COEVOL Multi-Scale Coevolution
Evolutionary Genetics of Interactions Group
Vavre Fabrice
Directeur de recherche
CNRS
Who am we? Who are I?
These two strange questions perfectly define my research interests. I study interspecific relationships, anotably symbiotic interactions, using as a model the interactions between arthropods and bacteria with mainly vertical transmission (from mother to offspring). The objective is to understand the dynamics of this chimeric individual, the factors that orient these interactions towards conflict or cooperation, and their consequences on the extended phenotype of the individual and the evolution of each of the partners. The subtlety of these interactions, which continually navigate between selfish and shared interests, is particularly important to consider and integrate into the trendy study of the holobiont and the microbiota. This general theme is currently structured around 3 main projects:
Co-adaptation within holobionts. Within the framework of the ANR Hmicmac project, we are seeking, with Laurence Mouton, to test the hypothesis that host-microbiota interactions should lead to co-adaptation between partners. This hypothesis is tested using experimental evolution based on situations where these possible co-adaptations are initially broken and then left free to evolve again. This approach is being carried out on the whitefly Bemisia tabaci and its symbiotic bacteria at the LBBE, and will be compared with similar experiments carried out on the pea aphid. This project also involves the IGEPP (Rennes) and BF2I (Lyon) laboratories.
Response of symbioses to stress. Within the framework of the RESIST project (ANR JCJC, coord. Natacha Kremer, LBBE), we are seeking to test whether symbiosis is a driving force or a barrier to adaptation to new environmental stresses. We are using the association between Drosophila melanogaster and Wolbachia (wMelPop strain), which is subjected to punctual or chronic stresses with either a pro-oxidant agent (the herbicide paraquat), or virus C, or both simultaneously.
Dynamics of obligate symbiotic interactions in ticks. Within the framework of the MICROM project (ANR, coord. O. Duron, MIVEGEC), we are seeking to understand the whys and wherefores of recurrent replacements of obligate nutritional symbionts in ticks. Indeed, these strict haematophagous arthropods depend on nutritional symbionts providing them with B vitamins. However, multiple replacement events have occurred during tick evolution. Future work at the LBBE will be dedicated to comparative genomics of symbionts from different tick species.
Finally, within the framework of several projects (SBP MicroBeHave, 2 CIFRE theses, an ANR and a project), we have developed with Julien Varaldi and Natacha Kremer, in collaboration with the BF2I laboratory and the company Izinovation, a new project on bedbugs, a re-emerging pest due to its resistance to insecticides, strictly haematophagous and totally dependent on symbionts of the Wolbachia genus for the supply of B vitamins. Our work seeks to characterise the genetic mechanisms of resistance and to better understand the genetic and metabolic dialogue between the insect and its symbiont.
Development of "One Health" approaches in Lyon
In addition to these scientific aspects, I am also involved in the construction of the research ecosystem in Lyon on One Health approaches. This has led me to lead the Symbiotron platform project for more than 10 years, and since 2021 to coordinate the recently funded Equipex+ Infectiotron project led by the University of Lyon 1. This project seeks to develop a set of coordinated tools for the operational development of projects on infectious diseases from their natural environment to the laboratory, with a particular focus on level 3 pathogens. I am also actively involved in the implementation and development of the SHAPE-Med@Lyon project, also led by the University of Lyon 1, and in particular for the development of the Lyon Transdisciplinary Health Institute.
Publications
Display of 1 to 30 publications on 105 in total
Study of host-symbionts coevolution in the whitefly Bemisia tabaci: an experimental evolution approach
13e Rencontre du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA) .
Conference paper
see the publicationSecondary symbionts influence feeding and oviposition behavior in the whitefly Bemisia tabaci
XII European Congress of Entomology .
Poster
see the publicationA major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bug Cimex lectularius
Evolutionary Applications . 16 ( 5 ) : 1012 - 1028
DOI: 10.1111/eva.13550
Journal article
see the publicationPlant choice for oviposition in the phytophagous insect Bemisia tabaci: cytotype, including symbionts, knows best!
Animal Behaviour . 200 : 147-157
Journal article
see the publicationGenomic changes during the evolution of the Coxiella genus along the parasitism-mutualism continuum
Peer Community Journal . 3 : e41
Journal article
see the publicationInfluence of bacterial symbionts on host niche and ecological diversification: an integrative approach in a whitefly model
26.International Congress of Entomology .
