GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Segurel Laure

Chargée de recherche

CNRS

Address: 43 bd du 11 novembre 1918
69622 VILLEURBANNE cedex

Tel: 04 72 43 26 28

Email

Batiment Mendel, 2ème étage. Bureau 12.025

Broad research interests : Using genetic data to understand human evolution : How are populations adapting to diverse environmental pressures (climate, diet, pathogens) ? How are humans and microbes co-evolving ? How various cultural features (matrimonial rules, language) shape the genetic diversity ? 

Thématiques de recherche : Chercheuse en génétique des populations humaines basée au LBBE à Lyon, je m’intéresse principalement à la manière dont les populations humaines s’adaptent à leur environnement, en particulier comment elles évoluent génétiquement en réponse à leur alimentation. D’une part, il s’agit de comprendre les adaptations qui ont eu lieu lors de la révolution néolithique, une transition culturelle majeure il y a environ 10 000 ans qui a été marquée par les débuts de l’agriculture et de l’élevage et au cours de laquelle diverses populations se sont mises à consommer en quantité des céréales et des produits laitiers. Pour cela, j’étudie la diversité génomique humaine et je cherche à détecter les signatures de la sélection naturelle. D’autre part, plus récemment, la révolution industrielle a entrainé de profondes modifications alimentaires. Bien que le génome humain n’ait pas eu le temps de s’adapter à ces contraintes trop récentes, les bactéries intestinales, elles, semblent avoir déjà évolué, ce qui n’est pas sans effet sur notre santé. J’étudie ainsi le microbiote intestinal de populations non-industrielles pour comprendre l’intime relation entre l’Homme et ses bactéries.

Publications

Display of 1 to 30 publications on 39 in total

Population designations in biomedical research: limitations and perspectives

Caroline Gombault, Guillaume Grenet, Laure Ségurel, Laurent Duret, François Gueyffier, Pascal Cathébras...

HLA: Immune Response Genetics .

DOI: 10.1111/tan.14852

Journal article

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Modelling the spatiotemporal spread of beneficial alleles using ancient genomes

Rasa Muktupavela, Martin Petr, Laure L. Segurel, Thorfinn Korneliussen, John Novembre, Fernando Racimo

DOI: 10.1101/2021.07.21.453231

Preprint

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Codiversification of gut microbiota with humans

Taichi Suzuki, J. Liam Fitzstevens, Victor Schmidt, Hagay Enav, Kelsey Huus, Mirabeau Mbong Ngwese...

Science . 377 ( 6612 ) : 1328-1332

DOI: 10.1126/science.abm7759

Journal article

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The human gut microbiome and health inequities

Katherine Amato, Marie-Claire Arrieta, Meghan Azad, Michael Bailey, Josiane Broussard, Carlijn Bruggeling...

Proceedings of the National Academy of Sciences of the United States of America . 118 ( 25 ) : e2017947118

DOI: 10.1073/pnas.2017947118

Journal article

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No evidence for female kin association, indications for extragroup paternity, and sex‐biased dispersal patterns in wild western gorillas

Shelly Masi, Frédéric Austerlitz, Chloé Chabaud, Sophie Lafosse, Nina Marchi, Myriam Georges...

Ecology and Evolution . 11 ( 12 ) : 7634-7646

DOI: 10.1002/ece3.7596

Journal article

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Elevated rates of horizontal gene transfer in the industrialized human microbiome

Mathieu Groussin, Mathilde Poyet, Ainara Sistiaga, Sean Kearney, Katya Moniz, Mary Noel...

Cell . 184 ( 8 ) : 2053-2067.e18

DOI: 10.1016/j.cell.2021.02.052

Journal article

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Changes in the Human Gut Microbiota Associated With Colonization by Blastocystis sp. and Entamoeba spp. in Non-Industrialized Populations

Gaël Even, Ana Lokmer, Jules Rodrigues, Christophe Audebert, Eric Viscogliosi, Laure L. Segurel...

Frontiers in Cellular and Infection Microbiology . 11 : 533528

DOI: 10.3389/fcimb.2021.533528

Journal article

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Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA

Laure Ségurel, Perle Guarino-Vignon, Nina Marchi, Sophie Lafosse, Romain Laurent, Céline Bon...

PLoS Biology . 18 ( 6 ) : e3000742

DOI: 10.1371/journal.pbio.3000742

Journal article

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Response of the human gut and saliva microbiome to urbanization in cameroon

Ana Lokmer, Sophie Aflalo, Norbert N. Amougou, Sophie Lafosse, Alain Froment, Francis Ekwin Tabe...

Scientific Reports . 10 ( 1 )

DOI: 10.1038/s41598-020-59849-9

Journal article

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Use of shotgun metagenomics for the identification of protozoa in the gut microbiota of healthy individuals from worldwide populations with various industrialization levels

Ana Lokmer, Amandine Cian, Alain Froment, Nausicaa Gantois, Eric Viscogliosi, Magali Chabé...

