Statistiques et Modélisation pour les Sciences de la Santé

Should busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children

M. Philippe, Sylvain Goutelle, J. Guitton, X. Fonrose, C. Bergeron, Pascal Girard...

Bone Marrow Transplantation . 51 : 72-78

DOI: 10.1038/bmt.2015.218

2016

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Comparison of the static in vivo approach to a physiologically based pharmacokinetic approach for metabolic drug-drug interactions prediction

M. Tod, P.B. Pierrillas, Laurent Bourguignon, Sylvain Goutelle

International Journal of Pharmacokinetics . : 1-10

2016

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Accurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software

M. Neely, M. Philippe, T. Rushing, X. Fu, M. van Guilder, D. Bayard...

Therapeutic Drug Monitoring . 38 : 332-342

DOI: 10.1097/FTD.0000000000000276

2016

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Quantitative Prediction of Drug Interactions Caused by CYP1A2 Inhibitors and Inducers

L. Gabriel, M. Tod, Sylvain Goutelle

Clinical Pharmacokinetics . 55 : 977-990

DOI: 10.1007/s40262-016-0371-x

2016

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Quality of qualitative studies centred on patients in family practice: a systematic review

Benedicte Eschalier, Stéphane Descamps, Bruno Pereira, Hélène Vaillant-Roussel, Guillaume Girard, Stéphane Boisgard...

Family Practice . 33 ( 6 ) : 580 - 587

DOI: 10.1093/fampra/cmw095

2016

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Référentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux

Catherine Cornu, Anne Donche, Carine Coffre, Amélie Le Gouge, Boulkedid Rym, Isabelle Vaugier...

Thérapie .

DOI: 10.2515/therapie/2015042

2016

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One-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial

Cyril Villat, Jean-Pierre Attal, Nathalie Brulat, Franck Decup, Sophie Doméjean, Elisabeth Dursun...

Trials . 17 ( 1 ) : 404

DOI: 10.1186/s13063-016-1484-0

2016

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Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

H.-H. Le, C. El-Khatib, M. Mombled, F. Guitarian, M. Al-Gobari, M. Fall...

PLoS ONE . 11 : e0145958

DOI: 10.1371/journal.pone.0145958

2016

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Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals

G. Taverny, Y. Mimouni, A. Ledigarcher, P. Chevalier, L. Thijs, J.M. Wright...

Cochrane database of systematic reviews (Online) . 3 : CD011745

DOI: 10.1002/14651858.CD011745.pub2

2016

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Metformin as firstline treatment for type 2 diabetes: are we sure?

R. Boussageon, François Gueyffier, Catherine Cornu

BMJ-BRITISH MEDICAL JOURNAL . 352 : h6748

DOI: 10.1136/bmj.h6748

2016

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Different treatment benefits were estimated by clinical trials performed in adults compared with those performed in children

Perrine Janiaud, A. Lajoinie, F. Cour-Andlauer, Catherine Cornu, P. Cochat, Michel Cucherat...

Journal of Clinical Epidemiology . 68 : 1221-1231

2015

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Is legacy a myth or a reality? We should know, and we do not

F. Gueyffier, Michel Cucherat

Journal of Hypertension . 33 : 2207-9

2015

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Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias

Pascal Richette, Xavier Chevalier, Hang Korng Ea, Florent Eymard, Yves Henrotin, Paul Ornetti...

RMD Open : Rheumatic & Musculoskeletal Diseases . 1 : e000071

DOI: 10.1136/rmdopen-2015-000071

2015

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An 18F-FDG-PET maximum standardized uptake value > 10 represents a novel valid marker for discerning Richter’s Syndrome

Anne-Sophie Michallet, Pierre Sesques, Kari Rabe, Emmanuel Itti, Jérémy Tordot, Christelle Tychyj-Pinel...

Leukemia & lymphoma . 57 ( 6 ) : 1474-1477

DOI: 10.3109/10428194.2015.1099643

2015

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Spatially regularized mixture model for lesion segmentation with application to stroke patients

B. Ozenne, Fabien Subtil, L. Ostergaard, Delphine Maucort-Boulch

Biostatistics . 16 : 580-95

2015

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The precision–recall curve overcame the optimism of the receiver operating characteristic curve in rare diseases

B. Ozenne, Fabien Subtil, Delphine Maucort-Boulch

Journal of Clinical Epidemiology . 68 : 855-9

2015

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Sequential combination of gemcitabine, vinorelbine, pegylated liposomal doxorubicin and Brentuximab as a bridge regimen to transplant in relapsed or refractory Hodgkin lymphoma

As. Michallet, Y. Guillermin, B. Deau, L. Lebras, S. Harel, S. Amorin...

