GECO Evolutionary and Computational Genomics

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 721 to 750 publications on 1415 in total

Taxonomie et phylogénie des procaryotes. Chapitre 6

Pierre Caumette, Céline Brochier-Armanet, Philippe Normand

Ecologie Microbienne : Microbiologie des milieux naturels et anthropisés . 2-35311-022-3 9782353110223 : 1004 p.

2011

Book chapter

see the publication

Ultra-fast sequence clustering from similarity networks with SiLiX

V. Miele, Simon Penel, L. Duret

BMC Bioinformatics . 12(116) : 1-9

DOI: 10.1186/1471-2105-12-116

2011

Journal article

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Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

C. Chureau, S. Chantalat, A. Romito, A. Galvani, Laurent Duret, P. Avner...

Human Molecular Genetics . 20 : 705-718

DOI: 10.1093/hmg/ddq516

2011

Journal article

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Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations

Thierry Rouxel, J. Grandaubert, Jk. Hane, Claire Hoede, Angela P. van de Wouw, A. Couloux...

Nature Communications . 2 : 202

DOI: 10.1038/ncomms1189

2011

Journal article

see the publication

Wolbachia detection: an assessment of standard PCR protocols.

P. M. Simões, G. Mialdea, D. Reiss, Marie-France Sagot, S. Charlat

Molecular Ecology Resources . 11 ( 3 ) : 567-72

DOI: 10.1111/j.1755-0998.2010.02955.x

2011

Journal article

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Finding Long and Multiple Repeats with Edit Distance

Maria Federico, Pierre Peterlongo, Nadia Pisanti, Marie-France Sagot

The Prague Stringology Conference 2011 .

2011

Conference paper

see the publication

ArthropodaCyc: a BioCyc database powered by CycADS to study and compare the metabolism of arthropods

Patrice Baa-Puyoulet, Augusto F Vellozo, Jaime Huerta-Cepas, Gérard Febvay, T. Gabaldon, Marie-France Sagot...

5th Annual Arthropod Genomics Symposium "Arthropod Genomics 2011: Exploring Diversity, Relating Similarity" .

2011

Conference paper

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Close 3D proximity of evolutionary breakpoints argues for the notion of spatial synteny

Amélie Véron, Claire Lemaitre, Christian Gautier, Vincent Lacroix, Marie-France Sagot

BMC Genomics . 12 ( 1 ) : 303

DOI: 10.1186/1471-2164-12-303

2011

Journal article

see the publication

Initial metabolic reconstruction of Klebsiella pneumoniae Kp13, a multidrug resistant pathogen involved in nosocomial outbreaks in Brazil

P. Ivan, Cecilia C. Klein, Ludovic Cottret, Ana T Vasconcelos, Ac Gales, Marie-France Sagot...

X-meeting .

2011

Conference paper

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Tpms: a Tree Pattern-matching Utility for Querying Gene Trees Collections

Thomas Bigot, Vincent Daubin, G. Perrière

Journées Ouvertes Biologie Informatique Mathématiques (JOBIM) . : 111-112

2011

Conference paper

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Apport des nouvelles générations de séquençage pour accéder à la diversité des communautés microbiennes du sol : nécessité d’un ‘pipeline’ bio-informatique pour les biologistes

Sébastien Terrat, Richard Christen, Samuel S. Dequiedt, Pierre-Alain Maron, Christophe Mougel, Guy Perriere...

1ères Rencontres bioinformaticiens et statisticiens de l’INRA . : 1 p.

2011

Conference paper

see the publication

Adaptation to Environmental Temperature Is a Major Determinant of Molecular Evolutionary Rates in Archaea

M. Groussin, Manolo Gouy

Molecular Biology and Evolution . 28 : 2661-2674

DOI: 10.1093/molbev/msr098

2011

Journal article

see the publication

Pendant trois milliards d'années les micro-organismes sont les seuls habitants de la terre

J.C. Bertrand, Céline Brochier-Armanet, Manolo Gouy, F. Westall

incollection . 2-35311-022-3 9782353110223 : 94-U259

2011

Book chapter

see the publication

NGS without a reference genome, comparison and visualisation of non assembled data

Vincent Lacroix

Statistical Methods for Post-Genomic Data (SMPGD) .

2011

Conference paper

see the publication

Complete-fosmid and fosmid-end sequences reveal frequent horizontal gene transfers in marine uncultured planktonic archaea.

