Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 751 to 780 publications on 1006 in total

Mitochondrial DNA evidence for admixed origins of central Siberian populations

Brigitte Pakendorf, Victor Wiebe, Larissa Tarskaia, Victor Spitsyn, Himla Soodyall, Alexander Rodewald...

American Journal of Physical Anthropology . 120 ( 3 ) : 211-224

DOI: 10.1002/ajpa.10145

Journal article

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Neutral effect of recombination on base composition in Drosophila

Gabriel Marais, Dominique Mouchiroud, L. Duret

Genetical Research . 81 : 79-89

Journal article

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Placenta-Specific INSL4 Expression Is Mediated by a Human Endogenous Retrovirus Element

I. Bièche, A. Laurent, I. Laurendeau, L. Duret, Y. Giovangrandi, J.L. Frendo...

Biology of Reproduction . 68 : 1422-1429.

Journal article

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Patterns of selection against transposons inferred from the distribution of Tc1 Tc3 and Tc5 insertions in the mut-7 line of the nematode Caenorhabditis elegans

C. Rizzon, E. Martin, Gabriel Marais, L. Duret, L. Segalat, C. Biémont

Genetics . 165 : 1127-1135

Journal article

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G+C3 structuring along the genome: a common feature in prokaryotes

Vincent Daubin, G. Perrière

Molecular Biology and Evolution . 20 : 471-483

Journal article

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The source of laterally transferred genes in bacterial genomes

Vincent Daubin, E. Lerat, G. Perrière

Genome Biology . 4 : R57.1-R57.12

Journal article

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RTKdb: database of Receptor Tyrosine Kinase

J. Grassot, G. Mouchiroud, G. Perrière

Nucleic Acids Research . 31 : 353-358

Journal article

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Quelques problèmes statistiques rencontrés dans l`estimation de la température minimale de croissance de Listeria monocytogenes

S. Charles-Bajard, Jean-Pierre Flandrois, R. Tomassone

Revue de Statistique Appliquée . LI : 59-71

Journal article

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MgtC as a horizontally-acquired virulence factor of intracellular bacterial pathogens: evidence from molecular phylogeny and comparative genomics.

Anne-Béatrice Blanc-Potard, Bénédicte Lafay

Journal of Molecular Evolution . 57 ( 4 ) : 479-86

DOI: 10.1007/s00239-003-2496-4

Journal article

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From gene trees to organismal phylogeny in prokaryotes: the case of the gamma-Proteobacteria

Emmanuelle Lerat, Vincent Daubin, Nancy Moran

PLoS Biology . 1 ( 1 ) : 101-109

DOI: 10.1371/journal.pbio.0000019

Journal article

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Sequence divergence within transposable element families in the Drosophila melanogaster genome

E. Lerat, C. Rizzon, C. Biémont

Genome Research . 13 : 1889-1896

Journal article

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Integrated databanks access and sequence/structure analysis services at the PBIL.

G. Perriere, C. Combet, Simon Penel, Christophe Blanchet, J. Thioulouse, C. Geourjon...

Nucleic Acids Research . 31 ( 13 ) : 3393-3399

DOI: 10.1093/nar/gkg530

Journal article

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Patterns of selection against transposons inferred from the distribution of Tc1, Tc3 and Tc5 insertions in the mut-7 line of the nematode Caenorhabditis elegans.

Carène Rizzon, Edwige Martin, Gabriel Marais, Laurent Duret, Laurent Ségalat, Christian Biémont

Genetics . 165 ( 3 ) : 1127-35

Journal article

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ROSO: a software to search optimized oligonucleotide probes for microarrays

Nancie Reymond, Hubert Charles, Guillaume Beslon, Laurent Duret, Jean-Michel Fayard

14. Rencontres Régionales de la Recherche .

Poster

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Subcellular localization of 14-3-3 proteins in Toxoplasma gondii tachyzoites and evidence for a lipid raft-associated form

Jean-Pierre Rouault, Olga Assossou, Franã§oise Besson, Florence Persat, Christine Brisson, Laurent Duret...

