Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 541 to 570 publications on 628 in total

Heterogeneity prevails: the state of clinical trial data management in Europe - results of a survey of ECRIN centres

W. Kuchinke, C. Ohmann, Q. Yang, N. Salas, J. Lauritsen, F. Gueyffier...

Trials . 11 : 79

DOI: 10.1186/1745-6215-11-79

Journal article

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Isolated Recurrent Pleuritis Revealing Familial Mediterranean Fever in Adulthood

J.C. Lega, C. Khouatra, Vincent Cottin, Jean-François Cordier

Respiration . 80 ( 3 ) : 262

DOI: 10.1159/000315474

Journal article

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A mathematical model of inflammation during ischemic stroke

Cristiana Di Russo, Jean-Baptiste Lagaert, Guillemette Chapuisat, Marie-Aimée Dronne

ESAIM: Proceedings . 30 : 15-33

DOI: 10.1051/proc/2010003

Journal article

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In silico study of the influence of intensity and duration of blood flow reduction on cell death through necrosis or apoptosis during acute ischemic stroke

Guillemette Chapuisat, Marie-Aimée Dronne, Emmanuel Grenier, Marc Hommel, Jean-Pierre Boissel

Acta Biotheoretica . 58 ( 2-3 ) : 171-190

DOI: 10.1007/s10441-010-9100-2

Journal article

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A phenomenological model of the growth of the necrotic area in ischemic stroke

Emmanuel Grenier, Didier Bresch, Marie-Aimée Dronne, Marc Hommel, Jean-Pierre Boissel

Mathematical and Computer Modelling . 51 ( 9-10 ) : 1011-1025

DOI: 10.1016/j.mcm.2008.07.025

Journal article

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Hyperpolarized 3He MR for sensitive imaging of ventilation function and treatment efficiency in young cystic fibrosis patients with normal lung function.

Elise Bannier, Katarzyna Cieslar, Karim Mosbah, Françoise Aubert, François Duboeuf, Zahir Salhi...

Radiology . 255 ( 1 ) : 225-32

DOI: 10.1148/radiol.09090039

Journal article

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Intrapulmonary Pharmacokinetics and Pharmacodynamics of Micafungin in Adult Lung Transplant Patients

T. Walsh, Sylvain Goutelle, R.-W. Jelliffe, J.A. Golden, E.A. Little, C. Devoe...

Antimicrobial Agents and Chemotherapy . 54 ( 8 ) : 3451-3459

DOI: 10.1128/AAC.01647-09

Journal article

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Oral Voriconazole Dose in children: One size does not fit all

Sylvain Goutelle, R. Larcher, C. Padoin, V. Mialou, N. Bleyzac

Clinical Infectious Diseases . 51 ( 7 ) : 870-870

DOI: 10.1086/656293

Journal article

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A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial.

Catherine Cornu, Laurent Remontet, Florence Noel-Baron, Alain Nicolas, Nathalie Feugier-Favier, Pascal Roy...

BMC Complementary and Alternative Medicine . 10 ( 1 ) : 29

DOI: 10.1186/1472-6882-10-29

Journal article

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Treatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials

T. Bejan-Angoulvant, M. Saadatian-Elahi, Jm. Wright, E.B. Schron, Lh. Lindholm, R. Fagard...

Journal of Hypertension . 28 : 1366-1372

DOI: 10.1097/HJH.0b013e328339f9c5

Journal article

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Both extrauterine and intrauterine growth restriction impair renal function in children born very preterm

J. Bacchetta, J. Harambat, L. Dubourg, B. Guy, A. Liutkus, I. Canterino...

Kidney International . 76 ( 4 ) : 445-452

DOI: 10.1038/ki.2009.201

Journal article

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Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus

A. Doreau, Al. Belot, J. Bastid, B. Riche, M.-C. Trescol-Biemont, B. Ranchin...

Nature Immunology . 10(7) : 778-788

Journal article

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Visual estimation of patients' right body weight in hospital: the more observers, the better?

S. Goutelle, Laurent Bourguignon, N. Bertrand-Passeron, R-W. Jelliffe, Pascal Maire

Pharmacy World and Science . : 1-4

DOI: 10.1007/s11096-009-9295-y

Journal article

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Comment: Modification of Diet in Renal Disease and Modified Cockcroft-Gault Formulas in Predicting Aminoglycoside Elimination

Sylvain Goutelle, Laurent Bourguignon, Michel Ducher, Pascal Maire

Annals of Pharmacotherapy . 43 ( 6 ) : 1145-1146

DOI: 10.1345/aph.1L144a

Journal article

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[Amikacin pharmacokinetics in adults: a variability that question the dose calculation based on weight].

