Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 271 to 300 publications on 1006 in total

The non-equilibrium allele frequency spectrum in a Poisson random field framework

Ingemar Kaj, Carina Mugal

Theoretical Population Biology . 111 : 51-64

DOI: 10.1016/j.tpb.2016.06.003

Journal article

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Detection and interpretation of shared genetic influences on 42 human traits

Joseph Pickrell, Tomaz Berisa, Jimmy Liu, Laure Ségurel, Joyce Tung, David A Hinds

Nature Genetics . 48 ( 7 ) : 709-717

DOI: 10.1038/ng.3570

Journal article

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Detection of Allelic Frequency Differences between the Sexes in Humans: A Signature of Sexually Antagonistic Selection

Elise Lucotte, Romain Laurent, Evelyne Heyer, Laure Ségurel, Bruno Toupance

Genome Biology and Evolution . 8 ( 5 ) : 1489-1500

DOI: 10.1093/gbe/evw090

Journal article

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Oxygen isotope fractionation between bird eggshell calcite and body water: application to fossil eggs from Lanzarote (Canary Islands)

Nicolas Lazzerini, Christophe Lécuyer, Romain Amiot, Delphine Angst, Eric Buffetaut, François Fourel...

The Science of Nature Naturwissenschaften . 103 ( 9-10 )

DOI: 10.1007/s00114-016-1404-x

Journal article

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Genome-wide analysis identifies gain and loss/change of function within the small multigenic insecticidal Albumin 1 family of Medicago truncatula

L Karaki, P da Silva, F Rizk, C Chouabe, N Chantret, V Eyraud...

BMC Plant Biology . 16 ( 1 ) : 63

DOI: 10.1186/s12870-016-0745-0

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Novel genomic island modifies DNA with 7-deazaguanine derivatives

J.J. Thiaville, S.M. Kellner, Y. Yuan, G. Hutinet, P.C. Thiaville, W. Jumpathong...

Proceedings of the National Academy of Sciences of the United States of America . 113 : e1452-e1459

Journal article

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Evolutionary history of the mammalian synaptonemal complex

J. Fraune, Céline Brochier-Armanet, M. Alsheimer, J. N. Volff, K. Schucker, R. Benavente

Chromosoma . 125 : 355-60

DOI: 10.1007/s00412-016-0583-8

Journal article

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Closing the gap between rocks and clocks using total-evidence dating

F. Ronquist, Nicolas Lartillot, M.J. Phillips

Philosophical Transactions of the Royal Society B: Biological Sciences . 371 : 20150136

DOI: 10.1098/rstb.2015.0136

Journal article

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Lower prevalence but similar fitness in a parasitic fungus at higher radiation levels near Chernobyl

Gabriela G. Aguileta, Helene Badouin, Michael E Hood, Anders Pape Møller, Stephanie Le Prieur, Alodie Snirc...

Molecular Ecology . 25 ( 14 ) : 3370-83

DOI: 10.1111/mec.13675

Journal article

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The changing view of eukaryogenesis - fossils, cells, lineages and how they all come together

J. B. Dacks, M. C. Field, R. Buick, L. Eme, Simonetta Gribaldo, A. J. Roger...

Journal of Cell Science . 129 ( 20 ) : 3695-3703

DOI: 10.1242/jcs.178566

Journal article

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A mixed relaxed clock model

Nicolas Lartillot, M. J. Phillips, F. Ronquist

Philosophical Transactions of the Royal Society B: Biological Sciences . 371 : 20150132

DOI: 10.1098/rstb.2015.0132

Journal article

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Polymorphic Microsatellite Markers for the Tetrapolar Anther-Smut Fungus Microbotryum saponariae Based on Genome Sequencing

Taiadjana M. Fortuna, Alodie Snirc, Hélène Badouin, Jerome Gouzy, Sophie Siguenza, Diane Esquerre...

PLoS ONE . 11 ( 11 ) : e0165656

DOI: 10.1371/journal.pone.0165656

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Qualité des données NGS : de la séquence aux bases de données

Pierre Peyret, Julie Aubert, Vincent Breton, François Enault, Line Le Gall, Denis Le Paslier...

La génomique environnementale . 978-1-78405-151-8 : 180 p.

Book chapter

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Gene Acquisitions from Bacteria at the Origins of Major Archaeal Clades Are Vastly Overestimated

Mathieu Groussin, Bastien Boussau, Gergely J Szollosi, Laura Eme, Manolo Gouy, Céline Brochier-Armanet...

