Computing services

Members

 

info@listes-lbbe.univ-lyon1.fr

 

 

The "Pôle informatique" (hereafter called "PI") is constituted of 8 engineers (1T, 4IE, 3IR). Our activities are distributed among three main directions: computing and storage infrastructure management (shared resources, and invidual equipment), software and service development and data analysis in molecular biology and ecology.

Infrastructures managment

  • Microcomputing: the PI is in charge of managing the laboratory's microcomputer equipment, from choosing the most appropriate solution in consultation with the future user to managing maintenance, including installation and configuration of the equipment.
  • Laboratory Information System: the PI provides laboratory and community members with a number of services, including several web servers (apache), numerous database servers (relational or indexed) and several collaborative tools (Git, Redmine, Seafile...). These services are hosted on largely virtualized machines.
Cluster de calcul UMR5558/PRABI
  • Compute and storage: since 2009, the PI manages a computing cluster with almost 1200 avalaible computing cores. The cluster is linked to a 600 TB high performing distributed storage system under BeeGFS and an object mode storage based on iRods (~400 useful TB).
  • Cloud and containerization: cloud-girofle (224 vcpu and 120 To), the local cloud operated by the PI since 2017, is part of the Biosphere cloud federation from the French Institute of Bioinformatics (IFB). We are starting to converge our virtualization infrastructure towards containerization technologies (docker, singularity).  
  • User support: the PI provides user support for all the resources and tools available to the laboratory's members. It trains and supports users in their use of shared resources through trainingsessions, information and monitoring meetings and mailing lists.

Software and methodological development

Members of the PI are involved in numerous software development projects in collaboration with the lab researchers, covering a large range of programming languages (R, Python, C++, OCaml, Javascript, SQL, shell). It goes from optimized parallel numerical codes to web services and dedicated databases (SQL or no-SQL). A peculiar effort is also performed to share the best practices of modern software development and make these software codes reproducible and available following the standards and requirements of the community.

Data analysis

Members of the PI are in the front line facing the data avalanche (and the data diversity) of this decade.
A large part of our activity is related to the quantity of data coming from sequencing technologies. The PI develops and proposes pipelines for genomic data assembly and annotation, RNA-seq and RAD-seq data analysis. More recently, computer image processing has become an important issue for future ecological studies performed in the lab in the Evolutionary Ecology.

Animation, training and scientific expertise

Our group has set up a series of dedicated workshops  to improve internal skills in software engineering, distributed computing, programming and data analysis, which complements more formal teaching sessions. Members of the group are also involved in training activities in universities (UCBL1) and CNRS (Formation permanente).
In their respective fields, members of the PI actively monitor technological developments and participate in major events such as JOBIM (bioinfo), the JRES (system administration), the JDEV (development), the Aramis days (system and network administration and software development) and the 'Rencontres R' (programmation). The PI is also involved in dedicated networks and/or projects of national scope such as the LyonCalcul group, the RLyon group and the IFB-NNCR and IFB-Core projects.

We works in close cooperation with the bioinformatics platform PRABI (Pôle Rhône-Alpes de BioInformatique), notably for the management of the computing and storage infrastructure, the diffusion of our lab's software production, the organization of teaching sessions and for sharing expertise in genomic/transcriptomic data analysis.

Poster

Publications

Display of 61 to 90 publications on 169 in total

Modelling of omics dose-response data for ecological risk assessment

Marie-Laure Delignette-Muller, F. Larras, E. Billoir, Aurélie Siberchicot, V. Baillard, Mechthild Schmitt-Jansen

Journées du GDR Ecologie Statistique (EcoStat) .

Conference paper

see the publication

New goodness-of-fit plots for censored data in the package fitdistrplus

Marie-Laure Delignette-Muller, Christophe Dutang, Aurélie Siberchicot

7ème rencontres R .

Conference paper

see the publication

Pollen limitation as a main driver of fruiting dynamics in oak populations

Éliane Schermer, Marie‐claude Bel‐venner, David Fouchet, Aurélie Siberchicot, Vincent Boulanger, Thomas Caignard...

Ecology Letters . 22 ( 1 ) : 98-107

DOI: 10.1111/ele.13171

Journal article

see the publication

questionr

Julien Barnier, François Briatte, Joseph Larmarange

Software

see the publication

Gearing up to handle the mosaic nature of life in the quest for orthologs

Kristoffer Forslund, Cécile Pereira, Salvador Capella-Gutiérrez, Alan Sousa da Silva, Adrian M Altenhoff, Jaime Huerta-Cepas...

Bioinformatics . 34 ( 2 ) : 323-329

DOI: 10.1093/bioinformatics/btx542

Journal article

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DRomics: A Turnkey Tool to Support the Use of the Dose–Response Framework for Omics Data in Ecological Risk Assessment

Floriane Larras, Elise Billoir, Vincent Baillard, Aurélie Siberchicot, Stefan Scholz, Tesfaye Wubet...

Environmental Science and Technology . 52 ( 24 ) : 14461-14468

DOI: 10.1021/acs.est.8b04752

Journal article

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Multivariate Analysis of Ecological Data with ade4

Jean Thioulouse, Stéphane Dray, Anne-Béatrice Dufour, Aurélie Siberchicot, Thibaut Jombart, Sandrine Pavoine

DOI: 10.1007/978-1-4939-8850-1

Book

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Maternal reproductive senescence shapes the fitness consequences of the parental age difference in ruffed lemurs

Morgane Tidière, Xavier Thevenot, Adamantia Deligiannopoulou, Guillaume Douay, Mylisa Whipple, Aurélie Siberchicot...

