Who am we? Who are I?
These two strange questions perfectly define my research interests. I study interspecific relationships, anotably symbiotic interactions, using as a model the interactions between arthropods and bacteria with mainly vertical transmission (from mother to offspring). The objective is to understand the dynamics of this chimeric individual, the factors that orient these interactions towards conflict or cooperation, and their consequences on the extended phenotype of the individual and the evolution of each of the partners. The subtlety of these interactions, which continually navigate between selfish and shared interests, is particularly important to consider and integrate into the trendy study of the holobiont and the microbiota. This general theme is currently structured around 3 main projects:
Co-adaptation within holobionts. Within the framework of the ANR Hmicmac project, we are seeking, with Laurence Mouton, to test the hypothesis that host-microbiota interactions should lead to co-adaptation between partners. This hypothesis is tested using experimental evolution based on situations where these possible co-adaptations are initially broken and then left free to evolve again. This approach is being carried out on the whitefly Bemisia tabaci and its symbiotic bacteria at the LBBE, and will be compared with similar experiments carried out on the pea aphid. This project also involves the IGEPP (Rennes) and BF2I (Lyon) laboratories.
Response of symbioses to stress. Within the framework of the RESIST project (ANR JCJC, coord. Natacha Kremer, LBBE), we are seeking to test whether symbiosis is a driving force or a barrier to adaptation to new environmental stresses. We are using the association between Drosophila melanogaster and Wolbachia (wMelPop strain), which is subjected to punctual or chronic stresses with either a pro-oxidant agent (the herbicide paraquat), or virus C, or both simultaneously.
Dynamics of obligate symbiotic interactions in ticks. Within the framework of the MICROM project (ANR, coord. O. Duron, MIVEGEC), we are seeking to understand the whys and wherefores of recurrent replacements of obligate nutritional symbionts in ticks. Indeed, these strict haematophagous arthropods depend on nutritional symbionts providing them with B vitamins. However, multiple replacement events have occurred during tick evolution. Future work at the LBBE will be dedicated to comparative genomics of symbionts from different tick species.
Finally, within the framework of several projects (SBP MicroBeHave, 2 CIFRE theses, an ANR and a project), we have developed with Julien Varaldi and Natacha Kremer, in collaboration with the BF2I laboratory and the company Izinovation, a new project on bedbugs, a re-emerging pest due to its resistance to insecticides, strictly haematophagous and totally dependent on symbionts of the Wolbachia genus for the supply of B vitamins. Our work seeks to characterise the genetic mechanisms of resistance and to better understand the genetic and metabolic dialogue between the insect and its symbiont.
Development of "One Health" approaches in Lyon
In addition to these scientific aspects, I am also involved in the construction of the research ecosystem in Lyon on One Health approaches. This has led me to lead the Symbiotron platform project for more than 10 years, and since 2021 to coordinate the recently funded Equipex+ Infectiotron project led by the University of Lyon 1. This project seeks to develop a set of coordinated tools for the operational development of projects on infectious diseases from their natural environment to the laboratory, with a particular focus on level 3 pathogens. I am also actively involved in the implementation and development of the SHAPE-Med@Lyon project, also led by the University of Lyon 1, and in particular for the development of the Lyon Transdisciplinary Health Institute.
Display of 1 to 30 publications on 95 in total
Role of symbionts in insects’ ecological diversification: cytotype influences exploitation of an unfavorable host plant in the whitefly Bemisia tabaci (Hemiptera: Aleyrodidae)
G-RREMI 2021 - Groupe Régional de Recherche en Microbiologie des Interactions .
Cytotype Affects the Capability of the Whitefly Bemisia tabaci MED Species To Feed and Oviposit on an Unfavorable Host Plant
mBio . 12 ( 6 ) : 1-16
CPCN - BILAN DE MANDATURE 2016 – 2021
CPCN - BILAN DE MANDATURE 2016 – 2021
Wolbachia load variation in Drosophila is more likely caused by drift than by host genetic factors
Peer Community in Evolutionary Biology .
