Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 571 to 600 publications on 613 in total

Présentation pulmonaire inhabituelle d’une histiocytose à cellules de Langerhans systémique

Jean-Christophe Lega, Vincent Cottin, Aurélien Schuller, Romain Lazor, Denis Jullien, Jean-François Cordier

La Revue de Médecine Interne . 29 ( 8 ) : 669-672

DOI: 10.1016/j.revmed.2007.12.017

Journal article

see the publication

The Hill equation: a review of its capabilities in pharmacological modelling

Sylvain Goutelle, M. Maurinc, F. Rougier, X. Barbaut, Laurent Bourguignon, M. Ducher...

Fundamental & Clinical Pharmacology . 22 : 633-648

Journal article

see the publication

New insights on the relation between untreated and treated outcomes for a given therapy effect model is not necessarily linear

J.-P. Boissel, Michel Cucherat, P. Nonyc, Sylvie Chabaud, François Gueyffier, Jm. Wright...

Journal of Clinical Epidemiology . 61 : 301-307

Journal article

see the publication

Meta-analysis of continuous outcomes combining individual patient data and aggregate data

Rd. Riley, Pc. Lambert, Ja. Staessen, J. Wang, François Gueyffier, L. Thijs...

Statistics in Medicine . 27(11) : 1870-1893

Journal article

see the publication

Ciclesonide noninferiority to placebo on growth velocity

Behrouz Kassai, Michel Cucherat, G. Bellon

Pediatrics . 122 : 676-677

Journal article

see the publication

Pharmacocinétique de la teicoplanine chez le sujet âgé : construction d'un modèle pour le suivi thérapeutique

Laurent Bourguignon, Sylvain Goutelle, P. Bouniot, A. Guillermet, J. Burdin de Saint-Martin, P. Maire...

Journal de Pharmacie Clinique . 27 ( 3 ) : 189-194

Journal article

see the publication

Effets indésirables à long terme des médicaments: comment améliorer la prise en charge?

Behrouz Kassai, J. Bacchetta

Archives de Pédiatrie . 14(6) : 603-604

Journal article

see the publication

Presentation of the French Network of Paediatric Clinical Investigation Centres (CIC.P)

E. Jacqz-Aigraina, Behrouz Kassaï

Fundamental & Clinical Pharmacology . 21 : 105--110

Journal article

see the publication

Role of astrocytes in grey matter during stroke: a modelling approach.

Marie-Aimée Dronne, Emmanuel Grenier, Thierry Dumont, Marc Hommel, Jean-Pierre Boissel

Brain Research . 1138 : 231-42

DOI: 10.1016/j.brainres.2006.12.062

Journal article

see the publication

When to stop in the quest of formes frustes of connective tissue disease ?

Vincent Cottin, Jean-Christophe Lega, Nicole Fabien, Jean-François Cordier

Clinical Rheumatology . 26 ( 4 ) : 615-616

Journal article

see the publication

Some reflexions about double blind

R. Boussageon, François Gueyffier, A. Moreau, Y. Gansel, V. Boussageon

L'Encéphale . 34(4) : 347-351

Journal article

see the publication

Do We Need to Assess the Effect of Treatment Withdrawal? The Paradigm of Life-Long Prevention

François Gueyffier, T. Bejan-Angoulvant

Journal of the American Hearth Association . -- : 219-226

Journal article

see the publication

Critères intermédiaires et critères de substitution

Behrouz Kassai, François Gueyffier, J-P. Boissel

Médecine Thérapeutique . 13(4) : 279-286

Journal article

see the publication

Severe myoclonic epilepsy in infancy: A systematic review and a meta-analysis of individual patient data

Behrouz Kassai, C. Chiron, S. Augier, Michel Cucherat, E. Rey, François Gueyffier...

