Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 451 to 480 publications on 613 in total

Rehabilitation of 190 non-ambulatory children with cerebral palsy in structures of care or in liberal sector

I. Poirot, V. Laudy, M. Rabilloud, S. Roche, T. Ginhoux, I. Joubrel...

Annals of physical and rehabilitation medicine . 56 : 551--60

DOI: 10.1016/j.rehab.2013.08.002

Journal article

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Études pharmaco-épidémiologiques : quels niveaux de preuve et comment les atteindre ?

M. Lapeyre-Mestre, C. Sapède, N. Moore, P. Bilbault, P. Blin, D. Chopy...

Thérapie . 68 : 241--246

DOI: 10.2515/therapie/2013037

Journal article

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Is there excess mortality in women screened with mammography: a meta-analysis of non-breast cancer mortality

Sylvie Erpeldinger, Laure Fayolle, Rémy Boussageon, Marie Flori, Xavier Lainé, Moreau Alain...

Trials . 14 ( 1 )

DOI: 10.1186/1745-6215-14-368

Journal article

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Are concomitant treatments confounding factors in randomized controlled trials on intensive blood-glucose control in type 2 diabetes? a systematic review

Rémy Boussageon, Irène Supper, Sylvie Erpeldinger, Michel Cucherat, Theodora Bejan-Angoulvant, Behrouz Kassai...

BMC Medical Research Methodology . 13 ( 1 ) : 107

Journal article

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Bayesian networks: a new method for the modeling of bibliographic knowledge: application to fall risk assessment in geriatric patients

L. Lalande, Laurent Bourguignon, C. Carlier, M. Ducher

Medical and Biological Engineering and Computing . 51 : 657--64

DOI: 10.1007/s11517-013-1035-8

Journal article

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Calculation of the first dose of amikacine: evaluation of the current dosage recommendations

E. Jean-Bart, G. Debeurme, M. Ducher, Laurent Bourguignon

Annales Pharmaceutiques Françaises . 71 : 7--12

DOI: 10.1016/j.pharma.2012.10.002

Journal article

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Individual patient data systematic review and meta-analysis of optic nerve sheath diameter ultrasonography for detecting raised intracranial pressure: protocol of the ONSD research group.

Julie Dubourg, Mahmoud Messerer, Dimitrios Karakitsos, Venkatakrishna Rajajee, Erik Antonsen, Etienne Javouhey...

Systematic Reviews . 2 ( 1 ) : 62

DOI: 10.1186/2046-4053-2-62

Journal article

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Variabilité pharmacocinétique inter- et intra-individuelle lors de traitements par teicoplanine chez les sujets âgés. Inter-individual and intra-individual pharmacokinetic variability during teicoplanin therapy ingeriatric patients

Mathieu Uhart, B. Leroy, A. Michaud, Pascal Maire, Laurent Bourguignon

Médecine et Maladies Infectieuses . : 1-4

DOI: 10.1016/j.medmal.2013.05.008

Journal article

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Beta-blockers for the prevention of sudden cardiac death in heart failure patients: a meta-analysis of randomized controlled trials

M. Al-Gobari, C. El Khatib, F. Pillon, François Gueyffier

BMC Cardiovascular Disorders . 13 : 52

DOI: 10.1186/1471-2261-13-52

Journal article

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Anti-Trypanosoma cruzi cross-reactive antibodies detected at high rate in non-exposed individuals living in non-endemic regions: seroprevalence and association to other viral serologies.

Esber S Saba, Lucie Gueyffier, Marie-Laure Dichtel-Danjoy, Bruno Pozzetto, Thomas Bourlet, François Gueyffier...

PLoS ONE . 8 ( 9 ) : e74493

DOI: 10.1371/journal.pone.0074493

Journal article

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Clinically Relevant Efficacy of Insulin Therapy in Patients with Type 2 Diabetes

R. Boussageon, J. M. Gamble, François Gueyffier, C. Cornu

Thérapie . 68 : 415--7

DOI: 10.2515/therapie/2013063

Journal article

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Correspondance à propos de l\textquoterightarticle \guillemotleft Objectifs glycémiques dans la prise en charge du diabète de type 2 \guillemotright

R. Boussageon, François Gueyffier, C. Cornu

La Presse Médicale . 42 : 1284--1286

DOI: 10.1016/j.lpm.2013.04.005

Journal article

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Expected impact of a public health intervention in the presence of synergistic risk factors

Hadrien Charvat, François Gueyffier, Aurélien Belot, Pascal Roy

Journal of Clinical Epidemiology . 66 : 445-52

DOI: 10.1016/j.jclinepi.2012.11.004

Journal article

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Essais cliniques institutionnels : quel monitoring ?

