Statistiques et Modélisation pour les Sciences de la Santé

Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer

T. Aparicio, O. Bouché, E. Francois, F. Retornaz, E. Barbier, J. Taieb...

European Journal of Cancer . 97 : 16-24

DOI: 10.1016/j.ejca.2018.03.030

2018

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Effect of Optimal Medical Therapy at Discharge in Patients With Reperfused ST-Segment Elevation Myocardial Infarction on 1-Year Mortality (from the Regional RESCUe Registry)

Danka Tomasevic, Carlos El Khoury, Fabien Subtil, Pierre-Yves Dubien, Thomas Bochaton, Patrice Serre...

American Journal of Cardiology . 121 ( 4 ) : 403-409

DOI: 10.1016/j.amjcard.2017.11.002

2018

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Whole exome sequencing in three families segregating a pediatric case of sarcoidosis

Alain Calender, Pierre Antoine Rollat Farnier, Adrien Buisson, Stéphane Pinson, Abderrazzaq Bentaher, Serge Lebecque...

BMC Medical Genomics . 11 ( 1 ) : 23

DOI: 10.1186/s12920-018-0338-x

2018

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Single, short in-del, and copy number variations detection in monogenic dyslipidemia using a next-generation sequencing strategy

Oriane Marmontel, Sybil Charriere, T. Simonet, V. Bonnet, S. Dumont, M. Mahl...

Clinical Genetics . 94 ( 1 ) : 132-140

DOI: 10.1111/cge.13250

2018

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Determinants of amikacin first peak concentration in critically ill patients

Clément Boidin, Sophie Jenck, Laurent Bourguignon, Sejad Torkmani, Aurore Roussey-Jean, Stanislas Ledochowski...

Fundamental and Clinical Pharmacology .

DOI: 10.1111/fcp.12374

2018

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Antituberculous drugs modulate bacterial phagolysosome avoidance and autophagy in Mycobacterium tuberculosis-infected macrophages

Charlotte Genestet, Fanny Bernard-Barret, Elisabeth Hodille, Christophe Ginevra, Florence Ader, Sylvain Goutelle...

Tuberculosis . 111 : 67-70

DOI: 10.1016/j.tube.2018.05.014

2018

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Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy

Claire Triffault-Fillit, Florent Valour, Ronan Guillo, Michel Tod, Sylvain Goutelle, Sébastien Lustig...

ANTIMICROB. AGENTS CHEMOTHER. . 62 ( 10 )

DOI: 10.1128/AAC.00163-18

2018

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Assessing the Combined Antibacterial Effect of Isoniazid and Rifampin on Four Mycobacterium tuberculosis Strains Using In Vitro Experiments and Response-Surface Modeling

Charlotte Genestet, Florence Ader, Catherine Pichat, Gérard Lina, Oana Dumitrescu, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 62 ( 1 )

DOI: 10.1128/AAC.01413-17

2018

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Sex gap in aging and longevity: can sex chromosomes play a role?

Gabriel A.B. Marais, Jean-Michel Gaillard, Cristina Vieira, Ingrid Plotton, Damien Sanlaville, François Gueyffier...

Biology of Sex Differences . 9 ( 1 ) : 1-14

DOI: 10.1186/s13293-018-0181-y

2018

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Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals

Victor Ronget, Jean-Michel Gaillard, Tim Coulson, Michael Garratt, François Gueyffier, Jean-Christophe Lega...

Biol. Rev . 93 : 1 - 27

DOI: 10.1111/brv.12329

2018

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Multifaceted intervention to improve obstetric practices: The OPERA cluster-randomized controlled trial

Corinne Dupont, Norbert Winer, Muriel Rabilloud, Sandrine Touzet, Bernard Branger, Jacques Lansac...

European Journal of Obstetrics & Gynecology and Reproductive Biology . 215 : 206 - 212

DOI: 10.1016/j.ejogrb.2017.06.026

2017

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Restricted mean survival time over 15 years for patients starting renal replacement therapy

Cécile Couchoud, Emmanuelle Dantony, Mad-Hélénie Elsensohn, Emmanuel Villar, Cécile Vigneau, Olivier Moranne...

Nephrology Dialysis Transplantation . 32 ( Suppl.2 ) : ii60-ii67

DOI: 10.1093/ndt/gfw386

2017

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Thigh Ultrasound Monitoring Identifies Decreases in Quadriceps Femoris Thickness as a Frequent Observation in Critically Ill Children

Frederic V. Valla, David K. Young, Muriel Rabilloud, Uvaraj Periasami, Manoj John, Florent Baudin...