Haematologica . 100 : e269-e271

2015

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An enhancement of ROC curves made them clinically relevant for diagnostic-test comparison and optimal-threshold determination

Fabien Subtil, Muriel Rabilloud

Journal of Clinical Epidemiology . 68 : 752-9

DOI: 10.1016/j.jclinepi.2015.01.003

2015

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Comparison of two next-generation sequencing kits for diagnosis of epileptic disorders with a user-friendly tool for displaying gene coverage, DeCovA

S. Dimassi, T. Simonet, A. Labalme, N. Boutry-Kryza, Amandine Campan-Fournier, R. Lamy...

Applied & Translational Genomics . 7 : 19-25

2015

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CSF IgA NMDAR antibodies are potential biomarkers for teratomas in anti-NMDAR encephalitis

V. Desestret, A. Chefdeville, A. Viaccoz, C. Bost, F. Ducray, G. Picard...

Neurology neuroimmunology & neuroinflammation . 2 : e166

2015

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An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

S. Blein, Claire Bardel, V. Danjean, L. Mcguffog, S. Healey, D. Barrowdale...

Breast Cancer Research . 17 : 61

DOI: 10.1186/s13058-015-0567-2

2015

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High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention

I. Marchant, Jp. Boissel, Patrice Nony, F. Gueyffier

PLoS ONE . 10 : e0140793

2015

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Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs

Laure Lalande, Laurent Bourguignon, S. Bihari, P. Maire, M. Neely, R. Jelliffe...

Antimicrobial Agents and Chemotherapy . 59 : 5181-9

2015

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A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells-using rifampicin as an example

O. Clewe, Sylvain Goutelle, Jr. Conte, Ush. Simonsson

European journal of clinical pharmacology . 71 : 313-9

2015

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Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients

A. Glatard, Laurent Bourguignon, R. W. Jelliffe, P. Maire, M. N. Neely, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 59 : 2986-94

2015

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Model-Based Determination of Effective Blood Concentrations of Cyclosporine for Neutrophil Response in the Treatment of Severe Aplastic Anemia in Children

M. Philippe, E. Henin, Y. Bertrand, D. Plantaz, Sylvain Goutelle, N. Bleyzac

AAPS Journal . 17 : 1157-67

2015

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A Prediction Model of Drug Exposure in Cirrhotic Patients According to Child-Pugh Classification

J. Steelandt, E. Jean-Bart, Sylvain Goutelle, M. Tod

Clinical Pharmacokinetics . 54 : 1245-58

DOI: 10.1007/s40262-015-0288-9

2015

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Quantitative methods for prediction of the effect of cytochrome P450 gene polymorphisms on substrate drug exposure

Sylvain Goutelle, M. Tod

Clinical Pharmacokinetics . 54 : 319-20

2015

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Subcutaneous administration of levetiracetam in geriatrics

O. Maison, B. Gastine, L. Peter-Derex, C. Berger, Sylvain Goutelle

Revue Neurologique . 171 : 398-399

2015

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Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

C. Vale, L. Rydzewska, M. Rovers, J. Emberson, François Gueyffier, L. Stewart

British medical journal . 350 : h1088

DOI: 10.1136/bmj.h1088

2015

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Statistiques et Modélisation pour les Sciences de la Santé

Equipe Biostatistiques Santé

Equipe Evaluation et Modélisation des Effets Thérapeutiques

Publications

Should busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children

Comparison of the static in vivo approach to a physiologically based pharmacokinetic approach for metabolic drug-drug interactions prediction

Accurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software

Quantitative Prediction of Drug Interactions Caused by CYP1A2 Inhibitors and Inducers

Quality of qualitative studies centred on patients in family practice: a systematic review

Référentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux

One-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial

Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals

Metformin as firstline treatment for type 2 diabetes: are we sure?

Different treatment benefits were estimated by clinical trials performed in adults compared with those performed in children

Is legacy a myth or a reality? We should know, and we do not

Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias

An 18F-FDG-PET maximum standardized uptake value > 10 represents a novel valid marker for discerning Richter’s Syndrome

Spatially regularized mixture model for lesion segmentation with application to stroke patients

The precision–recall curve overcame the optimism of the receiver operating characteristic curve in rare diseases

Sequential combination of gemcitabine, vinorelbine, pegylated liposomal doxorubicin and Brentuximab as a bridge regimen to transplant in relapsed or refractory Hodgkin lymphoma

An enhancement of ROC curves made them clinically relevant for diagnostic-test comparison and optimal-threshold determination

Comparison of two next-generation sequencing kits for diagnosis of epileptic disorders with a user-friendly tool for displaying gene coverage, DeCovA

CSF IgA NMDAR antibodies are potential biomarkers for teratomas in anti-NMDAR encephalitis

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention

Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs

A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells-using rifampicin as an example

Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients

Model-Based Determination of Effective Blood Concentrations of Cyclosporine for Neutrophil Response in the Treatment of Severe Aplastic Anemia in Children

A Prediction Model of Drug Exposure in Cirrhotic Patients According to Child-Pugh Classification

Quantitative methods for prediction of the effect of cytochrome P450 gene polymorphisms on substrate drug exposure

Subcutaneous administration of levetiracetam in geriatrics

Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

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