Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 631 to 660 publications on 1098 in total

The evolutionary dynamics of the Helena retrotransposon revealed by sequenced Drosophila genomes.

Adriana Granzotto, Fabrício R Lopes, Emmanuelle Lerat, Cristina Vieira, Claudia M A Carareto

BMC Evolutionary Biology . 9 : 174

DOI: 10.1186/1471-2148-9-174

Journal article

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Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance.

Jacques Oberto, Norman Breuil, Arnaud Hecker, Francesca Farina, Céline Brochier-Armanet, Emmanuel Culetto...

Nucleic Acids Research . : epub ahead of print

DOI: 10.1093/nar/gkp557

Journal article

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Computational Methods for Evaluating Phylogenetic Models of Coding Sequence Evolution with Dependence between Codons

Nicolas Rodrigue, Claudia L Kleinman, Hervé Philippe, Nicolas Lartillot

Molecular Biology and Evolution . 26 ( 7 ) : 1663 - 1676

DOI: 10.1093/molbev/msp078

Journal article

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In Retrospect: Lamarck's treatise at 200

Dan Graur, Manolo Gouy, David Wool

Nature . 460 ( 7256 ) : 688-689

DOI: 10.1038/460688a

Journal article

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A White Campion textit(Silene latifolia) floral expressed sequence tag (EST) library: annotation EST-SSR characterization transferability and utility for comparative mapping

Md. Moccia, C. Oger-Desfeux, Gabriel Marais, A. Widmer

BMC Genomics . 10(243) : 1-14

Journal article

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Silene as a model system in ecology and evolution

G. Bernasconi, J. Antonovics, A. Biere, D. Charlesworth, Lf. Delph, D. Filatov...

Heredity . 103 : 583-589

Journal article

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Differential retention of metabolic genes following whole-genome duplication

Jean-François Gout, Laurent Duret, Daniel Kahn

Molecular Biology and Evolution . 26 ( 5 ) : 1067-1072

DOI: 10.1093/molbev/msp026

Journal article

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Databases of Homologous Gene Families for Comparative Genomics

Simon Penel, Anne-Muriel Arigon Chifolleau, Jean-François Dufayard, Anne-Sophie Sertier, Vincent Daubin, L. Duret...

BMC Bioinformatics . 10 (Suppl.6) :S3 : 13

DOI: 10.1186/1471-2105-10-S6-S3

Journal article

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Evolution of the mitochondrial ribosomal proteome

Elie Desmond-Le Quéméner, Celine Brochier-Armanet, Patrick Forterre, Simonetta Gribaldo

16th Annual Meeting of the Society of Molecular Biology and Evolution (SMBE'08) .

Poster

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Dynamic nature of the proximal AZFc region of the human Y chromosome: multiple independent deletion and duplication events revealed by microsatellite analysis.

Patricia Balaresque, Georgina Bowden, Emma Parkin, Ghada Omran, Evelyne Heyer, Lluis Quintana-Murci...

Human Mutation . 29 ( 10 ) : 1171-80

DOI: 10.1002/humu.20757

Journal article

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Transcription-Induced Mutational Strand Bias and Its Effect on Substitution Rates in Human Genes

Carina Mugal, Hans-Hennig von Grunberg, Martin Peifer

Molecular Biology and Evolution . 26 ( 1 ) : 131-142

DOI: 10.1093/molbev/msn245

Journal article

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Sex-specific genetic structure and social organization in Central Asia: insights from a multi-locus study.

Laure Ségurel, Begoña Martínez-Cruz, Lluis Quintana-Murci, Patricia Balaresque, Myriam Georges, Tatiana Hegay...

PLoS Genetics . 4 ( 9 ) : e1000200

DOI: 10.1371/journal.pgen.1000200

Journal article

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ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in Ribosome biogenesis.

Yohann Couté, Karine Kindbeiter, Stéphane Belin, Régis Dieckmann, L. Duret, Laurent Bezin...

Molecular and Cellular Proteomics . 7 : epub ahead of print

DOI: 10.1074/mcp.M700510-MCP200

Journal article

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Translational control of intron splicing in eukaryotes

Olivier Jaillon, Khaled Bouhouche, Jean-François Gout, Jean-Marc Aury, Benjamin Noel, Baptiste Saudemont...

