Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 451 to 480 publications on 628 in total

Impaired baroreflex sensitivity and the risks of new-onset ambulatory hypertension, in an elderly population-based study

V. Dauphinot, M. P. Kossovsky, François Gueyffier, V. Pichot, P. Gosse, F. Roche...

International Journal of Cardiology . 168 : 4010-4

DOI: 10.1016/j.ijcard.2013.06.080

Journal article

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Meta-analysis of randomised trials with a continuous outcome according to baseline imbalance and availability of individual participant data

Richard Riley, Iram Kauser, Martin Bland, Lutgarde Thijs, Jan Staessen, Jiguang Wang...

Statistics in Medicine . 32 ( 16 ) : 2747-2766

DOI: 10.1002/sim.5726

Journal article

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Are we using blood pressure-lowering drugs appropriately? Perhaps now is the time for a change

François Gueyffier, J. Wright

Journal of human hypertension . 28 : 68-70

DOI: 10.1038/jhh.2013.79

Journal article

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Practical application of the charter of pharmaceutical sales visit

B. Leroy, M. Uhart, A. Lajoinie, P. Maire, M. Ducher, Laurent Bourguignon

Annales Pharmaceutiques Françaises . 70 : 348--52

DOI: 10.1016/j.pharma.2012.06.001

Journal article

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Impact of double-blind vs. open study design on the observed treatment effects of new oral anticoagulants in atrial fibrillation: a meta-analysis

Jc. Lega, P. Mismetti, M. Cucherat, T. Fassier, L. Bertoletti, C. Chapelle...

Journal of Thrombosis and Haemostasis . 98 : 97--102

DOI: 10.1111/jth.12294

Journal article

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Simulation of human ischemic stroke in realistic 3D geometry

Thierry Dumont, Max Duarte, Stéphane Descombes, Marie-Aimée Dronne, Marc Massot, Violaine Louvet

Communications in Nonlinear Science and Numerical Simulation . 18 ( 6 ) : 1539-1557

DOI: 10.1016/j.cnsns.2012.10.002

Journal article

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Impact of Genetic Polymorphism on Drug-Drug Interactions Mediated by Cytochromes: A General Approach

M. Tod, C. Nkoud-Mongo, François Gueyffier

AAPS journal . 15 : 1242--1252

DOI: 10.1208/s12248-013-9530-2

Journal article

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Quantitative Prediction of the Impact of Drug Interactions and Genetic Polymorphisms on Cytochrome P450 2C9 Substrate Exposure

Anne-Charlotte Castellan, M. Tod, François Gueyffier, M. Audars, F. Cambriels, Berouz Kassai...

Clinical Pharmacokinetics . 52 : 199-209

DOI: 10.1007/s40262-013-0031-3

Journal article

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In Vivo Quantitative Prediction of the Effect of Gene Polymorphisms and Drug Interactions on Drug Exposure for CYP2C19 Substrates

Sylvain Goutelle, Laurent Bourguignon, Nathalie Bleyzac, J. Berry, F. Clavel-Grabit, M. Tod

AAPS Journal . 15 : 415-26

DOI: 10.1208/s12248-012-9431-9

Journal article

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New insights into pediatric idiopathic pulmonary hemosiderosis: the French RespiRare(R) cohort.

Jessica Taytard, Nadia Nathan, Jacques de Blic, Mickael Fayon, Ralph Epaud, Antoine Deschildre...

Orphanet Journal of Rare Diseases . 8 ( 1 ) : 161

DOI: 10.1186/1750-1172-8-161

Journal article

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Prognostic value of troponins in sepsis: a meta-analysis

F. Bessiere, S. Khenifer, J. Dubourg, I. Durieu, Jean-Christophe Lega

Intensive Care Medicine . 39 : 1181-9

DOI: 10.1007/s00134-013-2902-3

Journal article

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Revising the ECRIN standard requirements for information technology and data management in clinical trials.

Christian Ohmann, Steve Canham, Catherine Cornu, Jochen Dress, François Gueyffier, Wolfgang Kuchinke...

Trials . 14 ( 1 ) : 97

DOI: 10.1186/1745-6215-14-97

Journal article

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Pharmacoepidemiology studies: what levels of evidence and how can they be reached?

Maryse Lapeyre-Mestre, Claudine Sapède, Nicholas Moore, Pascal Bilbault, Patrick Blin, Damien Chopy...

Thérapie . 68 ( 4 ) : 241-52

DOI: 10.2515/therapie/2013038

Journal article

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Pharmacokinetic-pharmacodynamic modeling of unboosted Atazanavir in a cohort of stable HIV-infected patients.

Sylvain Goutelle, Thomas Baudry, Marie-Claude Gagnieu, André Boibieux, Jean-Michel Livrozet, Dominique Peyramond...

