Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 511 to 540 publications on 626 in total

Étude coût-efficacité de l'adaptation bayésienne des posologies des aminosides en gériatrie

C. Burgos Leon-Dijan, Laurent Bourguignon, H-M. Späth, Pascal Maire

Pharmacoéconomie . 66 : 445-452

DOI: 10.2515/therapie/2011058

Journal article

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The value of population pharmacokinetics and simulation for postmarketing safety evaluation of dosing guidelines for drugs with a narrow therapeutic index: buflomedil as a case study

Laurent Bourguignon, Michel Ducher, David Matanza, Nathalie Bleyzac, Mathieu Uhart, Emmanuel Odouard...

Fundamental & Clinical Pharmacology . 26 ( 2 ) : 279-285

DOI: 10.1111/j.1472-8206.2011.01000.x

Journal article

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Quantitative Prediction of Cytochrome P450 (CYP) 2D6-Mediated Drug Interactions

Michel Tod, Sylvain Goutelle, Fannie Clavel-Grabit, Grégoire Nicolas, Bruno Charpiat

Clinical Pharmacokinetics . 50 ( 8 ) : 519-530

DOI: 10.2165/11592620-000000000-00000

Journal article

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A New Animal Model of Obstructive Sleep Apnea Responding to Continuous Positive Airway Pressure

Pc. Neuzeret, F. Gormand, Philippe Reix, S. Parrot, Jp. Sastre, C. Buda...

Sleep . 34 : 541-548

Journal article

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Intrafamilial transmission of Staphylococcus aureus Panton-Valentine leukocidin responsible for two cases of neonatal necrotizing pneumonia

G. Catho, Y. Gillet, O. Dumitrescu, G. Lina, G. Labbé, G. Bellon...

Archives de Pédiatrie . 18 : 1090-1094

DOI: 10.1016/j.arcped.2011.07.019

Journal article

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Combined pulmonary fibrosis and emphysema syndrome associated with familial SFTPC mutation

V. Cottin, Philippe Reix, C. Khouatra, F. Thivolet-Bejui, D. Feldmann, J. F. Cordier

Thorax . 66 ( 10 ) : 918-9

DOI: 10.1136/thx.2010.151407

Journal article

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Programmed death-1 levels correlate with increased mortality nosocomial infection and immune dysfunctions in septic shock patients

C. Guignant, C. Lepage, X. Huang, H. Kherouf, L. Denis, F. Poitevin...

Critical Care . 15 ( 2 ) : R99

DOI: 10.1186/cc10112

Journal article

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Effect of intensive glucose lowering treatment on all cause mortality cardiovascular death and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials

R. Boussageon, T. Bejan-Angoulvant, M. Saadatian-Elahi, S. Lafont, C. Bergeonneau, Behrouz Kassai...

British medical journal . 343 : 1-12

DOI: 10.1136/bmj.d4169

Journal article

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Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients.

Caroline Guignant, Alain Lepape, Xin Huang, Hakim Kherouf, Laure Denis, Françoise Poitevin...

Critical Care . 15 ( 2 ) : R99

DOI: 10.1186/cc10112

Journal article

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The Global Risk Approach Should Be Better Applied in French Hypertensive Patients: A Comparison between Simulation and Observation Studies

I. Marchant, Patrice Nony, Michel Cucherat, J-P. Boissel, S.R. Thomas, T. Bejan-Angoulvant...

PLoS ONE . 6 ( 3 ) : 1-7

DOI: 10.1371/journal.pone.0017508

Journal article

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Probable Drug Interaction Between Intravenous Ciprofloxacin and Mycophenolate Mofetil in a Bone Marrow Transplant Recipient

Sylvain Goutelle, V. Mialou, A. Gouraud, F. Parant, N. Bleyzac

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy . 31(1) : 36-40

Journal article

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Towards personalized medicine: exploring the consequences of the effect model-based approach

Jp. Boissel, R. Kaboul, E. Amsallem, François Gueyffier, M. Haugh, F. H. Boissel

Personalized Medicine . 8 : 581-586

DOI: 10.2217/pme.11.54

Journal article

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Problématique des cibles de pression artérielle

R. Boussageon, T. Bejan-Angoulvant, François Gueyffier

Revue médicale Suisse . : 873

Journal article

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l-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial.

