Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 571 to 600 publications on 628 in total

Patient versus general practitioner perception of problems with treatment adherence in type 2 diabetes: From adherence to concordance

Moreau Alain, Vincent Aroles, Gilbert Souweine, Marie Flori, Sylvie Erpeldinger, Sophie Figon...

European Journal of General Practice . ( 15 ) : 147-53.

Journal article

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Patient versus general practitioner perception of problems with treatment adherence in type 2 diabetes: From adherence to concordance

Moreau Alain, Vincent Aroles, Gilbert Souweine, Marie Flori, Sylvie Erpeldinger, Sophie Figon...

European Journal of General Practice . 15 ( 3 ) : 147-153

Journal article

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Pharmacocinétique de l'amikacine chez l'adulte : une hétérogénéité qui remet en cause le calcul de la dose basé sur le poids

Laurent Bourguignon, Sylvain Goutelle, C. Gérard, A. Guillermet, J. Burdin de Saint Martin, P. Maire...

Thérapie . 64 ( 1 ) : 189-194

Journal article

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Critique du modèle additif de l’essai clinique randomisé

Rémy Boussageon, François Gueyffier, Theodora Bejan-Angoulvant, Géraldine Felden-Dominiak

Therapies . 63 ( 1 ) : 29-35

DOI: 10.2515/therapie:2008015

Journal article

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Renal hypersensitivity' to inulin and IgA nephropathy

J. Bacchetta, F. Villard, T. Vial, L. Dubourg, R. Bouvier, Behrouz Kassai Koupai...

Pediatric Nephrology . 23 ( 10 ) : 1883-1885

DOI: 10.1007/s00467-008-0819-9

Journal article

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‘Renal hypersensitivity' to inulin and IgA nephropathy

J. Bacchetta, F. Villard, T. Vial, L. Dubourg, R. Bouvier, Behrouz Kassai...

Pediatric Nephrology . 23(10) : 1883-1885

Journal article

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Hypersensitivity to inulin : a rare and mostly benign event

J. Bacchetta, P. Cochat, F. Villard, M. Astier, T. Vial, L. Dubourg...

American Journal of Kidney Diseases . 52(3) : 632-633

Journal article

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Comment lire un article rapportant un test diagnostique?

Behrouz Kassai, J. Bacchetta

Médecine . 1 : 1-3

Journal article

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Critique du modèle additif de l'essai clinique randomisé

R. Boussageon, F. Gueyffier, T. Bejan-Angoulvant, Géraldine Felden

Thérapie . 63 ( 1 ) : 29-35

Journal article

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A modelling approach to explore some hypotheses of the failure of neuroprotective trials in ischemic stroke patients.

Marie-Aimée Dronne, Emmanuel Grenier, Guillemette Chapuisat, Marc Hommel, Jean-Pierre Boissel

Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 60-78

DOI: 10.1016/j.pbiomolbio.2007.10.001

Journal article

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A numerical study of the blocking of migraine by Rolando sulcus.

Emmanuel Grenier, Marie-Aimée Dronne, Stéphane Descombes, Hervé Gilquin, Agnès Jaillard, Marc Hommel...

Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 54-9

DOI: 10.1016/j.pbiomolbio.2007.10.002

Journal article

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Modelling methodology in physiopathology.

Jean-Pierre Boissel, Benjamin Ribba, Emmanuel Grenier, Guillemette Chapuisat, Marie-Aimée Dronne

Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 28-39

DOI: 10.1016/j.pbiomolbio.2007.10.005

Journal article

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A global phenomenological model of ischemic stroke with stress on spreading depressions.

Guillemette Chapuisat, Marie-Aimée Dronne, Emmanuel Grenier, Marc Hommel, Hervé Gilquin, Jean-Pierre Boissel

Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 4-27

DOI: 10.1016/j.pbiomolbio.2007.10.004

Journal article

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Behavior learning using emotional conditioning

Guillaume Grenet, Frédéric Alexandre

IROS Workshop "From motor to interaction learning in robots" .

Conference paper

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Effectiveness of home treatment for patients with cystic fibrosis: the intravenous administration of antibiotics to treat respiratory infections.

Anne Termoz, Sandrine Touzet, Stéphanie Bourdy, Evelyne Decullier, Laeticia Bouveret, Cyrille Colin...

