GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 661 to 690 publications on 1402 in total

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data.

Milana Frenkel-Morgenstern, Alessandro Gorohovski, Vincent Lacroix, Mark Rogers, Kristina Ibanez, Cesar Boullosa...

Nucleic Acids Research . 41 ( D1 ) : D142-D151

DOI: 10.1093/nar/gks1041

Journal article

see the publication

Chimeras taking shape: potential functions of proteins encoded by chimeric RNA transcripts.

Milana Frenkel-Morgenstern, Vincent Lacroix, Iakes Ezkurdia, Yishai Levin, Alexandra Gabashvili, Jaime Prilusky...

Genome Research . 22 ( 7 ) : 1231-1242

DOI: 10.1101/gr.130062.111

Journal article

see the publication

Evidence for transcript networks composed of chimeric RNAs in human cells

Sarah Djebali, Julien Lagarde, Philipp Kapranov, Vincent Lacroix, Christelle Borel, Jonathan M. Mudge...

PLoS ONE . 7 ( 1 ) : Non paginé

DOI: 10.1371/journal.pone.0028213

Journal article

see the publication

Evidence for Transcript Networks Composed of Chimeric RNAs in Human Cells

Sarah Djebali, Julien Lagarde, Philipp Kapranov, Vincent Lacroix, Christelle Borel, Jonathan M. Mudge...

PLoS ONE . 7 : 1-22

Journal article

see the publication

Horizontal gene transfer of a chloroplast DnaJ-Fer protein to Thaumarchaeota and the evolutionary history of the DnaK chaperone system in Archea

C. Petitjean, D. Moreira, P. Lopez-Garcia, Céline Brochier-Armanet

BMC Evolutionary Biology . 12 : 226

DOI: 10.1186/1471-2148-12-226

Journal article

see the publication

Disentangling the effects of breakdown of self-incompatibility and transition to selfing in North-American Arabidopsis lyrata

A. Haudry, H.G. Zha, M. Stift, B.K. Mable

Molecular Ecology . 21 : 1130-1142

DOI: 10.1111/j.1365-294X.2011.05435.x

Journal article

see the publication

Primate evolutionary history contribution to the deciphering of SIV/HIV origin and diversification

Bénédicte Lafay

Evolution Ottawa - 1th Joint Congress on Evolutionary Biology .

Conference paper

see the publication

De novo metagenomic assembly reveals abundant novel major lineage of Archaea in hypersaline microbial communities.

Priya Narasingarao, Sheila Podell, Juan A Ugalde, Céline Brochier-Armanet, Joanne B Emerson, Jochen J Brocks...

The International Society of Microbiologial Ecology Journal . 6 ( 1 ) : 81-93

DOI: 10.1038/ismej.2011.78

Journal article

see the publication

Interaction between Selection and Biased Gene Conversion in Mammalian Protein-Coding Sequence Evolution Revealed by a Phylogenetic Covariance Analysis

Nicolas Lartillot

Molecular Biology and Evolution . 30 : 356 - 368

DOI: 10.1093/molbev/mss231

Journal article

see the publication

Rapport du groupe de travail sur la gestion et le partage des données

Christine Gaspin, Dominique Pontier, Laurence Colinet, Frédéric Dardel, Alain Franc, Odile Hologne...

Report

see the publication

Rapid De Novo Evolution of X Chromosome Dosage Compensation in Silene latifolia a Plant with Young Sex Chromosomes

A. Muyle, N. Zemp, C. Deschamps, Sylvain Mousset, A. Wildmer, Gabriel Marais

PLoS Biology . 10 ( 4 ) : e1001308

DOI: 10.1371/journal.pbio.1001308

Journal article

see the publication

Repeated evolution of testis-specific new genes: the case of telomere-capping genes in Drosophila.

Raphaëlle Dubruille, Gabriel A.B. Marais, Benjamin Loppin

Int J Evol Biol . 2012 : 708980

DOI: 10.1155/2012/708980

Journal article

see the publication

Mammalian X chromosome inactivation evolved as a dosage-compensation mechanism for dosage-sensitive genes on the X chromosome

E. Pessia, T. Makino, M. Bailly-Bechet, A. Mclysaght, Gabriel Marais

Proceedings of the National Academy of Sciences of the United States of America . 109 ( 14 ) : 5346-5351

DOI: 10.1073/pnas.1116763109

Journal article

see the publication

Structural and dynamical analysis of biological networks.

Cecilia C. Klein, Andrea Marino, Marie-France Sagot, Paulo Vieira Milreu, Matteo Brilli

Briefings in Functional Genomics and Proteomics . 14 : 309

DOI: 10.1093/bfgp/els030

Journal article

see the publication

BRASERO: A resource for benchmarking RNA secondary structure comparison algorithms

Julien Allali, Cédric Saule, Cedric Chauve, Yves d'Aubenton-Carafa, Alain Denise, Christine Drevet...

