Bioinformatics, Phylogeny and Evolutionary Genomics Group

Members

Our group focuses on two main axes: phylogenomics (i.e. the inference of evolutionary history based on genomics data) and evolutionary genomics (understanding the molecular and population processes that drive genome evolution). We see genomes both as a subject of research (how do genomes evolve, why are they structured the way they are?), but also as a main source of empirical knowledge about the macroevolutionary patterns (what do they tell us about the history of life on Earth?), or about the phenotypes and life-history strategies of organisms. Our works heavily rely on methodological developments (bioinformatics, modeling and statistical inference).

Evolution of genome architecture and expression

Genomes are the result of a long-term evolutionary process, shaped by multiple evolutionary forces. Some genomic features are adaptive (i.e. are beneficial for the fitness of organisms), others result from non-adaptive processes (random drift and biased gene conversion - BGC) or are caused by conflicts between multiple levels of selection (e.g. meiotic drive or the spread of selfish genetic elements). We explore different aspects of genome architecture (base composition landscapes, genome structure and size, impact of transposable elements, …) or functioning (gene expression, lncRNAs, epigenetic landscapes, …), and try to disentangle the relative contribution of adaptive and non-adaptive processes to their evolution. For this purpose, we consider both the molecular mechanisms (mutation, repair, recombination) and the population processes (selection, drift, BGC, …) that shape genetic variation.

Phylogenomics

We are interested in reconstructing the history of life on Earth. This research unfolds along several axes. First, we develop phylogenomic databases of aligned genetic sequences (e.g. BIBI, RiboDB or HOGENOM). Second, we conduct methodological research on how to accurately reconstruct deep phylogenies, infer divergence times, reconstruct ancestral genetic sequences, gene repertoires and life-history traits. This methodological work is translated into publicly available software programs (e.g. SeaView, PhyloBayes, Coevol). Finally, we apply these approaches to several important problems, among which: reconstructing the phylogeny of animals, of archaea, or the global tree of life; using phylogenies and ancestral gene repertoires to investigate the evolution of complex systems and the emergence of molecular and cellular functions in the three domains of life; reconstructing ancestral genetic sequences, a research activity that has industrial and biotechnological applications.

Teaching and outreach

We teach at University Lyon 1 (Master Bioinfo@Lyon), INSA, ENS Lyon, we organize bioinformatics internships. We regularly give conferences on evolution (tree of life, human evolution, genetic diversity, …).
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.
 
Keywords: Molecular evolution and Population Genomics; Phylogenomics; Computational Genomics; Comparative genomics; Bioinformatics; Statistical inference.

Publications

Display of 661 to 690 publications on 1006 in total

Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia.

Jean-Marc Aury, Olivier Jaillon, L. Duret, Benjamin Noel, Claire Jubin, Betina M Porcel...

Nature . 444 ( 7116 ) : 171-8

DOI: 10.1038/nature05230

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The GC Content of Primates and Rodents Genomes Is Not at Equilibrium : a Reply to Antezana

L. Duret

Journal of Molecular Evolution . -- : 803-806

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The Xist RNA Gene Evolved in Eutherians by Pseudogenization of a Protein-Coding Gene

L. Duret, C. Chureau, S. Samain, J. Weissenbach, P. Avner

Science . 312 : 1653-1655

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Evolutionary origin and maintenance of coexpressed gene clusters in mammals.

M. Sémon, L. Duret

Molecular Biology and Evolution . 23 : 1715-1723

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Physiological oxygenation status is required for fully differentiated phenotype in kidney cortex proximal tubules.

Elodie de Laplanche, Karine Gouget, Guilhem Cléris, Franck Dragounoff, Jocelyne Demont, Anne Morales...

AJP Renal Physiology . 291 ( 4 ) : F750-60

DOI: 10.1152/ajprenal.00022.2006

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HoSeql : automated homologous sequence identification in gene family databases

Anne-Muriel Arigon Chifolleau, G. Perrière, Manolo Gouy

Bioinformatics . 22 ( 14 ) : 1786-1787

DOI: 10.1093/bioinformatics/btl179

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Relationship between morphological taxonomy and molecular divergence within Crustacea : Proposal of a molecular threshold to help species delimitation

T. Lefébure, C.J. Douady, Manolo Gouy, J. Gibert

Molecular Phylogenetics and Evolution . 40 ( 2 ) : 435-447

DOI: 10.1016/j.ympev.2006.03.014

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Use of PCR-Restriction Enzyme Pattern Analysis and Sequencing Database for hsp65 Gene-Based Identification of Nocardia Species

V. Rodriguez-Nava, A. Couble, G. Devulder, Jean-Pierre Flandrois, P. Boiron, F. Laurent

Journal of Clinical Microbiology . 44 ( 2 ) : 536-546

DOI: 10.1128/JCM.44.2.536-546.2006

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16S rRNA sequencing in routine bacterial identification : A 30-month experiment

