Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 601 to 630 publications on 1110 in total

SeaView Version 4: a Multiplatform Graphical User Interface for Sequence Alignment and Phylogenetic Tree Building

Manolo Gouy, Stéphane Guindon, Olivier Gascuel

Molecular Biology and Evolution . 27 : 221-224

DOI: 10.1093/molbev/msp259

Journal article

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The origin of eukaryotes and their relationship with the Archaea: are we at a phylogenomic impasse?

Simonetta Gribaldo, Anthony M. Poole, Vincent Daubin, Patrick Forterre, C. Brochier-Armanet

Nature Reviews Microbiology . 8 ( 10 ) : 743-753

DOI: 10.1038/nrmicro2426

Journal article

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Distinct gene set in two different lineages of ammoniaoxidizing archaea supports the phylum Thaumarchaeota

A. Spang, R. Hatzenpichler, Céline Brochier-Armanet, T. Rattei, P. Tischler, E. Spieck...

Trends Microbiol . 18(8) : 331-40

Journal article

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Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea

C.B. Walker, J.R. La Torre, M.G. Klotz, H. Urakawa, N. Pinel, D.J. Arp...

Proceedings of the National Academy of Sciences of the United States of America . 107 ( 19 ) : 8818-23

DOI: 10.1073/pnas.0913533107

Journal article

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Structure, function, and evolution of the Thiomonas spp. genome.

Florence Arsène-Ploetze, Sandrine Koechler, Marie Marchal, Jean-Yves Coppée, Michael Chandler, Violaine Bonnefoy...

PLoS Genetics . 6 ( 2 ) : e1000859

DOI: 10.1371/journal.pgen.1000859

Journal article

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RECONSTRUCTING ORIGINS OF LOSS OF SELF-INCOMPATIBILITY AND SELFING IN NORTH AMERICAN ARABIDOPSIS LYRATA: A POPULATION GENETIC CONTEXT

John Paul Foxe, Marc Stift, Andrew Tedder, Annabelle A. Haudry, Stephen Wright, Barbara Mable

Evolution - International Journal of Organic Evolution . 64 ( 12 ) : 3495 - 3510

DOI: 10.1111/j.1558-5646.2010.01094.x

Journal article

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Reconstructing origins of loss of self-incompatibility and selfing in North American Arabidopsis lyrata: a population genetic context

John Paul Foxe, Marc Stift, Andrew Tedder, Annabelle A. Haudry, Stephen Wright, Barbara Mable

Evolution - International Journal of Organic Evolution . 64 : 3495-3510

DOI: 10.1111/j.1558-5646.2010.01094.x

Journal article

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A Phylogenetic Model for Investigating Correlated Evolution of Substitution Rates and Continuous Phenotypic Characters

Nicolas Lartillot, Raphaël Poujol

Molecular Biology and Evolution . 28 ( 1 ) : 729 - 744

DOI: 10.1093/molbev/msq244

Journal article

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A Dirichlet Process Covarion Mixture Model and Its Assessments Using Posterior Predictive Discrepancy Tests

Yan Zhou, Henner Brinkmann, Nicolas Rodrigue, Nicolas Lartillot, Herve Philippe

Molecular Biology and Evolution . 27 ( 2 ) : 371-384

DOI: 10.1093/molbev/msp248

Journal article

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Proposals for classification methods dedicated to biological data

Anne-Muriel Arigon Chifolleau, Guy Perrière, Manolo Gouy

International Journal of Biomedical Engineering and Technology (IJBET) . 3 ( 1/2 ) : 4-21

DOI: 10.1504/IJBET.2010.029649

Journal article

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Specialization of a Drosophila capping protein essential for the protection of sperm telomeres.

Raphaëlle Dubruille, Guillermo A Orsi, Lætitia Delabaere, Elisabeth Cortier, Pierre Couble, Gabriel A.B. Marais...

