GECO Génomique Computationnelle et Evolutive
Equipe Bioinformatique, Phylogénie et Génomique Evolutive
Segurel Laure
Chargée de recherche
CNRS
Tél : 04 72 43 26 28
Batiment Mendel, 2ème étage. Bureau 12.025
Broad research interests : I am a CNRS researcher in population genetics, broadly interested in using genetic data to understand species evolution, more specifically to investigate how species adapt to their environment. During my PhD at the Musée de l'Homme with E Heyer and R Vitalis (UMR7206 - Paris), I worked in anthropological genetics, to decipher how various cultural features (matrimonial rules, language) shape the genetic diversity in Central Asia. I further worked on identifying selective pressures on various metabolic genes involved in adaptation to diet in herders and farmers from Central Asia. During my post-doc at UChicago with M Przeworski, I studied how recombination evolved between humans and chimpanzees, and across human populations, and I looked for signatures of balancing selection in humans and chimpanzees genomes. I also investigated what are the different determinants of neutral genetic diversity, as well as the factors influencing mutation rates. Since I got recruited at the CNRS in 2013 (UMR7206 - Paris), I continued working on human adaptation to changes in diet by studying lactase persistence using both modern and ancient DNA. In parallel, I am interested in understanding how humans and their associated microbes are co-evolving. Specifically, I developed a project in Cameroon to better understand how the human gut (and oral) microbiota evolved in response to changes in human diet, especially linked to the growing urbanisation and industrialisation of human populations. I am currently working at the LBBE (UMR5558 - Lyon) and developing projects on balancing selection (a mode of adaptation that maintains genetic diversity), to study its prevalence and underlying mechanisms both in primates and in birds, which have contrasted recombination landscapes and effective population sizes.
Publications
Affichage des publications 1 à 30 sur 39 au total
Population designations in biomedical research: limitations and perspectives
HLA: Immune Response Genetics .
DOI: 10.1111/tan.14852
Article dans une revue
voir la publicationModelling the spatiotemporal spread of beneficial alleles using ancient genomes
Pré-publication
voir la publicationCodiversification of gut microbiota with humans
Science . 377 ( 6612 ) : 1328-1332
Article dans une revue
voir la publicationThe human gut microbiome and health inequities
Proceedings of the National Academy of Sciences of the United States of America . 118 ( 25 ) : e2017947118
Article dans une revue
voir la publicationNo evidence for female kin association, indications for extragroup paternity, and sex‐biased dispersal patterns in wild western gorillas
Ecology and Evolution . 11 ( 12 ) : 7634-7646
DOI: 10.1002/ece3.7596
Article dans une revue
voir la publicationElevated rates of horizontal gene transfer in the industrialized human microbiome
Cell . 184 ( 8 ) : 2053-2067.e18
Article dans une revue
voir la publicationChanges in the Human Gut Microbiota Associated With Colonization by Blastocystis sp. and Entamoeba spp. in Non-Industrialized Populations
Frontiers in Cellular and Infection Microbiology . 11 : 533528
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voir la publicationWhy and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA
PLoS Biology . 18 ( 6 ) : e3000742
Article dans une revue
voir la publicationResponse of the human gut and saliva microbiome to urbanization in cameroon
Scientific Reports . 10 ( 1 )
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voir la publicationUse of shotgun metagenomics for the identification of protozoa in the gut microbiota of healthy individuals from worldwide populations with various industrialization levels
PLoS ONE . 14 ( 2 ) : e0211139
Article dans une revue
voir la publicationClose inbreeding and low genetic diversity in Inner Asian human populations despite geographical exogamy
Scientific Reports . 8 : 9397
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voir la publicationGut Protozoa: Friends or Foes of the Human Gut Microbiota?
Trends in Parasitology . 33 ( 12 ) : 925-934
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voir la publicationMicrobiome intestinal ancien et problématiques médicales contemporaines
Médecine/Sciences . 33 : 984-990
Autre publication
voir la publicationOn the Evolution of Lactase Persistence in Humans
Annual Review of Genomics and Human Genetics . 18 ( 1 ) : 297-319
Article dans une revue
voir la publicationSex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations
American Journal of Physical Anthropology . 162 ( 4 ) : 627-640
DOI: 10.1002/ajpa.23151
Article dans une revue
voir la publicationLatitude as a co-driver of human gut microbial diversity?
BioEssays . 39 ( 3 ) : 1600145
Article dans une revue
voir la publicationDetection of Allelic Frequency Differences between the Sexes in Humans: A Signature of Sexually Antagonistic Selection
Genome Biology and Evolution . 8 ( 5 ) : 1489-1500
DOI: 10.1093/gbe/evw090
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voir la publicationDetection and interpretation of shared genetic influences on 42 human traits
Nature Genetics . 48 ( 7 ) : 709-717
DOI: 10.1038/ng.3570
Article dans une revue
voir la publicationVariation in Rural African Gut Microbiota Is Strongly Correlated with Colonization by Entamoeba and Subsistence
PLoS Genetics . 11 ( 11 ) : e1005658
Article dans une revue
voir la publicationPreserving immune diversity through ancient inheritance and admixture
Current Opinion in Immunology . 30 : 79-84
Article dans une revue
voir la publicationDeterminants of Mutation Rate Variation in the Human Germline
Annual Review of Genomics and Human Genetics . 15 ( 1 ) : 47-70
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voir la publicationTroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception
Bioinformatics . 30 ( 14 ) : 2035-2042
Article dans une revue
voir la publicationMicrosatellite data show recent demographic expansions in sedentary but not in nomadic human populations in Africa and Eurasia
European Journal of Human Genetics . 22 ( 10 ) : 1201-1207
DOI: 10.1038/ejhg.2014.2
Article dans une revue
voir la publicationMultiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees
Science . 339 ( 6127 ) : 1578-1582
Article dans une revue
voir la publicationPositive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia
European Journal of Human Genetics . 21 ( 10 ) : 1146-1151
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voir la publicationThe complex binding of PRDM9
Genome Biology . 14 ( 4 ) : 112
Article dans une revue
voir la publicationHuman Genetic Data Reveal Contrasting Demographic Patterns between Sedentary and Nomadic Populations That Predate the Emergence of Farming
Molecular Biology and Evolution . 30 ( 12 ) : 2629 - 2644
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voir la publicationAncestry runs deeper than blood: The evolutionary history of ABO points to cryptic variation of functional importance
BioEssays . : n/a-n/a
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voir la publicationRevisiting an Old Riddle: What Determines Genetic Diversity Levels within Species?
PLoS Biology . 10 ( 9 ) : e1001388
Article dans une revue
voir la publicationA Fine-Scale Chimpanzee Genetic Map from Population Sequencing
Science . 336 ( 6078 ) : 193-198
Article dans une revue
voir la publication