Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Stagiaire
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
Doctorante
autre
Tel: 04 72 44 81 42
Praticien hospitalier
HCL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier émérite
UCBL
Stagiaire
HCL
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
Maîtresse de conférences - praticienne hospitalière
UCBL
Stagiaire
HCL
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
Doctorante
UCBL
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 31 to 60 publications on 256 in total
Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients.
Rheumatology .
Journal article
see the publicationArterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Thorax . 76 ( 10 ) : 970-979
Journal article
see the publicationAssessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department
Annales de Biologie Clinique . 79 ( 4 ) : 315-324
Journal article
see the publicationPopulation pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference
Journal of Antimicrobial Chemotherapy . 76 ( 5 ) : 1250-1257
DOI: 10.1093/jac/dkab006
Journal article
see the publicationModel-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile
Antimicrobial Agents and Chemotherapy . 65 ( 9 ) : e0104321
DOI: 10.1128/AAC.01043-21
Journal article
see the publicationExpected Evolution of COVID-19 Epidemic in France for Several Combinations of Vaccination Strategies and Barrier Measures
Vaccines . 9 ( 12 ) : 1462
Journal article
see the publicationPopulation Pharmacokinetics and Dosing Simulation of Vancomycin Administered by Continuous Injection in Critically Ill Patient
Antibiotics . 10 ( 10 ) : 1228
Journal article
see the publicationRifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion
PLoS Pathogens . 17 ( 6 ) : e1009643
Journal article
see the publicationClinical response to lumacaftor-ivacaftor in patients with cystic fibrosis according to baseline lung function
Journal of Cystic Fibrosis .
Journal article
see the publicationReal-Life Safety and Effectiveness of Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis
American Journal of Respiratory and Critical Care Medicine . 201 ( 2 ) : 188-197
Journal article
see the publicationImpact of Coexistence Phenotype Between Staphylococcus aureus and Pseudomonas aeruginosa Isolates on Clinical Outcomes Among Cystic Fibrosis Patients
Frontiers in Cellular and Infection Microbiology . 10 : 105996
Journal article
see the publicationEarly trajectories of skin thickening are associated with severity and mortality in systemic sclerosis
Arthritis Research and Therapy . 22 ( 1 ) : 30
Journal article
see the publicationFrench recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)
Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351
Journal article
see the publicationEarly-onset autoimmunity associated with SOCS1 haploinsufficiency
Nature Communications . 11 ( 1 )
Journal article
see the publicationInconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis
Annals of physical and rehabilitation medicine . 63 ( 3 ) : 230-240
Journal article
see the publicationContribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
The Lancet Rheumatology . 2 ( 2 ) : e99-e109
Journal article
see the publicationPublication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials
PLoS ONE . 15 ( 3 ) : e0229822
Journal article
see the publicationContribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
The Lancet Rheumatology . 2 ( 2 ) : e99-e109
Journal article
see the publicationUsefulness of bronchoalveolar lavage in a French pediatric cohort with hypersensitivity pneumonitis
Pediatric Pulmonology . 55 ( 1 ) : 136-140
DOI: 10.1002/ppul.24546
Journal article
see the publicationHealth-related quality of life in children interstitial lung disease.
European Respiratory Society (ERS) Congress .
Conference paper
see the publicationHealth‐related quality of life in infants and children with interstitial lung disease
Pediatric Pulmonology . 54 ( 6 ) : 828-836
DOI: 10.1002/ppul.24308
Journal article
see the publicationViral respiratory tract infections in young children with cystic fibrosis: a prospective full-year seasonal study
Virology Journal . 16 ( 1 ) : 111
Journal article
see the publicationSurvival and prognosis factors in systemic sclerosis data of a French multicenter cohort, systematic review, and meta-analysis of the literature
Arthritis Research and Therapy . 21 ( 1 ) : 86
Journal article
see the publicationMonogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 )
Journal article
see the publicationTreatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis
Autoimmunity Reviews . 18 ( 2 ) : 113 - 122
Journal article
see the publicationThe contribution of genomics in the medicine of tomorrow, clinical applications and issues
Thérapie . 74 ( 1 ) : 9-15
Journal article
see the publicationAmikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual Patients
Antimicrobial Agents and Chemotherapy . 63 ( 11 ) : e00993-19
DOI: 10.1128/AAC.00993-19
Journal article
see the publicationPharmacokinetic variability of beta-lactams in critically ill patients: A narrative review
Anaesthesia Critical Care & Pain Medicine .
Journal article
see the publicationDo patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis
Journal of Cystic Fibrosis .
Journal article
see the publicationThe limitations of observation studies for decision making regarding drugs efficacy and safety
Alternative and Complementary Therapies . 74 ( 2 ) : 181-185
Journal article
see the publication
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