GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 811 to 840 publications on 1402 in total

A Mixture Model and a Hidden Markov Model to Simultaneously Detect Recombination Breakpoints and Reconstruct Phylogenies

Bastien Boussau, Laurent Guéguen, Manolo Gouy

Evolutionary Bioinformatics . 5 : 67-79

DOI: 10.4137/EBO.S2242

Journal article

see the publication

Phylogeny of prokaryotes: does it exist and why should we care?

Simonetta Gribaldo, Céline Brochier-Armanet

Research in Microbiology . 160 : 513-21

Journal article

see the publication

Happy together: genomic insights into the unique Nanoarchaeum/Ignicoccus association.

Patrick Forterre, Simonetta Gribaldo, Céline Brochier-Armanet

Journal of Biology . 8 ( 1 ) : 7

DOI: 10.1186/jbiol110

Journal article

see the publication

Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila

M. Fablet, E. Lerat, R. Rebollo, B. Horard, N. Burlet, S. Martinez...

FASEB Journal . 23 : 54-62

Journal article

see the publication

Infra- and Transspecific Clues to Understanding the Dynamics of Transposable Elements

Cristina Vieira, M. Fablet, E. Lerat

genome dyn stab . -- : 115-123

Journal article

see the publication

Identifying repeats and transposable elements in sequenced genomes: how to find your way through the dense forest of programs

E. Lerat

Heredity . -- : 1-14

Journal article

see the publication

The relationship between DNA replication and human genome organization.

Anamaria Necsulea, Claire Guillet, Jean-Charles Cadoret, Marie-Noëlle Prioleau, L. Duret

Molecular Biology and Evolution . 26 ( 4 ) : 729-741

DOI: 10.1093/molbev/msn303

Journal article

see the publication

Multiple alignment of biological networks: A flexible approach

Yves-Pol Deniélou, Frédéric Boyer, Alain Viari, Marie-France Sagot

Combinatorial Pattern Matching (CPM) . 5577 : 263-273

DOI: 10.1007/978-3-642-02441-2_23

Conference paper

see the publication

Assessing the exceptionality of coloured motifs in networks

Sophie S. Schbath, Vincent Lacroix, Marie-France Sagot

EURASIP Journal on Bioinformatics and Systems Biology . 2009 : 9 pages on line

DOI: 10.1155/2009/616234

Journal article

see the publication

Fast optimization of statistical potentials for structurally constrained phylogenetic models

Cécile Bonnard, Claudia L. Kleinman, Nicolas Rodrigue, Nicolas Lartillot

BMC Evolutionary Biology . 9 ( 1 ) : 227

DOI: 10.1186/1471-2148-9-227

Journal article

see the publication

Comment on “Human-Specific Gain of Function in a Developmental Enhancer”

L. Duret, N. Galtier

Science . 323(5915) : 714-715

Journal article

see the publication

Biased Gene Conversion and the Evolution of Mammalian Genomic Landscapes

L. Duret, N. Galtier

Annual Review of Genomics and Human Genetics . 10 : 285-311

Journal article

see the publication

L’évolution des chromosomes sexuels humains

Gabriel Marais, L. Duret

Biofutur . 304 : 40-41

Journal article

see the publication

Current tools for the identification of miRNA genes and their targets

N.D. Mendes, A.T. Freitas, M.-F. Sagot

Nucleic Acids Research . 2009 : 2419-2433

Journal article

see the publication

Lossless filter for multiple repeats with bounded edit distance

Pierre Peterlongo, Gustavo Akio Tominaga Sacomoto, Alair Pereira Do Lago, Nadia Pisanti, Marie-France Sagot

Algorithms for Molecular Biology . 4 ( 1 ) : 3

DOI: 10.1186/1748-7188-4-3

Journal article

see the publication

An asymmetric approach to preserve common intervals while sorting by reversals

Marília D.V. Braga, Christian Gautier, Marie-France Sagot

Algorithms for Molecular Biology . 4 ( 1 ) : 16

DOI: 10.1186/1748-7188-4-16

Journal article

see the publication

AcypiCyc (Acyrthosiphon pisum Cyc database) and CycADS (Cyc Annotation Database System): moving from genome sequence annotation to metabolic network analyses

Stefano Colella, A. Vellozo, L. Cottret, G. Febvay, Federica Calevro, Yvan Rahbé...