Carine Domenech, Xavier Thomas, Sylvie Chabaud, Andre Baruchel, François Gueyffier, Françoise Mazingue...

British Journal of Haematology . 153 ( 1 ) : 58-65

DOI: 10.1111/j.1365-2141.2011.08588.x

Journal article

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Standard requirements for GCP-compliant data management in multinational clinical trials

C. Ohmann, W. Kuchinke, S. Canham, J. Lauritsen, N. Salas, C. Schade-Brittinger...

Trials . 12 : 85

DOI: 10.1186/1745-6215-12-85

Journal article

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Blood pressure lowering in the oldest old: a step toward abandoning arbitrary blood pressure targets

François Gueyffier, M.I. Perez, Jm. Wright, I. Marchant, V.M. Musini, T. Bejan-Angoulvant

Journal of Hypertension . 29 : 171-175

Journal article

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Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin

Sylvain Goutelle, Laurent Bourguignon, Roger W. Jelliffe, John E. Conte, Pascal Maire

Journal of Theoretical Biology .

DOI: 10.1016/j.jtbi.2011.05.013

Journal article

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Mathematical modeling of pulmonary tuberculosis therapy: Insights from a prototype model with rifampin

Sylvain Goutelle, Laurent Bourguignon, R-W. Jelliffe, J.E. Conte, P. Maire

Journal of Theoretical Biology . 282 ( 1 ) : 80-92

DOI: 10.1016/j.jtbi.2011.05.013

Journal article

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Genotype-Based Quantitative Prediction of Drug Exposure for Drugs Metabolized by CYP2D6

Michel Tod, Sylvain Goutelle, M.C. Gagnieu, Working Group The Genophar Ii

Clinical Pharmacology and Therapeutics . 90 : 582-587

Journal article

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Quantitative prediction of cytochrome P450(CYP) 2D6-Mediated drug interactions

Michel Tod, Sylvain Goutelle, F. Clavel-Grabit, G. Nicolas, B. Charpiat

Clinical Pharmacokinetics . 50(8) : 519-530

Journal article

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Information et éducation des familles des enfants en situation d'urgence: objectifs des messages de santé

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 850-851

Journal article

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Réduction des consultations non programmées et non justifiées dans le cadre des urgences pédiatriques grâce à une plateforme téléphonique

J. Stagnara, J. Vermont, J. Jacquel, G. Bagou, S. Masson, Behrouz Kassai...

La Presse Médicale . 39(11) : e258-e263

Journal article

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Information et éducation des familles des enfants en situation d'urgence: méthodes d'élaboration des messages

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 852-853

Journal article

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Information et éducation des familles des enfants en situation d\textquoterighturgence: diffusion téléphonique des messages

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai Koupai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 854-855

Journal article

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Information et éducation des familles des enfants en situation d\textquoterighturgence: méthodes d\textquoterightélaboration des messages

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai Koupai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 852-853

Journal article

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Information et éducation des familles des enfants en situation d'urgence: suivi d'intervention

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 856-857

Journal article

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Information et éducation des familles des enfants en situation d'urgence: diffusion téléphonique des messages

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 854-855

Journal article

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Information et éducation des familles des enfants en situation d\textquoterighturgence: objectifs des messages de santé

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai Koupai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 850-851

Journal article

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Heterogeneity prevails: the state of clinical trial data management in Europe - results of a survey of ECRIN centres

W. Kuchinke, C. Ohmann, Q. Yang, N. Salas, J. Lauritsen, F. Gueyffier...

Trials . 11 : 79

DOI: 10.1186/1745-6215-11-79

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