Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 811 to 840 publications on 1006 in total

GC-content evolution in mammalian genomes: the biased gene conversion hypothesis

N. Galtier, G. Piganeau, Dominique Mouchiroud, L. Duret

Genetics . 159 : 907-911

Journal article

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Plant Physiol.A Medicago truncatula homoglutathione synthetase is derived from glutathione synthetase by gene duplication

P. Frendo, M.J. Jimenez, C. Mathieu, L. Duret, D. Gallesi, G. van de Sype...

Plant Physiology . 126 : 1706-1715

Journal article

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The elevated GC content at exonic third sites is not evidence against neutralist models of isochore evolution

L. Duret, L.D. Hurst

Molecular Biology and Evolution . 18 : 757-762

Journal article

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Intragenomic base content variation is a potential source of biases when searching for horizontally transferred genes

Stéphane Guindon, G. Perrière

Molecular Biology and Evolution . 18 ( 9 ) : 1838-1840

DOI: 10.1093/oxfordjournals.molbev.a003972

Journal article

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Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis

A. Aouacheria, Estelle Arnaud, S. Venet, P. Lalle, M. Gouy, D. Rigal...

Oncogene . 20 : 5846-5855

DOI: 10.1038/sj.onc.1204740

Journal article

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Molecular evidence for the existence of two species of Marteilia in Europe

F. Le Roux, G. Lorenzo, P. Peyret, C. Audemard, A. Figueras, C. Vivares...

Journal of Eukaryotic Microbiology . 48 ( 4 ) : 449-454

DOI: 10.1111/j.1550-7408.2001.tb00178.x

Journal article

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Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi

M.D. Katinka, S. Duprat, E. Cornillot, G. Metenier, F. Thomarat, G. Prensier...

Nature . 414 : 450-453

DOI: 10.1038/35106579

Journal article

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A mathematical model describing the thermal virus inactivation

C. Noel, Sandrine Charles, A. Francon, Jean-Pierre Flandrois

Vaccine . 19 : 3575-3582

Journal article

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Comparaison de séquences d`éléments transposables et de gènes d`hôtes chez cinq espèces : A. Thaliana C. Elegans D. Melanogaster H. Sapiens S. Cerevisiae

E. Lerat

incollection . -- : 347-354

Journal article

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Small-subunit rRNA genotyping of rhizobia nodulating Australian Acacia spp.

Bénédicte Lafay, Jeremy J. Burdon

Applied and Environmental Microbiology . 67 ( 1 ) : 396-402

DOI: 10.1128/AEM.67.1.396-402.2001

Journal article

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Fitness and competitive growth advantage of new gentamicin-susceptible MRSA clones spreading in French hospitals

Jean-Pierre Flandrois, F. Laurent

Journal of Antimicrobial Chemotherapy . 47 ( 3 ) : 277-283

DOI: 10.1093/jac/47.3.277

Journal article

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Gene flow in a facultative apomictic poacea the savanna grass Hyparrhenia diplandra

J. Durand, L. Garnier, I. Dajoz, Sylvain Mousset, M. Veuille

Genetics . 156 : 823-831

Journal article

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Selective sweep near the In(2L)t inversion breakpoint in an African population of Drosophila melanogaster

F. Depaulis, L. Brazier, Sylvain Mousset, A. Turbe, M. Veuille

Genetical Research . 76 : 149-158

Journal article

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Identification and molecular analysis of BANP

Anne-Marie Birot, Laurent Duret, Laurent Bartholin, Bénédicte Santalucia, Isabelle Tigaud, Jean-Pierre Magaud...

Gene . 253 ( 2 ) : 189-196

DOI: 10.1016/S0378-1119(00)00244-4

Journal article

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EuGene an eurocaryotic gene finder that combines several sources of evidence

Thomas Schiex, A. Moisan, L. Duret, Pierre Rouzé

Journées ouvertes biologie informatique mathématiques .

Conference paper

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tRNA gene number and codon usage in the C. elegans genome are co-adapted for optimal translation of highly expressed genes

L. Duret

Trends in Genetics . 16 : 287-289

Journal article

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HOBACGEN: database system for comparative genomics in bacteria

G. Perrière, L. Duret, Manolo Gouy

Genome Research . 10 : 379-385

DOI: 10.1101/gr.10.3.379

Journal article

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The covariation between TpA deficiency CpG deficiency and G+C content of human isochores is due to a mathematical artifact

L. Duret, N. Galtier

Molecular Biology and Evolution . 17 : 1620-1625

Journal article

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Nature and structure of human genes that generate retropseudogenes

I. Goncalves, L. Duret, Dominique Mouchiroud

Genome Research . 10 : 672-678

Journal article

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Determinants of substitution rates in mammalian genes: expression pattern affects selection intensity but not mutation rate

L. Duret, Dominique Mouchiroud

Molecular Biology and Evolution . 17 : 68-74

Journal article

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Use of a TT virus ORF1 recombinant protein to detect anti-TT virus antibodies in human sera

C. Ott, L. Duret, I. Chemin, C. Trepo, B. Mandrand, F. Komurian-Pradel

Journal of General Virology . 81 : 2949-2958

Journal article

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The Enhanced Microbial Genomes Library

G. Perrière, P. Bessieres, B. Labedan

Nucleic Acids Research . 27 : 63-65

Journal article

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EMGLib: the enhanced microbial genomes library (update 2000)

G. Perrière, P. Bessieres, B. Labedan

Nucleic Acids Research . 28 ( 1 ) : 68-71

DOI: 10.1093/nar/28.1.68

Journal article

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Phylogenetic analysis of the small subunit ribosomal RNA of Marteilia refringens validates the existence of phylum Paramyxea (Desportes and Perkins 1990)

F.C. Berthe, F. Le Roux, E. Peyretaillade, P. Peyret, D. Rodriguez, Manolo Gouy...

Journal of Eukaryotic Microbiology . 47 ( 3 ) : 288-293

DOI: 10.1111/j.1550-7408.2000.tb00049.x

Journal article

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Codon usage and the origin of P elements

E. Lerat, C. Biémont, P. Capy

Molecular Biology and Evolution . 17 : 467-468

Journal article

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Transposons but not retrotransposons are located preferentially in regions of high recombination rate in Caenorhabditis elegans

L. Duret, Gabriel Marais, C. Biémont

Genetics . 156 : 1661-1669

Journal article

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Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family

C. Voisset, O. Bouton, F. Bedin, L. Duret, B. Mandrand, Frédéric Mallet...

AIDS Research and Human Retroviruses . 16 : 731-740

Journal article

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Multiple alignments for structural functional or phylogenetic analyses of homologous sequences

L. Duret, S. Abdeddaim

incollection . -- : 51-76

Journal article

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Sequence of the Small Subunit Ribosomal RNA Gene of Perkinsus atlanticus-like Isolated from Carpet Shell Clam in Galicia Spain

A. Figueras, G. Lorenzo, M.C. Ordas, Manolo Gouy, B. Novoa

Marine Biotechnology . 2 : 419-428

DOI: 10.1007/s101260000015

Journal article

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Phylogénies moléculaires et génomes

Céline Brochier-Armanet, H. Philippe

incollection . 206 : 50-53

Journal article

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