Laurent Bourguignon, Sylvain Goutelle, Cécile Gérard, Anne Guillermet, Julie Burdin de Saint Martin, Pascal Maire...

Therapies . 64 ( 1 ) : 47-53

DOI: 10.2515/therapie/2009009

Journal article

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Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells.

Taïssia Lelekov-Boissard, Guillemette Chapuisat, Jean-Pierre Boissel, Emmanuel Grenier, Marie-Aimée Dronne

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences . 367 ( 1908 ) : 4699-4716

DOI: 10.1098/rsta.2009.0184

Journal article

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A mathematical approach to model stroke pathophysiology

Marie-Aimée Dronne, Emmanuel Grenier, Thierry Dumont, Marc Hommel, Jean-Pierre Boissel

International Heart Forum .

Conference paper

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Examples of the influence of the geometry on the propagation of progressive waves

Marie-Aimée Dronne, Stéphane Descombes, Emmanuel Grenier, Hervé Gilquin

Mathematical and Computer Modelling . 49 ( 11-12 ) : 2138-2144

DOI: 10.1016/j.mcm.2008.07.024

Journal article

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New surfactant protein C gene mutations associated with diffuse lung disease

Loïc Guillot, Ralph Epaud, Guillaume Thouvenin, Laurence Jonard, Amira Mohsni, Remy Couderc...

Journal of Medical Genetics . 46 ( 7 ) : 490

DOI: 10.1136/jmg.2009.066829

Journal article

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Cognitive Therapy versus Rogerian Supportive Therapy in Borderline Personality Disorder

J. Cottraux, I. Druon Note, F. Boutitie, M. Milliery, V. Genouihlac, S.N. Yao...

Psychotherapy and Psychosomatics . 78(5) : 307-316

Journal article

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Modélisation pharmacocinétique-pharmacodynamique et techniques de simulation appliquées à l’évaluation de stratégies thérapeutiques en infectiologie

Laurent Bourguignon

Thesis

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A positioning pillow to improve lumbar puncture success rate in paediatric haematology-oncology patients: a randomized controlled trial

P. Marec-Bérard, A. Bissery, K. Kebaïli, M. Schell, F. Aubert, Sophie Gaillard...

BMC Cancer . 9(21) : 1399-1406

Journal article

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Fondements de l`évaluation des tests diagnostiques

B. Kassai, François Gueyffier, Muriel Rabilloud

Lecture critique d`article . 59 : 375-379

Journal article

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Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors.

Albert Fournier, Roxana Oprisiu-Fournier, Jean-Marie Serot, Olivier Godefroy, Jean-Michel Achard, Sébastien Faure...

Expert Review of Neurotherapeutics . 9 ( 9 ) : 1413-31

DOI: 10.1586/ern.09.89

Journal article

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Recueil systématique et actif des evènements indésirables médicamenteux chez les enfants admis aux urgences pédiatriques

F. Planchamp, K.-A. Nguyen, T. Vial, S. Nasri, E. Javouhey, Y. Gillet...

Archives de Pédiatrie . 16(2) : 106-111

Journal article

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SCORE should be preferred to Framingham to predict cardiovascular death in French population

I. Marchant, J-P. Boissel, Behrouz Kassai, T. Bejan-Angoulvant, J. Massol, C. Vidal...

European Journal of Cardiovascular Prevention and Rehabilitation . 16(5) : 609-615

DOI: 10.1097/HJR.0b013e32832da006

Journal article

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Evaluation of various gentamicin dosage regimens in geriatric patients: a simulation study

Laurent Bourguignon, Sylvain Goutelle, J. Burdin de Saint Martin, P. Maire, M. Ducher

Fundamental & Clinical Pharmacology . -- : 1-5

Journal article

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Modification of Diet in Renal Disease and Modified Cockcroft-Gault Formulas in Predicting Aminoglycoside Elimination

Sylvain Goutelle, Laurent Bourguignon, M. Ducher, P. Maire

The Annals of Pharmacotherapy . 43 : 1143-1146

Journal article

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Variabilité pharmacocinétique intra-individuelle et traitement antibiotique prolongé

Laurent Bourguignon, Sylvain Goutelle, Julie Burdin de Saint Martin, Anne Guillermet, P. Bouniot, Pascal Maire...

Médecine et Maladies Infectieuses . 2859 : 38-41

DOI: 10.1016/j.medmal.2009.03.003

Journal article

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Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs

Sylvain Goutelle, Laurent Bourguignon, P. Maire, M. van Guilder, J.-D. Conte, R.-W. Jelliffe

Antimicrobial Agents and Chemotherapy . 53(7) : 2974-2981

Journal article

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