Céline Brochier-Armanet, Philippe Deschamps, Purificación López-García, Yvan Zivanovic, Francisco Rodríguez-Valera, David Moreira

The International Society of Microbiologial Ecology Journal . 5 ( 8 ) : 1291-302

DOI: 10.1038/ismej.2011.16

2011

Journal article

see the publication

A New Highly Conserved Antibiotic Sensing/Resistance Pathway in Firmicutes Involves an ABC Transporter Interplaying with a Signal Transduction System

S. Coumes-Florens, Céline Brochier-Armanet, A. Guiseppi, F. Denizot, M. Foglino

PLoS ONE . 6 : e15951

DOI: 10.1371/journal.pone.0015951

2011

Journal article

see the publication

Emergence and Modular Evolution of a Novel Motility Machinery in Bacteria

J. Luciano, R. Agrebi, A.V. Le Gall, M. Wartel, F. Fiegna, A. Ducret...

PLoS Genetics . 7 ( 9 ) : 1409-1418

DOI: 10.1371/journal.pgen.1002268

2011

Journal article

see the publication

Characterization of Halorubrum sfaxense sp. nov. a New Halophilic Archaeon Isolated from the Solar Saltern of Sfax in Tunisia

H. Trigui, Salma Masmoudi, Céline Brochier-Armanet, S. Maalej, S. Dukan

Int J Microbiol . -- : 347-58

2011

Journal article

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Unsuspected Diversity of Arsenite-Oxidizing Bacteria Revealed by a Widespread Distribution of the aoxB Gene in Prokaryotes

A. Heinrich-Salmeron, A. Cordi, Céline Brochier-Armanet, D. Halter, C. Pagnout, E. Abbaszadeh-Fard...

Applied and Environmental Microbiology . 77 : 4685-92

DOI: 10.1128/AEM.02884-10

2011

Journal article

see the publication

Archaea and the tree of life

Simonetta Gribaldo, Patrick Forterre, Celine Brochier-Armanet

Research in Microbiology . 162 ( 1 ) : 1-4

DOI: 10.1016/j.resmic.2010.11.007

2011

Journal article

see the publication

On the last common ancestor and early evolution of eukaryotes: reconstructing the history of mitochondrial ribosomes.

Elie Desmond-Le Quéméner, Celine Brochier-Armanet, Patrick Forterre, Simonetta Gribaldo

Research in Microbiology . 162 ( 1 ) : 53-70

DOI: 10.1016/j.resmic.2010.10.004

2011

Journal article

see the publication

A eukaryotic-like sulfiredoxin involved in oxidative stress responses and in the reduction of the sulfinic form of 2 Cys-peroxiredoxin in the cyanobacterium Anabaena PCC 7120

C. Boileau, L. Eme, Céline Brochier-Armanet, A. Janicki, C-C. Zhang, A. Latifi

New Phytologist . 191 : 1108-1118

DOI: 10.1111/j.1469-8137.2011.03774.x

2011

Journal article

see the publication

Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases.

Sylvie Auxilien, Anette Rasmussen, Simon Rose, Céline Brochier-Armanet, Clotilde Husson, Dominique Fourmy...

RNA . 17 ( 1 ) : 45-53

DOI: 10.1261/rna.2323411

2011

Journal article

see the publication

Characteristics of a phylogenetically ambiguous, arsenic-oxidizing Thiomonas sp., Thiomonas arsenitoxydans strain 3As(T) sp. nov.

D. Slyemi, D. Moinier, Céline Brochier-Armanet, V. Bonnefoy, D. B. Johnson

Archives of Microbiology . 193 : 439-449

DOI: 10.1007/s00203-011-0684-y

2011

Journal article

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Phylogenetic and genetic variation among Fe(II)-oxidizing acidithiobacilli supports the view that these comprise multiple species with different ferrous iron oxidation pathways

A. Amouric, Céline Brochier-Armanet, D. B. Johnson, V. Bonnefoy, K. B. Hallberg

Microbiology . 155 : 111-122

DOI: 10.1099/mic.0.044537-0

2011

Journal article

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An oxygen reduction chain in the hyperthermophilic anaerobe Thermotoga maritima highlights horizontal gene transfer between Thermococcales and Thermotogales

C. Le Fourn, G. Brasseur, Céline Brochier-Armanet, L. Pieulle, A. Brioukhanov, B. Ollivier...

Environmental Microbiology . 13 : 2132-45

DOI: 10.1111/j.1462-2920.2011.02439.x

2011

Journal article

see the publication

Comparative analysis of transposable elements in the melanogaster subgroup sequenced genomes.

