Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 421 to 450 publications on 1095 in total

Comparative population genomics in animals uncovers the determinants of genetic diversity

Jonathan Romiguier, P Gayral, M Ballenghien, Arnaud Bernard, V Cahais, Anne Chenuil...

Nature . 515 ( 7526 ) : 261-263

DOI: 10.1038/nature13685

Journal article

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Phylogenomic test of the hypotheses for the evolutionary origin of eukaryotes

Nc. Rochette, Céline Brochier-Armanet, M. Gouy

Molecular Biology and Evolution . 31 ( 4 ) : 832-45

DOI: 10.1093/molbev/mst272

Journal article

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Fungal evolutionary genomics provides insight into the mechanisms of adaptive divergence in eukaryotes

Pierre P. Gladieux, Jeanne Ropars, Helene Badouin, Antoine Branca, Gabriela G. Aguileta, Damien M. de Vienne...

Molecular Ecology . 23 ( 4 ) : 753-773

DOI: 10.1111/mec.12631

Journal article

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Optimization of the reactional medium and a food impact study for a colorimetric in situ Salmonella spp. detection method

L. Morand, D. Michel, Jean-Pierre Flandrois, T. Junillon, D. Mosticon, B. Mallen...

International Journal of Food Microbiology . 181 : 48-52

Journal article

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Enhanced tetrazolium violet reduction of Salmonella spp. by magnesium addition to the culture media

T. Junillon, L. Morand, Jean-Pierre Flandrois

Food Microbiology . 42 : 132-135

Journal article

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Ribosomal proteins: Toward a next generation standard for prokaryotic systematics?

Hemalatha Golaconda Ramulu, Mathieu Groussin, Emmanuel Talla, Rémi Planel, Vincent Daubin, Céline Brochier-Armanet

Molecular Phylogenetics and Evolution . 75 : 103 - 117

DOI: 10.1016/j.ympev.2014.02.013

Journal article

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Anaerobic oxidation of long-chain n-alkanes by the hyperthermophilic sulfate-reducing archaeon, Archaeoglobus fulgidus.

Nadia Khelifi, Oulfat Amin Ali, Philippe Roche, Vincent Grossi, Céline Brochier-Armanet, Odile Valette...

The International Society of Microbiologial Ecology Journal . : 18

DOI: 10.1038/ismej.2014.58

Journal article

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Halomonas olivaria sp. nov., a moderately halophilic bacterium isolated from olive-processing effluents

A. Amouric, Pierre-Pol Liebgott, M. Joseph, Céline Brochier-Armanet, J. Lorquin

International Journal of Systematic and Evolutionary Microbiology . 64 ( Pt 1 ) : 46 - 54

DOI: 10.1099/ijs.0.049007-0

Journal article

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Global phylogenomic analysis disentangles the complex evolutionary history of DNA replication in archaea.

Kasie Raymann, Patrick Forterre, Céline Brochier-Armanet, Simonetta Gribaldo

Genome Biology and Evolution . 6 ( 1 ) : 192-212

DOI: 10.1093/gbe/evu004

Journal article

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“One code to find them all”: a perl tool to conveniently parse RepeatMasker output files

Marc Bailly-Bechet, Annabelle Haudry, Emmanuelle Lerat

Mobile DNA . 5 : 13

DOI: 10.1186/1759-8753-5-13

Journal article

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Dioecy is associated with higher diversification rates in flowering plants

Jos Käfer, Hugo J de Boer, Sylvain Mousset, Anneleen Kool, Mathilde Dufaÿ, Gabriel A.B. Marais

Journal of Evolutionary Biology . 27 : 1478-1490

DOI: 10.1111/jeb.12385

Journal article

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Reductive genome evolution at both ends of bacterial population size spectrum

Bérénice Batut, Carole Knibbe, Gabriel Marais, Vincent Daubin

Nature Reviews Microbiology . 12 ( 12 ) : 841-850

DOI: 10.1038/nrmicro3331

Journal article

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Identification and Analysis of Transposable Elements in Genomic Sequences

Laurent Modolo, Emmanuelle Lerat

Genome analysis, current procedures and applications . 978-1-908230-29-4

Book chapter

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Formation of chromosome in bacteria

Olivier Poirion, Bénédicte Lafay

FEBS-EMBO 2014 Conference .

Conference paper

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A Haploid System of Sex Determination in the Brown Alga Ectocarpus sp.

Sophia S. Ahmed, J. Mark Cock, Eugenie Pessia, Remy Luthringer, Alexandre Cormier, Marine Robuchon...

