Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 511 to 540 publications on 1072 in total

Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

Corinne Chureau, Sophie Chantalat, Antonio Romito, Angélique Galvani, Laurent Duret, Philip Avner...

Human Molecular Genetics . 20 ( 4 ) : 705-718

DOI: 10.1093/hmg/ddq516

Journal article

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Meiotic recombination favors the spreading of deleterious mutations in human populations

Anamaria Necsulea, L. Duret, Alexandra Popa, David N. Cooper, Peter Stentson, Dominique Mouchiroud...

Human Mutation . 32 ( 2 ) : 198-206

DOI: 10.1002/humu.21407

Journal article

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Modélisation des systèmes biologiques, bioinformatique

Olivier Gascuel, P. Benas, C. Brun, D. Burnouf, Alexandre de Brevern, A. Denise...

Rapport de conjoncture 2010 du Comité national de la recherche scientifique . 978-2-271-07263-4 : chapitre 43, 845-858

Book chapter

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Bioinformatics developments for NGS data analysis at PRABI

F. Picard, Guy Perrière

EMBNet.journal . 17 : 12

Journal article

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Species identification of staphylococci by amplification and sequencing of the tuf gene compared to the gap gene and by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

Marie Bergeron, Olivier Dauwalder, Manolo Gouy, Anne-Marie Freydiere, Michèle Bes, Hélène Meugnier...

European Journal of Clinical Microbiology and Infectious Diseases . 30 ( 3 ) : 343-54

DOI: 10.1007/s10096-010-1091-z

Journal article

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Species-driven interpretation guidelines in case of a single-sampling strategy for blood culture

D. Leyssene, S. Gardes, P. Vilquin, Jp. Flandrois, Gérard Carret, B. Lamy

European Journal of Clinical Microbiology and Infectious Diseases . 30 : 1537-1541

DOI: 10.1007/s10096-011-1257-3

Journal article

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Phylogeny and evolution of the Archaea: one hundred genomes later.

Celine Brochier-Armanet, Patrick Forterre, Simonetta Gribaldo

Current Opinion in Microbiology . : epub ahead of print

DOI: 10.1016/j.mib.2011.04.015

Journal article

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Genome sequence of the stramenopile Blastocystis, a human anaerobic parasite.

France Denoeud, Michaël Roussel, Benjamin Noel, Ivan Wawrzyniak, Corinne da Silva, Marie Diogon...

Genome Biology . 12 ( 3 ) : R29

DOI: 10.1186/gb-2011-12-3-r29

Journal article

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Cultivation of the first mesophilic representative ("mesotoga") within the order Thermotogales

Wajdi Ben Hania, Ramzi Ghodbane, Anne Postec, Celine Brochier-Armanet, Moktar Hamdi, Marie Laure Fardeau...

Systematic and Applied Microbiology . 34 : 581-585

DOI: 10.1016/j.syapm.2011.04.001

Journal article

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The GTPase Function of YvcJ and Its Subcellular Relocalization Are Dependent on Growth Conditions in Bacillus subtilis

F. Pompeo, J. Luciano, Céline Brochier-Armanet, A. Galinier

Journal of Molecular Microbiology and Biotechnology . 20 : 156-67

Journal article

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Survival of extremely and moderately halophilic isolates of Tunisian solar salterns after UV-B or oxidative stress

H. Trigui, Salma Masmoudi, Céline Brochier-Armanet, S. Maalej, S. Dukan

Canadian Journal of Microbiology . 57(11) : 923-33

Journal article

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The phylogenomic analysis of the anaphase promoting complex and its targets points to complex and modern-like control of the cell cycle in the last common ancestor of eukaryotes

L. Eme, A. Trilles, D. Moreira, Céline Brochier-Armanet

BMC Evolutionary Biology . 11 : 923-33

DOI: 10.1186/1471-2148-11-265

Journal article

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The Assembly Mode of the Pseudopilus: a hallmark to distinguish a novel secretion system subtype

E. Durand, S. Alphonse, Céline Brochier-Armanet, G. Ball, Badreddine Douzi, A. Filloux...

Journal of Biological Chemistry . 286 ( 27 ) : 24407-24416

DOI: 10.1074/jbc.M111.234278

Journal article

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Multiple Nuclear Gene Phylogenetic Analysis of the Evolution of Dioecy and Sex Chromosomes in the Genus Silene

Gabriel Marais, A. Forrest, E. Kamau, Jos Käfer, Vincent Daubin, D. Charlesworth

PLoS ONE . 6 : e21915

DOI: 10.1371/journal.pone.0021915

Journal article

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Taxonomie et phylogénie des procaryotes. Chapitre 6

Pierre Caumette, Céline Brochier-Armanet, Philippe Normand

Ecologie Microbienne : Microbiologie des milieux naturels et anthropisés . 2-35311-022-3 9782353110223 : 1004 p.

