Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 601 to 630 publications on 1006 in total

Metagenome Annotation Using a Distributed Grid of Undergraduate Students

P. Hingamp, Céline Brochier-Armanet, E. Talla, D. Gautheret, D. Thieffry, C. Herrmann

PLoS Biology . 6 : 239-241

Journal article

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Full molecular characterization of a simian immunodeficiency virus, SIVwrcpbt from Temminck's red colobus (Piliocolobus badius temminckii) from Abuko Nature Reserve, The Gambia

Sabrina Locatelli, Bénédicte Lafay, Florian Liegeois, Nelson Ting, Eric Delaporte, Martine Peeters

Virology . 376 ( 1 ) : 90-100

DOI: 10.1016/j.virol.2008.01.049

Journal article

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Prevalence and genetic diversity of simian immunodeficiency virus infection in wild-living red colobus monkeys (Piliocolobus badius badius) from the Taï forest, Côte d'Ivoire SIVwrc in wild-living western red colobus monkeys.

Sabrina Locatelli, Florian Liegeois, Bénédicte Lafay, Amy D Roeder, Michael W Bruford, Pierre Formenty...

Infection, Genetics and Evolution . 8 ( 1 ) : 1-14

DOI: 10.1016/j.meegid.2007.08.004

Journal article

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A Site- and Time-Heterogeneous Model of Amino Acid Replacement

Samuel Blanquart, Nicolas Lartillot

Molecular Biology and Evolution . 25 ( 5 ) : 842-858

DOI: 10.1093/molbev/msn018

Journal article

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Etude des patrons d'évolution asymétrique dans les séquences d'ADN

Anamaria Necsulea

Thesis

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Additional molecular support for the new chordate phylogeny.

Frédéric Delsuc, Georgia Tsagkogeorga, Nicolas Lartillot, Herve Philippe

Genesis - The Journal of Genetics and Development . 46 ( 11 ) : 592-604

DOI: 10.1002/dvg.20450

Journal article

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Parallel Adaptations to High Temperatures in the Archean Eon

Bastien Boussau, Samuel Blanquart, Anamaria Necsulea, Nicolas Lartillot, Manolo Gouy

Nature . 456 ( 7224 ) : 942-945

DOI: 10.1038/nature07393

Journal article

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Analyse et exploitation de la diversité génétique des polykétides synthases de type I dans l'ADN metagénomique d'un sol

Aurélien Ginolhac, Sandrine Demanèche, Cyrille Jarrin, Patrick Robe, Fabrice Lefevre, Renaud Nalin...

7ème colloque national "Ressources génétiques" . : 201-213

Conference paper

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Genome-wide studies highlight indirect links between human replication origins and gene regulation.

Jean-Charles Cadoret, Françoise Meisch, Vahideh Hassan-Zadeh, Isabelle Luyten, Claire Guillet, L. Duret...

Proceedings of the National Academy of Sciences of the United States of America . 105 ( 41 ) : 15837-42

DOI: 10.1073/pnas.0805208105

Journal article

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Evolution of the proteome of mitochondrial ribosomes: a clue for the eukaryotic tree?

Elie Desmond-Le Quéméner, Celine Brochier-Armanet, Patrick Forterre, Simonetta Gribaldo

Journées Ouvertes Biologie Informatique et Mathématiques JOBIM .

Poster

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Population genetic inference using a fixed number of segregating sites : a reassessment

S.E. Ramos-Onsins, Sylvain Mousset, T. Mitchell-Olds, W. Stephan

Genetical Research . 89 : 231-244

Journal article

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A melanocortin 1 receptor allele suggests varying pigmentation among neanderthals

Carles Lalueza-Fox, Holger Römpler, David Caramelli, Claudia Stäubert, Giulio Catalano, David Hughes...

