Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 361 to 390 publications on 626 in total

Introduction of a paediatric anaesthesia comic information leaflet reduced preoperative anxiety in children

B. Kassai, Muriel Rabilloud, E. Dantony, S. Grousson, O. Revol, S. Malik...

British Journal of Anaesthesia . 117 : 95-102

DOI: 10.1093/bja/aew154

Journal article

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Accurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software

M. Neely, M. Philippe, T. Rushing, X. Fu, M. van Guilder, D. Bayard...

Therapeutic Drug Monitoring . 38 : 332-342

DOI: 10.1097/FTD.0000000000000276

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Should busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children

M. Philippe, Sylvain Goutelle, J. Guitton, X. Fonrose, C. Bergeron, Pascal Girard...

Bone Marrow Transplantation . 51 : 72-78

DOI: 10.1038/bmt.2015.218

Journal article

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Mathematical modeling and systems pharmacology of tuberculosis: Isoniazid as a case study

L. Lalande, Laurent Bourguignon, P. Maire, Sylvain Goutelle

Journal of Theoretical Biology . 399 : 43-52

DOI: 10.1016/j.jtbi.2016.03.038

Journal article

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Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals

G. Taverny, Y. Mimouni, A. Ledigarcher, P. Chevalier, L. Thijs, J.M. Wright...

Cochrane database of systematic reviews (Online) . 3 : CD011745

DOI: 10.1002/14651858.CD011745.pub2

Journal article

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One-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial

Cyril Villat, Jean-Pierre Attal, Nathalie Brulat, Franck Decup, Sophie Doméjean, Elisabeth Dursun...

Trials . 17 ( 1 ) : 404

DOI: 10.1186/s13063-016-1484-0

Journal article

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Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

H.-H. Le, C. El-Khatib, M. Mombled, F. Guitarian, M. Al-Gobari, M. Fall...

PLoS ONE . 11 : e0145958

DOI: 10.1371/journal.pone.0145958

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Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

Sylvain Goutelle, Sandrine Roux, Marie-Claude Gagnieu, Florent Valour, Sebastien Lustig, Florence Ader...

Antimicrobial Agents and Chemotherapy . 60 ( 5 ) : pp. 3148-3151

DOI: 10.1128/AAC.02597-15

Journal article

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Comparison of the static in vivo approach to a physiologically based pharmacokinetic approach for metabolic drug-drug interactions prediction

M. Tod, P.B. Pierrillas, Laurent Bourguignon, Sylvain Goutelle

International Journal of Pharmacokinetics . : 1-10

Journal article

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Metformin as firstline treatment for type 2 diabetes: are we sure?

R. Boussageon, François Gueyffier, Catherine Cornu

BMJ-BRITISH MEDICAL JOURNAL . 352 : h6748

DOI: 10.1136/bmj.h6748

Journal article

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Is the raised volume rapid thoracic compression technique ready for use in clinical trials in infants with cystic fibrosis?

Stefan Matecki, Lisa Kent, Kris de Boeck, Muriel Le Bourgeois, Stefan Zielen, Cesare Braggion...

Journal of Cystic Fibrosis . 15 ( 1 ) : 10 - 20

DOI: 10.1016/j.jcf.2015.03.015

Journal article

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Baclofen for alcohol dependence: relationships between baclofen and alcohol dosing and the occurrence of major sedation

Benjamin Rolland, Julien Labreuche, Alain Duhamel, Sylvie Deheul, Sophie Gautier, Marine Auffret...

European Neuropsychopharmacology . 25 : 1631-1636

DOI: 10.1016/j.euroneuro.2015.05.008

Journal article

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Des ruptures de stock aux conséquences parfois graves : l’exemple de la phénytoïne, à propos de 7 cas

Marine Auffret, Louise Tyvaert, Marie-Laure Laroche, Bertrand Godet, Roland Peyron, Claire Guy...

Thérapie . 70 ( 4 ) : 377-380

DOI: 10.2515/therapie/2015018

Journal article

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Attitudes of community pharmacists to off-label prescribing of baclofen in Northern France

Marine Auffret, Benjamin Rolland, Anne-Sylvie Caous, Sylvie Deheul, Johana Béné, Olivier Cottencin...

International Journal of Clinical Pharmacy . 37 ( 2 ) : 296-299

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Temporary Recommendation for Use on Off-label Baclofen: Viewpoint of Prescribers of the CAMTEA System

Benjamin Rolland, Sylvie Deheul, Thierry Danel, Camille Bence, Marie-Christine Blanquart, Alexandre Bonord...

Thérapie . 70 ( 2 ) : 235-238

DOI: 10.2515/therapie/2014210

Journal article

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Bullous pemphigoid induced by vildagliptin: a report of three cases

Johana Bene, Aurélie Jacobsoone, Patrick Coupe, Marine Auffret, Samy Babai, Dominique Hillaire-Buys...

