Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 511 to 540 publications on 613 in total

l-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial.

Carine Domenech, Xavier Thomas, Sylvie Chabaud, Andre Baruchel, François Gueyffier, Françoise Mazingue...

British Journal of Haematology . 153 ( 1 ) : 58-65

DOI: 10.1111/j.1365-2141.2011.08588.x

Journal article

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Standard requirements for GCP-compliant data management in multinational clinical trials

C. Ohmann, W. Kuchinke, S. Canham, J. Lauritsen, N. Salas, C. Schade-Brittinger...

Trials . 12 : 85

DOI: 10.1186/1745-6215-12-85

Journal article

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Blood pressure lowering in the oldest old: a step toward abandoning arbitrary blood pressure targets

François Gueyffier, M.I. Perez, Jm. Wright, I. Marchant, V.M. Musini, T. Bejan-Angoulvant

Journal of Hypertension . 29 : 171-175

Journal article

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Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin

Sylvain Goutelle, Laurent Bourguignon, Roger W. Jelliffe, John E. Conte, Pascal Maire

Journal of Theoretical Biology .

DOI: 10.1016/j.jtbi.2011.05.013

Journal article

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Mathematical modeling of pulmonary tuberculosis therapy: Insights from a prototype model with rifampin

Sylvain Goutelle, Laurent Bourguignon, R-W. Jelliffe, J.E. Conte, P. Maire

Journal of Theoretical Biology . 282 ( 1 ) : 80-92

DOI: 10.1016/j.jtbi.2011.05.013

Journal article

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Genotype-Based Quantitative Prediction of Drug Exposure for Drugs Metabolized by CYP2D6

Michel Tod, Sylvain Goutelle, M.C. Gagnieu, Working Group The Genophar Ii

Clinical Pharmacology and Therapeutics . 90 : 582-587

Journal article

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Quantitative prediction of cytochrome P450(CYP) 2D6-Mediated drug interactions

Michel Tod, Sylvain Goutelle, F. Clavel-Grabit, G. Nicolas, B. Charpiat

Clinical Pharmacokinetics . 50(8) : 519-530

Journal article

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Information et éducation des familles des enfants en situation d'urgence: objectifs des messages de santé

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 850-851

Journal article

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Réduction des consultations non programmées et non justifiées dans le cadre des urgences pédiatriques grâce à une plateforme téléphonique

J. Stagnara, J. Vermont, J. Jacquel, G. Bagou, S. Masson, Behrouz Kassai...

La Presse medicale . 39(11) : e258-e263

Journal article

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Information et éducation des familles des enfants en situation d'urgence: méthodes d'élaboration des messages

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 852-853

Journal article

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Information et éducation des familles des enfants en situation d\textquoterighturgence: diffusion téléphonique des messages

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai Koupai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 854-855

Journal article

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Information et éducation des familles des enfants en situation d\textquoterighturgence: méthodes d\textquoterightélaboration des messages

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai Koupai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 852-853

Journal article

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Information et éducation des familles des enfants en situation d'urgence: suivi d'intervention

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 856-857

Journal article

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Information et éducation des familles des enfants en situation d'urgence: diffusion téléphonique des messages

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 854-855

Journal article

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Information et éducation des familles des enfants en situation d\textquoterighturgence: objectifs des messages de santé

J. Stagnara, B. Racle, J. Vermont, Behrouz Kassai Koupai, J. Jacquel, A. Duquesne...

Archives de Pédiatrie . 17 : 850-851

Journal article

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Heterogeneity prevails: the state of clinical trial data management in Europe - results of a survey of ECRIN centres

W. Kuchinke, C. Ohmann, Q. Yang, N. Salas, J. Lauritsen, F. Gueyffier...

Trials . 11 : 79

DOI: 10.1186/1745-6215-11-79

Journal article

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Isolated Recurrent Pleuritis Revealing Familial Mediterranean Fever in Adulthood