Pediatric Critical Care Medicine . 18 ( 8 ) : e339-e34

DOI: 10.1097/PCC.0000000000001235

2017

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Diagnostic value and relative weight of sequence-specific magnetic resonance features in characterizing clinically significant prostate cancers

O. Rouviere, T. Dagonneau, F. Cros, F. Bratan, L. Roche, F. Mege-Lechevallier...

PLoS ONE . 12 : e0178901

DOI: 10.1371/journal.pone.0178901

2017

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Reproducibility of in vivo magnetic resonance imaging T 1 rho and T 2 relaxation time measurements of hip cartilage at 3.0T in healthy volunteers

Angeline Nemeth, Lucy Di Marco, Florent Boutitie, Michael Sdika, Denis Grenier, Muriel Rabilloud...

Journal of Magnetic Resonance Imaging . 47 ( 4 ) : 1022-1033

DOI: 10.1002/jmri.25799

2017

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Focal High Intensity Focused Ultrasound of Unilateral Localized Prostate Cancer: A Prospective Multicentric Hemiablation Study of 111 Patients

P. Rischmann, A. Gelet, B. Riche, A. Villers, G. Pasticier, P. Bondil...

European Urology . 71 : 267-273

DOI: 10.1016/j.eururo.2016.09.039

2017

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Sensitivity and specificity of different methods for cystic fibrosis-related diabetes screening: is the oral glucose tolerance test still the standard?

C. Mainguy, G. Bellon, V. Delaup, T. Ginoux, B. Kassai-Koupai, S. Mazur...

Journal of pediatric endocrinology & metabolism . 30 : 27-35

DOI: 10.1515/jpem-2016-0184

2017

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Trajectories and Predictors of Allograft Dysfunction after Renal Transplantation in Children

C.D. Garcia, B. Ranchin, J. Iwaz, L. Selistre, L. Dubourg, V.C. de Souza...

American Journal of Nephrology . 45 : 63-68

DOI: 10.1159/000453076

2017

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Methodological Quality of Surgical Mortality Studies Using Large Hospital Databases: A Systematic Review

C. Payet, Jc. Lifante, Mj. Carty, Muriel Rabilloud, A. Duclos

Annals of Surgery . 265 : 1113-1118

DOI: 10.1097/SLA.0000000000002119

2017

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Vancomycin treatment is a risk factor for vancomycin-nonsusceptible Staphylococcus capitis sepsis in preterm neonates

Marine Butin, Jean-Philippe Rasigade, F. Subtil, Patricia Martins-Simões, C. Pralong, A.-M. Freydière...

Clinical Microbiology and Infection . 23 ( 11 ) : 839-844

DOI: 10.1016/j.cmi.2017.03.022

2017

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Dynamics of Ebola RNA Persistence in Semen: A Report From the Postebogui Cohort in Guinea

Fabien Subtil, Charlotte Delaunay, Alpha Kabinet Keita, Mamadou Saliou Sow, Abdoulaye Touré, Sandrine Leroy...

Clinical Infectious Diseases . 64 ( 12 ) : 1788 - 1790

DOI: 10.1093/cid/cix210

2017

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Ibrutinib in very elderly patients with relapsed/refractory chronic lymphocytic leukemia: A real-world experience of 71 patients treated in France: A study from the French Innovative Leukemia Organization (FILO) group

Sophie Michallet, Arnaud Campidelli, Helene Lequeu, Marie-Sarah Dilhuydy, Olivier Tournilhac, Luc-Matthieu Fornecker...

American Journal of Hematology . 92 ( 6 ) : E105 - E107

DOI: 10.1002/ajh.24715

2017

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Cementless lateralized stems in primary THA: Mid-term survival and risk factors for failure in 172 stems

Cyril Courtin, Anthony Viste, Fabien Subtil, Olivier Catin, Romain Desmarchelier, Michel-Henri Fessy

Orthopaedics and Traumatology - Surgery and Research . 103 ( 1 ) : pp. 15-19

DOI: 10.1016/j.otsr.2016.10.011

2017

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Strong incidence of pseudomonas aeruginosa on bacterial rrs and ITS genetic structures of cystic fibrosis sputa

Laurence Pages-Monteiro, Romain Martin, Carine Commun, Nolwenn Alliot, Claire Bardel, Hélène Meugnier...

