Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 271 to 300 publications on 613 in total

Maximal concentration of intravenous busulfan as a determinant of veno-occlusive disease: a pharmacokinetic-pharmacodynamic analysis in 293 hematopoietic stem cell transplanted children

Michaël Philippe, Michael Neely, Teresa Rushing, Yves Bertrand, Nathalie Bleyzac, Sylvain Goutelle

Bone Marrow Transplantation . 54 ( 3 ) : 448-457

DOI: 10.1038/s41409-018-0281-7

Journal article

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[Pharmacokinetic risk factors of beta-blockers overdose in the elderly: Case report and pharmacology approach].

L. Lafarge, L. Bourguignon, N. Bernard, T. Vial, M.-J. Dehan-Moya, B. de la Gastine...

Annales de Cardiologie et d'Angéiologie . 67 ( 2 ) : 91-97

DOI: 10.1016/j.ancard.2018.02.001

Journal article

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Identification of Cytochrome P450-Mediated Drug–Drug Interactions at Risk in Cases of Gene Polymorphisms by Using a Quantitative Prediction Model

Nicolas Fermier, Laurent Bourguignon, Sylvain Goutelle, Nathalie Bleyzac, Michel Tod

Clinical Pharmacokinetics . 57 ( 12 ) : 1581-1591

DOI: 10.1007/s40262-018-0651-8

Journal article

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Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5

Nicolas Naudet, Aubin Moutal, Hong Nhung Vu, Naura Chounlamountri, Chantal Watrin, Sylvie Cavagna...

Cellular and Molecular Life Sciences . 75 ( 1 ) : 67-79

DOI: 10.1007/s00018-017-2634-6

Journal article

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Functional assessment of newly identified SFTPA1 and SFTPA2 mutations in patients with idiopathic interstitial pneumonia (IIP) and lung cancer.

Nadia Nathan, Marie Legendre, Emilie Filhol-Blin, Raphaël Borie, Diane Bouvry, Caroline Kannengiesser...

uropean Respiratory Society (ERS) Congress, .

Conference paper

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Functional assessment of newly identified SFTPA1 and SFTPA2 mutations in patients with idiopathic interstitial pneumonia (IIP) and lung cancer28th International Congress of the European-Respiratory-Society (ERS)

Nadia Nathan, Marie Legendre, Emilie Filhol-Blin, Raphael Borie, Diane Bouvry, Caroline Kannengiesser...

28th International Congress of the European-Respiratory-Society (ERS) .

DOI: 10.1183/13993003.congress-2018.PA2235

Conference paper

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Down syndrome and pulmonary hemosiderosis: an under-recognized association

Aurelia Alimi, Jessica Taytard, Rola Abou Taam, Véronique Houdouin, Aude Forgeron, Marc Lubrano Lavadera...

European Respiratory Society (ERS) Congress .

Conference paper

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Contribution of mutations in genes of the surfactant system to idiopathic interstitial pneumonia (IIP)

Nadia Nathan, Marie Legendre, Emilie Filhol-Blin, Raphael Borie, Diane Bouvry, Mickael Afanetti...

ERS International Congress 2018 abstracts . : OA547

DOI: 10.1183/13993003.congress-2018.OA547

Conference paper

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Place de l’analyse des gènes du surfactant dans la démarche diagnostique des pneumopathies interstitielles diffuses de l’enfant et l’adulte

Nadia Nathan, Marie Legendre, Raphaël Borie, Diane Bouvry, Mickael Afanetti, Juliette Albuisson...

Assises de Génétique Humaine et Médicale .

Poster

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Eosinophilic granulomatosis with polyangiitis in children: Data from the French RespiRare (R) cohort

Agnes Fina, Jean-Christophe Dubus, Antoine Tran, Jocelyne Derelle, Philippe Reix, Michael Fayon...

Pediatric Pulmonology . 53 ( 12 ) : 1640-1650

DOI: 10.1002/ppul.24089

Journal article

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Pulmonary hemosiderosis in children with Down syndrome: a national experience

Aurelia Alimi, Jessica Taytard, Rola Abou Taam, Véronique Houdouin, Aude Forgeron, Marc Lubrano Lavadera...

Orphanet Journal of Rare Diseases . 13 ( 1 ) : 60

DOI: 10.1186/s13023-018-0806-6

Journal article

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Mortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry

Sabine Jardel, Xavier Puéchal, Alain Le Quellec, Christian Pagnoux, Mohamed Hamidou, François Maurier...

Autoimmunity Reviews . 17 ( 7 ) : 653--659

DOI: 10.1016/j.autrev.2018.01.022

Journal article

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Pediatric renal transplantation: A retrospective single-center study on epidemiology and morbidity due to EBV

A. Laurent, A. Klich, Pascal Roy, Bruno Lina, B. Kassai, J. Bacchetta...

Pediatric Transplantation . 22 ( 3 ) : e13151

DOI: 10.1111/petr.13151

Journal article

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Glucose trajectories in cystic fibrosis and their association with pulmonary function

Quitterie Reynaud, Muriel Rabilloud, Sylvain Roche, Stéphanie Poupon-Bourdy, Jean Iwaz, Raphaële Nové-Josserand...

Journal of Cystic Fibrosis . 17 ( 3 ) : 400 - 406

DOI: 10.1016/j.jcf.2017.09.010

Journal article

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Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals

Victor Ronget, Jean-Michel Gaillard, Tim Coulson, Michael Garratt, François Gueyffier, Jean-Christophe Lega...

