Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 361 to 390 publications on 1095 in total

Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns

H. Philippon, Céline Brochier-Armanet, G. Perriere

BMC Evolutionary Biology . 15 : 226

DOI: 10.1186/s12862-015-0498-7

Journal article

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Molecular and functional evolution of the fungal diterpene synthase genes

Marc Fischer, Camille Rustenhloz, Véronique Leh-Louis, Guy Perrière

BMC Microbiology . 15 ( 1 ) : 221

DOI: 10.1186/s12866-015-0564-8

Journal article

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leBIBIQBPP: a set of databases and a webtool for automatic phylogenetic analysis of prokaryotic sequences

Jean-Pierre Flandrois, G. Perrière, Manolo Gouy

BMC Bioinformatics . 16 ( 1 ) : 251

DOI: 10.1186/s12859-015-0692-z

Journal article

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A Toolbox for Nonlinear Regression in R: The Package nistools

F. Baty, C. Ritz, Sandrine Charles, M. Brutsche, Jean-Pierre Flandrois, Marie Laure Delignette-Muller

Journal of Statistical Software . 66 : 1-21

Journal article

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Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for Colonization

Daniel Vinella, Frédéric Fischer, Egor Vorontsov, Julien Gallaud, Christian Malosse, Valérie Michel...

PLoS Pathogens . 11 ( 12 ) : e1005312

DOI: 10.1371/journal.ppat.1005312

Journal article

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Exploration of Frankia genomes to identify genetic determinants involved in sporogenesis: Towards promising tracks to understand in plant sporuration

Lorine Bethencourt, N. Taib, J. Briolay, P. Fournier, M.P. Fernandez, Céline Brochier-Armanet...

18th International Meeting on Frankia and Actinorhizal plants .

Poster

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Evolution and Design Governing Signal Precision and Amplification in a Bacterial Chemosensory Pathway

Mathilde Guzzo, Rym Agrebi, Leon Espinosa, Gregory Baronian, Virginie Molle, Emilia M. F. Mauriello...

PLoS Genetics . 11 ( 8 ) : e1005460

DOI: 10.1371/journal.pgen.1005460

Journal article

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Taxonomy and Phylogeny of Prokaryotes

Pierre Caumette, Céline Brochier-Armanet, Philippe Normand

Environmental Microbiology: Fundamentals and Applications . 978-94-017-9118-2 : 145-190

DOI: 10.1007/978-94-017-9118-2_6

Book chapter

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Draft genome sequence of Mesotoga strain PhosAC3, a mesophilic member of the bacterial order Thermotogales, isolated from a digestor treating phosphogypsum in Tunisia

Wajdi Ben Hania, Khaled Fadhlaoui, Céline Brochier-Armanet, Cecile Persillon, Anne Postec, Moktar Hamdi...

Standards in Genomic Sciences . 10

DOI: 10.1186/1944-3277-10-12

Journal article

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Genome-wide survey of two-component signal transduction systems in the plant growth-promoting bacterium Azospirillum

Stéphanie Borland, Anne Oudart, Claire Prigent-Combaret, Céline Brochier-Armanet, Florence Wisniewski-Dyé

BMC Genomics . 16 : 833

DOI: 10.1186/s12864-015-1962-x

Journal article

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Extending the conserved phylogenetic core of \textitarchaea disentangles the evolution of the third domain of life

C. Petitjean, P. Deschamps, P. Lopez-Garcia, D. Moreira, Céline Brochier-Armanet

Molecular Biology and Evolution . 32 : 1242-54

Journal article

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Constitutive arsenite oxidase expression detected in arsenic-hypertolerant Pseudomonas xanthomarina S11

S. Koechler, F. Arsene-Ploetze, Céline Brochier-Armanet, F. Goulhen-Chollet, A. Heinrich-Salmeron, B. Jost...

Research in Microbiology . 166 : 205-14

Journal article

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Degeneration of the Nonrecombining Regions in the Mating-Type Chromosomes of the Anther-Smut Fungi

Eric Fontanillas, Michael E Hood, Hélène Badouin, Elsa Petit, Valérie Barbe, Jerome Gouzy...

Molecular Biology and Evolution . 32 ( 4 ) : 928-943

DOI: 10.1093/molbev/msu396

Journal article

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Chaos of Rearrangements in the Mating-Type Chromosomes of the Anther-Smut Fungus Microbotryum lychnidis-dioicae

Hélène Badouin, Michael E Hood, Jerome Gouzy, Gabriela Aguileta, Sophie Siguenza, Michael H Perlin...

Genetics . 200 ( 4 ) : 1275-1284

DOI: 10.1534/genetics.115.177709

Journal article

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Sex and parasites: genomic and transcriptomic analysis of Microbotryum lychnidis-dioicae, the biotrophic and plant-castrating anther smut fungus

Michael H Perlin, Joelle J. Amselem, Eric Fontanillas, Su San Toh, Zehua Chen, Jonathan Goldberg...