Book chapter

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Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

C. Chureau, S. Chantalat, A. Romito, A. Galvani, Laurent Duret, P. Avner...

Human Molecular Genetics . 20 : 705-718

DOI: 10.1093/hmg/ddq516

Journal article

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Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations

Thierry Rouxel, J. Grandaubert, Jk. Hane, Claire Hoede, Angela P. van de Wouw, A. Couloux...

Nature Communications . 2 : 202

DOI: 10.1038/ncomms1189

Journal article

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Tpms: a Tree Pattern-matching Utility for Querying Gene Trees Collections

Thomas Bigot, Vincent Daubin, G. Perrière

Journées Ouvertes Biologie Informatique Mathématiques (JOBIM) . : 111-112

Conference paper

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Apport des nouvelles générations de séquençage pour accéder à la diversité des communautés microbiennes du sol : nécessité d’un ‘pipeline’ bio-informatique pour les biologistes

Sébastien Terrat, Richard Christen, Samuel S. Dequiedt, Pierre-Alain Maron, Christophe Mougel, Guy Perriere...

1ères Rencontres bioinformaticiens et statisticiens de l’INRA . : 1 p.

Conference paper

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Adaptation to Environmental Temperature Is a Major Determinant of Molecular Evolutionary Rates in Archaea

M. Groussin, Manolo Gouy

Molecular Biology and Evolution . 28 : 2661-2674

DOI: 10.1093/molbev/msr098

Journal article

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Pendant trois milliards d'années les micro-organismes sont les seuls habitants de la terre

J.C. Bertrand, Céline Brochier-Armanet, Manolo Gouy, F. Westall

incollection . 2-35311-022-3 9782353110223 : 94-U259

Book chapter

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Complete-fosmid and fosmid-end sequences reveal frequent horizontal gene transfers in marine uncultured planktonic archaea.

Céline Brochier-Armanet, Philippe Deschamps, Purificación López-García, Yvan Zivanovic, Francisco Rodríguez-Valera, David Moreira

The International Society of Microbiologial Ecology Journal . 5 ( 8 ) : 1291-302

DOI: 10.1038/ismej.2011.16

Journal article

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A New Highly Conserved Antibiotic Sensing/Resistance Pathway in Firmicutes Involves an ABC Transporter Interplaying with a Signal Transduction System

S. Coumes-Florens, Céline Brochier-Armanet, A. Guiseppi, F. Denizot, M. Foglino

PLoS ONE . 6 : e15951

DOI: 10.1371/journal.pone.0015951

Journal article

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Emergence and Modular Evolution of a Novel Motility Machinery in Bacteria

J. Luciano, R. Agrebi, A.V. Le Gall, M. Wartel, F. Fiegna, A. Ducret...

PLoS Genetics . 7 ( 9 ) : 1409-1418

DOI: 10.1371/journal.pgen.1002268

Journal article

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Characterization of Halorubrum sfaxense sp. nov. a New Halophilic Archaeon Isolated from the Solar Saltern of Sfax in Tunisia

H. Trigui, Salma Masmoudi, Céline Brochier-Armanet, S. Maalej, S. Dukan

Int J Microbiol . -- : 347-58

Journal article

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Unsuspected Diversity of Arsenite-Oxidizing Bacteria Revealed by a Widespread Distribution of the aoxB Gene in Prokaryotes

A. Heinrich-Salmeron, A. Cordi, Céline Brochier-Armanet, D. Halter, C. Pagnout, E. Abbaszadeh-Fard...

Applied and Environmental Microbiology . 77 : 4685-92

DOI: 10.1128/AEM.02884-10

Journal article

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On the last common ancestor and early evolution of eukaryotes: reconstructing the history of mitochondrial ribosomes.

Elie Desmond-Le Quéméner, Celine Brochier-Armanet, Patrick Forterre, Simonetta Gribaldo

Research in Microbiology . 162 ( 1 ) : 53-70

DOI: 10.1016/j.resmic.2010.10.004

Journal article

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A eukaryotic-like sulfiredoxin involved in oxidative stress responses and in the reduction of the sulfinic form of 2 Cys-peroxiredoxin in the cyanobacterium Anabaena PCC 7120

C. Boileau, L. Eme, Céline Brochier-Armanet, A. Janicki, C-C. Zhang, A. Latifi

New Phytologist . 191 : 1108-1118

DOI: 10.1111/j.1469-8137.2011.03774.x

Journal article

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