COEVOL Multi-Scale Coevolution

Evolutionary Genetics of Interactions Group

Varaldi Julien

Maître de conférence universitaire

UCBL

Address: 69622 VILLEURBANNE cedex
69622 VILLEURBANNE cedex

Tel: 33 04 72 44 81 01

Email

My work focuses on the evolutionary genetics of insects. I am currently developing three main themes:

1.        Organisms face many viral infections during their life. Although viruses are known for their pathogenic effects, a number of them, under studied, reveal more subtle effects, and are potentially heritable. We have discovered such a virus in a parasitoid wasp. Its main effect is to manipulate the wasp's egg-laying behavior, thus promoting its horizontal transmission. To improve our global understanding of insect-associated viral diversity we are conducting metagenomic programs in insect communities.

2.        During evolution, sequences of these viruses have been able to integrate into the chromosomes of their hosts (whether or not the integration is part of their natural cycle). Some of these insertions have allowed major genetic innovations such as the "invention" of the placenta in mammals. In hymenopteran insects, which live as parasites of other insects, several clades have "domesticated" viruses, which allows them today to address virulence factors to their hosts. These endogenized viruses are currently necessary for the good development of parasitoids. The first documented cases concerned the superfamily Ichneumonoidea. Our recent work has revealed similar phenomena, although completely independent, in other superfamilies (Di Giovanni et al. 2020, thesis in progress B. Guinet). One of the challenges is to define the extent and evolutionary impact of these domestications in insects.

3.        Bed bugs are a re-emerging pest. These hematophagous insects have experienced an extremely large population boom in recent years, probably related to the evolution of insecticide resistance. We are currently investigating the genetic determinants underlying the resistance phenotype (CIFRE thesis in progress Chloé Haberkorn).

 

            Parasitoid depositing an egg (and its virus) in a Drosophila larva. (drawing credit : J. Martinez)

 

Publications

Display of 1 to 30 publications on 35 in total

Dating the origin of a viral domestication event in parasitoid wasps attacking Diptera

Benjamin Guinet, Jonathan Vogel, Ralph Peters, Jan Hrcek, Matthew Buffington, Julien Varaldi

DOI: 10.1101/2024.05.24.595704

Preprint

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Transcriptomic Response to Pyrethroid Treatment in Closely Related Bed Bug Strains Varying in Resistance

Chloé Haberkorn, Zaïnab Belgaïdi, Romain Lasseur, Fabrice Vavre, Julien Varaldi

Genome Biology and Evolution . 16 ( 8 ) : evae158

DOI: 10.1093/gbe/evae158

Journal article

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A novel and diverse family of filamentous DNA viruses associated with parasitic wasps

Benjamin Guinet, Matthieu Leobold, Elisabeth Herniou, Pierrick Bloin, Nelly Burlet, Justin Bredlau...

Virus Evolution . 10 ( 1 ) : veae022

DOI: 10.1093/ve/veae022

Journal article

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Community structure of heritable viruses in a Drosophila-parasitoids complex

Julien Varaldi, David Lepetit, Nelly Burlet, Camille Faber, Bérénice Baretje, Roland Allemand

Peer Community Journal . 4 : e16

DOI: 10.24072/pcjournal.371

Journal article

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A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bug Cimex lectularius

Chloé Haberkorn, Jean‐philippe David, Hélène Henri, Jean‐marie Delpuech, Romain Lasseur, Fabrice Vavre...

Evolutionary Applications . 16 ( 5 ) : 1012 - 1028

DOI: 10.1111/eva.13550

Journal article

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Endoparasitoid lifestyle promotes endogenization and domestication of dsDNA viruses

Benjamin Guinet, D. Lepetit, S. Charlat, Peter N Buhl, David G Notton, Astrid Cruaud...

eLife . 12 : e85993

DOI: 10.7554/eLife.85993

Journal article

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RNA Viruses Are Prevalent and Active Tenants of the Predatory Mite Phytoseiulus persimilis (Acari: Phytoseiidae)

Tali Sarah Berman, Yehuda Izraeli, Maya Lalzar, Netta Mozes-Daube, David Lepetit, Arnon Tabic...

Microbial ecology .

DOI: 10.1007/s00248-023-02210-0

Journal article

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Genomic characterization of viruses associated with the parasitoid Anagyrus vladimiri (Hymenoptera: Encyrtidae)

Yehuda Izraeli, David Lepetit, Shir Atias, Netta Mozes-Daube, Gal Wodowski, Oded Lachman...

Journal of General Virology . 103 ( 12 )

DOI: 10.1099/jgv.0.001810

Journal article

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DROP: Molecular voucher database for identification of Drosophila parasitoids

Chia-Hua Lue, Matthew L Buffington, Sonja Scheffer, Matthew Lewis, Tyler A Elliott, Amelia R I Lindsey...

Molecular Ecology Resources .

DOI: 10.1111/1755-0998.13435

Journal article

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A behavior-manipulating virus relative as a source of adaptive genes for Drosophila parasitoids

D Di Giovanni, D. Lepetit, B Guinet, B Bennetot, M. Boulesteix, Yohann Couté...