Epilepsia . 48 : 1-6

Journal article

see the publication

Does a change in angiotensin-II-formation caused by antihypertensive drugs affect the risk of stroke ? A meta-analysis of trials according to treatment with potentially different effects on angiotensin-II

F. Boutitie, R. Oprisiu, J.M. Achard, H. Mazouz, J. Wang, F.H. Messerli...

Journal of Hypertension . 25 : 1543-1553

Journal article

see the publication

The JIKEI trial

F. Boutitie, François Gueyffier, Jm. Achard

The Lancet . 370 : 1825-1826

Journal article

see the publication

Literature search parameters marginally improved the pooled estimate accuracy for ultrasound in detecting deep venous thrombosis

Behrouz Kassai, S. Soniéb, N.R. Shah, J.-P. Boissel

Journal of Clinical Epidemiology . 59 : 710-714

Journal article

see the publication

La mise en place en Europe des réseaux d`investigation des médicaments chez l`enfant

Behrouz Kassai, J.M. Treluyer, E. Jacqz-Aigrain, Gérard Pons

Archives de Pédiatrie . 13 : 631-634

Journal article

see the publication

A mathematical model of ion movements in grey matter during a stroke

Marie-Aimée Dronne, Jean-Pierre Boissel, Emmanuel Grenier

Journal of Theoretical Biology . 240 : 599-615

Journal article

see the publication

The CF-CIRC study: a French collaborative study to assess the accuracy of cystic fibrosis diagnosis in neonatal screening.

Isabelle Sermet-Gaudelus, Delphine Roussel, Stéphanie Bui, Eric Deneuville, Frédéric Huet, Philippe Reix...

BMC Pediatrics . 6 : 25

DOI: 10.1186/1471-2431-6-25

Journal article

see the publication

Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock

G. Monneret, A. Lepape, N. Voirin, J. Bohé, F. Venet, A.-L. Debard...

Intensive Care Medicine . 32 : 1175-1183

Journal article

see the publication

Cardiovascular Risk Stratification in Decision Support Systems: A Probabilistic Approach. Application to pHealth

H. Atoui, J. Fayn, François Gueyffier, P. Rubel

2006 Computers in Cardiology .

Conference paper

see the publication

The lower the better: Does simplicity lead to absurdity?

François Gueyffier, Jm. Wright

Editorial comment . 24(3) : 431-433

Journal article

see the publication

Safety of computerized drug management: a case report

K.-A. Nguyen, T. Vial, François Gueyffier, S. Marignier, P. Cochat, Behrouz Kassai

British Journal of Clinical Pharmacology . 63 : 245-246

Journal article

see the publication

Estimation of attributable burden of disease: authors' reply

François Gueyffier, Jm. Wright

Journal of Hypertension . 24 ( 5 ) : 933-936

Journal article

see the publication

L'attitude des parents face à la fièvre de leurs enfants

J. Stagnara, J. Vermont, F. Dürr, K. Ferradji, L. Mege, A. Duquesne...

Press Med . 34 : 1129-1136

Journal article

see the publication

Methods for evaluation of total cardiovascular risk

A. Barna, M. Baudet, J.-P. Cambou, G. Chatellier, Michel Cucherat, J. Dallongeville...

Médecine thérapeutique . 11 : 233--236

Journal article

see the publication

La modélisation des interactions en pharmacologie : un outil d'intégration des connaissances complexes

Samira Bakiri, Marie-Aimée Dronne, S. Randall Thomas, François Gueyffier

Arch Mal C'ur Vais . 98 : 61

Conference paper

see the publication

[Readability of informed consent forms for subjects participating in biomedical research: updating is required]

Adeline Paris, Jean-Luc Cracowski, Nadia Ravanel, Catherine Cornu, François Gueyffier, Béatrice Deygas...

La Presse Médicale . 34 ( 1 ) : 13-8

Journal article

see the publication

The true treatment benefit is unpredictable in clinical trials using surrogate outcome measured with diagnostic tests

Behrouz Kassai, N.R. Shah, A. Leizorovicz, Michel Cucherat, François Gueyffier, J.-P. Boissel

Journal of Clinical Epidemiology . 58 : 1042-1051

Journal article

see the publication

You also, comment on this article

Choose an avatar
(Will not be posted on the site)
(Will not be posted on the site)