Statistiques et Modélisation pour les Sciences de la Santé

Cementless lateralized stems in primary THA: Mid-term survival and risk factors for failure in 172 stems

Cyril Courtin, Anthony Viste, Fabien Subtil, Olivier Catin, Romain Desmarchelier, Michel-Henri Fessy

Orthopaedics and Traumatology - Surgery and Research . 103 ( 1 ) : pp. 15-19

DOI: 10.1016/j.otsr.2016.10.011

2017

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Strong incidence of pseudomonas aeruginosa on bacterial rrs and ITS genetic structures of cystic fibrosis sputa

Laurence Pages-Monteiro, Romain Martin, Carine Commun, Nolwenn Alliot, Claire Bardel, Hélène Meugnier...

PLoS ONE . 12 ( 3 ) : 1-19

DOI: 10.1371/journal.pone.0173022

2017

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Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

Nathalie Eymard, Vitaly Volpert, Polina Kurbatova, Nikolai Bessonov, Kayode Ogungbenro, Leon Aarons...

Mathematical Medicine and Biology .

DOI: 10.1093/imammb/dqw019

2017

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Conditions of microvessel occlusion for blood coagulation in flow

A Bouchnita, T Galochkina, P Kurbatova, Patrice Nony, V Volpert

International Journal for Numerical Methods in Biomedical Engineering .

DOI: 10.1002/cnm.2850

2017

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Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.

Céline Pouzot-Névoret, Mathieu Magnin, Jean-Yves Ayoub, Laurent Bourguignon, Pascal Maire, Damien Wertz...

International Journal of Antimicrobial Agents .

DOI: 10.1016/j.ijantimicag.2017.03.029

2017

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Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen

Yoann Cazaubon, Nicolas Venisse, Olivier Mimoz, Pascal Maire, Michel Ducher, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 72 ( 10 ) : 2804-2812

DOI: 10.1093/jac/dkx242

2017

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Mechanisms of drug-drug interaction between rifampicin and fusidic acid

Florianne Bel, Laurent Bourguignon, Michel Tod, Tristan Ferry, Sylvain Goutelle

British Journal of Clinical Pharmacology . 83 ( 8 ) : 1862-1864

DOI: 10.1111/bcp.13277

2017

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Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

O. Maison, B. Gastine, L. Dayot, Sylvain Goutelle

Drugs & aging . 34 : 545-553

DOI: 10.1007/s40266-017-0467-5

2017

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Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

A. Bel Kamel, Laurent Bourguignon, M. Marcos, M. Ducher, Sylvain Goutelle

Therapeutic Drug Monitoring . 39 : 83-87

DOI: 10.1097/FTD.0000000000000359

2017

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A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

M. Tod, Laurent Bourguignon, N. Bleyzac, Sylvain Goutelle

AAPS Journal . 19 : 497-509

DOI: 10.1208/s12248-016-0021-0

2017

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The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus

Elisabeth Hodille, Warren Rose, Binh An Diep, Sylvain Goutelle, Gérard Lina, Oana Dumitrescu

Clinical Microbiology Reviews . 30 ( 4 ) : 887-917

DOI: 10.1128/CMR.00120-16

2017

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A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics

M. Philippe, M. Neely, Y. Bertrand, N. Bleyzac, Sylvain Goutelle

Clinical Pharmacokinetics . 56 : 435-447

DOI: 10.1007/s40262-016-0448-6

2017

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Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

E. Cartet-Farnier, L. Goutelle-Audibert, P. Maire, B. Gastine, Sylvain Goutelle

Fundamental and Clinical Pharmacology . 31 : 110-119

DOI: 10.1111/fcp.12241

2017

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Effet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes

Marion Gougain, Moreau Alain, Rémy Boussageon, Gisèle Pickering, François Gueyffier

Thérapie . 72 ( 5 ) : 609 - 613

DOI: 10.1016/j.therap.2017.02.004

2017

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Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design

G. Grenet, A. Lajoinie, S. Ribault, G. B. Nguyen, T. Linet, A. Metge...

Fundamental and Clinical Pharmacology . 31 ( 3 ) : 258-264

DOI: 10.1111/fcp.12263

2017

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Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials

M. Rehman, B.V. Tudrej, J. Soustre, M. Buisson, P. Archambault, D. Pouchain...

Diabetes and Metabolism . 43 ( 1 ) : 48 - 58

DOI: 10.1016/j.diabet.2016.09.005

2017

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Efficiency of physical therapy on postural imbalance after stroke: study protocol for a systematic review and meta-analysis

H Hugues, J. Di Marco, J Janiaud, Y Xue, J Pires, H Khademi...

BMJ Open . 7 ( 1 ) : e013348

DOI: 10.1136/bmjopen-2016-013348

2017

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No benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials

M. Al-Gobari, H.H. Le, M. Fall, François Gueyffier, B. Burnand

PLoS ONE . 12 : e0171168

DOI: 10.1371/journal.pone.0171168

2017

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Nadroparin for the prevention of venous thromboembolism in nonsurgical patients: a systematic review and meta-analysis

Walter Ageno, Jacqueline Bosch, Michel Cucherat, John Eikelboom

Journal of Thrombosis and Thrombolysis . 42 ( 1 ) : 90-98

DOI: 10.1007/s11239-015-1294-3

2016

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A bench evaluation of fraction of oxygen in air delivery and tidal volume accuracy in home care ventilators available for hospital use

L. Baboi, Fabien Subtil, C. Guerin

Journal of Thoracic Disease . 8 ( 12 ) : 3639-3647

DOI: 10.21037/jtd.2016.12.64

2016

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Le médecin généraliste face à la prise en charge de « l’allergie au médicament » : un éclairage sur la pratique actuelle en région Rhône-Alpes, et perspectives d’amélioration

V.-A. Huynh, E. Lungoci, Audrey Nosbaum, Florence Hacard, F. Subtil, Jean-François Nicolas...