Fundamental & Clinical Pharmacology . 29 ( 1 ) : 112-114

DOI: 10.1111/fcp.12083

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Safety and drinking outcomes among patients with comorbid alcohol dependence and borderline personality disorder treated with high-dose baclofen: a comparative cohort study

Benjamin Rolland, Thomas Valin, Carole Langlois, Marine Auffret, Sophie Gautier, Sylvie Deheul...

International Clinical Psychopharmacology . 30 ( 1 ) : 49-53

DOI: 10.1097/YIC.0000000000000054

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[Drug Shortage May Have Serious Outcome: the French Exemple of Phenytoine].

Marine Auffret, Louise Tyvaert, Marie-Laure Laroche, Bertrand Godet, Roland Peyron, Claire Guy...

Thérapie . 70 ( 4 ) : 377-80

Journal article

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Incorrect evaluation of the frequency of malnutrition and of its screening in hospitalized children by health care professionals

L. Restier, A. Duclos, L. Jarri, S. Touzet, A. Denis, P. Occelli...

Journal of Evaluation in Clinical Practice . 21 ( 5 ) : 958-62

DOI: 10.1111/jep.12412

Journal article

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Choisir la forme pharmaceutique orale la plus adaptée à l'enfant

A. Lajoinie, Emilie Henin, B. Kassai

Archives de Pédiatrie . 22 : 877-85

Journal article

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Risk of medication error administering ciprofloxacin oral suspension in children

A. Lajoinie, Fv. Valla, Behrouz Kassai

European journal of clinical pharmacology . 71 : 769-70

Journal article

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Overview of pediatric organ transplantation: current opinion and future perspectives on immunosuppression

S. Malik, Behrouz Kassai, P. Cochat

Current Opinion in Organ Transplantation . 20 : 527-35

Journal article

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Gastrointestinal tolerance of erythritol-containing beverage in young children: a double-blind, randomised controlled trial

E. Jacqz-Aigrain, Behrouz Kassai, C. Cornu, Jm. Cazaubiel, B. Housez, M. Cazaubiel...

European Journal of Clinical Nutrition . 69 ( 6 ) : 746-751

DOI: 10.1038/ejcn.2015.4

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Is HbA a valid surrogate for macrovascular and microvascular complications in type 2 diabetes?

T. Bejan-Angoulvant, Catherine Cornu, P. Archambault, B. Tudrej, P. Audier, Y. Brabant...

Diabetes & Metabolism . 41 : 195-201

Journal article

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A Bayesian Model to Describe Factors Influencing Trough Levels of Vancomycin in Hemodialysis Patients

C. Sansot, E. Kalbacher, Sandrine Lemoine, Laurent Bourguignon, J. P. Fauvel, M. Ducher

Nephron Physiology . 131 ( 2 ) : 131-7

DOI: 10.1159/000439230

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Are ciprofloxacin dosage regimens adequate for antimicrobial efficacy and prevention of resistance? Pseudomonas aeruginosa bloodstream infection in elderly patients as a simulation case study

Yoann Cazaubon, Laurent Bourguignon, Sylvain Goutelle, Olivier Martin, Pascal Maire, Michel Ducher

Fundamental & Clinical Pharmacology . 29 ( 6 ) : 615-624

DOI: 10.1111/fcp.12156

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Œdèmes des membres inférieurs au cours d’un traitement par valpromide : cas clinique et revue de la littérature

L. Gabriel, C. Darcissac, Sylvain Goutelle, P. Sève, T. Vial, B. de La Gastine

La Revue de Médecine Interne . 36 ( 10 ) : 698-700

DOI: 10.1016/j.revmed.2014.11.011

Journal article

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Quantitative Methods for Prediction of the Effect of Cytochrome P450 Gene Polymorphisms on Substrate Drug Exposure

Sylvain Goutelle, Michel Tod

Clinical Pharmacokinetics . 54 ( 3 ) : 319-320

DOI: 10.1007/s40262-014-0217-3

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Can we identify response markers to antihypertensive drugs? First results from the Ideal Trial

F. Gueyffier, F. Subtil, T. Bejan-Angoulvant, Y. Zerbib, J. P. Baguet, J. M. Boivin...

Journal of human hypertension . 29 ( 1 ) : 22-27

DOI: 10.1038/jhh.2014.29

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Unlicensed and off-label drug use: a prospective study in French NICU

S. Riou, F. Plaisant, Delphine Maucort-Boulch, B. Kassai, O. Claris, K. A. Nguyen

Acta Paediatrica . 104 : e228-31

DOI: 10.1111/apa.12924

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