Nature . 451 ( 7176 ) : 359-362

DOI: 10.1038/nature06495

Journal article

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Biased Gene Conversion and its Impact on Human Genome Evolution

N. Galtier, L. Duret

incollection . -- : 273-277

Journal article

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Polymorphism of the Staphylococcus aureus Panton-Valentine LeukocidinGenes and Its Possible Link with the Fitness of Community-Associated Methicillin-Resistant S. aureus

O. Dumitrescu, A. Tristan, H. Meugnier, M. Bes, Manolo Gouy, J. Etienne...

Journal of Infectious Diseases . 198 ( 5 ) : 792-794

DOI: 10.1086/590914

Journal article

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Acquisition of a bacterial RumA-type tRNA(uracil-54 C5)methyltransferase by Archaea through an ancient horizontal gene transfer

J. Urbonavicius, S. Auxilien, H. Walbott, K. Trachana, B. Golinelli-Pimpaneau, Céline Brochier-Armanet...

Molecular Microbiology . 67 : 323-335

Journal article

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Giant viruses giant chimeras: The multiple evolutionary histories of Mimivirus genes

D. Moreira, Céline Brochier-Armanet

BMC Evolutionary Biology . 8 : 1-7

Journal article

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Acquisition of a bacterial RumA-type tRNA(uracil-54, C5)-methyltransferase by Archaea through an ancient horizontal gene transfer.

Jaunius Urbonavicius, Sylvie Auxilien, Hélène Walbott, Kalliopi Trachana, Béatrice Golinelli-Pimpaneau, Céline Brochier-Armanet...

Molecular Microbiology . 67 ( 2 ) : 323-35

DOI: 10.1111/j.1365-2958.2007.06047.x

Journal article

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Exploring the FL-160-CRP gene family through sequence variability of the complement regulatory protein (CRP) expressed by the trypomastigote stage of Trypanosoma cruzi.

Françoise Mathieu-Daudé, Bénédicte Lafay, Olivia Touzet, Joël Lelièvre, Favio Parrado, Marie-France Bosseno...

Infection, Genetics and Evolution . 8 ( 3 ) : 258-66

DOI: 10.1016/j.meegid.2007.12.010

Journal article

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Quantitative predictions for DNA two-dimensional display according to size and nucleotide sequence composition

Jean-François Mercier, Christine Kingsburry, Gary W. Slater, Bénédicte Lafay

Electrophoresis . 29 ( 6 ) : 1264 - 1272

DOI: 10.1002/elps.200700407

Journal article

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Phylogenetic Mixture Models for Proteins

Quang Le Si, Nicolas Lartillot, Olivier Gascuel

Philosophical Transactions of the Royal Society B: Biological Sciences . 363 : 3965-3976

DOI: 10.1098/rstb.2008.0180

Journal article

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Bayesian computation for statistical models with intractable normalizing constants

Yves Atchade, Nicolas Lartillot, Christian Robert

Preprint

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Improvement of Molecular Phylogenetic Inference and the Phylogeny of Bilateria

Nicolas Lartillot, Herve Philippe

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1934–1990) . 363 ( 1496 ) : 1463-1472

DOI: 10.1098/rstb.2007.2236

Journal article

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Uniformization for Sampling Realizations of Markov Processes: Applications to Bayesian Implementations of Codon Substitution Models

Nicolas Rodrigue, Herve Philippe, Nicolas Lartillot

Bioinformatics . 24 ( 1 ) : 56-62

DOI: 10.1093/bioinformatics/btm532

Journal article

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Etude des patrons d`évolution asymétrique dans les séquences d`ADN

A. Necşulea

incollection . -- : 476-482

Journal article

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Losing helena: The extinction of a drosophila line-like element

Rita Rebollo, Emmanuelle Lerat, Liliana Lopez Kleine, Christian Biémont, Cristina Vieira

BMC Genomics . 9 : 1-11

DOI: 10.1186/1471-2164-9-149

Journal article

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