Antimicrobial Agents and Chemotherapy . 57 ( 1 ) : 517-23

DOI: 10.1128/AAC.01822-12

Journal article

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Rehabilitation of 190 non-ambulatory children with cerebral palsy in structures of care or in liberal sector

I. Poirot, V. Laudy, M. Rabilloud, S. Roche, T. Ginhoux, I. Joubrel...

Annals of physical and rehabilitation medicine . 56 : 551--60

DOI: 10.1016/j.rehab.2013.08.002

Journal article

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Études pharmaco-épidémiologiques : quels niveaux de preuve et comment les atteindre ?

M. Lapeyre-Mestre, C. Sapède, N. Moore, P. Bilbault, P. Blin, D. Chopy...

Thérapie . 68 : 241--246

DOI: 10.2515/therapie/2013037

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Is there excess mortality in women screened with mammography: a meta-analysis of non-breast cancer mortality

Sylvie Erpeldinger, Laure Fayolle, Rémy Boussageon, Marie Flori, Xavier Lainé, Moreau Alain...

Trials . 14 ( 1 )

DOI: 10.1186/1745-6215-14-368

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Are concomitant treatments confounding factors in randomized controlled trials on intensive blood-glucose control in type 2 diabetes? a systematic review

Rémy Boussageon, Irène Supper, Sylvie Erpeldinger, Michel Cucherat, Theodora Bejan-Angoulvant, Behrouz Kassai...

BMC Medical Research Methodology . 13 ( 1 ) : 107

DOI: 10.1186/1471-2288-13-107

Journal article

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Bayesian networks: a new method for the modeling of bibliographic knowledge: application to fall risk assessment in geriatric patients

L. Lalande, Laurent Bourguignon, C. Carlier, M. Ducher

Medical and Biological Engineering and Computing . 51 : 657--64

DOI: 10.1007/s11517-013-1035-8

Journal article

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Calculation of the first dose of amikacine: evaluation of the current dosage recommendations

E. Jean-Bart, G. Debeurme, M. Ducher, Laurent Bourguignon

Annales Pharmaceutiques Françaises . 71 : 7--12

DOI: 10.1016/j.pharma.2012.10.002

Journal article

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Individual patient data systematic review and meta-analysis of optic nerve sheath diameter ultrasonography for detecting raised intracranial pressure: protocol of the ONSD research group.

Julie Dubourg, Mahmoud Messerer, Dimitrios Karakitsos, Venkatakrishna Rajajee, Erik Antonsen, Etienne Javouhey...

Systematic Reviews . 2 ( 1 ) : 62

DOI: 10.1186/2046-4053-2-62

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Variabilité pharmacocinétique inter- et intra-individuelle lors de traitements par teicoplanine chez les sujets âgés. Inter-individual and intra-individual pharmacokinetic variability during teicoplanin therapy ingeriatric patients

Mathieu Uhart, B. Leroy, A. Michaud, Pascal Maire, Laurent Bourguignon

Médecine et Maladies Infectieuses . : 1-4

DOI: 10.1016/j.medmal.2013.05.008

Journal article

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Beta-blockers for the prevention of sudden cardiac death in heart failure patients: a meta-analysis of randomized controlled trials

M. Al-Gobari, C. El Khatib, F. Pillon, François Gueyffier

BMC Cardiovascular Disorders . 13 : 52

DOI: 10.1186/1471-2261-13-52

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Anti-Trypanosoma cruzi cross-reactive antibodies detected at high rate in non-exposed individuals living in non-endemic regions: seroprevalence and association to other viral serologies.

Esber S Saba, Lucie Gueyffier, Marie-Laure Dichtel-Danjoy, Bruno Pozzetto, Thomas Bourlet, François Gueyffier...

PLoS ONE . 8 ( 9 ) : e74493

DOI: 10.1371/journal.pone.0074493

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Clinically Relevant Efficacy of Insulin Therapy in Patients with Type 2 Diabetes

R. Boussageon, J. M. Gamble, François Gueyffier, C. Cornu

Thérapie . 68 : 415--7

DOI: 10.2515/therapie/2013063

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Correspondance à propos de l\textquoterightarticle \guillemotleft Objectifs glycémiques dans la prise en charge du diabète de type 2 \guillemotright

R. Boussageon, François Gueyffier, C. Cornu

La Presse Médicale . 42 : 1284--1286

DOI: 10.1016/j.lpm.2013.04.005

Journal article

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Expected impact of a public health intervention in the presence of synergistic risk factors

Hadrien Charvat, François Gueyffier, Aurélien Belot, Pascal Roy

Journal of Clinical Epidemiology . 66 : 445-52

DOI: 10.1016/j.jclinepi.2012.11.004

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Essais cliniques institutionnels : quel monitoring ?

C. Cornu, C. Binquet, C. Thalamas, C. Vigouroux, S. Gaillard, T. Ginhoux...

Pharmacologie clinique . 68 : 135-141

DOI: 10.2515/therapie/2013032

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Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties

D. Dobre, J. S. Borer, K. Fox, K. Swedberg, K. F. Adams, J. G. Cleland...

European Journal of Heart Failure . 16 ( 1 ) : 76-85

DOI: 10.1093/eurjhf/hft129

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