Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 271 to 300 publications on 628 in total

Amikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual Patients

Clément Boidin, Laurent Bourguignon, Sabine Cohen, Claire Roger, Jean-Yves Lefrant, Jason A. Roberts...

Antimicrobial Agents and Chemotherapy . 63 ( 11 ) : e00993-19

DOI: 10.1128/AAC.00993-19

Journal article

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Pharmacokinetic variability of beta-lactams in critically ill patients: A narrative review

Clément Boidin, Parastou Moshiri, Claire Dahyot-Fizelier, Sylvain Goutelle, Sandrine Lefeuvre

Anaesthesia Critical Care & Pain Medicine .

DOI: 10.1016/j.accpm.2019.07.016

Journal article

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Do patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis

Julie Coton, Ha-Hai Le, Victor Veuillet, Perrine Janiaud, Michel Cucherat, Behrouz Kassai-Koupai...

Journal of Cystic Fibrosis .

DOI: 10.1016/j.jcf.2019.02.003

Journal article

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The limitations of observation studies for decision making regarding drugs efficacy and safety

François Gueyffier, Michel Cucherat

Alternative and Complementary Therapies . 74 ( 2 ) : 181-185

DOI: 10.1016/j.therap.2018.11.001

Journal article

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Apport de la génomique dans la médecine de demain, applications cliniques et enjeux

Bruno Laviolle, Olivier Perche, François Gueyffier, Élodie Bégué, Pascal Bilbault, Hélène Esperou...

Thérapie . 74 ( 1 ) : 1-8

DOI: 10.1016/j.therap.2018.11.011

Journal article

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Immune system modelling in case of a septic shock

Jean Tallon, Françoise Couenne, Claire Bordes, Melaz Tayakout-Fayolle, Fabienne Venet, Guillaume Monneret...

29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, . : 1093-1098

DOI: 10.1016/B978-0-12-818634-3.50183-1

Book chapter

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Do non-steroidal anti-inflammatory drugs improve sport performance ? A meta-analysis of randomized trials Introduction

Catherine Cornu, Clémence Grange, Amanda Regalin, Justine Munier, Sonia Ounissi, Natane Reynaud...

23e Congrès de la Société Française de Pharmacologie et de Thérapeutique (SFPT 2019) .

Poster

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Extended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis

Vicky Mai, Laurent Bertoletti, Michel Cucherat, Sabine Jardel, Claire Grange, Steeve Provencher...

PLoS ONE . 14 ( 4 ) : e0214134

DOI: 10.1371/journal.pone.0214134

Journal article

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Clomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies

Marine Auffret, Judith Cottin, Thierry Vial, Michel Cucherat

BJOG: An International Journal of Obstetrics and Gynaecology .

DOI: 10.1111/1471-0528.15800

Journal article

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Risk of thrombosis with anti-phospholipid syndrome in systemic lupus erythematosus treated with thrombopoietin-receptor agonists.

Zelie Guitton, Louis Terriou, Jean-Christophe Lega, Raphaele Nove-Josserand, Miguel Hie, Zahir Amoura...

Rheumatology . 57 : 1432–1438

DOI: 10.1093/rheumatology/key119

Journal article

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A Generic Model for Quantitative Prediction of Interactions Mediated by Efflux Transporters and Cytochromes: Application to P-Glycoprotein and Cytochrome 3A4

Michel Tod, Sylvain Goutelle, N. Bleyzac, L. Bourguignon

Clinical Pharmacokinetics . 58 ( 4 ) : 503-523

DOI: 10.1007/s40262-018-0711-0

Journal article

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Comment on: MIC-based dose adjustment: facts and fables

Sylvain Goutelle, Charlotte Genestet, Florence Ader, Gérard Lina, Oana Dumitrescu

Journal of Antimicrobial Chemotherapy . 73 ( 9 ) : 2584-2585

DOI: 10.1093/jac/dky131

Journal article

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Population Pharmacokinetic Study of Amoxicillin-Treated Burn Patients Hospitalized at a Swiss Tertiary-Care Center

Anne Fournier, Sylvain Goutelle, Yok-Ai Que, Philippe Eggimann, Olivier Pantet, Farshid Sadeghipour...

Antimicrobial Agents and Chemotherapy . 62 ( 9 )

DOI: 10.1128/AAC.00505-18

Journal article

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Maximal concentration of intravenous busulfan as a determinant of veno-occlusive disease: a pharmacokinetic-pharmacodynamic analysis in 293 hematopoietic stem cell transplanted children

Michaël Philippe, Michael Neely, Teresa Rushing, Yves Bertrand, Nathalie Bleyzac, Sylvain Goutelle

Bone Marrow Transplantation . 54 ( 3 ) : 448-457

DOI: 10.1038/s41409-018-0281-7

Journal article

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[Pharmacokinetic risk factors of beta-blockers overdose in the elderly: Case report and pharmacology approach].

