Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 361 to 390 publications on 613 in total

Attitudes of community pharmacists to off-label prescribing of baclofen in Northern France

Marine Auffret, Benjamin Rolland, Anne-Sylvie Caous, Sylvie Deheul, Johana Béné, Olivier Cottencin...

International Journal of Clinical Pharmacy . 37 ( 2 ) : 296-299

Journal article

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Temporary Recommendation for Use on Off-label Baclofen: Viewpoint of Prescribers of the CAMTEA System

Benjamin Rolland, Sylvie Deheul, Thierry Danel, Camille Bence, Marie-Christine Blanquart, Alexandre Bonord...

Thérapie . 70 ( 2 ) : 235-238

DOI: 10.2515/therapie/2014210

Journal article

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Bullous pemphigoid induced by vildagliptin: a report of three cases

Johana Bene, Aurélie Jacobsoone, Patrick Coupe, Marine Auffret, Samy Babai, Dominique Hillaire-Buys...

Fundamental & Clinical Pharmacology . 29 ( 1 ) : 112-114

DOI: 10.1111/fcp.12083

Journal article

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Safety and drinking outcomes among patients with comorbid alcohol dependence and borderline personality disorder treated with high-dose baclofen: a comparative cohort study

Benjamin Rolland, Thomas Valin, Carole Langlois, Marine Auffret, Sophie Gautier, Sylvie Deheul...

International Clinical Psychopharmacology . 30 ( 1 ) : 49-53

DOI: 10.1097/YIC.0000000000000054

Journal article

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[Drug Shortage May Have Serious Outcome: the French Exemple of Phenytoine].

Marine Auffret, Louise Tyvaert, Marie-Laure Laroche, Bertrand Godet, Roland Peyron, Claire Guy...

Thérapie . 70 ( 4 ) : 377-80

Journal article

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Incorrect evaluation of the frequency of malnutrition and of its screening in hospitalized children by health care professionals

L. Restier, A. Duclos, L. Jarri, S. Touzet, A. Denis, P. Occelli...

Journal of Evaluation in Clinical Practice . 21 ( 5 ) : 958-62

DOI: 10.1111/jep.12412

Journal article

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Choisir la forme pharmaceutique orale la plus adaptée à l'enfant

A. Lajoinie, Emilie Henin, B. Kassai

Archives de Pédiatrie . 22 : 877-85

Journal article

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Risk of medication error administering ciprofloxacin oral suspension in children

A. Lajoinie, Fv. Valla, Behrouz Kassai

European journal of clinical pharmacology . 71 : 769-70

Journal article

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Overview of pediatric organ transplantation: current opinion and future perspectives on immunosuppression

S. Malik, Behrouz Kassai, P. Cochat

Current Opinion in Organ Transplantation . 20 : 527-35

Journal article

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Gastrointestinal tolerance of erythritol-containing beverage in young children: a double-blind, randomised controlled trial

E. Jacqz-Aigrain, Behrouz Kassai, C. Cornu, Jm. Cazaubiel, B. Housez, M. Cazaubiel...

European Journal of Clinical Nutrition . 69 ( 6 ) : 746-751

DOI: 10.1038/ejcn.2015.4

Journal article

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Is HbA a valid surrogate for macrovascular and microvascular complications in type 2 diabetes?

T. Bejan-Angoulvant, Catherine Cornu, P. Archambault, B. Tudrej, P. Audier, Y. Brabant...

Diabetes & Metabolism . 41 : 195-201

Journal article

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A Bayesian Model to Describe Factors Influencing Trough Levels of Vancomycin in Hemodialysis Patients

C. Sansot, E. Kalbacher, Sandrine Lemoine, Laurent Bourguignon, J. P. Fauvel, M. Ducher

Nephron Physiology . 131 ( 2 ) : 131-7

DOI: 10.1159/000439230

Journal article

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Are ciprofloxacin dosage regimens adequate for antimicrobial efficacy and prevention of resistance? Pseudomonas aeruginosa bloodstream infection in elderly patients as a simulation case study

Yoann Cazaubon, Laurent Bourguignon, Sylvain Goutelle, Olivier Martin, Pascal Maire, Michel Ducher

Fundamental & Clinical Pharmacology . 29 ( 6 ) : 615-624

DOI: 10.1111/fcp.12156

Journal article

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Œdèmes des membres inférieurs au cours d’un traitement par valpromide : cas clinique et revue de la littérature

L. Gabriel, C. Darcissac, Sylvain Goutelle, P. Sève, T. Vial, B. de La Gastine

La Revue de Médecine Interne . 36 ( 10 ) : 698-700

DOI: 10.1016/j.revmed.2014.11.011

Journal article

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Quantitative Methods for Prediction of the Effect of Cytochrome P450 Gene Polymorphisms on Substrate Drug Exposure