Current Biology . 24 ( 17 ) : 1945-1957

DOI: 10.1016/j.cub.2014.07.042

Journal article

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Sex uncovered: the evolutionary biology of reproductive systems

T. Schwander, Gabriel Marais, D. Roze

Journal of Evolutionary Biology . 27 : 1287-91

Journal article

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Specific Activation of an I-Like Element in Drosophila Interspecific Hybrids

Elias a G Carnelossi, Emmanuelle Lerat, Hélène Henri, Sonia Martinez, Claudia M A Carareto, Cristina Vieira

Genome Biology and Evolution . 6 : 1806 - 1817

DOI: 10.1093/gbe/evu141

Journal article

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GC-Biased Gene Conversion in Yeast Is Specifically Associated with Crossovers: Molecular Mechanisms and Evolutionary Significance

Y. Lesecque, D. Mouchiroud, L. Duret

Molecular Biology and Evolution . 30 : 1409--19

DOI: 10.1093/molbev/mst056

Journal article

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XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells

C. Vallot, C. Huret, Yann Lesecque, A. Resch, N. Oudrhiri, A. Bennaceur-Griscelli...

Nature Genetics . 45 : 239--41

DOI: 10.1038/ng.2530

Journal article

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The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes

S. B. Montgomery, D. L. Goode, E. Kvikstad, C. A. Albers, Z. D. Zhang, X. J. Mu...

Genome Research . 23 : 749--61

DOI: 10.1101/gr.148718.112

Journal article

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PCR survey of 50 introns in animals: Cross-amplification of homologous EPIC loci in eight non-bilaterian, protostome and deuterostome phyla

K. Gerard, E. Guilloton, S. Arnaud-Haond, Didier Aurelle, R. Bastrop, Pierre Chevaldonné...

Marine Genomics . 12 : 1-8

DOI: 10.1016/j.margen.2013.10.001

Journal article

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The short-term impact of wetland restoration on the genetic diversity of a predominantly clonal plant species

Jehanne Oudot-Canaff, Gudrun Bornette, Marie-Rose Viricel, Florence Piola, Sylvain Mousset, Evelyne Martel

Aquatic Botany . 110 : 16-23

DOI: 10.1016/j.aquabot.2013.04.006

Journal article

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Ancient Substructure in Early mtDNA Lineages of Southern Africa

Chiara Barbieri, Mário Vicente, Jorge Rocha, Sununguko w. Mpoloka, Mark Stoneking, Brigitte Pakendorf

American Journal of Human Genetics . 92 ( 2 ) : 285-292

DOI: 10.1016/j.ajhg.2012.12.010

Journal article

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Genome-wide analysis in chicken reveals that local levels of genetic diversity are mainly governed by the rate of recombination

Carina Mugal, Benoit Nabholz, Hans Ellegren

BMC Genomics . 14 ( 1 ) : 86

DOI: 10.1186/1471-2164-14-86

Journal article

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Twisted Signatures of GC-Biased Gene Conversion Embedded in an Evolutionary Stable Karyotype

Carina Mugal, Peter Arndt, Hans Ellegren

Molecular Biology and Evolution . 30 ( 7 ) : 1700-1712

DOI: 10.1093/molbev/mst067

Journal article

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Human Genetic Data Reveal Contrasting Demographic Patterns between Sedentary and Nomadic Populations That Predate the Emergence of Farming

Carla Aimé, Guillaume Laval, Etienne Patin, Paul Verdu, Laure L. Segurel, Raphaëlle Chaix...

Molecular Biology and Evolution . 30 ( 12 ) : 2629 - 2644

DOI: 10.1093/molbev/mst156

Journal article

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Ancestry runs deeper than blood: The evolutionary history of ABO points to cryptic variation of functional importance

Laure L. Segurel, Ziyue Gao, Molly Przeworski

BioEssays . : n/a-n/a

DOI: 10.1002/bies.201300030

Journal article

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Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees

E. Leffler, Z. Gao, S. Pfeifer, L. Segurel, A. Auton, O. Venn...

Science . 339 ( 6127 ) : 1578-1582

DOI: 10.1126/science.1234070

Journal article

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Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia

Laure Ségurel, Frédéric Austerlitz, Bruno Toupance, Mathieu M. Gautier, Joanna L Kelley, Patrick Pasquet...

European Journal of Human Genetics . 21 ( 10 ) : 1146-1151

DOI: 10.1038/ejhg.2012.295

Journal article

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