BMC Genomics . 16 ( 461 ) : np

DOI: 10.1186/s12864-015-1660-8

Journal article

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An evolutionary link between capsular biogenesis and surface motility in bacteria

Rym Agrebi, Morgane Wartel, Céline Brochier-Armanet, Tam Mignot

Nature Reviews Microbiology . 13 ( 5 ) : 318--326

DOI: 10.1038/nrmicro3431

Journal article

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The two-domain tree of life is linked to a new root for the Archaea

Kasie Raymann, Céline Brochier-Armanet, Simonetta Gribaldo

Proceedings of the National Academy of Sciences of the United States of America . 112 : 6670-6675

DOI: 10.1073/pnas.1420858112

Journal article

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The Prediction and Validation of Small CDSs Expand the Gene Repertoire of the Smallest Known Eukaryotic Genomes

Abdel Belkorchia, Cyrielle Gasc, Valérie Polonais, Nicolas Parisot, Nicolas Gallois, Céline Ribière...

PLoS ONE . 10 ( 9 ) : 1-12

DOI: 10.1371/journal.pone.0139075

Journal article

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Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome

R. A. Wiberg, D. L. Halligan, R. W. Ness, A. Necsulea, H. Kaessmann, P. D. Keightley

Genome Biology and Evolution . 7 : 2432-44

DOI: 10.1093/gbe/evv155

Journal article

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Probabilistic models of eukaryotic evolution: time for integration

Nicolas Lartillot

Philosophical Transactions of the Royal Society B: Biological Sciences . 370 ( 1678 ) : 20140338

DOI: 10.1098/rstb.2014.0338

Journal article

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Genomic data do not support comb jellies as the sister group to all other animals

Davide Pisani, Walker Pett, Martin Dohrmann, Roberto Feuda, Omar Rota Stabelli, Herve Philippe...

Proceedings of the National Academy of Sciences of the United States of America . 112 ( 50 ) : 15402-15407

DOI: 10.1073/pnas.1518127112

Journal article

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Toward more accurate ancestral protein genotype-phenotype reconstructions with the use of species tree-aware gene trees

M. Groussin, J. K. Hobbs, G. J. Szollosi, S. Gribaldo, V. L. Arcus, Manolo Gouy

Molecular Biology and Evolution . 32 : 13-22

DOI: 10.1093/molbev/msu305

Journal article

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Occurrence of a non deleterious gene conversion event in the BRCA1 gene

C. Tessereau, M. Leone, M. Buisson, L. Duret, O. M. Sinilnikova, S. Mazoyer

Genes, Chromosomes & Cancer . 54 : 646-52

DOI: 10.1002/gcc.22278

Journal article

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Prévalence et diversité des éléments intégratifs conjugatifs et mobilisables chez les streptocoques

Charles Coluzzi

: 70

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Human genetic data reveal contrasting demographic patterns between sedentary and nomadic populations that predate the emergence of farming

Carla Aimé, Guillaume Laval, Etienne Patin, Paul Verdu, Laure Ségurel, Raphaëlle Chaix...

European Journal of Human Genetics . 22 ( 10 ) : 1201-1207

DOI: 10.1093/molbev/mst156

Journal article

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Estimation of the RNU2 macrosatellite mutation rate by BRCA1 mutation tracing

C. Tessereau, Yann Lesecque, N. Monnet, M. Buisson, L. Barjhoux, M. Leone...

Nucleic Acids Research . 42 ( 14 ) : 9121-30

DOI: 10.1093/nar/gku639

Journal article

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Tracing Pastoralist Migrations to Southern Africa with Lactase Persistence Alleles

Enrico Macholdt, Vera Lede, Chiara Barbieri, Sununguko Mpoloka, Hua Chen, Montgomery Slatkin...

Current Biology . 24 ( 8 ) : 875-879

DOI: 10.1016/j.cub.2014.03.027

Journal article

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Ancient west Eurasian ancestry in southern and eastern Africa

Joseph Pickrell, Nick Patterson, Po-Ru Loh, Mark Lipson, Bonnie Berger, Mark Stoneking...

Proceedings of the National Academy of Sciences of the United States of America . 111 ( 7 ) : 2632-2637

DOI: 10.1073/pnas.1313787111

Journal article

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Unraveling the complex maternal history of southern African Khoisan populations

Chiara Barbieri, Tom Güldemann, Linda Gerlach, Falko Berthold, Hirosi Nakagawa, Sununguko Mpoloka...

American Journal of Physical Anthropology . 153 ( 3 ) : 435-448

DOI: 10.1002/ajpa.22441

Journal article

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New insights into the history of the C-14010 lactase persistence variant in Eastern and Southern Africa

Enrico Macholdt, Montgomery Slatkin, Brigitte Pakendorf, Mark Stoneking

American Journal of Physical Anthropology . 156 ( 4 ) : 661-664

DOI: 10.1002/ajpa.22675

Journal article

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