Current Biology . 20 ( 23 ) : 2090-9

DOI: 10.1016/j.cub.2010.11.013

Journal article

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Can Intra-Y Gene Conversion Oppose the Degeneration of the Human Y Chromosome? A Simulation Study

Gabriel Marais, P.R.A. Campos, I. Gordo

Genome Biology and Evolution . 2 : 347-357

Journal article

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Structure and evolution of Apetala3 a sex-linked gene in Silene latifolia

R. Cegan, Gabriel Marais, H. Kubekova, N. Blavet, A. Widmer, B. Vyskot...

BMC Plant Biology . 10 : 1-10

Journal article

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Chromosomal Redistribution of Male-Biased Genes in Mammalian Evolution with Two Bursts of Gene Gain on the X Chromosome

Y.E. Zhang, M.D. Vibranovski, P. Landback, Gabriel Marais, M. Long

PLoS Biology . 8 ( 10 ) : 1-13

DOI: 10.1371/journal.pbio.1000494

Journal article

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Specialization of a Drosophila Capping Protein Essential for the Protection of Sperm Telomeres

R. Dubruille, G.A. Orsi, L. Delabaere, E. Cortier, P. Couble, Gabriel Marais...

Current Biology . 20 : 1-10

DOI: 10.1016/j.cub.2010.11.013

Journal article

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The relationship among gene expression, the evolution of gene dosage, and the rate of protein evolution

Jean-François Gout, Daniel Kahn, Laurent Duret

PLoS Genetics . 6 ( 5 ) : e1000944

DOI: 10.1371/journal.pgen.1000944

Journal article

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Evolution of the ribosome: testing eukaryotic origins

Elie Desmond-Le Quéméner, Celine Brochier-Armanet, Patrick Forterre, Simonetta Gribaldo

Archaea and the tree of life .

Conference paper

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Genetic Admixture History of Eastern Indonesia as Revealed by Y-Chromosome and Mitochondrial DNA Analysis

S. Mona, K. Grunz, S. Brauer, Brigitte Pakendorf, L. Castri, H. Sudoyo...

Molecular Biology and Evolution . 26 ( 8 ) : 1865-1877

DOI: 10.1093/molbev/msp097

Journal article

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Genetic diversity and the emergence of ethnic groups in Central Asia

Evelyne Heyer, Patricia Balaresque, Mark Jobling, Lluis Quintana-Murci, Raphaelle Chaix, Laure Segurel...

BMC Genetics . 10 ( 1 ) : 49

DOI: 10.1186/1471-2156-10-49

Journal article

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Mutation Patterns in the Human Genome:More Variable Than Expected

L. Duret

PLoS Biology . 7(2) e1000028 : 803-806

Journal article

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Monoallelic expression and tissue specificity are associated with high crossover rates

A. Necşulea, M. Sémon, L. Duret, L.D. Hurst

Trends in Genetics . 25(12) : 519-522

Journal article

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GC-biased gene conversion promotes the fixation of deleterious amino acid changes in primates

N. Galtier, L. Duret, S. Glémin, Vincent Ranwez

Trends in Genetics . 25(1) : 1-5

Journal article

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A Mixture Model and a Hidden Markov Model to Simultaneously Detect Recombination Breakpoints and Reconstruct Phylogenies

Bastien Boussau, Laurent Guéguen, Manolo Gouy

Evolutionary Bioinformatics . 5 : 67-79

DOI: 10.4137/EBO.S2242

Journal article

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Phylogeny of prokaryotes: does it exist and why should we care?

Simonetta Gribaldo, Céline Brochier-Armanet

Research in Microbiology . 160 : 513-21

Journal article

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Happy together: genomic insights into the unique Nanoarchaeum/Ignicoccus association.

Patrick Forterre, Simonetta Gribaldo, Céline Brochier-Armanet

Journal of Biology . 8 ( 1 ) : 7

DOI: 10.1186/jbiol110

Journal article

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Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila

M. Fablet, E. Lerat, R. Rebollo, B. Horard, N. Burlet, S. Martinez...

FASEB Journal . 23 : 54-62

Journal article

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Infra- and Transspecific Clues to Understanding the Dynamics of Transposable Elements

Cristina Vieira, M. Fablet, E. Lerat

genome dyn stab . -- : 115-123

Journal article

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Identification of expressed transposable element insertions in the sequenced genome of Drosophila melanogaster

M. Deloger, F.M.G. Cavalli, E. Lerat, C. Biémont, M.-F. Sagot, Cristina Vieira

Gene . 439 : 55-62

Journal article

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Identifying repeats and transposable elements in sequenced genomes: how to find your way through the dense forest of programs

E. Lerat

Heredity . -- : 1-14

Journal article

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