Molecular Biology and Evolution . 37 ( 10 ) : 2791-2807

DOI: 10.1093/molbev/msaa030

Journal article

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A behavior-manipulating virus relative as a source of adaptive genes for parasitoid wasps

Deborah Di Giovanni, D. Lepetit, Matthieu Boulesteix, Marc Ravallec, Julien Varaldi

Preprint

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Deciphering the behaviour manipulation imposed by a virus on its parasitoid host: insights from a dual transcriptomic approach

Julien Varaldi, David Lepetit

Parasitology . 145 ( 14 ) : 1979-1989

DOI: 10.1017/S0031182018000835

Journal article

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Genome sequencing of the behaviour manipulating virus LbFV reveals a possible new virus family

D. Lepetit, B. Gillet, S. Hughes, K. Kraaijeveld, Julien Varaldi

Genome Biology and Evolution . 8 : 3718-3738

DOI: 10.1093/gbe/evw277

Journal article

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Additional heritable virus in the parasitic wasp Leptopilina boulardi: prevalence, transmission and phenotypic effects

Julien Martinez, David Lepetit, Marc Ravallec, Frédéric Fleury, Julien Varaldi

Journal of General Virology . 97 : 523-535

DOI: 10.1099/jgv.0.000360

Journal article

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Competitive outcome of multiple infections in a behavior-manipulating virus/wasp interaction

Julien Martinez, Frédéric Fleury, J. Varaldi

Ecology and Evolution . 5 ( 24 ) : S934-S945

DOI: 10.1002/ece3.1749

Journal article

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The influence of male wing shape on mating success in Drosophila melanogaster

Bf. Menezes, Fm. Vigoder, Aa. Peixoto, J. Varaldi, Bc. Bitner-Mathé

Animal Behaviour . 85 : 1217--1223

DOI: 10.1016/j.anbehav.2013.03.008

Journal article

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An inherited virus influences the coexistence of parasitoid species through behaviour manipulation.

Sabine Patot, Roland Allemand, Frédéric Fleury, Julien Varaldi

Ecology Letters . 15 ( 6 ) : 603-10

DOI: 10.1111/j.1461-0248.2012.01774.x

Journal article

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Influence of the virus LbFV and of Wolbachia in a host-parasitoid interaction.

Julien Martinez, Anne Duplouy, Megan Woolfit, Fabrice Vavre, Scott L O'Neill, Julien Varaldi

PLoS ONE . 7 ( 4 ) : 1-10

DOI: 10.1371/journal.pone.0035081

Journal article

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Heritable variation in an extended phenotype: the case of a parasitoid manipulated by a virus.

Julien Martinez, Frédéric Fleury, Julien Varaldi

Journal of Evolutionary Biology . 25 ( 1 ) : 54-65

DOI: 10.1111/j.1420-9101.2011.02405.x

Journal article

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An inherited Virus manipulating the behavior of its parasitoid host : epidemiology and evolutionary consequences

Julien Varaldi, Julien Martinez, Sabine Patot, David Lepetit, Frédéric Fleury, Sylvain Gandon

Parasitoid Viruses. Symbionts and Pathogens . 978-0-12-384858-1 : 203-214

DOI: 10.1016/B978-0-12-384858-1.00017-5

Book chapter

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Prevalence of a virus inducing behavioural manipulation near species range border

S. Patot, J. Martinez, R. Allemand, S. Gandon, Julien Varaldi, Frédéric Fleury

Molecular Ecology . 19(14) : 2995-3007

Journal article

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Evolution and manipulation of parasitoid eggload

Sylvain Gandon, Julien Varaldi, Frédéric Fleury, Ana R Rivero

Evolution - International Journal of Organic Evolution . 63 ( 11 ) : 2974-2984

DOI: 10.1111/j.1558-5646.2009.00776.x

Journal article

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Molecular Detection Penetrance and Transmission of an Inherited Virus Responsible for Behavioral Manipulation of an Insect Parasitoid

S. Patot, D. Lepetit, D. Charif, Julien Varaldi, Frédéric Fleury

Applied and Environmental Microbiology . 75 ( 3 ) : 703-710

DOI: 10.1128/AEM.01778-08

Journal article

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A Virus-Shaping Reproductive Strategy in a Drosophila Parasitoid

Julien Varaldi, S. Patot, M. Nardin, S. Gandon

incollection . 70 : 334-359

Journal article

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Behavioural manipulation of insect parasitoids by a maternally inherited virus: ecological consequences and potential applications for biological control

Julien Varaldi, S. Patot, M. Maache, D. Lepetit, Frédéric Fleury

Entomological Research . 37 : A11-A73

Journal article

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Superparasitism evolution: adaptation or manipulation?

Sylvain Gandon, Ana R Rivero, Julien Varaldi

The American Naturalist . 167 ( 1 ) : E1-E22

DOI: 10.1086/498398

Journal article

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The virus infecting the parasitoid Leptopilina boulardi exerts a specific action on superparasitism behaviour

Julien Varaldi, S. Petit, M. Boulétreau, Frédéric Fleury

Parasitology . 132 : 747-756

Journal article

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Artifical transfer and morphological description of virus particles associated with superparasitism behaviour in a parasitoid wasp.

Julien Varaldi, M. Ravallec, C. Labrosse, M. Lopez-Ferber, M. Boulétreau, Frédéric Fleury

Journal of Insect Physiology . 52 ( 11-12 ) : 1202-1212

DOI: 10.1016/j.jinsphys.2006.09.002

Journal article

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A Newly Discovered Virus Manipulates Superparasitism Behavior in a Parasitoid Wasp

Julien Varaldi, S. Gandon, A. Rivero, S. Patot, Frédéric Fleury

incollection . 2 : 119-139

Journal article

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Superparasitism acceptance and patch-leaving mechanisms in parasitoids: A comparison between two sympatric wasps

Julien Varaldi, P. Fouillet, M. Boulétreau, Frédéric Fleury

Animal Behaviour . 69 : 1227-1234

Journal article

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