Advances in Bioinformatics . 2012 : 1-5

DOI: 10.1155/2012/893048

Journal article

see the publication

Structural, functional and evolutionary analysis of the unusually large stilbene synthase gene family in grapevine (Vitis vinifera)

C. Parage, R. Tavares, S. Réty, R. Baltenweck-Guyot, A. Poutaraud, L. Renault...

Plant Physiology . 160 : 1407-1419

Journal article

see the publication

Lateral gene transfer as a support for the tree of life.

Sophie S Abby, Eric Tannier, Manolo Gouy, Vincent Daubin

Proceedings of the National Academy of Sciences of the United States of America . 109 ( 13 ) : 4962-4967

DOI: 10.1073/pnas.1116871109

Journal article

see the publication

High-quality sequence clustering guided by network topology and multiple alignment likelihood.

Vincent Miele, Simon Penel, Vincent Daubin, Franck Picard, Daniel Kahn, L. Duret

Bioinformatics . 28 ( 8 ) : 1078-85

DOI: 10.1093/bioinformatics/bts098

Journal article

see the publication

High-throughput sequencing of complete human mtDNA genomes from the Caucasus and West Asia: high diversity and demographic inferences.

Ivan Nasidze, Anna Schönberg, Christoph Theunert, Mingkun Li, Mark Stoneking

European Journal of Human Genetics .

DOI: 10.1038/ejhg.2011.62

Journal article

see the publication

Y-Chromosomal Variation in Sub-Saharan Africa: Insights Into the History of Niger-Congo Groups

C. de Filippo, C. Barbieri, M. Whitten, S. Mpoloka, E. Gunnarsdottir, K. Bostoen...

Molecular Biology and Evolution . 28 ( 3 ) : 1255-1269

DOI: 10.1093/molbev/msq312

Journal article

see the publication

Larger mitochondrial DNA than Y-chromosome differences between matrilocal and patrilocal groups from Sumatra

Ellen Dröfn Gunnarsdóttir, Madhusudan Nandineni, Mingkun Li, Sean Myles, David Gil, Brigitte Pakendorf...

Nature Communications . 2 : 228

DOI: 10.1038/ncomms1235

Journal article

see the publication

Substitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content

Carina Mugal, Hans Ellegren

Genome Biology . 12 ( 6 ) : R58

DOI: 10.1186/gb-2011-12-6-r58

Journal article

see the publication

Analysis of the variability of human normal urine by 2D-GE reveals a "public" and a "private" proteome

Laurence Molina, Nicolas Salvetat, Randa Ben Ameur, Sabine Pérès, Nicolas Sommerer, Faycal Jarraya...

Journal of Proteomics . 75 ( 1 ) : 70 - 80

DOI: 10.1016/j.jprot.2011.06.031

Journal article

see the publication

ACoM: A classification method for elementary flux modes based on motif finding

Sabine Pérès, Francois Vallee, Marie M. Beurton-Aimar, Jean-Pierre Mazat

BioSystems . 103 ( 3 ) : 410-419

Journal article

see the publication

Lactase persistence in central Asia: phenotype, genotype, and evolution.

Evelyne Heyer, Lionel Brazier, Laure Ségurel, Tatiana Hegay, Frédéric Austerlitz, Lluis Quintana-Murci...

Human Biology . 83 ( 3 ) : 379-92

DOI: 10.3378/027.083.0304

Journal article

see the publication

The Case of the Fickle Fingers: How the PRDM9 Zinc Finger Protein Specifies Meiotic Recombination Hotspots in Humans

Laure Ségurel, Ellen Miranda Leffler, Molly M. Przeworski

PLoS Biology . 9 ( 12 ) : e1001211

DOI: 10.1371/journal.pbio.1001211

Journal article

see the publication

“ArthropodaCyc”: a BioCyc database powered by CycADS to study and compare the metabolism of arthropods

Patrice Baa-Puyoulet, Augusto Vellozo, Jaime Huerta-Cepas, Gérard Febvay, Toni Gabaldon, Marie-France Sagot...

5. Annual Arthropod Genomics Symposium “Arthropod Genomics 2011: Exploring Diversity, Relating Similarity” . : 33 p.

Poster

see the publication

Preventing dangerous nonsense: selection for robustness to transcriptional error in human genes.

Brian P. Cusack, Peter F. Arndt, L. Duret, Hugues Roest Crollius

PLoS Genetics . 7 ( 10 ) : e1002276

DOI: 10.1371/journal.pgen.1002276

Journal article

see the publication

Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

Corinne Chureau, Sophie Chantalat, Antonio Romito, Angélique Galvani, Laurent Duret, Philip Avner...

Human Molecular Genetics . 20 ( 4 ) : 705-718

DOI: 10.1093/hmg/ddq516

Journal article

see the publication

Meiotic recombination favors the spreading of deleterious mutations in human populations

Anamaria Necsulea, L. Duret, Alexandra Popa, David N. Cooper, Peter Stentson, Dominique Mouchiroud...

Human Mutation . 32 ( 2 ) : 198-206

DOI: 10.1002/humu.21407

Journal article

see the publication