Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 391 to 420 publications on 626 in total

Sweat test practice in pediatric pulmonology after introduction of cystic fibrosis newborn screening

Céline Grimaldi, François Brémont, Michèle Berlioz-Baudoin, Jacques Brouard, Harriet Corvol, Laure Couderc...

European Journal of Pediatrics . 174 ( 12 ) : 1613 - 1620

DOI: 10.1007/s00431-015-2579-4

Journal article

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An impulse oscillometry system is less efficient than spirometry in tracking lung function improvements after intravenous antibiotic therapy in pediatric patients with cystic fibrosis

Clélia Buchs, Laurianne Coutier, Stéphanie Vrielynck, Virginie Jubin, Catherine Mainguy, Philippe Reix

Pediatric Pulmonology . 50 ( 11 ) : 1073 - 1081

DOI: 10.1002/ppul.23301

Journal article

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A French multicentric study and review of pulmonary Nocardia spp. in cystic fibrosis patients

Véronica Rodriguez-Nava, Stéphane Durupt, Sandra Chyderiotis, Anne-Marie Freydiere, Judith Karsenty, Michèle de Montclos...

Medical Microbiology and Immunology . 204 ( 4 ) : 493-504

DOI: 10.1007/s00430-014-0360-3

Journal article

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Idiopathic inflammatory myopathies and the lung

Jean-Christophe Lega, Quitterie Reynaud, Alexandre Belot, Nicole Fabien, Isabelle Durieu, Vincent Cottin

European Respiratory Review . 24 ( 136 ) : 216-238

DOI: 10.1183/16000617.00002015

Journal article

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Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

C. Vale, L. Rydzewska, M. Rovers, J. Emberson, François Gueyffier, L. Stewart

British medical journal . 350 : h1088

DOI: 10.1136/bmj.h1088

Journal article

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Subcutaneous administration of levetiracetam in geriatrics

O. Maison, B. de La Gastine, L. Peter-Derex, C. Berger, Sylvain Goutelle

Revue Neurologique . 171 : 398-399

Journal article

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A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells-using rifampicin as an example

O. Clewe, Sylvain Goutelle, Jr. Conte, Ush. Simonsson

European Journal of Clinical Pharmacology . 71 ( 3 ) : 313-9

DOI: 10.1007/s00228-014-1798-3

Journal article

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Quantitative methods for prediction of the effect of cytochrome P450 gene polymorphisms on substrate drug exposure

Sylvain Goutelle, M. Tod

Clinical Pharmacokinetics . 54 : 319-20

Journal article

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Model-Based Determination of Effective Blood Concentrations of Cyclosporine for Neutrophil Response in the Treatment of Severe Aplastic Anemia in Children

M. Philippe, E. Henin, Y. Bertrand, D. Plantaz, Sylvain Goutelle, N. Bleyzac

AAPS Journal . 17 ( 5 ) : 1157-67

DOI: 10.1208/s12248-015-9779-8

Journal article

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Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs

Laure Lalande, Laurent Bourguignon, S. Bihari, P. Maire, M. Neely, R. Jelliffe...

Antimicrobial Agents and Chemotherapy . 59 ( 9 ) : 5181-5189

DOI: 10.1128/AAC.00462-15

Journal article

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Management of adolescents with very poorly controlled type 1 diabetes by nurses: a parallel group randomized controlled trial

B. Kassai, Muriel Rabilloud, D. Bernoux, C. Michal, B. Riche, T. Ginhoux...

Trials . 16 ( 1 ) : 399

DOI: 10.1186/s13063-015-0923-7

Journal article

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Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients

A. Glatard, Laurent Bourguignon, R. W. Jelliffe, P. Maire, M. N. Neely, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 59 ( 6 ) : 2986-94

DOI: 10.1128/AAC.04132-14

Journal article

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Different treatment benefits were estimated by clinical trials performed in adults compared with those performed in children

Perrine Janiaud, A. Lajoinie, F. Cour-Andlauer, Catherine Cornu, P. Cochat, Michel Cucherat...

Journal of Clinical Epidemiology . 68 : 1221-1231

Journal article

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Is legacy a myth or a reality? We should know, and we do not

F. Gueyffier, Michel Cucherat

Journal of Hypertension . 33 : 2207-9

Journal article

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High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention

I. Marchant, Jp. Boissel, Patrice Nony, F. Gueyffier

PLoS ONE . 10 ( 11 ) : e0140793

DOI: 10.1371/journal.pone.0140793

Journal article

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A Prediction Model of Drug Exposure in Cirrhotic Patients According to Child-Pugh Classification

J. Steelandt, E. Jean-Bart, Sylvain Goutelle, M. Tod

Clinical Pharmacokinetics . 54 : 1245-58

DOI: 10.1007/s40262-015-0288-9

Journal article

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Population pharmacokinetics of ciprofloxacin in neonates and young infants less than three months of age

