Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Stagiaire
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
Doctorante
autre
Tel: 04 72 44 81 42
Praticien hospitalier
HCL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier émérite
UCBL
Stagiaire
HCL
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
Maîtresse de conférences - praticienne hospitalière
UCBL
Stagiaire
HCL
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
Doctorante
UCBL
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 91 to 120 publications on 256 in total
Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients
Therapeutic Drug Monitoring . 39 : 83-87
Journal article
see the publicationImplications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients
Fundamental & Clinical Pharmacology . 31 : 110-119
DOI: 10.1111/fcp.12241
Journal article
see the publicationA Model for Predicting the Interindividual Variability of Drug-Drug Interactions
AAPS Journal . 19 : 497-509
Journal article
see the publicationEvaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.
International Journal of Antimicrobial Agents .
Journal article
see the publicationEfficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials
Diabetes & Metabolism . 43 ( 1 ) : 48 - 58
Journal article
see the publicationNo benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials
PLoS ONE . 12 : e0171168
Journal article
see the publicationPopulation pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen
Journal of Antimicrobial Chemotherapy . 72 ( 10 ) : 2804-2812
DOI: 10.1093/jac/dkx242
Journal article
see the publicationMechanisms of drug-drug interaction between rifampicin and fusidic acid
British Journal of Clinical Pharmacology . 83 ( 8 ) : 1862-1864
DOI: 10.1111/bcp.13277
Journal article
see the publicationA Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics
Clinical Pharmacokinetics . 56 : 435-447
Journal article
see the publicationPrevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months
Drugs & aging . 34 : 545-553
Journal article
see the publicationSevere Pulmonary Fibrosis as the First Manifestation of Interferonopathy (TMEM173 Mutation)
Chest . 150 ( 3 ) : E65-E71
Journal article
see the publicationModerate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients
Prostaglandins, Leukotrienes and Essential Fatty Acids . 115 : 41 - 47
Journal article
see the publicationEfficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children
Journal of Allergy and Clinical Immunology . 138 ( 6 ) : 1752-1755
Journal article
see the publicationIs the raised volume rapid thoracic compression technique ready for use in clinical trials in infants with cystic fibrosis?
Journal of Cystic Fibrosis . 15 ( 1 ) : 10 - 20
Journal article
see the publicationHeterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study
Immunologic Research . 64 ( 3 ) : 677-686
Journal article
see the publicationTocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children
RMD Open : Rheumatic & Musculoskeletal Diseases . 2 ( 2 ) : e000271
Journal article
see the publicationQuality of qualitative studies centred on patients in family practice: a systematic review
Family Practice . 33 ( 6 ) : 580 - 587
Journal article
see the publicationRéférentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux
Thérapie .
Journal article
see the publicationQuantitative Prediction of Drug Interactions Caused by CYP1A2 Inhibitors and Inducers
Clinical Pharmacokinetics . 55 : 977-990
Journal article
see the publicationAccurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software
Therapeutic Drug Monitoring . 38 : 332-342
Journal article
see the publicationShould busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children
Bone Marrow Transplantation . 51 : 72-78
DOI: 10.1038/bmt.2015.218
Journal article
see the publicationMathematical modeling and systems pharmacology of tuberculosis: Isoniazid as a case study
Journal of Theoretical Biology . 399 : 43-52
Journal article
see the publicationAntihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals
Cochrane database of systematic reviews (Online) . 3 : CD011745
Journal article
see the publicationOne-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial
Trials . 17 ( 1 ) : 404
Journal article
see the publicationImpact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
PLoS ONE . 11 : e0145958
Journal article
see the publicationPharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections
Antimicrobial Agents and Chemotherapy . 60 ( 5 ) : pp. 3148-3151
DOI: 10.1128/AAC.02597-15
Journal article
see the publicationComparison of the static in vivo approach to a physiologically based pharmacokinetic approach for metabolic drug-drug interactions prediction
International Journal of Pharmacokinetics . : 1-10
Journal article
see the publicationMetformin as firstline treatment for type 2 diabetes: are we sure?
BMJ-BRITISH MEDICAL JOURNAL . 352 : h6748
DOI: 10.1136/bmj.h6748
Journal article
see the publicationSweat test practice in pediatric pulmonology after introduction of cystic fibrosis newborn screening
European Journal of Pediatrics . 174 ( 12 ) : 1613 - 1620
Journal article
see the publicationAn impulse oscillometry system is less efficient than spirometry in tracking lung function improvements after intravenous antibiotic therapy in pediatric patients with cystic fibrosis
Pediatric Pulmonology . 50 ( 11 ) : 1073 - 1081
DOI: 10.1002/ppul.23301
Journal article
see the publication
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