Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
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Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
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Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
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Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
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Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
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Doctorante
autre
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Praticien hospitalier
HCL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier émérite
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
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Maîtresse de conférences - praticienne hospitalière
UCBL
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Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
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Doctorante
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Post-doc
UCBL
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Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 391 to 420 publications on 450 in total
Chemotherapy may be delivered based on an integrated view of tumour dynamics.
IET Systems Biology . 3 ( 3 ) : 180-90
Journal article
see the publicationDevelopment of a drug - disease simulation model for rituximab in follicular non-Hodgkin lymphoma
Congrès P2T (13ème congrès annuel de la Sté Française de Pharmacologie et de Thérapeutique .
Conference paper
see the publication2009 - Development of a drug-disease simulation model for rituximab in follicular non-Hodgkin lymphoma
Congrès P2T (13ème congrès annuel de l a Société Française de Pharmacologie et de Thérapeutique .
Conference paper
see the publicationInvestigation of PK-PD drug-drug interaction between acenocoumarol and amoxicillin plus clavulanic acid.
Fundamental & Clinical Pharmacology . 23 ( 1 ) : 127-35
Journal article
see the publicationNew surfactant protein C gene mutations associated with diffuse lung disease
Journal of Medical Genetics . 46 ( 7 ) : 490
Journal article
see the publicationCognitive Therapy versus Rogerian Supportive Therapy in Borderline Personality Disorder
Psychotherapy and Psychosomatics . 78(5) : 307-316
Journal article
see the publicationModélisation pharmacocinétique-pharmacodynamique et techniques de simulation appliquées à l’évaluation de stratégies thérapeutiques en infectiologie
Thesis
see the publicationFondements de l`évaluation des tests diagnostiques
Lecture critique d`article . 59 : 375-379
Journal article
see the publicationPrevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors.
Expert Review of Neurotherapeutics . 9 ( 9 ) : 1413-31
DOI: 10.1586/ern.09.89
Journal article
see the publicationRecueil systématique et actif des evènements indésirables médicamenteux chez les enfants admis aux urgences pédiatriques
Archives de Pédiatrie . 16(2) : 106-111
Journal article
see the publicationSCORE should be preferred to Framingham to predict cardiovascular death in French population
European Journal of Cardiovascular Prevention and Rehabilitation . 16(5) : 609-615
Journal article
see the publicationEvaluation of various gentamicin dosage regimens in geriatric patients: a simulation study
Fundamental & Clinical Pharmacology . -- : 1-5
Journal article
see the publicationModification of Diet in Renal Disease and Modified Cockcroft-Gault Formulas in Predicting Aminoglycoside Elimination
The Annals of Pharmacotherapy . 43 : 1143-1146
Journal article
see the publicationVariabilité pharmacocinétique intra-individuelle et traitement antibiotique prolongé
Médecine et Maladies Infectieuses . 2859 : 38-41
Journal article
see the publicationPopulation Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs
Antimicrobial Agents and Chemotherapy . 53(7) : 2974-2981
Journal article
see the publicationPatient versus general practitioner perception of problems with treatment adherence in type 2 diabetes: From adherence to concordance
European Journal of General Practice . ( 15 ) : 147-53.
Journal article
see the publicationPatient versus general practitioner perception of problems with treatment adherence in type 2 diabetes: From adherence to concordance
European Journal of General Practice . 15 ( 3 ) : 147-153
Journal article
see the publicationPharmacocinétique de l'amikacine chez l'adulte : une hétérogénéité qui remet en cause le calcul de la dose basé sur le poids
Thérapie . 64 ( 1 ) : 189-194
Journal article
see the publicationA modelling approach to explore some hypotheses of the failure of neuroprotective trials in ischemic stroke patients.
Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 60-78
Journal article
see the publicationA numerical study of the blocking of migraine by Rolando sulcus.
Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 54-9
Journal article
see the publicationModelling methodology in physiopathology.
Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 28-39
Journal article
see the publicationA global phenomenological model of ischemic stroke with stress on spreading depressions.
Progress in Biophysics and Molecular Biology . 97 ( 1 ) : 4-27
Journal article
see the publicationEtoposide pharmacokinetics and survival in patients with small cell lung cancer: a multicentre study.
Lung Cancer . 62 ( 2 ) : 261-72
Journal article
see the publicationAdvantages of prostate-specific antigen (PSA) clearance model over simple PSA half-life computation to describe PSA decrease after prostate adenomectomy.
Clinical Biochemistry . 41 ( 10-11 ) : 785-95
Journal article
see the publicationA Physiological Model to Evaluate Drug Kinetics in Patients with Hemorrhagic Shock Followed by Fluid Resuscitation
Pharmaceutical Research . 25 ( 6 ) : 1431-1439
Journal article
see the publicationBehavior learning using emotional conditioning
IROS Workshop "From motor to interaction learning in robots" .
Conference paper
see the publicationEffectiveness of home treatment for patients with cystic fibrosis: the intravenous administration of antibiotics to treat respiratory infections.
Pediatric Pulmonology . 43 ( 9 ) : 908-15
DOI: 10.1002/ppul.20878
Journal article
see the publicationPrésentation pulmonaire inhabituelle d’une histiocytose à cellules de Langerhans systémique
La Revue de Médecine Interne . 29 ( 8 ) : 669-672
Journal article
see the publicationThe Hill equation: a review of its capabilities in pharmacological modelling
Fundamental & Clinical Pharmacology . 22 : 633-648
Journal article
see the publicationNew insights on the relation between untreated and treated outcomes for a given therapy effect model is not necessarily linear
Journal of Clinical Epidemiology . 61 : 301-307
Journal article
see the publication
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