Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 421 to 450 publications on 628 in total

Consistency of Safety and Efficacy of New Oral Anticoagulants across Subgroups of Patients with Atrial Fibrillation

Jean-Christophe Lega, L. Bertoletti, C. Gremillet, C. Chapelle, P. Mismetti, M. Cucherat...

PLoS ONE . 9 ( 3 ) : e91398

DOI: 10.1371/journal.pone.0091398

Journal article

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Mutations in CECR1 associated with a neutrophil signature in peripheral blood

Alexandre Belot, Evangeline Wassmer, Marinka Twilt, Jean-Christophe Lega, Leo Ah Zeef, Anthony Oojageer...

Pediatric Rheumatology . 12 : 44

DOI: 10.1186/1546-0096-12-44

Journal article

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Comparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population

R. Kahoul, François Gueyffier, E. Amsallem, M. Haugh, I. Marchant, F. H. Boissel...

Journal of the Royal Society Interface . 11 ( 100 ) : 20140867

DOI: 10.1098/rsif.2014.0867

Journal article

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The effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial

Laurence Lion-François, François Gueyffier, Catherine Mercier, Daniel Gérard, Vania Herbillon, Isabelle Kemlin...

Orphanet Journal of Rare Diseases . 9 : 142

DOI: 10.1186/s13023-014-0142-4

Journal article

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Effects of pharmacological treatments on micro- and macrovascular complications of type 2 diabetes: What is the level of evidence?

R. Boussageon, François Gueyffier, Catherine Cornu

Diabetes & Metabolism . 40 : 169-75

DOI: 10.1016/j.diabet.2013.12.010

Journal article

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Tranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease

S. Gaillard, S. Dupuis-Girod, F. Boutitie, S. Riviere, S. Moriniere, P. Y. Hatron...

Journal of Thrombosis and Haemostasis . 12 : 1494-502

DOI: 10.1111/jth.12654

Journal article

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Improving risk prediction performance for a better guidelines application

I. Marchant, Theodora Bejan-Angoulvant, Hh. Le, François Gueyffier

Journal of Hypertension . 32 : 1192-1193

DOI: 10.1097/HJH.0000000000000194

Journal article

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The Case for Using Higher Doses of First Line Anti-Tuberculosis Drugs to Optimize Efficacy

Sylvain Goutelle, Laurent Bourguignon, P. Maire, R. W. Jelliffe, M. Neely

Current Pharmaceutical Design . 20 : 6191-6206

Journal article

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Impact of the reduction of calcineurin inhibitors on renal function in heart transplant patients: a systematic review and meta-analysis

Catherine Cornu, C. Dufays, Ségolène Gaillard, François Gueyffier, M. Redonnet, Laurent Sebbag...

British Journal of Clinical Pharmacology . 78 ( 1 ) : 24-32

DOI: 10.1111/bcp.12289

Journal article

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Cardiovascular Events and Bleeding Risk Associated With Intravitreal Antivascular Endothelial Growth Factor Monoclonal Antibodies: Systematic Review and Meta-analysis

M. Thulliez, D. Angoulvant, M. L. Le Lez, Annie-Pierre Jonville-Bera, P. J. Pisella, François Gueyffier...

JAMA Ophthalmology . 132 ( 11 ) : 1317-26

DOI: 10.1001/jamaophthalmol.2014.2333

Journal article

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Guidelines for Managing High Blood Pressure

Dk. Cundiff, François Gueyffier, Jm. Wright

Journal of the American Medical Association . 312 ( 3 ) : 293-294

DOI: 10.1001/jama.2014.6590

Journal article

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Multivariate meta-analysis using individual participant data

R. D. Riley, M. J. Price, D. Jackson, M. Wardle, François Gueyffier, J. Wang...

Research Synthesis Methods . 6 ( 2 ) : 157-174

DOI: 10.1002/jrsm.1129

Journal article

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Can we identify response markers to antihypertensive drugs? First results from the Ideal Trial.

Gueyffier F., Subtil F., Bejan-Angoulvant T., Yves Zerbib, Baguet Jp, Boivin Jm...

Journal of Human Hypertension . : doi: 10.1038/jhh.2014.29

Journal article

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Determinants of torsades de pointes in older patients with drug-associated long QT syndrome: a case-control study

Sylvain Goutelle, E. Sidolle, M. Ducher, J. Caron, Q. Timour, Patrice Nony...