Sylvain Goutelle, Michel Tod

Clinical Pharmacokinetics . 54 ( 3 ) : 319-320

DOI: 10.1007/s40262-014-0217-3

Journal article

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Can we identify response markers to antihypertensive drugs? First results from the Ideal Trial

F. Gueyffier, F. Subtil, T. Bejan-Angoulvant, Y. Zerbib, J. P. Baguet, J. M. Boivin...

Journal of human hypertension . 29 ( 1 ) : 22-27

DOI: 10.1038/jhh.2014.29

Journal article

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Unlicensed and off-label drug use: a prospective study in French NICU

S. Riou, F. Plaisant, Delphine Maucort-Boulch, B. Kassai, O. Claris, K. A. Nguyen

Acta Paediatrica . 104 : e228-31

DOI: 10.1111/apa.12924

Journal article

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Sweat test practice in pediatric pulmonology after introduction of cystic fibrosis newborn screening

Céline Grimaldi, François Brémont, Michèle Berlioz-Baudoin, Jacques Brouard, Harriet Corvol, Laure Couderc...

European Journal of Pediatrics . 174 ( 12 ) : 1613 - 1620

DOI: 10.1007/s00431-015-2579-4

Journal article

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An impulse oscillometry system is less efficient than spirometry in tracking lung function improvements after intravenous antibiotic therapy in pediatric patients with cystic fibrosis

Clélia Buchs, Laurianne Coutier, Stéphanie Vrielynck, Virginie Jubin, Catherine Mainguy, Philippe Reix

Pediatric Pulmonology . 50 ( 11 ) : 1073 - 1081

DOI: 10.1002/ppul.23301

Journal article

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A French multicentric study and review of pulmonary Nocardia spp. in cystic fibrosis patients

Véronica Rodriguez-Nava, Stéphane Durupt, Sandra Chyderiotis, Anne-Marie Freydiere, Judith Karsenty, Michèle de Montclos...

Medical Microbiology and Immunology . 204 ( 4 ) : 493-504

DOI: 10.1007/s00430-014-0360-3

Journal article

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Idiopathic inflammatory myopathies and the lung

Jean-Christophe Lega, Quitterie Reynaud, Alexandre Belot, Nicole Fabien, Isabelle Durieu, Vincent Cottin

European Respiratory Review . 24 ( 136 ) : 216-238

DOI: 10.1183/16000617.00002015

Journal article

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Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

C. Vale, L. Rydzewska, M. Rovers, J. Emberson, François Gueyffier, L. Stewart

British medical journal . 350 : h1088

DOI: 10.1136/bmj.h1088

Journal article

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Subcutaneous administration of levetiracetam in geriatrics

O. Maison, B. de La Gastine, L. Peter-Derex, C. Berger, Sylvain Goutelle

Revue Neurologique . 171 : 398-399

Journal article

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A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells-using rifampicin as an example

O. Clewe, Sylvain Goutelle, Jr. Conte, Ush. Simonsson

European Journal of Clinical Pharmacology . 71 ( 3 ) : 313-9

DOI: 10.1007/s00228-014-1798-3

Journal article

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Quantitative methods for prediction of the effect of cytochrome P450 gene polymorphisms on substrate drug exposure

Sylvain Goutelle, M. Tod

Clinical Pharmacokinetics . 54 : 319-20

Journal article

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Model-Based Determination of Effective Blood Concentrations of Cyclosporine for Neutrophil Response in the Treatment of Severe Aplastic Anemia in Children

M. Philippe, E. Henin, Y. Bertrand, D. Plantaz, Sylvain Goutelle, N. Bleyzac

AAPS Journal . 17 ( 5 ) : 1157-67

DOI: 10.1208/s12248-015-9779-8

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Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs

Laure Lalande, Laurent Bourguignon, S. Bihari, P. Maire, M. Neely, R. Jelliffe...

Antimicrobial Agents and Chemotherapy . 59 ( 9 ) : 5181-5189

DOI: 10.1128/AAC.00462-15

Journal article

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Management of adolescents with very poorly controlled type 1 diabetes by nurses: a parallel group randomized controlled trial

B. Kassai, Muriel Rabilloud, D. Bernoux, C. Michal, B. Riche, T. Ginhoux...

Trials . 16 ( 1 ) : 399

DOI: 10.1186/s13063-015-0923-7

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Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients

A. Glatard, Laurent Bourguignon, R. W. Jelliffe, P. Maire, M. N. Neely, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 59 ( 6 ) : 2986-94

DOI: 10.1128/AAC.04132-14

Journal article

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Different treatment benefits were estimated by clinical trials performed in adults compared with those performed in children

Perrine Janiaud, A. Lajoinie, F. Cour-Andlauer, Catherine Cornu, P. Cochat, Michel Cucherat...

Journal of Clinical Epidemiology . 68 : 1221-1231

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