GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 721 to 750 publications on 1402 in total

Complete-fosmid and fosmid-end sequences reveal frequent horizontal gene transfers in marine uncultured planktonic archaea.

Céline Brochier-Armanet, Philippe Deschamps, Purificación López-García, Yvan Zivanovic, Francisco Rodríguez-Valera, David Moreira

The International Society of Microbiologial Ecology Journal . 5 ( 8 ) : 1291-302

DOI: 10.1038/ismej.2011.16

Journal article

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A New Highly Conserved Antibiotic Sensing/Resistance Pathway in Firmicutes Involves an ABC Transporter Interplaying with a Signal Transduction System

S. Coumes-Florens, Céline Brochier-Armanet, A. Guiseppi, F. Denizot, M. Foglino

PLoS ONE . 6 : e15951

DOI: 10.1371/journal.pone.0015951

Journal article

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Emergence and Modular Evolution of a Novel Motility Machinery in Bacteria

J. Luciano, R. Agrebi, A.V. Le Gall, M. Wartel, F. Fiegna, A. Ducret...

PLoS Genetics . 7 ( 9 ) : 1409-1418

DOI: 10.1371/journal.pgen.1002268

Journal article

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Characterization of Halorubrum sfaxense sp. nov. a New Halophilic Archaeon Isolated from the Solar Saltern of Sfax in Tunisia

H. Trigui, Salma Masmoudi, Céline Brochier-Armanet, S. Maalej, S. Dukan

Int J Microbiol . -- : 347-58

Journal article

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Unsuspected Diversity of Arsenite-Oxidizing Bacteria Revealed by a Widespread Distribution of the aoxB Gene in Prokaryotes

A. Heinrich-Salmeron, A. Cordi, Céline Brochier-Armanet, D. Halter, C. Pagnout, E. Abbaszadeh-Fard...

Applied and Environmental Microbiology . 77 : 4685-92

DOI: 10.1128/AEM.02884-10

Journal article

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On the last common ancestor and early evolution of eukaryotes: reconstructing the history of mitochondrial ribosomes.

Elie Desmond-Le Quéméner, Celine Brochier-Armanet, Patrick Forterre, Simonetta Gribaldo

Research in Microbiology . 162 ( 1 ) : 53-70

DOI: 10.1016/j.resmic.2010.10.004

Journal article

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A eukaryotic-like sulfiredoxin involved in oxidative stress responses and in the reduction of the sulfinic form of 2 Cys-peroxiredoxin in the cyanobacterium Anabaena PCC 7120

C. Boileau, L. Eme, Céline Brochier-Armanet, A. Janicki, C-C. Zhang, A. Latifi

New Phytologist . 191 : 1108-1118

DOI: 10.1111/j.1469-8137.2011.03774.x

Journal article

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Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases.

Sylvie Auxilien, Anette Rasmussen, Simon Rose, Céline Brochier-Armanet, Clotilde Husson, Dominique Fourmy...

RNA . 17 ( 1 ) : 45-53

DOI: 10.1261/rna.2323411

Journal article

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Characteristics of a phylogenetically ambiguous, arsenic-oxidizing Thiomonas sp., Thiomonas arsenitoxydans strain 3As(T) sp. nov.

D. Slyemi, D. Moinier, Céline Brochier-Armanet, V. Bonnefoy, D. B. Johnson

Archives of Microbiology . 193 : 439-449

DOI: 10.1007/s00203-011-0684-y

Journal article

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Phylogenetic and genetic variation among Fe(II)-oxidizing acidithiobacilli supports the view that these comprise multiple species with different ferrous iron oxidation pathways

A. Amouric, Céline Brochier-Armanet, D. B. Johnson, V. Bonnefoy, K. B. Hallberg

Microbiology . 155 : 111-122

DOI: 10.1099/mic.0.044537-0

Journal article

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An oxygen reduction chain in the hyperthermophilic anaerobe Thermotoga maritima highlights horizontal gene transfer between Thermococcales and Thermotogales

C. Le Fourn, G. Brasseur, Céline Brochier-Armanet, L. Pieulle, A. Brioukhanov, B. Ollivier...

Environmental Microbiology . 13 : 2132-45

DOI: 10.1111/j.1462-2920.2011.02439.x

Journal article

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Comparative analysis of transposable elements in the melanogaster subgroup sequenced genomes.

Emmanuelle Lerat, Nelly Burlet, Christian Biémont, Cristina Vieira

Gene . 473 ( 2 ) : 100-9

DOI: 10.1016/j.gene.2010.11.009

Journal article

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Characterization of heterotrophic prokaryote subgroups in the Sfax coastal solar salterns by combining flow cytometry cell sorting and phylogenetic analysis

Hana Trigui, Salma Masmoudi, Céline Brochier-Armanet, Aude Barani, Gérald Grégori, Michel Denis...

Extremophiles . 15 : 347-358

DOI: 10.1007/s00792-011-0364-5

Journal article

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Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases.

Sylvie Auxilien, Anette Rasmussen, Simon Rose, Céline Brochier-Armanet, Clotilde Husson, Dominique Fourmy...