Biol. Rev . 93 : 1 - 27

DOI: 10.1111/brv.12329

Journal article

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Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy

Claire Triffault-Fillit, Florent Valour, Ronan Guillo, Michel Tod, Sylvain Goutelle, Sébastien Lustig...

ANTIMICROB. AGENTS CHEMOTHER. . 62 ( 10 )

DOI: 10.1128/AAC.00163-18

Journal article

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Antituberculous drugs modulate bacterial phagolysosome avoidance and autophagy in Mycobacterium tuberculosis-infected macrophages

Charlotte Genestet, Fanny Bernard-Barret, Elisabeth Hodille, Christophe Ginevra, Florence Ader, Sylvain Goutelle...

Tuberculosis . 111 : 67-70

DOI: 10.1016/j.tube.2018.05.014

Journal article

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Determinants of amikacin first peak concentration in critically ill patients

Clément Boidin, Sophie Jenck, Laurent Bourguignon, Sejad Torkmani, Aurore Roussey-Jean, Stanislas Ledochowski...

Fundamental & Clinical Pharmacology .

DOI: 10.1111/fcp.12374

Journal article

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Sex gap in aging and longevity: can sex chromosomes play a role?

Gabriel A.B. Marais, Jean-Michel Gaillard, Cristina Vieira, Ingrid Plotton, Damien Sanlaville, François Gueyffier...

Biology of Sex Differences . 9 ( 1 ) : 1-14

DOI: 10.1186/s13293-018-0181-y

Journal article

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Assessing the Combined Antibacterial Effect of Isoniazid and Rifampin on Four Mycobacterium tuberculosis Strains Using In Vitro Experiments and Response-Surface Modeling

Charlotte Genestet, Florence Ader, Catherine Pichat, Gérard Lina, Oana Dumitrescu, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 62 ( 1 )

DOI: 10.1128/AAC.01413-17

Journal article

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A double-blind placebo-controlled randomised trial of omega-3 supplementation in children with moderate ADHD symptoms

Catherine Cornu, Catherine Mercier, Tiphanie Ginhoux, Sandrine Masson, Julie Mouchet, Patrice Nony...

European Child and Adolescent Psychiatry . 27 ( 3 ) : 377-384

DOI: 10.1007/s00787-017-1058-z

Journal article

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Justification de la prescription hors-AMM d’antibiotiques chez l’enfant hospitalisé

Christelle Berthod, Behrouz Kassaï, Remy Boussageon, Léopold Adelaide, Matthias Jacquet-Lagrèze, Audrey Lajoinie...

Therapies . 72 ( 6 ) : 649-658

DOI: 10.1016/j.therap.2017.04.002

Journal article

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Real-life acute lung function changes after lumacaftor/ivacaftor first administration in pediatric patients with cystic fibrosis

Aurélie Labaste, Camille Ohlmann, Catherine Mainguy, Virginie Jubin, Marie Perceval, Laurianne Coutier...

Journal of Cystic Fibrosis . 16 ( 6 ) : 709-712

DOI: 10.1016/j.jcf.2017.05.002

Journal article

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Les enjeux de sécurité de la prescription hors AMM : l’exemple du baclofène dans l’alcoolodépendance

Marine Auffret

Thesis

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The dose–effect relationship of baclofen in alcohol dependence: A 1-year cohort study

Baptiste Pignon, Marine Auffret, Sophie Gautier, Sylvie Deheul, Nicolas Simioni, Olivier Cottencin...

Human Psychopharmacology. Clinical and Experimental . 32 ( 4 )

DOI: 10.1002/hup.2593

Journal article

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Authors' reply to alain braillon's comment on

Marine Auffret, Julien Labreuche, Alain Duhamel, Sylvie Deheul, Olivier Cottencin, Regis Bordet...

Drug Safety . 40 : 361-362

DOI: 10.1007/s40264-017-0513-6

Journal article

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Familial and syndromic lupus share the same phenotype as other early-onset forms of lupus.

Olivia Weill, Stéphane Decramer, Christophe Malcus, Behrouz Kassai, Isabelle Rouvet, Tiphanie Ginhoux...

Joint Bone Spine . : 589-593

DOI: 10.1016/j.jbspin.2016.12.008

Journal article

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Trends in the number and the quality of trial protocols involving children submitted to a French Institutional Review Board

Isabelle Gautier, Perrine Janiaud, Nelly Rollet, Nicolas André, Michel Tsimaratos, Catherine Cornu...

BMC Medical Research Methodology . 17 ( 1 ) : 130

DOI: 10.1186/s12874-017-0395-4

Journal article

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Worldwide view of nephropathic cystinosis: results from a survey from 30 countries

Aurélia Bertholet-Thomas, Julien Berthiller, Velibor Tasic, Behrouz Kassai, Hasan Otukesh, Marcella Greco...

BMC Nephrology . 18 ( 1 ) : 210

DOI: 10.1186/s12882-017-0633-3

Journal article

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Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is it Worth It?

M Tod, Sylvain Goutelle, L Bourguignon, N Bleyzac

CPT: Pharmacometrics and Systems Pharmacology . 6 ( 4 ) : 226-226

DOI: 10.1002/psp4.12164

Journal article

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