Drugs & aging . 31 : 601-9

Journal article

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Exposure to anticholinergic and sedative drugs, risk of falls, and mortality: an elderly inpatient, multicenter cohort

V. Dauphinot, R. Faure, S. Omrani, Sylvain Goutelle, Laurent Bourguignon, P. Krolak-Salmon...

Journal of clinical psychopharmacology . 34 : 565-70

DOI: 10.1097/JCP.0000000000000195

Journal article

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Pharmacokinetic Drug Interaction Between Cyclosporine and Imatinib in Bone Marrow Transplant Children and Model-Based Reappraisal of Imatinib Drug Interaction Profile

Nathalie Bleyzac, K. Kebaili, V. Mialou, Y. Bertrand, Sylvain Goutelle

Therapeutic Drug Monitoring . 36 : 724-729

Journal article

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Pharmacokinetic drug-drug interaction of calcium channel blockers with cyclosporine in hematopoietic stem cell transplant children

E. Bernard, Sylvain Goutelle, Y. Bertrand, Nathalie Bleyzac

The Annals of Pharmacotherapy . 48 : 1580-4

DOI: 10.1177/1060028014550644

Journal article

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Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 2: 6-mercaptopurine and its interaction with methotrexate

Kayode Ogungbenro, Leon Aarons, A Bajard, C Ballot, Y Bertrand, F Bretz...

Journal of Pharmacokinetics and Pharmacodynamics . 41 ( 2 ) : 173-185

Journal article

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Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate

K. Ogungbenro, L. Aarons, The Cresim Project Group, The Epi-Cresim Project Groups, Catherine Cornu, Behrouz Kassai...

Journal of pharmacokinetics and pharmacodynamics . 41 : 159-71

Journal article

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A physiologically based pharmacokinetic model for Valproic acid in adults and children

K. Ogungbenro, L. Aarons, The Cresim Project Group, The Epi-Cresim Project Group, Catherine Cornu, Patrice Nony...

European Journal of Pharmaceutical Sciences . 63 : 45-52

Journal article

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A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children

K. Ogungbenro, L. Aarons, The Cresim Project Group, The Epi-Cresim Project Group, Catherine Cornu, Behrouz Kassai...

Pharmaceutical Research . 32 : 144-157

Journal article

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A methodological framework for drug development in rare diseases

Patrice Nony, Polina Kurbatova, Agathe Bajard, Salma Malik, Charlotte Castellan, Sylvie Chabaud...

Orphanet Journal of Rare Diseases . 9 ( 164 ) : 1-10

DOI: 10.1186/s13023-014-0164-y

Journal article

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Recruitment in pediatric clinical research was influenced by study characteristics and pediatricians' perceptions: a multicenter survey.

Florentia Kaguelidou, Philippe Amiel, Audrey Blachier, Catalina Iliescu, Jean-Christophe Rozé, Michel Tsimaratos...

Journal of Clinical Epidemiology . 66 ( 10 ) : epub ahead of print

DOI: 10.1016/j.jclinepi.2013.04.015

Journal article

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Experimental designs for small randomised clinical trials: an algorithm for choice.

Catherine Cornu, Behrouz Kassai, Roland Fisch, Catherine Chiron, Corinne Alberti, Renzo Guerrini...

Orphanet Journal of Rare Diseases . 8 ( 1 ) : 48

DOI: 10.1186/1750-1172-8-48

Journal article

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A revisited strategy for antiepileptic drug development in children: designing an initial exploratory step

C. Chiron, Behrouz Kassai, O. Dulac, Gérard Pons, R. Nabbout

CNS Drugs . 27 : 185-95

DOI: 10.1007/s40263-012-0035-9

Journal article

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A European approach to clinical investigator training

Jm. Boeynaems, C. Canivet, A. Chan, Mj. Clarke, C. Cornu, E. Daemen...

Frontiers in Pharmacology . 4 : 112

DOI: 10.3389/fphar.2013.00112

Journal article

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L\textquoterighteffet placebo chez l\textquoterightenfant est méconnu et peu étudié

B. Kassai, H. Gheit, R. Boussageon, F. Gueyffier

La Lettre du Pharmacologue . 27 : 17--20

Journal article

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Information et participation active des patients à l\textquoterightaide d\textquoterightune brochure interactive lors de la prescription d\textquoterightantihypertenseurs en soins primaires

M. Keriel-Gascou, A. Badet-Phan, Ma. Le Pogam, S. Figon, L. Letrilliart, F. Gueyffier...

Santé Publique . 25 : 193--201

Journal article

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Physicians' knowledge and practice of lung cancer screening: a cross-sectional survey comparing general practitioners, thoracic oncologists, and pulmonologists in France

S. Couraud, N. Girard, S. Erpeldinger, François Gueyffier, G. Devouassoux, G. Llorca...

Clinical Lung Cancer . 14 : 574-80

DOI: 10.1016/j.cllc.2013.05.003

Journal article

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Biomarker-guided therapies in heart failure: a forum for unified strategies

M. Fiuzat, C. M. O'Connor, François Gueyffier, A. M. Mascette, N. L. Geller, A. Mebazaa...

Journal of Cardiac Failure . 19 : 592-9

DOI: 10.1016/j.cardfail.2013.05.012

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