FEMS Microbiology Letters . 224 ( 2 ) : 161-168

DOI: 10.1016/S0378-1097(03)00479-8

Journal article

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Subcellular localization of 14-3-3 proteins in Toxoplasma gondii tachyzoites and evidence for a lipid raft-associated form

O. Assossou, F. Besson, J.P. Rouault, F. Persat, C. Brisson, L. Duret...

FEMS Microbiology Letters . 224 : 161-168.

DOI: 10.1016/S0378-1097(03)00479-8

Journal article

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Patterns of selection against transposons inferred from the distribution of Tcl, Tc3 and Tc5 insertions in the mut-7 line of the nematode Caenorhabditis elegans.

C. Rizzon, E. Martin, G. Marais, L. Duret, L. Segalat, C. Biemont

Genetics . ( 165 ) : 1127-1135

Journal article

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Use of Correspondence Discriminant Analysis to predict the subcellular location of bacterial proteins

G. Perrière, J. Thioulouse

Computer Methods and Programs in Biomedicine . 70 : 99-105

Journal article

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Cross-platform comparison and visualisation of gene expression data using co-inertia analysis

A.C. Culhane, G. Perrière, D.G. Higgins

BMC Bioinformatics . 4 : 1-15

Journal article

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BIBI a bioinformatics bacterial identification tool

G. Devulder, G. Perrière, F. Baty, Jean-Pierre Flandrois

Journal of Clinical Microbiology . 41 : 1785-1787

Journal article

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RTKdb: database of Receptor Tyrosine Kinase.

Julien Grassot, Guy Mouchiroud, Guy Perrière

Nucleic Acids Research . 31 ( 1 ) : 353-8

Journal article

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A method to study the microscale 3-D spatial distribution of Bacteria in soil.

A. Dechesne, C. Pallud, D. Debouzie, Jean-Pierre Flandrois, J.P. Gaudet, G.L. Grundmann

Mycological Research . 107 : 1221-1230

Journal article

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Phylogenetic analysis of proteins homologous to the Salmonella MgtC virulence factor

Anne-Béatrice Blanc-Potard, Bénédicte Lafay

ASM Conference on Salmonella: Pathogenesis, Epidemiology, and Vaccine Development .

Conference paper

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A novel method for characterizing the microscale 3D spatial distribution of bacteria in soil

A. Dechesne, C. Pallud, D. Debouzie, J. P. Flandrois, T. M. Vogel, J. P. Gaudet...

Soil Biology and Biochemistry . 35 ( 12 ) : 1537-1546

DOI: 10.1016/S0038-0717(03)00243-8

Journal article

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Y-chromosomal evidence for a strong reduction in male population size of Yakuts

Brigitte Pakendorf, Bharti Morar, Larissa A Tarskaia, Manfred Kayser, Himla Soodyall, Alexander Rodewald...

Human Genetics . 110 ( 2 ) : 198-200

DOI: 10.1007/s00439-001-0664-4

Journal article

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Expected Relationship Between the Silent Substitution Rate and the GC Content: Implications for the Evolution of Isochores

G. Piganeau, Dominique Mouchiroud, L. Duret, Christian Gautier

Journal of Molecular Evolution . 54 : 129-133.

Journal article

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Detecting genomic features under weak selective pressure: the example of codon usage in animals and plants

L. Duret

Bioinformatics . 18 : S91-S91

Journal article

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A phylogenomic approach to bacterial phylogeny: evidence of a core of genes sharing a common history

Vincent Daubin, Manolo Gouy, G. Perrière

Genome Research . 12 : 1080-1090

DOI: 10.1101/gr.187002

Journal article

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Between-group analysis of microarray data

A.C. Culhane, G. Perrière, E.C. Considine, T.G. Cotter, D.G. Higgins

Bioinformatics . 18 : 1600-1608

Journal article

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Use and misuse of correspondence analysis in codon usage studies

G. Perrière, J. Thioulouse

Nucleic Acids Research . 30 : 4548-4555

Journal article

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