DOI: 10.1126/science.1147417

Other publication

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A melanocortin 1 receptor allele suggests varying pigmentation among neanderthals

C. Lalueza-Fox, H. Rompler, D. Caramelli, C. Staubert, G. Catalano, D. Hughes...

DOI: 10.1126/science.1147417

Other publication

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In search of polymorphic Alu insertions with restricted geographic distributions

R. Cordaux, D. Srikanta, J. R. Lee, M. Stoneking, M.A. Batzer

Genomics . 90 : 154-158

DOI: 10.1016/j.ygeno.2007.03.010

Journal article

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Mating patterns amongst Siberian reindeer herders: Inferences from mtDNA and Y-chromosomal analyses

Brigitte Pakendorf, Innokentij Novgorodov, Vladimir Osakovskij, Mark Stoneking

American Journal of Physical Anthropology . 133 ( 3 ) : 1013-1027

DOI: 10.1002/ajpa.20590

Journal article

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Unexpected observations after mapping LongSAGE tags to the human genome

C. Keime, M. Sémon, Dominique Mouchiroud, L. Duret, Olivier Gandrillon

BMC Bioinformatics . 8 : 1-11

Journal article

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Identification of Mycobacterium using the EF-Tu encoding (tuf) gene and the tmRNA encoding (ssrA) gene

S. Mignard, J.-P. Flandrois

Journal of Medical Microbiology . 56 ( 8 ) : 1033-1041

DOI: 10.1099/jmm.0.47105-0

Journal article

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In vitro detection of the enzymatic activity of folate-dependent tRNA(U54 C5)methyltransferase

J. Urbonavicius, Céline Brochier-Armanet, S. Skouloubris, H. Myllykallio, H. Grosjean

Methods in Enzymology . 25 : 103-19

Journal article

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In vitro detection of the enzymatic activity of folate-dependent tRNA (Uracil-54,-C5)-methyltransferase: evolutionary implications.

Jaunius Urbonavicius, Céline Brochier-Armanet, Stéphane Skouloubris, Hannu Myllykallio, Henri Grosjean

Methods in Enzymology . 425 : 103-19

DOI: 10.1016/S0076-6879(07)25004-9

Journal article

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Comparative RNomics and modomics in mollicutes: prediction of gene function and evolutionary implications

V. de Crécy-Lagard, C. Marck, Céline Brochier-Armanet, H. Grosjean

IUBMB Life . 59 : 634-58

Journal article

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A General Comparison of Relaxed Molecular Clock Models

Thomas Lepage, David Bryant, Herve Philippe, Nicolas Lartillot

Molecular Biology and Evolution . 24 ( 12 ) : 2669-2680

DOI: 10.1093/molbev/msm193

Journal article

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Exploring Fast Computational Strategies for Probabilistic Phylogenetic analysis

Nicolas Rodrigue, Herve Philippe, Nicolas Lartillot

Systematic Biology . 56 : 711-726

DOI: 10.1080/10635150701611258

Journal article

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A New Method for Assessing the Effect of Replication on DNA Base Composition Asymmetry

A. Necşulea, J.R. Lobry

Molecular Biology and Evolution . 24 : 2169-2179

Journal article

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Influence of the transposable element neighborhood on human gene expression in normal and tumor tissues

E. Lerat, M. Sémon

Gene . 396 : 303-311

Journal article

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Horizontal Gene Transfer Regulation in Bacteria as a ‘‘Spandrel'' of DNA Repair Mechanisms

Saliou Fall, Anne Mercier, Franck Bertolla, Alexandra Calteau, Laurent Gueguen, Guy Perrière...

PLoS ONE . 2 ( 10 ) : e1055-e1066

DOI: 10.1371/journal.pone.0001055

Journal article

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Adaptation or biased gene conversion? Extending the null hypothesis of molecular evolution

Nicolas Galtier, L. Duret

Trends in Genetics . 23 ( 6 ) : 273-277

DOI: 10.1016/j.tig.2007.03.011

Journal article

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Unexpected observations after mapping LongSAGE tags to the human genome.

Céline Keime, Marie Sémon, Dominique Mouchiroud, Laurent Duret, Olivier Gandrillon

BMC Bioinformatics . 8 : 154

DOI: 10.1186/1471-2105-8-154

Journal article

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Integrating transcription factor binding site information with gene expression datasets

I.B. Jeffery, S.F. Madden, P.A. Mcgettigan, G. Perrière, A.C. Culhane, D.G. Higgins

Bioinformatics . 23 : 298-305

Journal article

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An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro.

Arnaud Hecker, Nicolas Leulliot, Danièle Gadelle, Marc Graille, Anthony Justome, Pierre Dorlet...

Nucleic Acids Research . 35 ( 18 ) : 6042-51

DOI: 10.1093/nar/gkm554

Journal article

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