PLoS ONE . 12 ( 3 ) : 1-19

DOI: 10.1371/journal.pone.0173022

2017

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Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.

Céline Pouzot-Névoret, Mathieu Magnin, Jean-Yves Ayoub, Laurent Bourguignon, Pascal Maire, Damien Wertz...

International Journal of Antimicrobial Agents .

DOI: 10.1016/j.ijantimicag.2017.03.029

2017

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Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen

Yoann Cazaubon, Nicolas Venisse, Olivier Mimoz, Pascal Maire, Michel Ducher, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 72 ( 10 ) : 2804-2812

DOI: 10.1093/jac/dkx242

2017

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Mechanisms of drug-drug interaction between rifampicin and fusidic acid

Florianne Bel, Laurent Bourguignon, Michel Tod, Tristan Ferry, Sylvain Goutelle

British Journal of Clinical Pharmacology . 83 ( 8 ) : 1862-1864

DOI: 10.1111/bcp.13277

2017

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Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

O. Maison, B. Gastine, L. Dayot, Sylvain Goutelle

Drugs & aging . 34 : 545-553

DOI: 10.1007/s40266-017-0467-5

2017

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Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

A. Bel Kamel, Laurent Bourguignon, M. Marcos, M. Ducher, Sylvain Goutelle

Therapeutic Drug Monitoring . 39 : 83-87

DOI: 10.1097/FTD.0000000000000359

2017

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A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

M. Tod, Laurent Bourguignon, N. Bleyzac, Sylvain Goutelle

AAPS Journal . 19 : 497-509

DOI: 10.1208/s12248-016-0021-0

2017

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Statistiques et Modélisation pour les Sciences de la Santé

Equipe Biostatistiques Santé

Equipe Evaluation et Modélisation des Effets Thérapeutiques

Publications

Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer

Effect of Optimal Medical Therapy at Discharge in Patients With Reperfused ST-Segment Elevation Myocardial Infarction on 1-Year Mortality (from the Regional RESCUe Registry)

Whole exome sequencing in three families segregating a pediatric case of sarcoidosis

Single, short in-del, and copy number variations detection in monogenic dyslipidemia using a next-generation sequencing strategy

Determinants of amikacin first peak concentration in critically ill patients

Antituberculous drugs modulate bacterial phagolysosome avoidance and autophagy in Mycobacterium tuberculosis-infected macrophages

Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy

Assessing the Combined Antibacterial Effect of Isoniazid and Rifampin on Four Mycobacterium tuberculosis Strains Using In Vitro Experiments and Response-Surface Modeling

Sex gap in aging and longevity: can sex chromosomes play a role?

Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals

Multifaceted intervention to improve obstetric practices: The OPERA cluster-randomized controlled trial

Restricted mean survival time over 15 years for patients starting renal replacement therapy

Thigh Ultrasound Monitoring Identifies Decreases in Quadriceps Femoris Thickness as a Frequent Observation in Critically Ill Children

Diagnostic value and relative weight of sequence-specific magnetic resonance features in characterizing clinically significant prostate cancers

Reproducibility of in vivo magnetic resonance imaging T 1 rho and T 2 relaxation time measurements of hip cartilage at 3.0T in healthy volunteers

Focal High Intensity Focused Ultrasound of Unilateral Localized Prostate Cancer: A Prospective Multicentric Hemiablation Study of 111 Patients

Sensitivity and specificity of different methods for cystic fibrosis-related diabetes screening: is the oral glucose tolerance test still the standard?

Trajectories and Predictors of Allograft Dysfunction after Renal Transplantation in Children

Methodological Quality of Surgical Mortality Studies Using Large Hospital Databases: A Systematic Review

Vancomycin treatment is a risk factor for vancomycin-nonsusceptible Staphylococcus capitis sepsis in preterm neonates

Dynamics of Ebola RNA Persistence in Semen: A Report From the Postebogui Cohort in Guinea

Ibrutinib in very elderly patients with relapsed/refractory chronic lymphocytic leukemia: A real-world experience of 71 patients treated in France: A study from the French Innovative Leukemia Organization (FILO) group

Cementless lateralized stems in primary THA: Mid-term survival and risk factors for failure in 172 stems

Strong incidence of pseudomonas aeruginosa on bacterial rrs and ITS genetic structures of cystic fibrosis sputa

Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.

Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen

Mechanisms of drug-drug interaction between rifampicin and fusidic acid

Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

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