, phylogenetically and geographically diverse across the gut microbiota of East Asian populations

Laure Ségurel, Thirumalai Selvi Ulaganathan, Sophie Mathieu, Mélanie Touvrey, Laurent Poulet, Sophie Drouillard...

DOI: 10.1101/2023.03.30.534863

Pré-publication

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Proposed mechanism for the selection of lactase persistence in childhood

Alexandre Fabre, Anne Fabre, Céline Bon, Paul Guerry, Laure Ségurel

BioEssays . 45 ( 7 )

DOI: 10.1002/bies.202200243

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Population designations in biomedical research: limitations and perspectives

Caroline Gombault, Guillaume Grenet, Laure Ségurel, Laurent Duret, François Gueyffier, Pascal Cathébras...

HLA: Immune Response Genetics . 101 ( 1 ) : 3-15

DOI: 10.1111/tan.14852

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Modelling the spatiotemporal spread of beneficial alleles using ancient genomes

Rasa Muktupavela, Martin Petr, Laure L. Segurel, Thorfinn Korneliussen, John Novembre, Fernando Racimo

DOI: 10.1101/2021.07.21.453231

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Modeling the spatiotemporal spread of beneficial alleles using ancient genomes

Rasa Muktupavela, Martin Petr, Laure Ségurel, Thorfinn Korneliussen, John Novembre, Fernando Racimo

eLife . 11

DOI: 10.7554/eLife.73767

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Codiversification of gut microbiota with humans

Taichi Suzuki, J. Liam Fitzstevens, Victor Schmidt, Hagay Enav, Kelsey Huus, Mirabeau Mbong Ngwese...

Science . 377 ( 6612 ) : 1328-1332

DOI: 10.1126/science.abm7759

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No evidence for female kin association, indications for extragroup paternity, and sex‐biased dispersal patterns in wild western gorillas

Shelly Masi, Frédéric Austerlitz, Chloé Chabaud, Sophie Lafosse, Nina Marchi, Myriam Georges...

Ecology and Evolution . 11 ( 12 ) : 7634-7646

DOI: 10.1002/ece3.7596

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Elevated rates of horizontal gene transfer in the industrialized human microbiome

Mathieu Groussin, Mathilde Poyet, Ainara Sistiaga, Sean Kearney, Katya Moniz, Mary Noel...

Cell . 184 ( 8 ) : 2053-2067.e18

DOI: 10.1016/j.cell.2021.02.052

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Changes in the Human Gut Microbiota Associated With Colonization by Blastocystis sp. and Entamoeba spp. in Non-Industrialized Populations

Gaël Even, Ana Lokmer, Jules Rodrigues, Christophe Audebert, Eric Viscogliosi, Laure L. Segurel...

Frontiers in Cellular and Infection Microbiology . 11 : 533528

DOI: 10.3389/fcimb.2021.533528

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The human gut microbiome and health inequities

Katherine Amato, Marie-Claire Arrieta, Meghan Azad, Michael Bailey, Josiane Broussard, Carlijn Bruggeling...

Proceedings of the National Academy of Sciences of the United States of America . 118 ( 25 ) : e2017947118

DOI: 10.1073/pnas.2017947118

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Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA

Laure Ségurel, Perle Guarino-Vignon, Nina Marchi, Sophie Lafosse, Romain Laurent, Céline Bon...

PLoS Biology . 18 ( 6 ) : e3000742

DOI: 10.1371/journal.pbio.3000742

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Response of the human gut and saliva microbiome to urbanization in cameroon

Ana Lokmer, Sophie Aflalo, Norbert N. Amougou, Sophie Lafosse, Alain Froment, Francis Ekwin Tabe...

Scientific Reports . 10 ( 1 )

DOI: 10.1038/s41598-020-59849-9

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Use of shotgun metagenomics for the identification of protozoa in the gut microbiota of healthy individuals from worldwide populations with various industrialization levels

Ana Lokmer, Amandine Cian, Alain Froment, Nausicaa Gantois, Eric Viscogliosi, Magali Chabé...

PLoS ONE . 14 ( 2 ) : e0211139

DOI: 10.1371/journal.pone.0211139

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Close inbreeding and low genetic diversity in Inner Asian human populations despite geographical exogamy

Nina Marchi, Philippe Mennecier, Myriam Georges, Sophie Lafosse, Tatyana Hegay, Choduraa Dorzhu...