RNA . 17 ( 1 ) : 45-53

DOI: 10.1261/rna.2323411

Journal article

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Using the “CycADS” annotation management system to develop a BioCyc metabolic network database for sequenced arthropods genomes: first steps towards “ArthropodsCyc”

Patrice Baa-Puyoulet, Augusto Vellozo, Jaime Huerta-Cepas, Gérard Febvay, Toni Gabaldon, Marie-France Sagot...

Rencontres bioinformaticiens et statisticiens de l’INRA . : 1 p.

Poster

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Comparative high-throughput transcriptome sequencing and development of SiESTa, the \textitSilene EST annotation database

N. Blavet, D. Charif, C. Oger-Desfeux, Gabriel Marais, A. Widmer

BMC Genomics . 12 : 1-11

DOI: 10.1186/1471-2164-12-376

Journal article

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Absence of a core metabolic network common to symbiotic bacteria

Cecilia Coimbra Klein, Ludovic Cottret, Hubert Charles, Christian Gautier, Ana Tereza Ribeiro de Vasconcelos, Vincent Lacroix...

6. Meeting GDRE-RA Comparative genomics . : 33 diapositives

Conference paper

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CycADS: an annotation database system to ease the development and update of BioCyc databases.

Augusto F Vellozo, Amélie S Véron, Patrice Baa-Puyoulet, Jaime Huerta-Cepas, Ludovic Cottret, Gérard Febvay...

Database - The journal of Biological Databases and Curation . 2011 : bar008

DOI: 10.1093/database/bar008

Journal article

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Bacterial syntenies: an exact approach with gene quorum.

Yves-Pol Deniélou, Marie-France Sagot, Frédéric Boyer, Alain Viari

BMC Bioinformatics . 12 : 193

DOI: 10.1186/1471-2105-12-193

Journal article

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BioNetCAD: design, simulation and experimental validation of synthetic biochemical networks

Stéphanie Rialle, Liza Felicori, Camila Dias-Lopes, Sabine Peres, Sanaâ El Atia, Alain Thierry...

Bioinformatics . 26 ( 18 ) : 2298-2304

DOI: 10.1093/bioinformatics/btq409

Journal article

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Computing biological functions using BioΨ, a formal description of biological processes based on elementary bricks of actions

Sabine Peres, Liza Felicori, Stéphanie Rialle, Elodie Jobard, Franck Molina

Bioinformatics . 26 ( 12 ) : 1542-1547

DOI: 10.1093/bioinformatics/btq169

Journal article

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An efficient method to find potentially universal population genetic markers applied to metazoans

A. Chenuil, Thierry B. Hoareau, E. Egea, G. Penant, C. Rocher, D. Aurelle...

BMC Evolutionary Biology . 10 ( 276 ) : 1-17

DOI: 10.1186/1471-2148-10-276

Journal article

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Genetic perspectives on forager-farmer interaction in the Luangwa Valley of Zambia

Cesare de Filippo, Patricia Heyn, Lawrence Barham, Mark Stoneking, Brigitte Pakendorf

American Journal of Physical Anthropology . 141 ( 3 ) : 382-394

DOI: 10.1002/ajpa.21155

Journal article

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Conservation of Neutral Substitution Rate and Substitutional Asymmetries in Mammalian Genes

Carina Mugal, J. Wolf, H. von Grünberg, H. Ellegren

Genome Biology and Evolution . 2 : 19-28

DOI: 10.1093/gbe/evp056

Journal article

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Molecular evolution of genes in avian genomes

Ki Woong Nam, Carina Mugal, Benoit Nabholz, Holger Schielzeth, Jochen B W Wolf, Niclas Backström...

Genome Biology . 11 ( 6 ) : 17 p.

DOI: 10.1186/gb-2010-11-6-r68

Journal article

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Phylogénie moléculaire

Samuel Blanquart, Alexis Criscuolo, Christophe J Douady, Emmanuel Douzery, Nicolas Lartillot, Herve Philippe...

Biologie évolutive . 9782804101619

Book chapter

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Towards a multi-scale and formalized representation of protein sequence-structure-function relationships : the nsLTP family as a case of study

Cécile Fleury, Marie Francoise M. F. Gautier, Pierre Larmande, Sabine Pérès, Frédéric F. de Lamotte, Franck Molina...

JOBIM2010 .

Conference paper

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Towards a multi-scale and formalized representation of protein sequence-structure-function relationships : the nsLTP family as a case of study

Cécile Fleury, Marie Francoise M. F. Gautier, Pierre Larmande, Sabine Pérès, Frédéric F. de Lamotte, Franck Molina...

18. Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) .

Conference paper

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Towards a multi-scale and formalized representation of protein sequence-structure-function relationships : the nsLTP family as a case of study

Cécile Fleury, Marie Francoise M. F. Gautier, Pierre Larmande, Sabine Pérès, Frédéric F. de Lamotte, Franck Molina...

Séminaire Génomique Végétale .

Conference paper

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