Pediatric Pulmonology . 43 ( 9 ) : 908-15

DOI: 10.1002/ppul.20878

Journal article

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Présentation pulmonaire inhabituelle d’une histiocytose à cellules de Langerhans systémique

Jean-Christophe Lega, Vincent Cottin, Aurélien Schuller, Romain Lazor, Denis Jullien, Jean-François Cordier

La Revue de Médecine Interne . 29 ( 8 ) : 669-672

DOI: 10.1016/j.revmed.2007.12.017

Journal article

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The Hill equation: a review of its capabilities in pharmacological modelling

Sylvain Goutelle, M. Maurinc, F. Rougier, X. Barbaut, Laurent Bourguignon, M. Ducher...

Fundamental & Clinical Pharmacology . 22 : 633-648

Journal article

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New insights on the relation between untreated and treated outcomes for a given therapy effect model is not necessarily linear

J.-P. Boissel, Michel Cucherat, P. Nonyc, Sylvie Chabaud, François Gueyffier, Jm. Wright...

Journal of Clinical Epidemiology . 61 : 301-307

Journal article

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Meta-analysis of continuous outcomes combining individual patient data and aggregate data

Rd. Riley, Pc. Lambert, Ja. Staessen, J. Wang, François Gueyffier, L. Thijs...

Statistics in Medicine . 27(11) : 1870-1893

Journal article

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Ciclesonide noninferiority to placebo on growth velocity

Behrouz Kassai, Michel Cucherat, G. Bellon

Pediatrics . 122 : 676-677

Journal article

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Pharmacocinétique de la teicoplanine chez le sujet âgé : construction d'un modèle pour le suivi thérapeutique

Laurent Bourguignon, Sylvain Goutelle, P. Bouniot, A. Guillermet, J. Burdin de Saint-Martin, P. Maire...

Journal de Pharmacie Clinique . 27 ( 3 ) : 189-194

Journal article

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Effets indésirables à long terme des médicaments: comment améliorer la prise en charge?

Behrouz Kassai, J. Bacchetta

Archives de Pédiatrie . 14(6) : 603-604

Journal article

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Presentation of the French Network of Paediatric Clinical Investigation Centres (CIC.P)

E. Jacqz-Aigraina, Behrouz Kassaï

Fundamental & Clinical Pharmacology . 21 : 105--110

Journal article

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Role of astrocytes in grey matter during stroke: a modelling approach.

Marie-Aimée Dronne, Emmanuel Grenier, Thierry Dumont, Marc Hommel, Jean-Pierre Boissel

Brain Research . 1138 : 231-42

DOI: 10.1016/j.brainres.2006.12.062

Journal article

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When to stop in the quest of formes frustes of connective tissue disease ?

Vincent Cottin, Jean-Christophe Lega, Nicole Fabien, Jean-François Cordier

Clinical Rheumatology . 26 ( 4 ) : 615-616

Journal article

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Some reflexions about double blind

R. Boussageon, François Gueyffier, A. Moreau, Y. Gansel, V. Boussageon

L'Encéphale . 34(4) : 347-351

Journal article

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Do We Need to Assess the Effect of Treatment Withdrawal? The Paradigm of Life-Long Prevention

François Gueyffier, T. Bejan-Angoulvant

Journal of the American Hearth Association . -- : 219-226

Journal article

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Critères intermédiaires et critères de substitution

Behrouz Kassai, François Gueyffier, J-P. Boissel

Médecine Thérapeutique . 13(4) : 279-286

Journal article

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Severe myoclonic epilepsy in infancy: A systematic review and a meta-analysis of individual patient data

Behrouz Kassai, C. Chiron, S. Augier, Michel Cucherat, E. Rey, François Gueyffier...

Epilepsia . 48 : 1-6

Journal article

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Does a change in angiotensin-II-formation caused by antihypertensive drugs affect the risk of stroke ? A meta-analysis of trials according to treatment with potentially different effects on angiotensin-II

F. Boutitie, R. Oprisiu, J.M. Achard, H. Mazouz, J. Wang, F.H. Messerli...

Journal of Hypertension . 25 : 1543-1553

Journal article

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