C. Cornu, C. Binquet, C. Thalamas, C. Vigouroux, S. Gaillard, T. Ginhoux...

Pharmacologie clinique . 68 : 135-141

DOI: 10.2515/therapie/2013032

Journal article

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Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties

D. Dobre, J. S. Borer, K. Fox, K. Swedberg, K. F. Adams, J. G. Cleland...

European Journal of Heart Failure . 16 ( 1 ) : 76-85

DOI: 10.1093/eurjhf/hft129

Journal article

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Approche individu-centrée pour l'exploration de stratégies de prescription médicale - un exemple dans l'hypertension artérielle

Nadia Abchiche-Mimouni, Monique Rousset, F. Gueyffier

Proc. de la 6ème Conférence Francophone d'Épidémiologie Clinique, 19èmes Journées des Statisticiens des Centres de Lutte contre le Cancer ( EPICLIN 2012) . : (elec. proc)

Conference paper

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Virtual reality exposure therapy versus cognitive behavior therapy for panic disorder with agoraphobia: a randomized comparison study

A. Pelissolo, M. Zaoui, G. Aguayo, S. Nan Yao, S. Roche, René Ecochard...

Journal of CyberTherapy & Rehabilitation . 5 : 35-43

Journal article

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A national internet-linked based database for pediatric interstitial lung diseases: the French network.

Nadia Nathan, Rola Abou Taam, Ralph Epaud, Christophe Delacourt, Antoine Deschildre, Philippe Reix...

Orphanet Journal of Rare Diseases . 7 ( 1 ) : 40

DOI: 10.1186/1750-1172-7-40

Journal article

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Successful management of severe infant bullous pemphigoid with omalizumab

C. Dufour, A. L. Souillet, C. Chaneliere, F. Jouen, C. Bodemer, D. Jullien...

British Journal of Dermatology . 166 : 1140--2

DOI: 10.1111/j.1365-2133.2011.10748.x

Journal article

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Late onset Ondine syndrome: literature review on a case report

M. Butin, G. Labbe, S. Vrielynck, P. Franco, B. Massenavette, G. Bellon...

Archives de Pédiatrie . 19 : 1205--7

DOI: 10.1016/j.arcped.2012.08.015

Journal article

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The IDEAL Study : Towards Personalized Drug Treatment of Hypertension

T. Bejan-Angoulvant, J-P. Baguet, S. Erpeldinger, J-M. Boivin, A. Mercier, G. Leftheriotis...

Thérapie . 67 : 195--204

DOI: 10.2515/therapie/2012031

Journal article

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Farnesoid X Receptor Targeting for Hepatitis C: Study Protocol for a Proof-of-concept Trial

C. Scholtes, P. Andre, C. Trepo, C. Cornu, Laurent Remontet, René Ecochard...

Thérapie . 67 : 423--427

DOI: 10.2515/therapie/2012058

Journal article

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Oseltamivir-zanamivir bitherapy compared to oseltamivir monotherapy in the treatment of pandemic 2009 influenza A(H1N1) influenza virus infections

V. Escuret, C. Cornu, F. Boutitie, V. Ernouf, A. Mosnier, M. Bouscambert-Duchamp...

Antiviral Research . 96 : 130--137

DOI: 10.1016/j.antiviral.2012.08.002

Journal article

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Modeling the impact of cardiovascular prevention strategies: toward better information for public health decisions

François Gueyffier, I. Marchant, B. Carlberg

Journal of Hypertension . 30 : 51--2

DOI: 10.1097/HJH.0b013e32834e089d

Journal article

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Individual patient data meta-analysis of survival data using Poisson regression models.

Michael Crowther, Richard Riley, Jan Staessen, Jiguang Wang, Francois Gueyffier, Paul Lambert

BMC Medical Research Methodology . 12 ( 1 ) : 34

DOI: 10.1186/1471-2288-12-34

Journal article

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Comparison of Four Renal Function Estimation Equations for Pharmacokinetic Modeling of Gentamicin in Geriatric Patients

N. Charhon, M.N. Neely, Laurent Bourguignon, P. Maire, R.W. Jelliffe, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 56 ( 4 ) : 1862-1869

DOI: 10.1128/AAC.05634-11

Journal article

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Exercise with incorporated expiratory manoeuvres was as effective as breathing techniques for airway clearance in children with cystic fibrosis: a randomised crossover trial

P. Reix, F. Aubert, Mc. Werck-Gallois, A. Toutain, C. Mazzocchi, N. Moreux...

Journal of Physiotherapy . 58 ( 4 ) : 241-247

DOI: 10.1016/S1836-9553(12)70125-X

Journal article

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