Poster
see the publicationAnalyses of symbiotic bacterial communities in the plant pest Bemisia tabaci reveal high prevalence of Candidatus Hemipteriphilus asiaticus on the African continent
Peer Community Journal . 2 ( e20 )
Journal article
see the publicationInfluence of secondary symbionts on host plant utilization and selection in the whitefly Bemisia tabaci.
10. Congress of the International Symbiosis Society - 3rd International Conference on Holobionts .
Poster
see the publicationRole of symbionts in insects' ecological diversification: cytotype influences exploitation of an unfavorable host plant in the sap-feeder Bemisia tabaci (Hemiptera: Aleyrodidae).
DECRYPthèse E2M2 .
Conference paper
see the publicationCytotype Affects the Capability of the Whitefly Bemisia tabaci MED Species To Feed and Oviposit on an Unfavorable Host Plant
mBio . 12 ( 6 ) : 1-16
Journal article
see the publicationWolbachia load variation in Drosophila is more likely caused by drift than by host genetic factors
Peer Community In Evolutionary Biology .
Journal article
see the publicationRole of symbionts in insects’ ecological diversification: cytotype influences exploitation of an unfavorable host plant in the sap-feeder Bemisia tabaci
DECRYPthèse E2M2 Edition 20 .
Conference paper
see the publicationRole of symbionts in insects’ ecological diversification: cytotype influences exploitation of an unfavorable host plant in the whitefly Bemisia tabaci (Hemiptera: Aleyrodidae)
G-RREMI 2021 - Groupe Régional de Recherche en Microbiologie des Interactions .
Conference paper
see the publicationEndosymbiont diversity in natural populations of Tetranychus mites is rapidly lost under laboratory conditions
Heredity . 124 ( 4 ) : 603-617
Journal article
see the publicationStress & Symbiosis: Heads or Tails?
Frontiers in Ecology and Evolution . : 1-9
Journal article
see the publicationExperimental evolution of virulence and associated traits in a Drosophila melanogaster - Wolbachia symbiosis
Peer Community In Evolutionary Biology . : e9
DOI: 10.24072/pcjournal.9
Journal article
see the publicationTick-Bacteria Mutualism Depends on B Vitamin Synthesis Pathways
Current Biology - CB . 28 ( 12 ) : 1896 - 1902.e5
Journal article
see the publicationCancer Is Not (Only) a Senescence Problem
Trends in Cancer . 4 ( 3 ) : 169 - 172
Journal article
see the publicationAbundance of Bemisia tabaci Gennadius (Hemiptera: Aleyrodidae) and its parasitoids on vegetables and cassava plants in Burkina Faso (West Africa)
Ecology and Evolution . 8 ( 12 ) : 6091-6103
DOI: 10.1002/ece3.4078
Journal article
see the publicationBack and forth Wolbachia transfers reveal efficient strains to control spotted wing drosophila populations
Journal of Applied Ecology . 55 ( 5 ) : 2408-2418
Journal article
see the publicationImpact of pest management practices on the frequency of insecticide resistance alleles in Bemisia tabaci (Hemiptera: Aleyrodidae) populations in three countries of West Africa
Crop Protection . 104 : 86 - 91
Journal article
see the publicationThe Importance of Revisiting Legionellales Diversity
Trends in Parasitology . 34 ( 12 ) : 1027 - 1037
Journal article
see the publicationObligate dependence does not preclude changing partners in a Russian dolls symbiotic system
Peer Community In Evolutionary Biology . : 1-2
Journal article
see the publicationEvolutionary changes in symbiont community structure in ticks
Molecular Ecology . 26 ( 11 ) : 2905–2921
DOI: 10.1111/mec.14094
Journal article
see the publicationImpact of Wolbachia on oxidative stress sensitivity in the parasitic wasp Asobara japonica
PLoS ONE . 5 : 10
Journal article
see the publicationSNP calling from RNA-seq data without a reference genome: identification, quantification, differential analysis and impact on the protein sequence
Nucleic Acids Research .
DOI: 10.1093/nar/gkw655
Journal article
see the publicationInfluence of oxidative homeostasis on bacterial density and cost of infection in Drosophila–Wolbachia symbioses
Journal of Evolutionary Biology . 29 : 1211-1222
DOI: 10.1111/jeb.12863
Journal article
see the publicationGenome reduction and potential metabolic complementation of the dual endosymbionts in the whitefly Bemisia tabaci
BMC Genomics . 16 : 226
Journal article
see the publicationThe Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii
PLoS Pathogens . 11 ( 5 )
Journal article
see the publication