8th International Symposium on Aphids (8 ISA 2009) . : 1-1

Conference paper

see the publication

A pharmacologically based multiscale mathematical model of angiogenesis and its use in investigating the efficacy of a new cancer treatment strategy.

Frédérique Billy, Benjamin Ribba, Olivier Saut, Hélène Morre-Trouilhet, Thierry Colin, Didier Bresch...

Journal of Theoretical Biology . 260 ( 4 ) : 545-62

DOI: 10.1016/j.jtbi.2009.06.026

Journal article

see the publication

Iron-sulfur (Fe/S) protein biogenesis: phylogenomic and genetic studies of A-type carriers

D. Vinella, Céline Brochier-Armanet, L. Loiseau, E. Talla, F. Barras

PLoS Genetics . 5 : 261-268

Journal article

see the publication

Qri7/OSGEPL the mitochondrial version of the universal Kae1/YgjD protein is essential for mitochondrial genome maintenance

J. Oberto, N. Breuil, A. Hecker, F. Farina, Céline Brochier-Armanet, E. Culetto...

Nucleic Acids Research . 37 : 5343-52

Journal article

see the publication

Comparison of alignment free string distances for complete genome phylogeny

F. Guyon, Céline Brochier-Armanet, A. Guénoche

Advances in Data Analysis and Classification . 3 : 95-108

Journal article

see the publication

Full-Length Genome Characterization of a Novel Simian Immunodeficiency Virus Lineage (SIVolc) from Olive Colobus (Procolobus verus) and New SIVwrcPbb Strains from Western Red Colobus (Piliocolobus badius badius) from the Taï Forest in Ivory Coast

Florian Liegeois, Bénédicte Lafay, Pierre Formenty, Sabrina Locatelli, Valérie Courgnaud, Eric Delaporte...

Journal of Virology . 83 ( 1 ) : 428-439

DOI: 10.1128/JVI.01725-08

Journal article

see the publication

Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila.

Marie Fablet, Emmanuelle Lerat, Rita Rebollo, Béatrice Horard, Nelly Burlet, Sonia Martinez...

FASEB Journal . 23 ( 5 ) : 1482-9

DOI: 10.1096/fj.08-123513

Journal article

see the publication

The evolutionary dynamics of the Helena retrotransposon revealed by sequenced Drosophila genomes.

Adriana Granzotto, Fabrício R Lopes, Emmanuelle Lerat, Cristina Vieira, Claudia M A Carareto

BMC Evolutionary Biology . 9 : 174

DOI: 10.1186/1471-2148-9-174

Journal article

see the publication

Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance.

Jacques Oberto, Norman Breuil, Arnaud Hecker, Francesca Farina, Céline Brochier-Armanet, Emmanuel Culetto...

Nucleic Acids Research . : epub ahead of print

DOI: 10.1093/nar/gkp557

Journal article

see the publication

Computational Methods for Evaluating Phylogenetic Models of Coding Sequence Evolution with Dependence between Codons

Nicolas Rodrigue, Claudia L Kleinman, Hervé Philippe, Nicolas Lartillot

Molecular Biology and Evolution . 26 ( 7 ) : 1663 - 1676

DOI: 10.1093/molbev/msp078

Journal article

see the publication

High-throughput single nucleotide polymorphism genotyping in wheat (Triticum spp.)

Aurélie A. Berard, Marie-Christine Le Paslier, Mireille M. Dardevet, Florence F. Exbrayat-Vinson, Isabelle I. Bonnin, Alberto A. Cenci...

Plant Biotechnology Journal . 7 ( 4 ) : 364-374

DOI: 10.1111/j.1467-7652.2009.00404.x

Journal article

see the publication

In Retrospect: Lamarck's treatise at 200

Dan Graur, Manolo Gouy, David Wool

Nature . 460 ( 7256 ) : 688-689

DOI: 10.1038/460688a

Journal article

see the publication

A White Campion textit(Silene latifolia) floral expressed sequence tag (EST) library: annotation EST-SSR characterization transferability and utility for comparative mapping

Md. Moccia, C. Oger-Desfeux, Gabriel Marais, A. Widmer

BMC Genomics . 10(243) : 1-14

Journal article

see the publication