Molecular Biology and Evolution . 33 ( 2 ) : 305 - 310

DOI: 10.1093/molbev/msv249

Journal article

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RiboDB database: a comprehensive resource for prokaryotic systematics

Frédéric Jauffrit, Simon Penel, Stéphane Delmotte, Carine Rey, Damien M de Vienne, Manolo Gouy...

Molecular Biology and Evolution . 33 ( 8 ) : 2170--2172

DOI: 10.1093/molbev/msw088

Journal article

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Combined Genotypic, Phylogenetic, and Epidemiologic Analyses of Mycobacterium tuberculosis Genetic Diversity in the Rhône Alpes Region, France

Catherine Pichat, David Couvin, Gérard Carret, Isabelle Frédénucci, Véronique Jacomo, Anne Carricajo...

PLoS ONE . 11 ( 4 ) : e0153580

DOI: 10.1371/journal.pone.0153580

Journal article

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Silencing of natural transformation by an RNA chaperone and a multitarget small RNA

Laetitia Attaiech, Aïda Boughammoura, Céline Brochier-Armanet, Omran Allatif, Flora Peillard-Fiorente, Ross A. Edwards...

Proceedings of the National Academy of Sciences of the United States of America . 113 ( 31 ) : 8813-8818

DOI: 10.1073/pnas.1601626113

Journal article

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Transcriptional start site turnover in the evolution of bacterial paralogous genes - the pelE-pelD virulence genes in Dickeya

Alexandre Duprey, William Nasser, Simon Leonard, Céline Brochier-Armanet, Sylvie Reverchon

FEBS Journal . 283 ( 22 ) : 4192-4207

Journal article

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Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

R. Schep, A. Necsulea, E. Rodriguez-Carballo, I. Guerreiro, G. Andrey, T.H. Nguyen Huynh...

Proceedings of the National Academy of Sciences of the United States of America . 113 ( 48 ) : e7720-e7729

DOI: 10.1073/pnas.1617141113

Journal article

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Phylogenomic analysis supports the ancestral presence of LPS-outer membranes in the Firmicutes.

Luisa Cs Antunes, Daniel Poppleton, Andreas Klingl, Alexis Criscuolo, Bruno Dupuy, Céline Brochier-Armanet...

eLife . 5 : e14589

DOI: 10.7554/eLife.14589.020

Journal article

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Cell division of Streptococcus pneumoniae: think positive!

P. S. Garcia, J. P. Simorre, Céline Brochier-Armanet, C. Grangeasse

Current Opinion in Microbiology . 34 : 18-23

DOI: 10.1016/j.mib.2016.07.014

Journal article

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Reply to Halanych et al.

Davide Pisani, Walker Pett, Martin Dohrmann, Roberto Feuda, Omar Rota-Stabelli, Herve Philippe...

Proceedings of the National Academy of Sciences of the United States of America . 113 ( 8 ) : E948-E949

DOI: 10.1073/pnas.1525718113

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A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

L. Beccari, N. Yakushiji-Kaminatsui, J. M. Woltering, A. Necsulea, N. Lonfat, E. Rodriguez-Carballo...

Genes and Development . 30 : 1172-86

DOI: 10.1101/gad.281055.116

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RevBayes: Bayesian Phylogenetic Inference Using Graphical Models and an Interactive Model-Specification Language

S. Hohna, M. J. Landis, T. A. Heath, Bastien Boussau, Nicolas Lartillot, B. R. Moore...

Systematic Biology . 65 : 726-36

DOI: 10.1093/sysbio/syw021

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The transposable element environment of human genes is associated with histone and expression changes in cancer

Laura Grégoire, Annabelle A. Haudry, Emmanuelle Lerat

BMC Genomics . 17 ( 1 )

DOI: 10.1186/s12864-016-2970-1

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No Evidence That Nitrogen Limitation Influences the Elemental Composition of Isopod Transcriptomes and Proteomes

Clémentine François, L. Duret, Laurent Simon, Florian Mermillod-Blondin, Florian Malard, Lara Konecny-Dupré...

Molecular Biology and Evolution . 33 ( 10 ) : 2605–2620

DOI: 10.1093/molbev/msw131

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Recombination Rate Variation Modulates Gene Sequence Evolution Mainly via GC-Biased Gene Conversion, Not Hill–Robertson Interference, in an Avian System

Paulina Bolívar, Carina Mugal, Alexander Nater, Hans Ellegren

Molecular Biology and Evolution . 33 ( 1 ) : 216-227

DOI: 10.1093/molbev/msv214

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