Emmanuelle Lerat, Nelly Burlet, Christian Biémont, Cristina Vieira

Gene . 473 ( 2 ) : 100-9

DOI: 10.1016/j.gene.2010.11.009

2011

Journal article

see the publication

Characterization of heterotrophic prokaryote subgroups in the Sfax coastal solar salterns by combining flow cytometry cell sorting and phylogenetic analysis

Hana Trigui, Salma Masmoudi, Céline Brochier-Armanet, Aude Barani, Gérald Grégori, Michel Denis...

Extremophiles . 15 : 347-358

DOI: 10.1007/s00792-011-0364-5

2011

Journal article

see the publication

Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases.

Sylvie Auxilien, Anette Rasmussen, Simon Rose, Céline Brochier-Armanet, Clotilde Husson, Dominique Fourmy...

RNA . 17 ( 1 ) : 45-53

DOI: 10.1261/rna.2323411

2011

Journal article

see the publication

Using the “CycADS” annotation management system to develop a BioCyc metabolic network database for sequenced arthropods genomes: first steps towards “ArthropodsCyc”

Patrice Baa-Puyoulet, Augusto Vellozo, Jaime Huerta-Cepas, Gérard Febvay, Toni Gabaldon, Marie-France Sagot...

Rencontres bioinformaticiens et statisticiens de l’INRA . : 1 p.

2011

Poster

see the publication

GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

Publications

Taxonomie et phylogénie des procaryotes. Chapitre 6

Ultra-fast sequence clustering from similarity networks with SiLiX

Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations

Wolbachia detection: an assessment of standard PCR protocols.

Finding Long and Multiple Repeats with Edit Distance

ArthropodaCyc: a BioCyc database powered by CycADS to study and compare the metabolism of arthropods

Close 3D proximity of evolutionary breakpoints argues for the notion of spatial synteny

Initial metabolic reconstruction of Klebsiella pneumoniae Kp13, a multidrug resistant pathogen involved in nosocomial outbreaks in Brazil

Tpms: a Tree Pattern-matching Utility for Querying Gene Trees Collections

Apport des nouvelles générations de séquençage pour accéder à la diversité des communautés microbiennes du sol : nécessité d’un ‘pipeline’ bio-informatique pour les biologistes

Adaptation to Environmental Temperature Is a Major Determinant of Molecular Evolutionary Rates in Archaea

Pendant trois milliards d'années les micro-organismes sont les seuls habitants de la terre

NGS without a reference genome, comparison and visualisation of non assembled data

Complete-fosmid and fosmid-end sequences reveal frequent horizontal gene transfers in marine uncultured planktonic archaea.

A New Highly Conserved Antibiotic Sensing/Resistance Pathway in Firmicutes Involves an ABC Transporter Interplaying with a Signal Transduction System

Emergence and Modular Evolution of a Novel Motility Machinery in Bacteria

Characterization of Halorubrum sfaxense sp. nov. a New Halophilic Archaeon Isolated from the Solar Saltern of Sfax in Tunisia

Unsuspected Diversity of Arsenite-Oxidizing Bacteria Revealed by a Widespread Distribution of the aoxB Gene in Prokaryotes

Archaea and the tree of life

On the last common ancestor and early evolution of eukaryotes: reconstructing the history of mitochondrial ribosomes.

A eukaryotic-like sulfiredoxin involved in oxidative stress responses and in the reduction of the sulfinic form of 2 Cys-peroxiredoxin in the cyanobacterium Anabaena PCC 7120

Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases.

Characteristics of a phylogenetically ambiguous, arsenic-oxidizing Thiomonas sp., Thiomonas arsenitoxydans strain 3As(T) sp. nov.

Phylogenetic and genetic variation among Fe(II)-oxidizing acidithiobacilli supports the view that these comprise multiple species with different ferrous iron oxidation pathways

An oxygen reduction chain in the hyperthermophilic anaerobe Thermotoga maritima highlights horizontal gene transfer between Thermococcales and Thermotogales

Comparative analysis of transposable elements in the melanogaster subgroup sequenced genomes.

Characterization of heterotrophic prokaryote subgroups in the Sfax coastal solar salterns by combining flow cytometry cell sorting and phylogenetic analysis

Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases.

Using the “CycADS” annotation management system to develop a BioCyc metabolic network database for sequenced arthropods genomes: first steps towards “ArthropodsCyc”