Proceedings of the Royal Society B: Biological Sciences . 285 ( 1886 ) : 20181479

DOI: 10.1098/rspb.2018.1479

Journal article

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MOSAIC : une plate-forme web pour l’analyse statistique des données d’écotoxicologie. Fiche Thématique N°13

Sandrine Charles, Virgile Baudrot, Philippe Veber

: 4 p.

see the publication

Persistent Interactions with Bacterial Symbionts Direct Mature-Host Cell Morphology and Gene Expression in the Squid-Vibrio Symbiosis

Natacha Kremer, Eric Koch, Adil El Filali, Lawrence Zhou, Elizabeth Heath-Heckman, Edward Ruby...

mSystems . 3 ( 5 )

DOI: 10.1128/mSystems.00165-18

Journal article

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MareyMap online: A user-friendly web application and database service for estimating recombination rates using physical and genetic maps

Aurélie Siberchicot, Adrien Bessy, Laurent Gueguen, Gabriel A. B. Marais

Genome Biology and Evolution . 9 ( 10 ) : 2506-2509

DOI: 10.1093/gbe/evx178

Journal article

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adegraphics: An S4 Lattice-Based Package for the Representation of Multivariate Data

Aurélie Siberchicot, A. Julien-Laferrière, Ab. Dufour, J. Thioulouse, S. Dray

The R Journal . 9 ( 2 ) : 198-212

DOI: 10.32614/RJ-2017-042

Journal article

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Response to Comment on "Robust Fit of Toxicokinetic-Toxicodynamic Models Using Prior Knowledge Contained in the Design of Survival Toxicity Tests

Marie Laure Delignette-Muller, P. Veber

Environmental Science and Technology . 51 : 8202-8203

DOI: 10.1021/acs.est.7b02548

Journal article

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Robust Fit of Toxicokinetic-Toxicodynamic Models Using Prior Knowledge Contained in the Design of Survival Toxicity Tests

Marie Laure Delignette-Muller, P. Ruiz, P. Veber

Environmental Science and Technology . 51 : 4038-4045

DOI: 10.1021/acs.est.6b05326

Journal article

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Ancestral Genome Estimation Reveals the History of Ecological Diversification in Agrobacterium

Florent Lassalle, Rémi Planel, Simon Penel, David Chapulliot, Valérie Barbe, Audrey Dubost...

Genome Biology and Evolution . 9 ( 12 ) : 3413 - 3431

DOI: 10.1093/gbe/evx255

Journal article

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MaxTiC: Fast Ranking Of A Phylogenetic Tree By Maximum Time Consistency With Lateral Gene Transfers

Cédric Chauve, Akbar A Rafiey, Adrian A Davin, Celine Scornavacca, Philippe Veber, Bastien Boussau...

DOI: 10.1101/127548

Other publication

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Les Ateliers Pratiques Numériques en SHS des laboratoires lyonnais

Julien Barnier, Séverine Gedzelman, Nicolas Genis, Emmanuelle Morlock, Hervé Parmentier, Samantha Saïdi

Forum Humanités Numériques et données ouvertes .

Poster

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Fruiting Strategies of Perennial Plants: A Resource Budget Model to Couple Mast Seeding to Pollination Efficiency and Resource Allocation Strategies

Samuel Venner, A. Siberchicot, P.F. Pélisson, E. Schermer, Marie-Claude Bel-Venner, M. Nicolas...

The American Naturalist . 188 ( 1 ) : 66-75

DOI: 10.1086/686684

Journal article

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Quantitative Molecular Detection of 19 Major Pathogens in the Interdental Biofilm of Periodontally Healthy Young Adults

Florence Carrouel, Stéphane Viennot, Julie Santamaria, Philippe Veber, Denis Bourgeois

Frontiers in Microbiology . 7 : 840 - 840

DOI: 10.3389/fmicb.2016.00840

Journal article

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RiboDB database: a comprehensive resource for prokaryotic systematics

Frédéric Jauffrit, Simon Penel, Stéphane Delmotte, Carine Rey, Damien M de Vienne, Manolo Gouy...

Molecular Biology and Evolution . 33 ( 8 ) : 2170--2172

DOI: 10.1093/molbev/msw088

Journal article

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SNP calling from RNA-seq data without a reference genome: identification, quantification, differential analysis and impact on the protein sequence

Hélène Lopez-Maestre, Lilia Brinza, Camille Marchet, Janice Kielbassa, Sylvère Bastien, Mathilde Boutigny...

Nucleic Acids Research .

DOI: 10.1093/nar/gkw655

Journal article

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No Evidence That Nitrogen Limitation Influences the Elemental Composition of Isopod Transcriptomes and Proteomes

Clémentine François, L. Duret, Laurent Simon, Florian Mermillod-Blondin, Florian Malard, Lara Konecny-Dupré...

Molecular Biology and Evolution . 33 ( 10 ) : 2605–2620

DOI: 10.1093/molbev/msw131

Journal article

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L'enseignement et la formation au logiciel R : un retour d'expérience

Julien Barnier

Séminaire "R à l'usage des sciences sociales" (RUSS) .

Conference paper

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RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements

Amandine Chatagnon, Philippe Veber, Valérie Morin, Justin Bedő,, Gérard Triqueneaux, Marie Sémon...

Nucleic Acids Research . 43 ( 10 ) : 4833--4854

DOI: 10.1093/nar/gkv370

Journal article

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Unknown age in health disorders: A method to account for its cumulative effect and an application to feline viruses interactions.

Eléonore Hellard, Dominique Pontier, Aurélie Siberchicot, Frank Sauvage, David Fouchet

Epidemics . 11 : 48-55

DOI: 10.1016/j.epidem.2015.02.004

Journal article

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