Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
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Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
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Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
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Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
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Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
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Doctorante
autre
Tel: 04 72 44 81 42
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Praticien hospitalier
HCL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier émérite
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
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Maîtresse de conférences - praticienne hospitalière
UCBL
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Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
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Doctorante
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Post-doc
UCBL
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Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 331 to 360 publications on 450 in total
A Tumor Growth Inhibition Model for Low-Grade Glioma Treated with Chemotherapy or Radiotherapy.
Clinical Cancer Research . 18 ( 18 ) : 5071-5080
Journal article
see the publicationPrédiction quantitative des interactions médicamenteuses impliquant les cytochromes 3A4 et 2D6 : approche in vivo
La Lettre du Pharmacologue . 26 : 57--62
Journal article
see the publicationA pharmacodynamic model of ganciclovir antiviral effect and toxicity for lymphoblastoid cells suggests a new dosing regimen to treat cytomegalovirus infection
Antimicrobial Agents and Chemotherapy . 56 : 3732--8
DOI: 10.1128/AAC.06423-11
Journal article
see the publicationA Pharmacokinetic-Pharmacodynamic Model for Predicting the Impact of CYP2C9 and VKORC1 Polymorphisms on Fluindione and Acenocoumarol During Induction Therapy
Clinical Pharmacokinetics . 51 ( 1 ) : 41-53
Journal article
see the publicationA national internet-linked based database for pediatric interstitial lung diseases: the French network.
Orphanet Journal of Rare Diseases . 7 ( 1 ) : 40
Journal article
see the publicationSuccessful management of severe infant bullous pemphigoid with omalizumab
British Journal of Dermatology . 166 : 1140--2
Journal article
see the publicationLate onset Ondine syndrome: literature review on a case report
Archives de Pédiatrie . 19 : 1205--7
Journal article
see the publicationThe IDEAL Study : Towards Personalized Drug Treatment of Hypertension
Thérapie . 67 : 195--204
Journal article
see the publicationFarnesoid X Receptor Targeting for Hepatitis C: Study Protocol for a Proof-of-concept Trial
Thérapie . 67 : 423--427
Journal article
see the publicationOseltamivir-zanamivir bitherapy compared to oseltamivir monotherapy in the treatment of pandemic 2009 influenza A(H1N1) influenza virus infections
Antiviral Research . 96 : 130--137
Journal article
see the publicationModeling the impact of cardiovascular prevention strategies: toward better information for public health decisions
Journal of Hypertension . 30 : 51--2
Journal article
see the publicationPharmacotherapy for mild hypertension (Review)
Cochrane Database of Systematic Reviews . : 1--28
Journal article
see the publicationIndividual patient data meta-analysis of survival data using Poisson regression models.
BMC Medical Research Methodology . 12 ( 1 ) : 34
Journal article
see the publicationComparison of Four Renal Function Estimation Equations for Pharmacokinetic Modeling of Gentamicin in Geriatric Patients
Antimicrobial Agents and Chemotherapy . 56 ( 4 ) : 1862-1869
DOI: 10.1128/AAC.05634-11
Journal article
see the publicationReappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.
PLoS Medicine . 9 ( 4 ) : e1001204
Journal article
see the publicationApport de la modélisation et des populations virtuelles pour transposer les résultats des essais cliniques à la vie réelle et éclairer la décision publique
Thérapie . 67 : 359--66
Journal article
see the publicationContribution of modeling approaches and virtual populations in transposing the results of clinical trials into real life and in enlightening public health decisions
Thérapie . 67 : 367--74
Journal article
see the publicationVirtual Patients and Sensitivity Analysis of the Guyton Model of Blood Pressure Regulation: Towards Individualized Models of Whole-Body Physiology
PLoS Computational Biology . 8 : e1002571
Journal article
see the publicationEfficacy of a home-based intervention programme on the physical activity level and functional ability of older people using domestic services: A randomised study
Journal of Nutrition, Health & Aging . 16 : 370--377
Journal article
see the publicationImpact of the early reduction of cyclosporine on renal function in heart transplant patients: a French randomised controlled trial.
Trials . 13 ( 1 ) : 231
Journal article
see the publicationEvaluation of fluoroquinolone reduced dosage regimens in elderly patients by using pharmacokinetic modelling and Monte Carlo simulations
Journal of Antimicrobial Chemotherapy . 67 : 2207--2212
DOI: 10.1093/jac/dks195
Journal article
see the publicationRelationship between benzodiazepines use and falls in the elderly: A multicenter study in three geriatric centers of a university hospital
Annales Pharmaceutiques Françaises . 70 : 46-52
Journal article
see the publicationPrescriptions analysis by clinical pharmacists in the post-operative period: a 4-year prospective study.
Acta Anaesthesiologica Scandinavica . 56 ( 8 ) : 1047-51
Journal article
see the publicationModel-based design of rituximab dosing optimization in follicular non-hodgkin lymphoma
Fundamental & Clinical Pharmacology . 25 : 26-27
Journal article
see the publicationPharmacokinetic design optimization in children and estimation of maturation parameters: example of cytochrome P450 3A4
Journal of Pharmacokinetics and Pharmacodynamics . 38 ( 1 ) : 25 - 40
Journal article
see the publicationLinks between cyclosporin exposure in tissues and graft-versus-host disease in pediatric bone marrow transplantation: analysis by a PBPK model
Pharmaceutical Research . 28 : 531-539
Journal article
see the publicationA New Animal Model of Obstructive Sleep Apnea Responding to Continuous Positive Airway Pressure
Sleep . 34 : 541-548
Journal article
see the publicationIntrafamilial transmission of Staphylococcus aureus Panton-Valentine leukocidin responsible for two cases of neonatal necrotizing pneumonia
Archives de Pédiatrie . 18 : 1090-1094
Journal article
see the publicationCombined pulmonary fibrosis and emphysema syndrome associated with familial SFTPC mutation
Thorax . 66 ( 10 ) : 918-9
Journal article
see the publication
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