PLoS ONE . 14 ( 2 ) : e0211139

DOI: 10.1371/journal.pone.0211139

Journal article

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Close inbreeding and low genetic diversity in Inner Asian human populations despite geographical exogamy

Nina Marchi, Philippe Mennecier, Myriam Georges, Sophie Lafosse, Tatyana Hegay, Choduraa Dorzhu...

Scientific Reports . 8 : 9397

DOI: 10.1038/s41598-018-27047-3

Journal article

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Gut Protozoa: Friends or Foes of the Human Gut Microbiota?

Magali Chabé, Ana Lokmer, Laure Ségurel

Trends in Parasitology . 33 ( 12 ) : 925-934

DOI: 10.1016/j.pt.2017.08.005

Journal article

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Microbiome intestinal ancien et problématiques médicales contemporaines

Philippe Charlier, Anaïs Augias, Philippe Sansonetti, Céline Bon, Sean Kennedy, Laure Ségurel

médecine/sciences . 33 ( 11 ) : 984-990

DOI: 10.1051/medsci/20173311016

Journal article

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Sex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations

Nina Marchi, Tatyana Hegay, Philippe Mennecier, Myriam Georges, Romain Laurent, Mark Whitten...

American Journal of Physical Anthropology . 162 ( 4 ) : 627-640

DOI: 10.1002/ajpa.23151

Journal article

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Detection and interpretation of shared genetic influences on 42 human traits

Joseph Pickrell, Tomaz Berisa, Jimmy Liu, Laure Ségurel, Joyce Tung, David A Hinds

Nature Genetics . 48 ( 7 ) : 709-717

DOI: 10.1038/ng.3570

Journal article

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Detection of Allelic Frequency Differences between the Sexes in Humans: A Signature of Sexually Antagonistic Selection

Elise Lucotte, Romain Laurent, Evelyne Heyer, Laure Ségurel, Bruno Toupance

Genome Biology and Evolution . 8 ( 5 ) : 1489-1500

DOI: 10.1093/gbe/evw090

Journal article

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Variation in Rural African Gut Microbiota Is Strongly Correlated with Colonization by Entamoeba and Subsistence

Elise R Morton, Joshua Lynch, Alain Froment, Sophie Lafosse, Evelyne Heyer, Molly M. Przeworski...

PLoS Genetics . 11 ( 11 ) : e1005658

DOI: 10.1371/journal.pgen.1005658

Journal article

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Preserving immune diversity through ancient inheritance and admixture

Laure L. Segurel, Lluis Quintana-Murci

Current Opinion in Immunology . 30 : 79-84

DOI: 10.1016/j.coi.2014.08.002

Journal article

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TroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception

Amir Kermany, Laure L. Segurel, Tiffany Oliver, Molly Przeworski

Bioinformatics . 30 ( 14 ) : 2035-2042

DOI: 10.1093/bioinformatics/btu159

Journal article

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Microsatellite data show recent demographic expansions in sedentary but not in nomadic human populations in Africa and Eurasia

Carla Aimé, Paul Verdu, Laure L. Segurel, Begoña Martinez-Cruz, Tatyana Hegay, Evelyne Heyer...

European Journal of Human Genetics . 22 ( 10 ) : 1201-1207

DOI: 10.1038/ejhg.2014.2

Journal article

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Human Genetic Data Reveal Contrasting Demographic Patterns between Sedentary and Nomadic Populations That Predate the Emergence of Farming

Carla Aimé, Guillaume Laval, Etienne Patin, Paul Verdu, Laure L. Segurel, Raphaëlle Chaix...

Molecular Biology and Evolution . 30 ( 12 ) : 2629 - 2644

DOI: 10.1093/molbev/mst156

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Ancestry runs deeper than blood: The evolutionary history of ABO points to cryptic variation of functional importance

Laure L. Segurel, Ziyue Gao, Molly Przeworski

BioEssays . : n/a-n/a

DOI: 10.1002/bies.201300030

Journal article

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Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees

E. Leffler, Z. Gao, S. Pfeifer, L. Segurel, A. Auton, O. Venn...

Science . 339 ( 6127 ) : 1578-1582

DOI: 10.1126/science.1234070

Journal article

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Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia

Laure Ségurel, Frédéric Austerlitz, Bruno Toupance, Mathieu M. Gautier, Joanna L Kelley, Patrick Pasquet...

European Journal of Human Genetics . 21 ( 10 ) : 1146-1151

DOI: 10.1038/ejhg.2012.295

Journal article

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Revisiting an Old Riddle: What Determines Genetic Diversity Levels within Species?

Ellen Miranda Leffler, Kevin Bullaughey, Daniel R Matute, Wynn Meyer, Laure Ségurel, Aarti A. Venkat...

PLoS Biology . 10 ( 9 ) : e1001388

DOI: 10.1371/journal.pbio.1001388

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A Fine-Scale Chimpanzee Genetic Map from Population Sequencing

A. Auton, A. Fledel-Alon, S. Pfeifer, O. Venn, L. Segurel, T. Street...

Science . 336 ( 6078 ) : 193-198

DOI: 10.1126/science.1216872

Journal article

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