Scientific Reports . 8 : 9397

DOI: 10.1038/s41598-018-27047-3

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Microbiome intestinal ancien et problématiques médicales contemporaines

Philippe Charlier, Anaïs Augias, Philippe Sansonetti, Céline Bon, Sean Kennedy, Laure Ségurel

Médecine/Sciences . 33 : 984-990

DOI: 10.1051/medsci/20173311016

Autre publication

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Sex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations

Nina Marchi, Tatyana Hegay, Philippe Mennecier, Myriam Georges, Romain Laurent, Mark Whitten...

American Journal of Physical Anthropology . 162 ( 4 ) : 627-640

DOI: 10.1002/ajpa.23151

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Gut Protozoa: Friends or Foes of the Human Gut Microbiota?

Magali Chabé, Ana Lokmer, Laure Ségurel

Trends in Parasitology . 33 ( 12 ) : 925-934

DOI: 10.1016/j.pt.2017.08.005

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Detection and interpretation of shared genetic influences on 42 human traits

Joseph Pickrell, Tomaz Berisa, Jimmy Liu, Laure Ségurel, Joyce Tung, David A Hinds

Nature Genetics . 48 ( 7 ) : 709-717

DOI: 10.1038/ng.3570

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Detection of Allelic Frequency Differences between the Sexes in Humans: A Signature of Sexually Antagonistic Selection

Elise Lucotte, Romain Laurent, Evelyne Heyer, Laure Ségurel, Bruno Toupance

Genome Biology and Evolution . 8 ( 5 ) : 1489-1500

DOI: 10.1093/gbe/evw090

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Variation in Rural African Gut Microbiota Is Strongly Correlated with Colonization by Entamoeba and Subsistence

Elise R Morton, Joshua Lynch, Alain Froment, Sophie Lafosse, Evelyne Heyer, Molly M. Przeworski...

PLoS Genetics . 11 ( 11 ) : e1005658

DOI: 10.1371/journal.pgen.1005658

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Human genetic data reveal contrasting demographic patterns between sedentary and nomadic populations that predate the emergence of farming

Carla Aimé, Guillaume Laval, Etienne Patin, Paul Verdu, Laure Ségurel, Raphaëlle Chaix...

European Journal of Human Genetics . 22 ( 10 ) : 1201-1207

DOI: 10.1093/molbev/mst156

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TroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception

Amir Kermany, Laure L. Segurel, Tiffany Oliver, Molly Przeworski

Bioinformatics . 30 ( 14 ) : 2035-2042

DOI: 10.1093/bioinformatics/btu159

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Microsatellite data show recent demographic expansions in sedentary but not in nomadic human populations in Africa and Eurasia

Carla Aimé, Paul Verdu, Laure L. Segurel, Begoña Martinez-Cruz, Tatyana Hegay, Evelyne Heyer...

European Journal of Human Genetics . 22 ( 10 ) : 1201-1207

DOI: 10.1038/ejhg.2014.2

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Preserving immune diversity through ancient inheritance and admixture

Laure L. Segurel, Lluis Quintana-Murci

Current Opinion in Immunology . 30 : 79-84

DOI: 10.1016/j.coi.2014.08.002

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Human Genetic Data Reveal Contrasting Demographic Patterns between Sedentary and Nomadic Populations That Predate the Emergence of Farming

Carla Aimé, Guillaume Laval, Etienne Patin, Paul Verdu, Laure L. Segurel, Raphaëlle Chaix...

Molecular Biology and Evolution . 30 ( 12 ) : 2629 - 2644

DOI: 10.1093/molbev/mst156

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Ancestry runs deeper than blood: The evolutionary history of ABO points to cryptic variation of functional importance

Laure L. Segurel, Ziyue Gao, Molly Przeworski

BioEssays . : n/a-n/a

DOI: 10.1002/bies.201300030

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Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees

E. Leffler, Z. Gao, S. Pfeifer, L. Segurel, A. Auton, O. Venn...

Science . 339 ( 6127 ) : 1578-1582

DOI: 10.1126/science.1234070

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