Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
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Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
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Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
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Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
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Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
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Doctorante
autre
Tel: 04 72 44 81 42
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Praticien hospitalier
HCL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier émérite
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
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Maîtresse de conférences - praticienne hospitalière
UCBL
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Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
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Doctorante
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Post-doc
UCBL
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Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 241 to 270 publications on 450 in total
Improved outcome of children transplanted for high-risk leukemia by using a new strategy of cyclosporine-based GVHD prophylaxis
Bone Marrow Transplantation . 51 ( 5 ) : 698-704
DOI: 10.1038/bmt.2015.350
Journal article
see the publicationPharmacokinetic and Analytical Issues in Busulfan Area Under the Curve Estimation and Simulation
Biology of Blood and Marrow Transplantation . 22 ( 1 ) : 185
Journal article
see the publicationStereoselective determination of citalopram and desmethylcitalopram in human plasma and breast milk by liquid chromatography tandem mass spectrometry
Journal of Pharmaceutical and Biomedical Analysis . 131 : 233-245
Journal article
see the publicationOral drug dosage forms administered to hospitalized children: Analysis of 117,665 oral administrations in a French paediatric hospital over a 1-year period
International Journal of Pharmaceutics . 500 : 336-44
Journal article
see the publicationIdentification des lacunes de connaissances des étudiants en filière officine débutant le stage de 5e année
Annales Pharmaceutiques Françaises . 74 ( 5 ) : 404-12
Journal article
see the publicationIdentification des lacunes de connaissances des étudiants en filière officine débutant le stage de 5e année : propositions pour modifier le contenu de l’enseignement
Annales Pharmaceutiques Françaises . 74 ( 5 ) : 404-412
Journal article
see the publicationIdentification of Most Aggressive Carcinoma Among Patients Diagnosed With Prostate Cancer Using Mathematical Modeling of Prostate-Specific Antigen Increases
Clinical Genitourinary Cancer . 14 ( 3 ) : 210-217
Journal article
see the publicationTenofovir DF/emtricitabine and efavirenz combination therapy for HIV infection in patients treated for tuberculosis: the ANRS 129 BKVIR trial
Journal of Antimicrobial Chemotherapy .
DOI: 10.1093/jac/dkv384
Journal article
see the publicationSevere Pulmonary Fibrosis as the First Manifestation of Interferonopathy (TMEM173 Mutation)
Chest . 150 ( 3 ) : E65-E71
Journal article
see the publicationModerate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients
Prostaglandins, Leukotrienes and Essential Fatty Acids . 115 : 41 - 47
Journal article
see the publicationEfficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children
Journal of Allergy and Clinical Immunology . 138 ( 6 ) : 1752-1755
Journal article
see the publicationIs the raised volume rapid thoracic compression technique ready for use in clinical trials in infants with cystic fibrosis?
Journal of Cystic Fibrosis . 15 ( 1 ) : 10 - 20
Journal article
see the publicationHeterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study
Immunologic Research . 64 ( 3 ) : 677-686
Journal article
see the publicationTocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children
RMD Open : Rheumatic & Musculoskeletal Diseases . 2 ( 2 ) : e000271
Journal article
see the publicationQuality of qualitative studies centred on patients in family practice: a systematic review
Family Practice . 33 ( 6 ) : 580 - 587
Journal article
see the publicationRéférentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux
Thérapie .
Journal article
see the publicationQuantitative Prediction of Drug Interactions Caused by CYP1A2 Inhibitors and Inducers
Clinical Pharmacokinetics . 55 : 977-990
Journal article
see the publicationAccurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software
Therapeutic Drug Monitoring . 38 : 332-342
Journal article
see the publicationShould busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children
Bone Marrow Transplantation . 51 : 72-78
DOI: 10.1038/bmt.2015.218
Journal article
see the publicationMathematical modeling and systems pharmacology of tuberculosis: Isoniazid as a case study
Journal of Theoretical Biology . 399 : 43-52
Journal article
see the publicationAntihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals
Cochrane database of systematic reviews (Online) . 3 : CD011745
Journal article
see the publicationOne-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial
Trials . 17 ( 1 ) : 404
Journal article
see the publicationImpact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
PLoS ONE . 11 : e0145958
Journal article
see the publicationPharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections
Antimicrobial Agents and Chemotherapy . 60 ( 5 ) : pp. 3148-3151
DOI: 10.1128/AAC.02597-15
Journal article
see the publicationComparison of the static in vivo approach to a physiologically based pharmacokinetic approach for metabolic drug-drug interactions prediction
International Journal of Pharmacokinetics . : 1-10
Journal article
see the publicationMetformin as firstline treatment for type 2 diabetes: are we sure?
BMJ-BRITISH MEDICAL JOURNAL . 352 : h6748
DOI: 10.1136/bmj.h6748
Journal article
see the publicationAre ciprofloxacin dosage regimens adequate for antimicrobial efficacy and prevention of resistance? Pseudomonas aeruginosa bloodstream infection in elderly patients as a simulation case study
Fundamental & Clinical Pharmacology . 29 ( 6 ) : 615-624
DOI: 10.1111/fcp.12156
Journal article
see the publicationŒdèmes des membres inférieurs au cours d’un traitement par valpromide : cas clinique et revue de la littérature
La Revue de Médecine Interne . 36 ( 10 ) : 698-700
Journal article
see the publicationQuantitative Methods for Prediction of the Effect of Cytochrome P450 Gene Polymorphisms on Substrate Drug Exposure
Clinical Pharmacokinetics . 54 ( 3 ) : 319-320
Journal article
see the publicationSweat test practice in pediatric pulmonology after introduction of cystic fibrosis newborn screening
European Journal of Pediatrics . 174 ( 12 ) : 1613 - 1620
Journal article
see the publication
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