L. Lafarge, L. Bourguignon, N. Bernard, T. Vial, M.-J. Dehan-Moya, B. de la Gastine...

Annales de Cardiologie et d'Angéiologie . 67 ( 2 ) : 91-97

DOI: 10.1016/j.ancard.2018.02.001

Journal article

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Identification of Cytochrome P450-Mediated Drug–Drug Interactions at Risk in Cases of Gene Polymorphisms by Using a Quantitative Prediction Model

Nicolas Fermier, Laurent Bourguignon, Sylvain Goutelle, Nathalie Bleyzac, Michel Tod

Clinical Pharmacokinetics . 57 ( 12 ) : 1581-1591

DOI: 10.1007/s40262-018-0651-8

Journal article

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Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5

Nicolas Naudet, Aubin Moutal, Hong Nhung Vu, Naura Chounlamountri, Chantal Watrin, Sylvie Cavagna...

Cellular and Molecular Life Sciences . 75 ( 1 ) : 67-79

DOI: 10.1007/s00018-017-2634-6

Journal article

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Functional assessment of newly identified SFTPA1 and SFTPA2 mutations in patients with idiopathic interstitial pneumonia (IIP) and lung cancer.

Nadia Nathan, Marie Legendre, Emilie Filhol-Blin, Raphaël Borie, Diane Bouvry, Caroline Kannengiesser...

uropean Respiratory Society (ERS) Congress, .

Conference paper

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Functional assessment of newly identified SFTPA1 and SFTPA2 mutations in patients with idiopathic interstitial pneumonia (IIP) and lung cancer28th International Congress of the European-Respiratory-Society (ERS)

Nadia Nathan, Marie Legendre, Emilie Filhol-Blin, Raphael Borie, Diane Bouvry, Caroline Kannengiesser...

28th International Congress of the European-Respiratory-Society (ERS) .

DOI: 10.1183/13993003.congress-2018.PA2235

Conference paper

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Down syndrome and pulmonary hemosiderosis: an under-recognized association

Aurelia Alimi, Jessica Taytard, Rola Abou Taam, Véronique Houdouin, Aude Forgeron, Marc Lubrano Lavadera...

European Respiratory Society (ERS) Congress .

Conference paper

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Contribution of mutations in genes of the surfactant system to idiopathic interstitial pneumonia (IIP)

Nadia Nathan, Marie Legendre, Emilie Filhol-Blin, Raphael Borie, Diane Bouvry, Mickael Afanetti...

ERS International Congress 2018 abstracts . : OA547

DOI: 10.1183/13993003.congress-2018.OA547

Conference paper

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Place de l’analyse des gènes du surfactant dans la démarche diagnostique des pneumopathies interstitielles diffuses de l’enfant et l’adulte

Nadia Nathan, Marie Legendre, Raphaël Borie, Diane Bouvry, Mickael Afanetti, Juliette Albuisson...

Assises de Génétique Humaine et Médicale .

Poster

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Eosinophilic granulomatosis with polyangiitis in children: Data from the French RespiRare (R) cohort

Agnes Fina, Jean-Christophe Dubus, Antoine Tran, Jocelyne Derelle, Philippe Reix, Michael Fayon...

Pediatric Pulmonology . 53 ( 12 ) : 1640-1650

DOI: 10.1002/ppul.24089

Journal article

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Pulmonary hemosiderosis in children with Down syndrome: a national experience

Aurelia Alimi, Jessica Taytard, Rola Abou Taam, Véronique Houdouin, Aude Forgeron, Marc Lubrano Lavadera...

Orphanet Journal of Rare Diseases . 13 ( 1 ) : 60

DOI: 10.1186/s13023-018-0806-6

Journal article

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Mortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry

Sabine Jardel, Xavier Puéchal, Alain Le Quellec, Christian Pagnoux, Mohamed Hamidou, François Maurier...

Autoimmunity Reviews . 17 ( 7 ) : 653--659

DOI: 10.1016/j.autrev.2018.01.022

Journal article

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Pediatric renal transplantation: A retrospective single-center study on epidemiology and morbidity due to EBV

A. Laurent, A. Klich, Pascal Roy, Bruno Lina, B. Kassai, J. Bacchetta...

Pediatric Transplantation . 22 ( 3 ) : e13151

DOI: 10.1111/petr.13151

Journal article

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Glucose trajectories in cystic fibrosis and their association with pulmonary function

Quitterie Reynaud, Muriel Rabilloud, Sylvain Roche, Stéphanie Poupon-Bourdy, Jean Iwaz, Raphaële Nové-Josserand...

Journal of Cystic Fibrosis . 17 ( 3 ) : 400 - 406

DOI: 10.1016/j.jcf.2017.09.010

Journal article

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Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals

Victor Ronget, Jean-Michel Gaillard, Tim Coulson, Michael Garratt, François Gueyffier, Jean-Christophe Lega...

Biol. Rev . 93 : 1 - 27

DOI: 10.1111/brv.12329

Journal article

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Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy

Claire Triffault-Fillit, Florent Valour, Ronan Guillo, Michel Tod, Sylvain Goutelle, Sébastien Lustig...

ANTIMICROB. AGENTS CHEMOTHER. . 62 ( 10 )

DOI: 10.1128/AAC.00163-18

Journal article

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Antituberculous drugs modulate bacterial phagolysosome avoidance and autophagy in Mycobacterium tuberculosis-infected macrophages

Charlotte Genestet, Fanny Bernard-Barret, Elisabeth Hodille, Christophe Ginevra, Florence Ader, Sylvain Goutelle...

Tuberculosis . 111 : 67-70

DOI: 10.1016/j.tube.2018.05.014

Journal article

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