S. Mignard, Jean-Pierre Flandrois

Journal of Microbiological Methods . 67 : 574-581

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Rapid identification of Enterobacteriaceae by sequencing DNA gyrase subunit B encoding gene

J. Delmas, F. Breysse, G. Devulder, Jean-Pierre Flandrois, M. Chomarat

Diagnostic Microbiology and Infectious Disease . 55 : 263-268

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The origin and evolution of Archaea: a state of the art

Simonetta Gribaldo, Céline Brochier-Armanet

Philos Trans R Soc Lond B Biol Sci . 361 : 1007-22

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A Bayesian Compound Stochastic Process for Modeling Nonstationary and Nonhomogeneous Sequence Evolution

Samuel Blanquart, Nicolas Lartillot

Molecular Biology and Evolution . 23 ( 11 ) : 2058-2071

DOI: 10.1093/molbev/msl091

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Assessing Site-Interdependent Phylogenetic Models of Sequence Evolution

Nicolas Rodrigue, Herve Philippe, Nicolas Lartillot

Molecular Biology and Evolution . 23 ( 9 ) : 1762-1775

DOI: 10.1093/molbev/msl041

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Synonymous codon usage and its potential link with optimal growth temperature in prokaryotes.

J.R. Lobry, A. Necşulea

Gene . 385 : 128-136

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Revisiting the directionnal mutation pressure theory : The analysis of a particular genomic structure in Leishmania major

A. Necşulea, J.R. Lobry

Gene . 385 : 28-40

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Trypanosoma cruzi: sequence analysis of the variable region of kinetoplast minicircles

Jenny Telleria, Bénédicte Lafay, Myrna Virreira, Christian Barnabé, Michel Tibayrenc, Michal Svoboda

Experimental Parasitology . 114 ( 4 ) : 279-88

DOI: 10.1016/j.exppara.2006.04.005

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Recent Origin and Cultural Reversion of a Hunter–Gatherer Group

Hiroki Oota, Brigitte Pakendorf, Günter Weiss, Arndt von Haeseler, Surin Pookajorn, Wannapa Settheetham-Ishida...

PLoS Biology . 3 ( 3 ) : e71

DOI: 10.1371/journal.pbio.0030071

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Tree pattern matching in phylogenetic trees: automatic search for orthologs or paralogs in homologous gene sequence databases.

Jean-François Dufayard, L. Duret, Simon Penel, Manolo Gouy, F. Rechenmann, G. Perrière

Bioinformatics . 21 ( 11 ) : 2596-603

DOI: 10.1093/bioinformatics/bti325

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Integr8 and Genome Reviews: integrated views of complete genomes and proteomes.

P. Kersey, L. Bower, L. Morris, A. Horne, R. Petryszak, C. Kanz...

Nucleic Acids Research . 33 ( Database issue ) : D297-302

DOI: 10.1093/nar/gki039

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Homology-dependent methylation in primate repetitive DNA.

J. Meunier, A. Khelifi, V. Navratil, L. Duret

Proceedings of the National Academy of Sciences of the United States of America . 102 ( 15 ) : 5471-6

DOI: 10.1073/pnas.0408986102

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Natural history of the ERVWE1 endogenous retroviral locus

B. Bonnaud, J. Beliaeff, O. Bouton, G. Oriol, L. Duret, Frédéric Mallet

Retrovirology . 2 : 1-7

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Relationship between gene expression and GC-content in mammals: statistical significance and biological relevance

M. Sémon, Dominique Mouchiroud, L. Duret

Human Molecular Genetics . 14 : 421-427

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HOPPSIGEN: a database of human and mouse processed pseudogenes.

A. Khelifi, L. Duret, Dominique Mouchiroud

Nucleic Acids Research . 33 ( Database issue ) : D59-66

DOI: 10.1093/nar/gki084

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Phylogenomics of Life-Or-Death Switches in Multicellular Animals: Bcl-2, BH3-Only, and BNip Families of Apoptotic Regulators

A. Aouacheria, F. Brunet, Manolo Gouy

Molecular Biology and Evolution . 22 ( 12 ) : 2395-2416

DOI: 10.1093/molbev/msi234

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[From prevalence to predictive values: considerations on the antimicrobial susceptibility testing dealing with change of susceptibility rates].

Jean-Pierre Flandrois, B Lamy, G. Carret, M Delignette-Muller

Annales de Biologie Clinique . 63 ( 5 ) : 493-502

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A multigene approach to phylogenetic analysis using the genus Mycobacterium as a model

G. Devulder, M. Perouse de Montclos, Jean-Pierre Flandrois

International Journal of Systematic and Evolutionary Microbiology . 55 : 293-302

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[Luca: the last universal common ancestor]

Patrick Forterre, Simonetta Gribaldo, Céline Brochier

Médecine/Sciences . 21 ( 10 ) : 860-5

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