Revue francaise d'allergologie . 56 ( 5 ) : 401-406

DOI: 10.1016/j.reval.2016.02.007

2016

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kmlShape: An Efficient Method to Cluster Longitudinal Data (Time-Series) According to Their Shapes

Christophe Genolini, René Ecochard, Mamoun Benghezal, Driss Tarak, Sandrine Andrieu, Fabien Subtil

PLoS ONE . 11 ( 6 )

DOI: 10.1371/journal.pone.0150738

2016

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Performance of the 4-mg intravenous dexamethasone suppression test in differentiating Cushing disease from pseudo-Cushing syndrome

M. Nouvel, Muriel Rabilloud, V. Raverot, F. Subtil, J. Vouillarmet, Charles Thivolet...

Annales d'Endocrinologie . 77 ( 1 ) : 30-6

DOI: 10.1016/j.ando.2015.11.001

2016

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Early diagnosis of gestational trophoblastic neoplasia based on trajectory classification with compartment modeling

C. Burny, Muriel Rabilloud, F. Golfier, J. Massardier, T. Hajri, A. M. Schott...

BMC Medical Research Methodology . 16 : 3

DOI: 10.1186/s12874-015-0106-y

2016

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An 18F-FDG-PET maximum standardized uptake value \textgreater 10 represents a novel valid marker for discerning Richter's Syndrome

A.S. Michallet, P. Sesques, K.G. Rabe, E. Itti, J. Tordot, C. Tychyj-Pinel...

Leukemia & lymphoma . 57 : 1474--1477

DOI: 10.3109/10428194.2015.1099643

2016

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Impact du retard de croissance intra-utérin sur la concentration sérique maternelle du PlGF (Placental Growth Factor) : une étude cas-témoin

A. Margossian, C. Boisson-Gaudin, F. Subtil, R.-C. Rudigoz, G. Dubernard, F. Allias...

Gynécologie Obstétrique & Fertilité . 44 ( 1 ) : 23-28

DOI: 10.1016/j.gyobfe.2015.11.005

2016

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Familial vs. sporadic sarcoidosis: BTNL2 polymorphisms, clinical presentations, and outcomes in a French cohort

Yves Pacheco, Alain Calender, Dominique Israël-Biet, Pascal Roy, Serge Lebecque, Vincent Cottin...

Orphanet Journal of Rare Diseases . 11 ( 1 ) : np

DOI: 10.1186/s13023-016-0546-4

2016

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Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.

Polina Kurbatova, Fabrice Wendling, Anna Kaminska, Anna Rosati, Rima Nabbout, Renzo Guerrini...

Experimental Neurology . 283 ( Pt A ) : 57-72

DOI: 10.1016/j.expneurol.2016.05.037

2016

Articles

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Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

Sylvain Goutelle, Sandrine Roux, Marie-Claude Gagnieu, Florent Valour, Sebastien Lustig, Florence Ader...

Antimicrobial Agents and Chemotherapy . 60 ( 5 ) : pp. 3148-3151

DOI: 10.1128/AAC.02597-15

2016

Articles

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Mathematical modeling and systems pharmacology of tuberculosis: Isoniazid as a case study

L. Lalande, Laurent Bourguignon, P. Maire, Sylvain Goutelle

Journal of Theoretical Biology . 399 : 43-52

DOI: 10.1016/j.jtbi.2016.03.038

2016

Articles

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Statistiques et Modélisation pour les Sciences de la Santé

Equipe Biostatistiques Santé

Equipe Evaluation et Modélisation des Effets Thérapeutiques

Publications

Cementless lateralized stems in primary THA: Mid-term survival and risk factors for failure in 172 stems

Strong incidence of pseudomonas aeruginosa on bacterial rrs and ITS genetic structures of cystic fibrosis sputa

Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

Conditions of microvessel occlusion for blood coagulation in flow

Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.

Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen

Mechanisms of drug-drug interaction between rifampicin and fusidic acid

Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus

A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics

Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

Effet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes

Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design

Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials

Efficiency of physical therapy on postural imbalance after stroke: study protocol for a systematic review and meta-analysis

No benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials

Nadroparin for the prevention of venous thromboembolism in nonsurgical patients: a systematic review and meta-analysis

A bench evaluation of fraction of oxygen in air delivery and tidal volume accuracy in home care ventilators available for hospital use

Le médecin généraliste face à la prise en charge de « l’allergie au médicament » : un éclairage sur la pratique actuelle en région Rhône-Alpes, et perspectives d’amélioration

kmlShape: An Efficient Method to Cluster Longitudinal Data (Time-Series) According to Their Shapes

Performance of the 4-mg intravenous dexamethasone suppression test in differentiating Cushing disease from pseudo-Cushing syndrome

Early diagnosis of gestational trophoblastic neoplasia based on trajectory classification with compartment modeling

An 18F-FDG-PET maximum standardized uptake value \textgreater 10 represents a novel valid marker for discerning Richter's Syndrome

Impact du retard de croissance intra-utérin sur la concentration sérique maternelle du PlGF (Placental Growth Factor) : une étude cas-témoin

Familial vs. sporadic sarcoidosis: BTNL2 polymorphisms, clinical presentations, and outcomes in a French cohort

Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.

Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

Mathematical modeling and systems pharmacology of tuberculosis: Isoniazid as a case study

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