J.C. Lega, C. Khouatra, Vincent Cottin, Jean-François Cordier

Respiration . 80 ( 3 ) : 262

DOI: 10.1159/000315474

Journal article

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A mathematical model of inflammation during ischemic stroke

Cristiana Di Russo, Jean-Baptiste Lagaert, Guillemette Chapuisat, Marie-Aimée Dronne

ESAIM: Proceedings . 30 : 15-33

DOI: 10.1051/proc/2010003

Journal article

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In silico study of the influence of intensity and duration of blood flow reduction on cell death through necrosis or apoptosis during acute ischemic stroke

Guillemette Chapuisat, Marie-Aimée Dronne, Emmanuel Grenier, Marc Hommel, Jean-Pierre Boissel

Acta Biotheoretica . 58 ( 2-3 ) : 171-190

DOI: 10.1007/s10441-010-9100-2

Journal article

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A phenomenological model of the growth of the necrotic area in ischemic stroke

Emmanuel Grenier, Didier Bresch, Marie-Aimée Dronne, Marc Hommel, Jean-Pierre Boissel

Mathematical and Computer Modelling . 51 ( 9-10 ) : 1011-1025

DOI: 10.1016/j.mcm.2008.07.025

Journal article

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Hyperpolarized 3He MR for sensitive imaging of ventilation function and treatment efficiency in young cystic fibrosis patients with normal lung function.

Elise Bannier, Katarzyna Cieslar, Karim Mosbah, Françoise Aubert, François Duboeuf, Zahir Salhi...

Radiology . 255 ( 1 ) : 225-32

DOI: 10.1148/radiol.09090039

Journal article

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Intrapulmonary Pharmacokinetics and Pharmacodynamics of Micafungin in Adult Lung Transplant Patients

T. Walsh, Sylvain Goutelle, R.-W. Jelliffe, J.A. Golden, E.A. Little, C. Devoe...

Antimicrobial Agents and Chemotherapy . 54 ( 8 ) : 3451-3459

DOI: 10.1128/AAC.01647-09

Journal article

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Oral Voriconazole Dose in children: One size does not fit all

Sylvain Goutelle, R. Larcher, C. Padoin, V. Mialou, N. Bleyzac

Clinical Infectious Diseases . 51 ( 7 ) : 870-870

DOI: 10.1086/656293

Journal article

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A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial.

Catherine Cornu, Laurent Remontet, Florence Noel-Baron, Alain Nicolas, Nathalie Feugier-Favier, Pascal Roy...

BMC Complementary and Alternative Medicine . 10 ( 1 ) : 29

DOI: 10.1186/1472-6882-10-29

Journal article

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Treatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials

T. Bejan-Angoulvant, M. Saadatian-Elahi, Jm. Wright, E.B. Schron, Lh. Lindholm, R. Fagard...

Journal of Hypertension . 28 : 1366-1372

Journal article

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Both extrauterine and intrauterine growth restriction impair renal function in children born very preterm

J. Bacchetta, J. Harambat, L. Dubourg, B. Guy, A. Liutkus, I. Canterino...

Kidney International . 76 ( 4 ) : 445-452

DOI: 10.1038/ki.2009.201

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Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus

A. Doreau, Al. Belot, J. Bastid, B. Riche, M.-C. Trescol-Biemont, B. Ranchin...

Nature Immunology . 10(7) : 778-788

Journal article

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Visual estimation of patients' right body weight in hospital: the more observers, the better?

S. Goutelle, Laurent Bourguignon, N. Bertrand-Passeron, R-W. Jelliffe, Pascal Maire

Pharmacy World and Science . : 1-4

DOI: 10.1007/s11096-009-9295-y

Journal article

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Comment: Modification of Diet in Renal Disease and Modified Cockcroft-Gault Formulas in Predicting Aminoglycoside Elimination

Sylvain Goutelle, Laurent Bourguignon, Michel Ducher, Pascal Maire

Annals of Pharmacotherapy . 43 ( 6 ) : 1145-1146

DOI: 10.1345/aph.1L144a

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