W. Zhao, H. Hill, C. Le Guellec, T. Neal, S. Mahoney, S. Paulus...

Antimicrobial Agents and Chemotherapy . 58 ( 11 ) : 6572-80

DOI: 10.1128/AAC.03568-14

Journal article

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Solid oral forms availability in children: a cost saving investigation

A. Lajoinie, E. Henin, Behrouz Kassai, D. Terry

British Journal of Clinical Pharmacology . 78 ( 5 ) : 1080-9

DOI: 10.1111/bcp.12442

Journal article

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Practical interest of both skin prick test and specific IgE in the evaluation of tolerance acquisition in IgE mediated cow's milk allergy (CMA). A clinical retrospective study in a cohort of 184 children

F. Payot, J. Berthiller, Behrouz Kassai, A. S. Brunet, F. Villard-Truc, A. Lachaux

Allergologia et Immunopathologia . 42 : 395-401

Journal article

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Pharmacokinetic Drug-Drug Interaction of Calcium Channel Blockers With Cyclosporine in Hematopoietic Stem Cell Transplant Children

Elodie Bernard, Sylvain Goutelle, Yves Bertrand, Nathalie Bleyzac

Annals of Pharmacotherapy . 48 ( 12 ) : 1580-1584

DOI: 10.1177/1060028014550644

Journal article

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Determinants of Torsades de Pointes in Older Patients with Drug-Associated Long QT Syndrome: A Case-Control Study

Sylvain Goutelle, Elodie Sidolle, Michel Ducher, Jacques Caron, Quadiri Timour, Patrice Nony...

Drugs and Aging . 31 ( 8 ) : 601-609

DOI: 10.1007/s40266-014-0188-y

Journal article

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Response to Sarah Hilmer and Colleagues

Christelle Mouchoux, Rémi Faure, Virginie Dauphinot, Sylvain Goutelle, Pierre Krolak-Salmon

Journal of the American Geriatrics Society . 62 ( 4 ) : 792-793

DOI: 10.1111/jgs.12754

Journal article

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Exposure of Staphylococcus aureus to subinhibitory concentrations of β-lactam antibiotics induces heterogeneous vancomycin-intermediate Staphylococcus aureus

Mélanie Roch, Perrine Clair, Adriana Renzoni, Marie-Elisabeth Reverdy, Olivier Dauwalder, Michèle Bes...

Antimicrobial Agents and Chemotherapy . 58 ( 9 ) : 5306-5314

DOI: 10.1128/AAC.02574-14

Journal article

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Impact of Scedosporium apiospermum complex seroprevalence in patients with cystic fibrosis

Perrine Parize, Sandrine Nail-Billaud, Anne-Lise Bienvenu, Stéphanie Bourdy, Marie Le Pogam, Philippe Reix...

Journal of Cystic Fibrosis . 13 ( 6 ) : 667-673

DOI: 10.1016/j.jcf.2014.01.011

Journal article

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Consistency of safety profile of new oral anticoagulants in patients with renal failure

Jean-Christophe Lega, L. Bertoletti, C. Gremillet, C. Boissier, P. Mismetti, S. Laporte

Journal of Thrombosis and Haemostasis . 12 ( 2 ) : 337-43

DOI: 10.1111/jth.12486

Journal article

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Characteristics, prognosis, and outcomes of cutaneous ischemia and gangrene in systemic necrotizing vasculitides: a retrospective multicenter study

Jean-Christophe Lega, Raphaèle Seror, Thomas Fassier, Olivier Aumaître, Isabelle Quere, Jacques Pourrat...

Seminars in Arthritis and Rheumatism . 43 ( 5 ) : 681--688

DOI: 10.1016/j.semarthrit.2013.09.001

Journal article

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The clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome

Jean-Christophe Lega, N. Fabien, Q. Reynaud, I. Durieu, S. Durupt, M. Dutertre...

Autoimmunity Reviews . 13 : 883-91

Journal article

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The clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome

Jean-Christophe Lega, Nicole Fabien, Quitterie Reynaud, Isabelle Durieu, Stéphane Durupt, Marine Dutertre...

Autoimmunity Reviews . 13 ( 9 ) : 883-891

DOI: 10.1016/j.autrev.2014.03.004

Journal article

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Risk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: a systematic review and meta-analysis

Q. Reynaud, Jean-Christophe Lega, P. Mismetti, C. Chapelle, D. Wahl, P. Cathebras...

Autoimmunity Reviews . 13 : 595-608

Journal article

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Consistency of Safety and Efficacy of New Oral Anticoagulants across Subgroups of Patients with Atrial Fibrillation

Jean-Christophe Lega, L. Bertoletti, C. Gremillet, C. Chapelle, P. Mismetti, M. Cucherat...

PLoS ONE . 9 ( 3 ) : e91398

DOI: 10.1371/journal.pone.0091398

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