Role of symbionts in insects’ ecological diversification: cytotype influences exploitation of an unfavorable host plant in the sap-feeder Bemisia tabaci
DECRYPthèse E2M2 Edition 20 .
Endosymbiont diversity in natural populations of Tetranychus mites is rapidly lost under laboratory conditions
Heredity . 124 ( 4 ) : 603-617
Stress & Symbiosis: Heads or Tails?
Frontiers in Ecology and Evolution . : 1-9
Experimental evolution of virulence and associated traits in a Drosophila melanogaster - Wolbachia symbiosis
Peer Community in Evolutionary Biology .
Tick-Bacteria Mutualism Depends on B Vitamin Synthesis Pathways
Current Biology - CB . 28 ( 12 ) : 1896 - 1902.e5
Cancer Is Not (Only) a Senescence Problem
Trends in Cancer . 4 ( 3 ) : 169 - 172
Abundance of Bemisia tabaci Gennadius (Hemiptera: Aleyrodidae) and its parasitoids on vegetables and cassava plants in Burkina Faso (West Africa)
Ecology and Evolution . 8 ( 12 ) : 6091-6103
Back and forth Wolbachia transfers reveal efficient strains to control spotted wing drosophila populations
Journal of Applied Ecology . 55 ( 5 ) : 2408-2418
Impact of pest management practices on the frequency of insecticide resistance alleles in Bemisia tabaci (Hemiptera: Aleyrodidae) populations in three countries of West Africa
Crop Protection . 104 : 86 - 91
The Importance of Revisiting Legionellales Diversity
Trends in Parasitology . 34 ( 12 ) : 1027 - 1037
Obligate dependence does not preclude changing partners in a Russian dolls symbiotic system
Peer Community in Evolutionary Biology . : 1-2
Evolutionary changes in symbiont community structure in ticks
Molecular Ecology . 26 ( 11 ) : 2905–2921
Impact of Wolbachia on oxidative stress sensitivity in the parasitic wasp Asobara japonica
PLoS ONE . 5 : 10
SNP calling from RNA-seq data without a reference genome: identification, quantification, differential analysis and impact on the protein sequence
Nucleic Acids Research .
Influence of oxidative homeostasis on bacterial density and cost of infection in Drosophila–Wolbachia symbioses
Journal of Evolutionary Biology . 29 : 1211-1222
Genome reduction and potential metabolic complementation of the dual endosymbionts in the whitefly Bemisia tabaci
BMC Genomics . 16 : 226
The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii
PLoS Pathogens . 11 ( 5 )
Two Host Clades, Two Bacterial Arsenals: Evolution through Gene Losses in Facultative Endosymbionts.
Genome Biology and Evolution . 7 ( 3 ) : 839-855
Detection of genetically isolated entities within the Mediterranean species of Bemisia tabaci: new insights into the systematics of this worldwide pest
Pest Management Science . 71 ( 3 ) : 452-458
Parasite-Parasite Interactions in the Wild: How To Detect Them?
Trends in Parasitology .
Spodoptera frugiperda (Lepidoptera: Noctuidae) host-plant variants: two host strains or two distinct species?
Genetica . 143 ( 3 ) : 305-316
Microbial impacts on insect evolutionary diversification: from patterns to mechanisms
Current Opinion in Insect Science . 4 : 29--34
Epidemiology of asexuality induced by the endosymbiotic Wolbachia across phytophagous wasp species: host plant specialization matters.
Molecular Ecology Notes . 23 ( 9 ) : 2362-2375
Signs of Neutralization in a Redundant Gene Involved in Homologous Recombination in Wolbachia Endosymbionts
Genome Biology and Evolution . 10 ( 6 ) : 2654-2664
Manipulation of arthropod sex determination by endosymbionts: diversity and molecular mechanisms
Sexual Development . : 59-73